红学学术史研究的新路径——《红学学案》著者高淮生教授学术访谈录

自新红学创建以来,近几十年出版的红学史著述基本上是通史和专题史的写法,而"学案体"或"学案性质"的红学史著述至今鲜见。《红学学案》的"学案体"写作略有别于《明儒学案》和《宋元学案》这一传统学术史著述,它计划选取海内外60位"学人"为主线撰成红学史著述。现阶段高淮生教授已为当代红学小说批评派的12位代表人物撰写综论,并将12篇综论集结成册出版了《红学学案》一书,为读者呈现出中国大陆当代红学批评的概貌,引起了红学界的广泛关注。值此之际,《燕山大学学报》(哲社版)编辑董明伟特别采访了高淮生教授,围绕《红学学案》的"学案体"写作及其研究价值、《红学学案》工程的整体设想和学术追求、当前学界对《红学学案》及"学案体"写作的反响、当前红学研究的发展现状及未来走向等四个问题进行探讨。希望能引出更加深入和富有价值的学术话题,以飨读者。

Boolean operations of STL models based on edge-facet intersection

For the data processing of the Rapid Prototyping Manufacturing, Boolean operation can offer a versatile tool for editing or modifying the STL model, adding the artificial construction, and creating the complex assistant support structure to meet the special technical requests. The topological structure of STL models was built firstly in order to obtain the neighborhood relationship among the triangular facets. The intersection test between every edge of one solid and every facet of another solid was taken to get the intersection points. According to the matching relationship of the triangle index recorded in the data structure of the intersection points, the intersection segments array and the intersection loop were traced out. Each intersected triangle was subdivided by the Constrained Delaunay Triangulations. The intersected surfaces were divided into several surface patches along the intersection loops. The inclusion prediction between the surface patch and the other solid was taken by testing whether the candidate point was inside or outside the solid region of the slice. Detecting the loops for determination of the valid intersection lines greatly increases the efficiency and the reliability of the process.

Parallel hydrodynamic finite element model with an N-Best refining partition scheme

We enhance a robust parallel finite element model for coasts and estuaries cases with the use of N-Best refinement algorithms,in multilevel partitioning scheme.Graph partitioning is an important step to construct the parallel model,in which computation speed is a big concern.The partitioning strategy includes the division of the research domain into several semi-equal-sized sub-domains,minimizing the sum weight of edges between different sub-domains.Multilevel schemes for graph partitioning are divided into three phases:coarsening,partitioning,and uncoarsening.In the uncoarsening phase,many refinement algorithms have been proposed previously,such as KL,Greedy,and Boundary refinements.In this study,we propose an N-Best refinement algorithm and show its advantages in our case study of Xiamen Bay.Compared with original partitioning algorithm in previous models,the N-Best algorithm can speed up the computation by 1.9 times,and the simulation results are in a good match with the in-situ data.

The potential for liquid biopsies in the precision medical treatment of breast cancer

Currently the clinical management of breast cancer relies on relatively few prognostic/predictive clinical markers(estrogen receptor, progesterone receptor, HER2), based on primary tumor biology. Circulating biomarkers, such as circulating tumor DNA(ctDNA) or circulating tumor cells(CTCs) may enhance our treatment options by focusing on the very cells that are the direct precursors of distant metastatic disease, and probably inherently different than the primary tumor's biology. To shift the current clinical paradigm, assessing tumor biology in real time by molecularly profiling CTCs or ctDNA may serve to discover therapeutic targets, detect minimal residual disease and predict response to treatment. This review serves to elucidate the detection,characterization, and clinical application of CTCs and ctDNA with the goal of precision treatment of breast cancer.

Sex differences in exercise and drug addiction:A mini review of animal studies

Growing literature has demonstrated that exercise may be an effective prevention and treatment option for drug addiction. In the past few years, many studies have suggested that there were sex differences in all phases of drug addiction. However, very limited research has investigated sex differences in the effectiveness of exercise intervention in drug addiction and rehabilitation. In this mini review, we summarize the effect of sex on the results of using exercise to prevent and treat drug addiction. The studies we consider span various animal models and use multiple types of exercise to examine the effectiveness of exercise on the neurobiological mechanism of exercise rehabilitation. We believe that exercise as an adjuvant intervention strategy can be applied better in drug addiction prevention and recovery. Copyright 2014, Shanghai University of Sport. Production and hosting by Elsevier B.V. All rights reserved.

A hybrid ventilation scheme applied to bidirectional excavation tunnel construction with a long inclined shaft

The breakage and bending of ducts result in a difficulty to cope with ventilation issues in bidirectional excavation tunnels with a long inclined shaft using a single ventilation method based on ducts.To discuss the hybrid ventilation system applied in bidirectional excavation tunnels with a long inclined shaft,this study has established a full-scale computational fluid dynamics model based on field tests,the Poly-Hexcore method,and the sliding mesh technique.The distribution of wind speed,temperature field,and CO in the tunnel are taken as indices to compare the ventilation efficiency of three ventilation systems(duct,duct-ventilation shaft,duct–ventilated shaft-axial fan).The results show that the hybrid ventilation scheme based on duct-ventilation shaft–axial fan performs the best among the three ventilation systems.Compared to the duct,the wind speed and cooling rate in the tunnel are enhanced by 7.5%–30.6%and 14.1%–17.7%,respectively,for the duct-vent shaft-axial fan condition,and the volume fractions of CO are reduced by 26.9%–73.9%.This contributes to the effective design of combined ventilation for bidirectional excavation tunnels with an inclined shaft,ultimately improving the air quality within the tunnel.

Advances in cell lineage reprogramming

As a milestone breakthrough of stem cell and regenerative medicine in recent years, somatic cell reprogramming has opened up new applications of regenerative medicine by breaking through the ethical shackles of embryonic stern cells. However, induced pluripo- tent stem （iPS） cells are prepared with a complicated protocol that results in a low reprogramming rate. To obtain differentiated target cells, iPS cells and embryonic stem cells still need to be induced using step-by-step procedures. The safety of induced target cells from iPS cells is currently a further concerning matter. More broadly conceived is lineage reprogramming that has been investigated since 1987. Adult stem cell plasticity, which triggered interest in stem cell research at the end of the last century, can also be included in the scope of lineage reprogramming. With the promotion of iPS cell research, lineage reprogramming is now considered as one of the most promising fields in regenerative medicine, will hopefully lead to customized, personalized therapeutic options for patients in the future.