Clinical manifestations of inflammatory bowel disease(IBD) are not locally restricted to the gastrointestinal tract, and a significant portion of patients have involvement of other organs and systems. The visual syste...Clinical manifestations of inflammatory bowel disease(IBD) are not locally restricted to the gastrointestinal tract, and a significant portion of patients have involvement of other organs and systems. The visual system is one of the most frequently affected, mainly by inflammatory disorders such as episcleritis, uveitis and scleritis. A critical review of available literature concerning ocular involvement in IBD, as it appears in Pub Med, was performed. Episcleritis, the most common ocular extraintestinal manifestation(EIM), seems to be more associated with IBD activity when compared with other ocular EIMs. In IBD patients, anterior uveitis has an insidious onset, it is longstanding and bilateral, and not related to the intestinal disease activity. Systemic steroids or immunosuppressants may be necessary in severe ocular inflammation cases, and control of the underlying bowel disease is important to prevent recurrence. Our review revealed that ocular involvement is more prevalent in Crohn's disease than ulcerative colitis, in active IBD, mainly in the presence of other EIMs. The ophthalmic symptoms in IBD are mainly nonspecific and their relevance may not be recognized by the clinician; most ophthalmic manifestations are treatable, and resolve without sequel upon prompt treatment. A collaborative clinical care team for management of IBD that includes ophthalmologists is central for improvement of quality care for these patients, and it is also cost-effective.展开更多
Cardiac amyloidoses （CA）, a disease caused by the pre- cipitation of amyloid proteins in myocardial extracellular matrix, is difficult to diagnose due to its lack of specific clinical manifestations, and can be easi...Cardiac amyloidoses （CA）, a disease caused by the pre- cipitation of amyloid proteins in myocardial extracellular matrix, is difficult to diagnose due to its lack of specific clinical manifestations, and can be easily misdiagnosed.[1] However, due to the recent improved awareness and wide use of biopsy, most patients are now correctly diagnosed prior to death. This report concerns a 59-year-old male who presented with symptoms of double eyelid swelling and chest tightness without obvious causes.展开更多
文摘Clinical manifestations of inflammatory bowel disease(IBD) are not locally restricted to the gastrointestinal tract, and a significant portion of patients have involvement of other organs and systems. The visual system is one of the most frequently affected, mainly by inflammatory disorders such as episcleritis, uveitis and scleritis. A critical review of available literature concerning ocular involvement in IBD, as it appears in Pub Med, was performed. Episcleritis, the most common ocular extraintestinal manifestation(EIM), seems to be more associated with IBD activity when compared with other ocular EIMs. In IBD patients, anterior uveitis has an insidious onset, it is longstanding and bilateral, and not related to the intestinal disease activity. Systemic steroids or immunosuppressants may be necessary in severe ocular inflammation cases, and control of the underlying bowel disease is important to prevent recurrence. Our review revealed that ocular involvement is more prevalent in Crohn's disease than ulcerative colitis, in active IBD, mainly in the presence of other EIMs. The ophthalmic symptoms in IBD are mainly nonspecific and their relevance may not be recognized by the clinician; most ophthalmic manifestations are treatable, and resolve without sequel upon prompt treatment. A collaborative clinical care team for management of IBD that includes ophthalmologists is central for improvement of quality care for these patients, and it is also cost-effective.
文摘Cardiac amyloidoses （CA）, a disease caused by the pre- cipitation of amyloid proteins in myocardial extracellular matrix, is difficult to diagnose due to its lack of specific clinical manifestations, and can be easily misdiagnosed.[1] However, due to the recent improved awareness and wide use of biopsy, most patients are now correctly diagnosed prior to death. This report concerns a 59-year-old male who presented with symptoms of double eyelid swelling and chest tightness without obvious causes.
