In response to the downlink synchronization requirements of the user equipment(UE)or third-party radio equipment in fifth-generation(5G)mobile communication systems,a synchronization algorithm of primary synchroni-zat...In response to the downlink synchronization requirements of the user equipment(UE)or third-party radio equipment in fifth-generation(5G)mobile communication systems,a synchronization algorithm of primary synchroni-zation signal(PSS)was designed and developed in the 5G system based on block cross-correlation.According to the new characteristics of the 5G synchronization channel and broadcast channel,starting from the traditional downlink synchronization algorithm of long-term evolution(LTE),the detection performance of the algorithm under a low signal-to-noise ratio(SNR)is improved by introducing an incoherent accumulation,and the new scheme of joint coarse frequency offset estimation is used to improve the frequency offset estimation performance.Finally,the performance of the proposed synchronization algorithm is verified by conducting a simulation on a 5G downlink simulation platform based on MATLAB software.Simulation results show that the improved downlink synchronization algorithm has stable performance in the tapped delay line-C(TDL-C)and additive white Gaussian noise(AWGN)channels with large frequency deviation and low SNR.展开更多
Background: Nowadays, acute alcoholic intoxication has become the third public problem in China, and the anti-inebriation products mainly aimed at increasing the activity of enzyme involved in the alcohol metabolism, ...Background: Nowadays, acute alcoholic intoxication has become the third public problem in China, and the anti-inebriation products mainly aimed at increasing the activity of enzyme involved in the alcohol metabolism, which is a single mechanism that can accelerate alcohol metabolism. Thus, a new formula, Jiujiuguiyi (JJGY) which could protect liver, relieve the abnormal excitability of the center and improve muscle retardation at the same time is designed by us. Methods: The model of acute alcoholic intoxication was established by intragastric administration with 0.12 ml/10g 50% alcohol in mice. JJGY was orally administrated (gavage) once a day for 20 consecutive days before the establishment of acute alcoholic model. Mice were randomly divided into 8 groups with 8 each: blank control group (CON), model group (M), Haiwangjinzun positive control group (HWJZ), experimental groups (AL, AH, BL, BH, AB). Giant, crawling time on the rota-rod, the activities of aspartate amino trans- ferase (AST), alanine amino transferase (ALT) and superoxide dismutase (SOD) in both liver and serum, alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), glutathione peroxidase (GSH-PX) in liver as well as the HE staining of liver slices, the formation of malondialdehyde (MDA) in serum were determined after acute alcoholic intoxication. Results: Compared with model group, JJGY significantly decreased the AST and ALT activity in liver and serum and MDA activity in serum. Meanwhile, it enhanced the ADH and ALDH level in liver as well as the hepatic and serous SOD activity, indicating more efficient metabolism of alcohol and less hepatic injury. HE staining results also proved that JJGY could reduce alcoholic liver cell injury, and the effect was more obvious in the group medicated before alcohol administration. Moreover, JJGY significantly prolonged the crawling time on the rota-rod and improved the gait of mice and the effect was proved to be better than the widely used health product Haiwangjinzun. Conclusions: This study suggests that JJGY is able to protect liver, relieve the abnormal excitability of the center and improve muscle retardation after acute alcoholic intoxication. Its liver protection effect is likely related to its modulation on the alcohol metabolizing and antioxidant enzymes.展开更多
基金The Social Development Projects of Jiangsu Science and Technology Department(No.BE2018704).
文摘In response to the downlink synchronization requirements of the user equipment(UE)or third-party radio equipment in fifth-generation(5G)mobile communication systems,a synchronization algorithm of primary synchroni-zation signal(PSS)was designed and developed in the 5G system based on block cross-correlation.According to the new characteristics of the 5G synchronization channel and broadcast channel,starting from the traditional downlink synchronization algorithm of long-term evolution(LTE),the detection performance of the algorithm under a low signal-to-noise ratio(SNR)is improved by introducing an incoherent accumulation,and the new scheme of joint coarse frequency offset estimation is used to improve the frequency offset estimation performance.Finally,the performance of the proposed synchronization algorithm is verified by conducting a simulation on a 5G downlink simulation platform based on MATLAB software.Simulation results show that the improved downlink synchronization algorithm has stable performance in the tapped delay line-C(TDL-C)and additive white Gaussian noise(AWGN)channels with large frequency deviation and low SNR.
文摘Background: Nowadays, acute alcoholic intoxication has become the third public problem in China, and the anti-inebriation products mainly aimed at increasing the activity of enzyme involved in the alcohol metabolism, which is a single mechanism that can accelerate alcohol metabolism. Thus, a new formula, Jiujiuguiyi (JJGY) which could protect liver, relieve the abnormal excitability of the center and improve muscle retardation at the same time is designed by us. Methods: The model of acute alcoholic intoxication was established by intragastric administration with 0.12 ml/10g 50% alcohol in mice. JJGY was orally administrated (gavage) once a day for 20 consecutive days before the establishment of acute alcoholic model. Mice were randomly divided into 8 groups with 8 each: blank control group (CON), model group (M), Haiwangjinzun positive control group (HWJZ), experimental groups (AL, AH, BL, BH, AB). Giant, crawling time on the rota-rod, the activities of aspartate amino trans- ferase (AST), alanine amino transferase (ALT) and superoxide dismutase (SOD) in both liver and serum, alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), glutathione peroxidase (GSH-PX) in liver as well as the HE staining of liver slices, the formation of malondialdehyde (MDA) in serum were determined after acute alcoholic intoxication. Results: Compared with model group, JJGY significantly decreased the AST and ALT activity in liver and serum and MDA activity in serum. Meanwhile, it enhanced the ADH and ALDH level in liver as well as the hepatic and serous SOD activity, indicating more efficient metabolism of alcohol and less hepatic injury. HE staining results also proved that JJGY could reduce alcoholic liver cell injury, and the effect was more obvious in the group medicated before alcohol administration. Moreover, JJGY significantly prolonged the crawling time on the rota-rod and improved the gait of mice and the effect was proved to be better than the widely used health product Haiwangjinzun. Conclusions: This study suggests that JJGY is able to protect liver, relieve the abnormal excitability of the center and improve muscle retardation after acute alcoholic intoxication. Its liver protection effect is likely related to its modulation on the alcohol metabolizing and antioxidant enzymes.
