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天之骄子——东风“天龙”、“康霸”
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作者 晓青 《汽车与配件》 2002年第18期17-17,共1页
拥有新东风,创造新生活.东风公司紧跟时代的步伐,以人为本,充分体现了产品的人性化设计和细致入微服务的设计理念.东风"天龙"重卡,是瞄准国内高速公路的建设和运输需求而开发的全新牵引车,它的推出,首先是它代表东风人扛着&qu... 拥有新东风,创造新生活.东风公司紧跟时代的步伐,以人为本,充分体现了产品的人性化设计和细致入微服务的设计理念.东风"天龙"重卡,是瞄准国内高速公路的建设和运输需求而开发的全新牵引车,它的推出,首先是它代表东风人扛着"独立自主"的旗帜,发展适合我国汽车市场的民族工业. 展开更多
关键词 重型卡车 技术性能 东风 “天龙” “康霸”
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基于生物信息学、网络药理学与分子对接研究八桂天龙散治疗阿尔茨海默病的机制 被引量:3
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作者 姚春 林龙 +6 位作者 王萌 严倩 叶双庆 钟宇 张广发 黄良江 王涵 《中华中医药学刊》 CAS 北大核心 2023年第6期1-5,I0011-I0015,共10页
目的基于生物信息学、网络药理学与分子对接探讨八桂天龙散治疗阿尔茨海默病(alzheimer’s disease,AD)的作用靶点与分子机制。方法从TCMSP、HIT、HERB数据库检索八桂天龙散活性成分,通过Swiss Target Prediction平台预测潜在作用靶点... 目的基于生物信息学、网络药理学与分子对接探讨八桂天龙散治疗阿尔茨海默病(alzheimer’s disease,AD)的作用靶点与分子机制。方法从TCMSP、HIT、HERB数据库检索八桂天龙散活性成分,通过Swiss Target Prediction平台预测潜在作用靶点。采用GEO2R分析AD的差异基因,应用GeneCards、OMIM、DisGeNET数据库筛选AD靶点,交集获得八桂天龙散治疗AD的可能潜在作用靶点。采用STRING平台构建PPI网络,Cytoscape软件网络拓扑计算筛选潜在关键靶点,R语言进行GO及KEGG通路富集分析,构建“中药-活性成分-靶点-信号通路-疾病”网络。分子对接预测潜在活性成分和靶点的结合性能。结果筛选八桂天龙散有效活性成分115种,相应基因靶点1666个。AD差异基因2725个,靶点2236个。八桂天龙散治疗AD的潜在靶点99个,其中关键靶点为MAPK1、FN1、EGFR。KEGG富集分析显示关键信号通路包括PI3K-Akt、MAPK、Rap1、Ras、HIF-1、LTP等信号通路。分子对接结果显示人参二醇、次甲丹参醌可能是八桂天龙散治疗AD的核心活性化合物。结论八桂天龙散通过多组分、多靶点、多通路协同机制干预AD,与氧化应激、神经炎症、谷氨酸能突触、长时程增强、自噬、凋亡等机制密切相关。 展开更多
关键词 八桂 阿尔茨海默病 GEO芯片 网络药理学 分子对接
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全天龙补阳还五汤治疗中风偏瘫随机平行对照研究 被引量:1
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作者 应文连 《实用中医内科杂志》 2016年第10期27-29,共3页
[目的]观察全天龙补阳还五汤治疗中风偏瘫疗效。[方法]使用随机平行对照方法,将194例门诊患者按就诊顺序号简单随机分为两组。对照组97例阿司匹林,0.1g/次,1次/d;氯吡格雷,75mg/次,1次/d。治疗组97例全天龙补阳还五汤(石菖蒲、甘草各10g... [目的]观察全天龙补阳还五汤治疗中风偏瘫疗效。[方法]使用随机平行对照方法,将194例门诊患者按就诊顺序号简单随机分为两组。对照组97例阿司匹林,0.1g/次,1次/d;氯吡格雷,75mg/次,1次/d。治疗组97例全天龙补阳还五汤(石菖蒲、甘草各10g,川牛膝15g,桂枝、天麻各10g,全虫6g,红花、桃仁、地龙各10g,赤芍15g,当归10g,川芎20g,黄芪80g),1剂/d,水煎300m L,早晚口服。连续治疗30d为1疗程。观察临床症状、Fugl-Meyer评分、不良反应。治疗1疗程,判定疗效。[结果]治疗组痊愈69例,显效13例,有效10例,无效5例,总有效率94.85%;对照组痊愈43例,显效13例,有效13例,无效23例,总有效率76.29%;治疗组疗效优于对照组(P<0.01)。Fugl-Meyer评分两组均有明显升高(P<0.01),治疗组升高优于对照组(P<0.01)。[结论]全天龙补阳还五汤治疗中风偏瘫疗效满意,无严重不良反应,值得推广。 展开更多
关键词 中风偏瘫 补阳还五汤 阿司匹林 氯吡格雷 FUGL-MEYER评分 中医药治疗 随机平行对照研究
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沈(阳)吉(林)铁路的修建与1920年代奉天、吉林两省东部地区的城市化 被引量:5
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作者 曲晓范 王凤杰 《史学集刊》 CSSCI 北大核心 2011年第2期52-60,共9页
中华民国初期,以奉系军阀主导的中国东北三省地方政府曾大力引进和建设以铁路为代表的近代交通设施和近代交通工具,取得了一系列重要成就,使东北地区由此成为当时国内铁路交通最为现代化的一个地区。这其中,影响最大的一项工程是沈(阳)... 中华民国初期,以奉系军阀主导的中国东北三省地方政府曾大力引进和建设以铁路为代表的近代交通设施和近代交通工具,取得了一系列重要成就,使东北地区由此成为当时国内铁路交通最为现代化的一个地区。这其中,影响最大的一项工程是沈(阳)吉(林)铁路的修建。该路是东北地区第一条真正意义上的完全由中国人独资建设和管理的铁路,也是东北地区引进和消化吸收国外先进科学技术最成功的标志性铁路。它的开通不仅带动了其他铁路的建设,而且拉动了铁路沿线地区社会经济的快速进步。 展开更多
关键词 沈吉铁路 吉海铁路 奉海铁路 张作霖 张作相
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Landscape pattern and diversity of natural secondary forests in the eastern mountainous region, northeast China:A case study of Mao'ershan region in Heilongjiang Province
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作者 李淑娟 隋玉正 +2 位作者 冯海清 王凤友 李玉文 《Journal of Forestry Research》 SCIE CAS CSCD 2004年第3期181-186,共6页
Mao抏rshan region is a representative natural secondary forested region in the eastern mountainous region, north-east of China. Under the support of ARC/INFO, the landscape pattern and landscape diversity of Maoerhsha... Mao抏rshan region is a representative natural secondary forested region in the eastern mountainous region, north-east of China. Under the support of ARC/INFO, the landscape pattern and landscape diversity of Maoerhshan region were studied by combining the forest type map (1:10000), which was drawn from the aerial photographs (1999), field investigation and land utilization map (1:10000). The selected indices included patch number, patch size, patch density index, richness index, dominance index, evenness index and diversity index. The results showed that the landscape dominant forest type in Mao抏rshan region was softwood broad-leaved forest. In all landscape types, the average patch area of natural secondary for-ests was bigger than that of artificial forest. The patch density index of each landscape formed in artificial forest was higher than that of natural secondary forest. The landscape diversity index and landscape evenness index of natural forest were highest, the landscape heterogeneity was also, but the landscape dominance was lower. In natural forest, the control effects of landscape elements on landscape-structure, function and its change were weakened. The artificial forest was on the contrary. 展开更多
关键词 Landscape pattern Landscape diversity DOMINANCE EVENNESS Diversity index Maoershan region Heilongjiang
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Heart-shaped anastomosis for Hirschsprung's disease: Operative technique and long-term follow-up 被引量:6
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作者 GuoWang Xiao-YiSun Ming-FaWei Yi-ZhenWeng 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第2期296-298,共3页
AIM: To study the long-term therapeutic effect of 'heartshaped' anastomosis for Hirschsprung's disease.METHODS: From January 1986 to October 1997, we performed one-stage 'heart-shaped' anastomosis ... AIM: To study the long-term therapeutic effect of 'heartshaped' anastomosis for Hirschsprung's disease.METHODS: From January 1986 to October 1997, we performed one-stage 'heart-shaped' anastomosis for 193 patients with Hirschsprung's disease (HD). One hundred and fiftytwo patients were followed up patients (follow-up rate 79%).The operative outcome and postoperative complications were retrospectively analyzed.RESULTS: Early complications included urine retention in 2patients, enteritis in 10, anastomotic stricture in 1, and intestinal obstruction in 2. No infection of abdominal cavity or wound and anastomotic leakage or death occurred in any patients. Late complications were present in 22 cases,including adhesive intestinal obstruction in 2, longer anal in 5, incision hernia in 2, enteritis in 6, occasional stool stains in 7 and 6 related with improper diet. No constipation or incontinence occurred in any patient.CONCLUSION: The early and late postoperative complication rates were 7.8% and 11.4% respectively in our 'heartshaped anastomosis' procedure. 'Heart-shaped'anastomosis procedure for Hirschsprung's disease provides a better therapeutic effect compared to classic procedures. 展开更多
关键词 Hirschsprung's disease Heart-shaped anastomosis Follow-up studies
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Ambient noise during rough weather and cyclones in the shallow Bay of Bengal 被引量:1
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作者 M. C. SANJANA G. LATHA A. THIRUNAVUKKARASU 《Chinese Journal of Oceanology and Limnology》 SCIE CAS CSCD 2014年第4期921-932,共12页
This paper presents ambient noise analysis during rough weather, using time series measurements from an automated noise measurement system in the shallow southwest Bay of Bengal during October–November 2010. The peri... This paper presents ambient noise analysis during rough weather, using time series measurements from an automated noise measurement system in the shallow southwest Bay of Bengal during October–November 2010. The period witnessed low-pressure events including depressions and cyclones, with JAL cyclone passing close to the measurement site. The time series noise level shows a shift in mid-October, after which deep depressions and cyclones formed, with an average increase of 5–10 dB in the lower band and 2–3 dB in the higher band of frequencies. Furthermore, correlation between noise level and wave height(data from wave rider buoy deployed at the site) for sea state scale 3 and above shows good correlation with an increase in noise level with increase in wave height, the effect being most pronounced at 0.5 kHz. The noise captured during JAL was analysed to identify the spectrum components due to convective precipitation and heavy wind/wave activity and shows anomalously high levels during the crossing of the cyclone. Rain noise spectra from the rain bands associated with the wall of the cyclone are reported. This has been correlated with radar refl ectivity measurements to ascertain the presence of rain, and discriminate between convective and stratiform types. Also, vertical directionality pattern of ambient noise during JAL showed clearly distinct surface contributions. On the whole, knowledge of ambient noise fields during high sea states and precipitation is useful in optimizing SONAR performance. The findings at the study site have been compared with measurements from other shallow water locations during rough weather. 展开更多
关键词 ambient noise JAL cyclone shallow water
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Polymerase chain reaction-single strand conformational polymorphism analysis of rearranged during transfection proto-oncogene in Chinese familial hirschsprung's disease 被引量:1
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作者 TaoGuan Ji-ChengLi +1 位作者 Min-JuLi Jin-FaTou 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第2期275-279,共5页
AIM: To investigate the relationship between mutations of rearranged during transfection (RET) proto-oncogene and Chinese patients with Hirschsprung's disease (HD), and to elucidate the genetic mechanism of famili... AIM: To investigate the relationship between mutations of rearranged during transfection (RET) proto-oncogene and Chinese patients with Hirschsprung's disease (HD), and to elucidate the genetic mechanism of familial HD patient at the molecular level.METHODS: Genomic DNA was extracted from venous blood of probands and their relatives in two genealogies.Polymerase chain reaction (PCR) products, which were amplified using specific primers (RET, exons 11, 13, 15and 17), were electrophoresed to analyze the single-strand conformational polymorphism (SSCP) patterns. The positive amplified products were sequenced. Forty-eight sporadic HD patients and 30 normal children were screened for mutations of RET proto-oncogene simultaneously.RESULTS: Three cases with HD in one family were found to have a G heterozygous insertion at nucleotide 18 974 in exon 13 of RET cDNA (18 974insG), which resulted in a frameshift mutation. In another family, a heterozygosity for T to G transition at nucleotide 18 888 in the same exon which resulted in a synonymous mutation of Leu at codon 745 was detected in the proband and his father. Eight RET mutations were confirmed in 48 sporadic HD patients.CONCLUSION: Mutations of RET proto-oncogene may play an important role in the pathogenesis of Chinese patients with HD. Detection of mutated RET proto-oncogene carriers may be used for genetic counseling of potential risk for HD in the affected families. 展开更多
关键词 Hirschsprung's disease Proto-oncogene proteins RET TRANSFECTION PCR-SSCP
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The Natural Forest Protection Program in China: A Contingent Valuation Study in Heilongjiang Province 被引量:1
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作者 Frida Edstrom Hanna Nilsson Jesper Stage 《Journal of Environmental Science and Engineering(B)》 2012年第3期426-432,共7页
In 1998, the Chinese Government implemented the NFPP (Natural Forest Protection Program), which included logging restrictions, protected areas, replanting, and a range of other policies aimed at safeguarding the sta... In 1998, the Chinese Government implemented the NFPP (Natural Forest Protection Program), which included logging restrictions, protected areas, replanting, and a range of other policies aimed at safeguarding the state of the country's forests and reducing the risk of erosion and flooding. A second phase of this program is currently being discussed. In this paper, contingent valuation is used to estimate the WTP (willingness to pay) for maintaining the program among the inhabitants in Heilongjiang Province in northern China. The results show that, even with fairly conservative assumptions, the aggregated WTP for maintaining the program for another five years is some 3.24 billion yuan per year. This can be compared with the current cost of the Program in the province, which is some 1.57 billion yuan per year. 展开更多
关键词 China Heilongjiang natural forest protection program contingent valuation.
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Physiological Effect on Hylocereus undulatus and Hylocereus undatus under Simulated Karst Soil Water Deficiency 被引量:6
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作者 黄玉清 袁维园 +5 位作者 莫凌 徐广平 张中峰 曾丹娟 何成新 顾大形 《Journal of Resources and Ecology》 CSCD 2015年第4期269-275,共7页
Dragon fruit (Hylocereus undulates) was planted in a large area of karst region in recent years. To understand whether karst drought may impact on its physiological process is important and useful for planning and m... Dragon fruit (Hylocereus undulates) was planted in a large area of karst region in recent years. To understand whether karst drought may impact on its physiological process is important and useful for planning and management of this fruit. In this study, we contrasted with a relative species Hylocereus undatus, and set up experiment to study physiological and biochemical trait and its response to different karst soil water level deficiency, so as to understand the mechanism of H. undulates and H. undatus in adaptation to karst drought condition. The results showed that, trends of physiological and biochemical response to drought was similar between two species. With the intensive of soil water deficiency, such toxin substance as malonaldehyde (MDA) increased, but meanwhile, two protective enzymes superoxide dismutase (SOD) and peroxidases (POD) and osmotic adjustment Proline (Pro) increase as well. Under relative water content (RWC) 〉50% condition, the enzyme can effectively protect the cells from toxin MDA injure, and Pro can also maintain the water needs through osmotic adjustment. However, under RWC 〈 40% condition, protective enzymes were not enough for cleaning MDA. Biomass was largest under RWC=70%-80%, with low root shoot ratio and high aboveground biomass. Biomass significantly decreased under RWC 30%-40%, which decline by 73.28% and 73.56% in H. undulates and H. undatus respectively. Therefore, RWC=70%-80% would be an optimal soil moisture while developing dragon fruit in karst, which is favor to fruit production. Under moderate drought e.g. RWC=50%-60%, plants may regulate by metabolic process and balance unfavorable substance, but it allocated much more biomass to root, reduced the aboveground biomass, which is not advance for fruit production. 展开更多
关键词 Hylocereus undulatus and Hylocereus undatus physiological effect KARST DROUGHT
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