AIM:To investigate any protective effect of early propranolol administration in the development of portal hypertensive gastropathy in cirrhotic rats. METHODS:For the development of liver cirrhosis and portal hypertens...AIM:To investigate any protective effect of early propranolol administration in the development of portal hypertensive gastropathy in cirrhotic rats. METHODS:For the development of liver cirrhosis and portal hypertensive gastropathy,60 rats underwent ligation of the left adrenal vein and complete devascularization of the left renal vein,followed by phenobarbital and carbon tetrachloride(CCl4) administration.After two weeks of CCl4 administration, the rats were randomly separated into two groups.In group A,propranolol was continuously administered intragastrically throughout the study,whereas in group B normal saline(placebo)was administered instead. Hemodynamic studies and vascular morphometric analysis of gastric sections were performed after complete induction of cirrhosis. RESULTS:Vascular morphometric studies showed higher numbers of vessels in all mucosal layers in the control group.Statistical analysis revealed a significantly higher total vascular surface in the control group compared to the propranolol group,but with no statistically significant difference between the mean vascular surfaces between the groups.Our study clearly shows that the increased mucosal blood flow is manifested by a marked increase of vessel count. CONCLUSION:Early propranolol's administration in portal hypertensive cirrhotic rats seems to prevent intense gastric vascular congestion that characterizes portal hypertensive gastropathy.展开更多
The process of double fertilization and the characters of embryo and endosperm development in an autotetraploid polyembryonic mutant rice IR36-Shuang were studied with a laser scanning confocal microscopy. Some abnorm...The process of double fertilization and the characters of embryo and endosperm development in an autotetraploid polyembryonic mutant rice IR36-Shuang were studied with a laser scanning confocal microscopy. Some abnormalities including degenerated ovary, abortive embryo sac, single fertilization, double-ovule and double-embryo and so on. were found dudng double fertilization and embryo development in IR36-Shuang. The rate of the abnormalities was 46.67% in IR36-Shuang, significantly higher than that in the control, an autotetraploid rice line IR36-4X （33.00%）. Cytological and embryonic evidences were provided for seed setting decline and the initiation of additional embryo in IR36-Shuang.展开更多
The Sichuan Basin, located in the western margin of Yangtze Plate, is one of the important oil-gas-bearing basins in China. During the Early Permian-Middle Triassic, the Sichuan Basin experienced regional lithospheric...The Sichuan Basin, located in the western margin of Yangtze Plate, is one of the important oil-gas-bearing basins in China. During the Early Permian-Middle Triassic, the Sichuan Basin experienced regional lithospheric extension and Emeishan basalt activities, both of which influenced the basin development and thermal evolution. Here we simulated the thermal effects of lithospheric extension and the Emeishan mantle plume based on different geodynamical models. Modeling results indicated that the lithospheric temperature together with the basement heat flow was generally increasing with time due to extension. As the stretching factor was relatively small, the thinning of lithosphere, and consequently the thermal disturbance, was not great. The lithospheric extension yielded about 20% increase of the basement heat flow, with maximum value of 60?62 mW m?2 in the Early Triassic. Mantle plume model shows that the thermal evolution of the inner zone above the plume head was influenced greatly by plume activity. But the outer zone and its outside area where the Sichuan Basin is located were affected only slightly. The basalts that had erupted in the southwestern basin might disturb the basin temperature significantly, although shortly and locally. Generally, the thermal history of the Sichuan basin during the Early Permian-Middle Triassic was controlled by the lithospheric extension, but locally it superimposed thermal effects of basalt activities in its southwestern area.展开更多
The early phases of the shock interaction process on two-dimensional interfaces with different shapes are numerically investigated in this study,which are closely related to the shock refraction and reflection,vortici...The early phases of the shock interaction process on two-dimensional interfaces with different shapes are numerically investigated in this study,which are closely related to the shock refraction and reflection,vorticity production and transport.The numerical method employs an adaptive unstructured quadrilateral mesh,which can capture the wave pattern and interface evolution very well.Simulations are carried out under the conditions of an incident shock Mach number of 1.2 and the light/heavy (air/SF 6) interface.Five different shapes are considered in the simulations:rectangle,ellipse,diamond and two kinds of triangle.The results show that the interfacial shapes can influence the wave patterns particularly on the shape and evolution of refracted shock waves.The generation and the distribution of vorticity on the interfaces with five different shapes also have dissimilarities.The circulation deposition on five interfaces is quantitatively investigated and compared with theoretical model.A good agreement is found between the numerical results and the predictions by the theoretical model.Some characteristic scales of the interface are tracked.Under the influence of nonlinear-acoustic effect and vorticity effect,the interfaces present different evolution modes.展开更多
As the interval following the biggest Phanerozoic mass extinction at the end of Permian, the Early Triassic is characterized by an immature, poorly functioned ecosystem.The effects of these extreme environmental condi...As the interval following the biggest Phanerozoic mass extinction at the end of Permian, the Early Triassic is characterized by an immature, poorly functioned ecosystem.The effects of these extreme environmental conditions can be mirrored by the changes in the δ13C record of marine carbonates.However, the details about the carbon isotopic composition and evolution of the Early Triassic seawater remain poorly understood.A dataset of new δ13C and δ18O values as well as selected major and trace element data (including concentrations of CaO, MgO, Mn, and Sr) was obtained from 113 marine carbonate samples collected in Eastern Sichuan Basin.The isotopic and elemental data are used to evaluate effects of thermochemical sulfate reduction on δ13C.The δ13C values of a few samples affected by thermochemical sulfate reduction were corrected.By combining carbonate δ13C results in our investigated sections, we constructed a composite curve of the Lower Triassic.The results reveal a δ13C anomaly of carbonate rocks throughout the Early Triassic, accompanied by some rapid jumps and falls, such as those from approximately -2‰ to the extremely high value of 8‰ within a period of about 5 Ma.The Early Triassic δ13C profile derived from Eastern Sichuan Basin shows a close correspondence with Guandao section in Guizhou Province, whereas it yields an excursion pattern differing from Chaohu section in Anhui Province of the Lower Yangtze region (with the δ13C value from the minimum around -6‰ to the maximum near 4‰).The higher δ13C values and the positive carbon isotope excursions in the Lower Triassic from Eastern Sichuan Basin were most likely a consequence of the principal environmental change that may include: (1) the barren land surface due to the absence of vegetation, (2) the loss of diverse marine invertebrate groups and marine carbonates, (3) the thriving of bacteria, algae and methanogenus in ocean ecosystems, and (4) the local effect of the repositories of isotopically light carbon occurred in the form of methane hydrates.This process ended at the Early-Middle Triassic boundary, which indicates that the biotic recovery started at the end of the Lower Triassic.The terrestrial vegetation and marine invertebrates, as the regulators for carbon cycle, are irreplaceable and demand strong protections.展开更多
In recent years the Lower Cretaceous red beds of southwestern China have yielded more than 20 significant dinosaur-dominated tracksites. More than half occur in the Jiaguan Formation with the remainder in the Feitians...In recent years the Lower Cretaceous red beds of southwestern China have yielded more than 20 significant dinosaur-dominated tracksites. More than half occur in the Jiaguan Formation with the remainder in the Feitianshan and Xiaoba formations. Collectively these sites provide evidence of at least 13 distinct dinosaurian trackmaker morphotypes, in addition to two avian theropod(bird)morphotypes and pterosaur and turtle tracks. Together these total 17 morphotypes provide a data base of 479 potential trackmakers, probably representing the same number of individuals. Such an ichnological database provides a useful proxy paleoecological census of tetrapod communities in the area during the Early Cretaceous, and is especially significant given the complete absence or scarcity of skeletal remains reported from these formations.The composition of ichnofaunas in all three formations is heavily saurischian(theropod and sauropod) dominated with a high diversity of distinctive theropod morphotypes,mostly assignable to known ichnogenera. Moreover, ichnofaunal data from multiple sites are generally consistent between sites and an indication of the reliability and repeatability of track census data. Such regionally-widespread data are rapidly superseding the information available from the skeletal record in the corresponding area, and must therefore be considered of high paleontological value.展开更多
文摘AIM:To investigate any protective effect of early propranolol administration in the development of portal hypertensive gastropathy in cirrhotic rats. METHODS:For the development of liver cirrhosis and portal hypertensive gastropathy,60 rats underwent ligation of the left adrenal vein and complete devascularization of the left renal vein,followed by phenobarbital and carbon tetrachloride(CCl4) administration.After two weeks of CCl4 administration, the rats were randomly separated into two groups.In group A,propranolol was continuously administered intragastrically throughout the study,whereas in group B normal saline(placebo)was administered instead. Hemodynamic studies and vascular morphometric analysis of gastric sections were performed after complete induction of cirrhosis. RESULTS:Vascular morphometric studies showed higher numbers of vessels in all mucosal layers in the control group.Statistical analysis revealed a significantly higher total vascular surface in the control group compared to the propranolol group,but with no statistically significant difference between the mean vascular surfaces between the groups.Our study clearly shows that the increased mucosal blood flow is manifested by a marked increase of vessel count. CONCLUSION:Early propranolol's administration in portal hypertensive cirrhotic rats seems to prevent intense gastric vascular congestion that characterizes portal hypertensive gastropathy.
基金supported by the National Science & Technology Pillar Program of China in the Tenth Five-Year Plan Period(Grant No.2001BA302B)the Education Department of Henan Province, China(Grant No.2008A208019)
文摘The process of double fertilization and the characters of embryo and endosperm development in an autotetraploid polyembryonic mutant rice IR36-Shuang were studied with a laser scanning confocal microscopy. Some abnormalities including degenerated ovary, abortive embryo sac, single fertilization, double-ovule and double-embryo and so on. were found dudng double fertilization and embryo development in IR36-Shuang. The rate of the abnormalities was 46.67% in IR36-Shuang, significantly higher than that in the control, an autotetraploid rice line IR36-4X （33.00%）. Cytological and embryonic evidences were provided for seed setting decline and the initiation of additional embryo in IR36-Shuang.
基金supported by Sinopec Marine Forward-looking Projects (Grant No. YPH08101)
文摘The Sichuan Basin, located in the western margin of Yangtze Plate, is one of the important oil-gas-bearing basins in China. During the Early Permian-Middle Triassic, the Sichuan Basin experienced regional lithospheric extension and Emeishan basalt activities, both of which influenced the basin development and thermal evolution. Here we simulated the thermal effects of lithospheric extension and the Emeishan mantle plume based on different geodynamical models. Modeling results indicated that the lithospheric temperature together with the basement heat flow was generally increasing with time due to extension. As the stretching factor was relatively small, the thinning of lithosphere, and consequently the thermal disturbance, was not great. The lithospheric extension yielded about 20% increase of the basement heat flow, with maximum value of 60?62 mW m?2 in the Early Triassic. Mantle plume model shows that the thermal evolution of the inner zone above the plume head was influenced greatly by plume activity. But the outer zone and its outside area where the Sichuan Basin is located were affected only slightly. The basalts that had erupted in the southwestern basin might disturb the basin temperature significantly, although shortly and locally. Generally, the thermal history of the Sichuan basin during the Early Permian-Middle Triassic was controlled by the lithospheric extension, but locally it superimposed thermal effects of basalt activities in its southwestern area.
基金supported by the National Natural Science Foundation of China (Grant No.10972214)the Fundamental Research Funds for the Central Universities
文摘The early phases of the shock interaction process on two-dimensional interfaces with different shapes are numerically investigated in this study,which are closely related to the shock refraction and reflection,vorticity production and transport.The numerical method employs an adaptive unstructured quadrilateral mesh,which can capture the wave pattern and interface evolution very well.Simulations are carried out under the conditions of an incident shock Mach number of 1.2 and the light/heavy (air/SF 6) interface.Five different shapes are considered in the simulations:rectangle,ellipse,diamond and two kinds of triangle.The results show that the interfacial shapes can influence the wave patterns particularly on the shape and evolution of refracted shock waves.The generation and the distribution of vorticity on the interfaces with five different shapes also have dissimilarities.The circulation deposition on five interfaces is quantitatively investigated and compared with theoretical model.A good agreement is found between the numerical results and the predictions by the theoretical model.Some characteristic scales of the interface are tracked.Under the influence of nonlinear-acoustic effect and vorticity effect,the interfaces present different evolution modes.
基金supported by National Natural Science Foundation of China(Grant Nos.40839908,41172099)
文摘As the interval following the biggest Phanerozoic mass extinction at the end of Permian, the Early Triassic is characterized by an immature, poorly functioned ecosystem.The effects of these extreme environmental conditions can be mirrored by the changes in the δ13C record of marine carbonates.However, the details about the carbon isotopic composition and evolution of the Early Triassic seawater remain poorly understood.A dataset of new δ13C and δ18O values as well as selected major and trace element data (including concentrations of CaO, MgO, Mn, and Sr) was obtained from 113 marine carbonate samples collected in Eastern Sichuan Basin.The isotopic and elemental data are used to evaluate effects of thermochemical sulfate reduction on δ13C.The δ13C values of a few samples affected by thermochemical sulfate reduction were corrected.By combining carbonate δ13C results in our investigated sections, we constructed a composite curve of the Lower Triassic.The results reveal a δ13C anomaly of carbonate rocks throughout the Early Triassic, accompanied by some rapid jumps and falls, such as those from approximately -2‰ to the extremely high value of 8‰ within a period of about 5 Ma.The Early Triassic δ13C profile derived from Eastern Sichuan Basin shows a close correspondence with Guandao section in Guizhou Province, whereas it yields an excursion pattern differing from Chaohu section in Anhui Province of the Lower Yangtze region (with the δ13C value from the minimum around -6‰ to the maximum near 4‰).The higher δ13C values and the positive carbon isotope excursions in the Lower Triassic from Eastern Sichuan Basin were most likely a consequence of the principal environmental change that may include: (1) the barren land surface due to the absence of vegetation, (2) the loss of diverse marine invertebrate groups and marine carbonates, (3) the thriving of bacteria, algae and methanogenus in ocean ecosystems, and (4) the local effect of the repositories of isotopically light carbon occurred in the form of methane hydrates.This process ended at the Early-Middle Triassic boundary, which indicates that the biotic recovery started at the end of the Lower Triassic.The terrestrial vegetation and marine invertebrates, as the regulators for carbon cycle, are irreplaceable and demand strong protections.
基金supported by the National Basic Research Program of China (2012CB822000)a Special Project Grant of Chongqing People’s Government (QDBLR-2007-2015)the 2013 and 2015 Support Fund for Graduate Students’ Science and Technology Innovation from China University of Geosciences (Beijing), China (51223229)
文摘In recent years the Lower Cretaceous red beds of southwestern China have yielded more than 20 significant dinosaur-dominated tracksites. More than half occur in the Jiaguan Formation with the remainder in the Feitianshan and Xiaoba formations. Collectively these sites provide evidence of at least 13 distinct dinosaurian trackmaker morphotypes, in addition to two avian theropod(bird)morphotypes and pterosaur and turtle tracks. Together these total 17 morphotypes provide a data base of 479 potential trackmakers, probably representing the same number of individuals. Such an ichnological database provides a useful proxy paleoecological census of tetrapod communities in the area during the Early Cretaceous, and is especially significant given the complete absence or scarcity of skeletal remains reported from these formations.The composition of ichnofaunas in all three formations is heavily saurischian(theropod and sauropod) dominated with a high diversity of distinctive theropod morphotypes,mostly assignable to known ichnogenera. Moreover, ichnofaunal data from multiple sites are generally consistent between sites and an indication of the reliability and repeatability of track census data. Such regionally-widespread data are rapidly superseding the information available from the skeletal record in the corresponding area, and must therefore be considered of high paleontological value.
