In order to realize interoperability to a large number of autonomous and heterogeneous information sources with high efficiency, an agent-based multi-broker architecture (AMA)-HustEven, is constructed. A group of br...In order to realize interoperability to a large number of autonomous and heterogeneous information sources with high efficiency, an agent-based multi-broker architecture (AMA)-HustEven, is constructed. A group of broker agents are designed to provide brokering services in a peer-to-peer (P2P) manner for the non- broker agents (user agents, resource agents, query agents). Thus, the scalability and robustness of the system are enhanced. Ontology is also used by the broker agents for facilitating interoperability among all the agents in HustEven. Unlike any other AMAs, an interdomain ontology is built in this system to represent the relationships among the common concepts in the innerdomain ontologies. Therefore, a broker forwards the queries only to the other related brokers according to the interdomain ontology and the communication overhead among the brokers is reduced. Obviously, the application of the interdomain ontology enables a broker to fully take advantage of the multi-broker architecture. The experimental results show that the HustEven performs more efficiently than any other existing systems.展开更多
With rapid advances of solar blind ultraviolet LED and ultraviolet detecting technology in recent years, ultraviolet communication gradually becomes a research hotspot due to its inherent advantages: low solar backgro...With rapid advances of solar blind ultraviolet LED and ultraviolet detecting technology in recent years, ultraviolet communication gradually becomes a research hotspot due to its inherent advantages: low solar background noise, non-line-of-sight(NLOS) and good secrecy. The strong scattering characteristics in atmospheric render ultraviolet waveband the ideal choice for achieving NLOS optical communication. This paper reviews the research history and status of ultraviolet communication both in China and abroad, and especially introduces three main issues of ultraviolet communication: channel model, system analysis and design, light sources and detectors. For each aspect, current open issues and prospective research directions are analyzed.展开更多
AIM:To evaluate the main factors associated with mortality in patients undergoing surgery for perforated peptic ulcer referred to an academic department of general surgery in a large southern Italian city. METHODS:One...AIM:To evaluate the main factors associated with mortality in patients undergoing surgery for perforated peptic ulcer referred to an academic department of general surgery in a large southern Italian city. METHODS:One hundred and forty-nine consecutive patients (M:F ratio=110:39,mean age 52 yrs,range 16-95) with peptic ulcer disease were investigated for clinical history (including age,sex,previous history of peptic ulcer,associated diseases,delayed abdominal surgery,ulcer site,operation type,shock on admission,postoperative general complications, and intra-abdominal and/or wound infections),serum analyses and radiological findings. RESULTS:The overall mortality rate was 4.0%.Among all factors,an age above 65 years,one or more associated diseases,delayed abdominal surgery,shock on admission, postoperative abdominal complications and/or wound infections,were significantly associated (x^2) with increased mortality in patients undergoing surgery (0.0001<P<0.03). CONCLUSION:Factors such as concomitant diseases,shock on admission,delayed surgery,and postoperative abdominal and wound infections are significantly associated with fatal outcomes and need careful evaluation within the general workup of patients admitted for perforated peptic ulcer.展开更多
Small bowel strictures can be missed by current diagnostic methods. The Patency capsule is a new non-endoscopic dissolvable capsule which has as an objective of checking the patency of digestive tract, in a non-invasi...Small bowel strictures can be missed by current diagnostic methods. The Patency capsule is a new non-endoscopic dissolvable capsule which has as an objective of checking the patency of digestive tract, in a non-invasive manner. The available clinical trials have demonstrated that the Patency capsule is a good tool for assessment of the functional patency of the small bowel, and it allows identification of those patients who can safely undergo a capsule endoscopy, despite clinical and radiographic evidence of small-bowel obstruction. Some cases of intestinal occlusion have been reported with the Patency capsule, four of them needed surgery. So, a new capsule with two timer plugs (Agile capsule) has been recently developed in order to minimize the risk of occlusion. This new device stars its dissolution process earlier (30 h after ingestion) and its two timer plugs have been designed to begin the disintegration even when the device is blocked in a tight stricture.展开更多
In this paper the results of skeletal traction and irrigation therapy (STIT) used for open fracture complicated with large-sized full-thickness skin-deficit and infection wounds (OFIW) were presented. Fourteen patient...In this paper the results of skeletal traction and irrigation therapy (STIT) used for open fracture complicated with large-sized full-thickness skin-deficit and infection wounds (OFIW) were presented. Fourteen patients of OFIW were treated by the plaster cast and wound dressing (PCWD), and 30 patients of OFIW were treated by STIT. The results indicated that after one week of treatment, the white blood cell count in the STIT group, compared to 17. 6±l. 0×109/L from before treatment, returned to 8. 8±0. 8×109/L,and in contrast, the cell count of the PCWD group was about 13. 0±1. 4×109/L. All of wound exudate culture in the STIT group was negative, and those of 7 cases (7/14) in PCWD group were positive (P<0. 0l). The symptoms and signs such as pain, fever and septic exudate on the wound in the STIT group were much milder than those in the PCWD group. There were 5 cases (35. 7%) of toxicemia and septicemia, 2 cases (14. 3%) of osteomyelitis, 2 cases (14. 3 %) of amputation, 1 case (7. 1%) of delayed union and 3 cases (21. 4 %) of malunion in the PCWD group, and no complications in the STIT group.展开更多
Aimed at determining the appropriate caving–mining ratio for fully mechanized mining of 20 m thick coal seam, this research investigated the effects of caving–mining ratio on the flow fields of coal and waste rocks,...Aimed at determining the appropriate caving–mining ratio for fully mechanized mining of 20 m thick coal seam, this research investigated the effects of caving–mining ratio on the flow fields of coal and waste rocks, amount of cyclically caved coal and top coal loss by means of numerical modeling. The research was based on the geological conditions of panel 8102 in Tashan coal mine. The results indicated the loose coal and waste rocks formed an elliptical zone around the drawpoint. The ellipse enlarged with decreasing caving–mining ratio. And its long axis inclined to the gob gradually became vertical and facilitating the caving and recovery of top coal. The top coal loss showed a cyclical variation; and the loss cycle was shortened with the decreasing in caving–mining ratio. Moreover, the mean squared error(MSE) of the amount of cyclically caved coal went up with increasing caving–mining ratio, indicating a growing imbalance of amount of cyclically caved coal, which could impede the coordinated mining and caving operations. Finally it was found that a caving–mining ratio of 1:2.51 should be reasonable for the conditions.展开更多
A substantial part of the human genome is derived from transposable elements;remnants of ancient retroviral infections.Conservative estimates set the percentage of human endogenous retroviruses(HERVs) in the genome at...A substantial part of the human genome is derived from transposable elements;remnants of ancient retroviral infections.Conservative estimates set the percentage of human endogenous retroviruses(HERVs) in the genome at 8%.For the most part,the interplay between mutations,epigenetic mechanisms and posttranscriptional regulations silence HERVs in somatic cells.We first highlight mechanisms by which activation of members of several HERV families may be associated with tumor development before discussing the arising chances for both diagnosis and therapy.It has been shown that at least in some cases,tumor cells expressing HERV open reading frames(ORFs) thus gain tumor-promoting functions.However,since these proteins are not expressed in healthy tissues,they become prime target structures.Of potential pharmacological interest are the prevention of HERV transposition,the inhibition of HERV-encoded protein expression and the interference with these proteins' activities.Evidence from recent studies unequivocally proves that HERV ORFs represent a very interesting source of novel tumor-specific antigens with even the potential to surpass entity boundaries.The development of new tumor(immune-) therapies is a very active field and true tumor-specific targets are of outstanding interest since they minimize the risk of autoimmunity and could reduce side effects.Finally,we postulate on main future research streams in order to stimulate discussion on this hot topic.展开更多
The study analyzes the characteristics of roof movement in mining top coal of inclined coal seam,and establishes the mechanical model of support and surrounding-rock stability in inclined coal seam.Besides,this study ...The study analyzes the characteristics of roof movement in mining top coal of inclined coal seam,and establishes the mechanical model of support and surrounding-rock stability in inclined coal seam.Besides,this study carries out the numerical calculation and field observation of roof movement and support stability,and provides the critical control measures.The results show that the fracture firstly appears in middle-upper roof and extends upwards in top coal caving in inclined coal seam;regular and irregular caving zones appear in middle-upper stress concentration region,and the asymmetric caving arch is finally formed.Support load of middle-upper working face is larger than that of the middle-lower face;dynamic load coefficient of upper support is large,and the load on the front of support is larger than that on the rear of it,which leads to poor support stability.Stability of support and surrounding-rock system depends mainly on upper-support stability.展开更多
In view of the situation of excavation of should carry out simulation studies for the numerical open coal mine for the underground water disaster, we value of the water lowering project and improve the accuracy and th...In view of the situation of excavation of should carry out simulation studies for the numerical open coal mine for the underground water disaster, we value of the water lowering project and improve the accuracy and the level of the water lowering project. On the basis of the hydrological geological conditions of certain open mine digging, a more reasonable seepage numerical model was built according to MODFLOW. It was simulated in advance that the process of the confined water level descending with the time, and combining with the actual observations to test the correctness of the model. The calculation showed that the results coincided well with the results of actual measurement. Based on this, different water lowering numerical simulations were built for the open coal mine digging. It could be simulated and forecast that the changes of the groundwater level in drainage process within and outside the mine pit, and it was quantitatively assessed that the possible water lowering result of the opencast water drainage process, which provide an important basis for the actual water lowering project and the possible project disposal.展开更多
AIM:To conduct a meta-analysis to determine the safety and efficacy of laparoscopic liver resection(LLR) and open liver resection(OLR) for hepatocellular carcinoma(HCC).METHODS:PubMed(Medline),EMBASE and Science Citat...AIM:To conduct a meta-analysis to determine the safety and efficacy of laparoscopic liver resection(LLR) and open liver resection(OLR) for hepatocellular carcinoma(HCC).METHODS:PubMed(Medline),EMBASE and Science Citation Index Expanded and Cochrane Central Register of Controlled Trials in the Cochrane Library were searched systematically to identify relevant comparative studies reporting outcomes for both LLR and OLR for HCC between January 1992 and February 2012.Two authors independently assessed the trials for inclusion and extracted the data.Meta-analysis was performed using Review Manager Version 5.0 software(The Cochrane Collaboration,Oxford,United Kingdom).Pooled odds ratios(OR) or weighted mean differences(WMD) with 95%CI were calculated using either fixed effects(Mantel-Haenszel method) or random effects models(DerSimonian and Laird method).Evaluated endpoints were operative outcomes(operation time,intraoperative blood loss,blood transfusion requirement),postoperative outcomes(liver failure,cirrhotic decompensation/ascites,bile leakage,postoperative bleeding,pulmonary complications,intraabdominal abscess,mortality,hospital stay and oncologic outcomes(positive resection margins and tumor recurrence).RESULTS:Fifteen eligible non-randomized studies were identified,out of which,9 high-quality studies involving 550 patients were included,with 234 patients in the LLR group and 316 patients in the OLR group.LLR was associated with significantly lower intraoperative blood loss,based on six studies with 333 patients [WMD:-129.48 mL;95%CI:-224.76-(-34.21) mL;P = 0.008].Seven studies involving 416 patients were included to assess blood transfusion requirement between the two groups.The LLR group had lower blood transfusion requirement(OR:0.49;95%CI:0.26-0.91;P = 0.02).While analyzing hospital stay,six studies with 333 patients were included.Patients in the LLR group were found to have shorter hospital stay [WMD:-3.19 d;95%CI:-4.09-(-2.28) d;P < 0.00001] than their OLR counterpart.Seven studies including 416 patients were pooled together to estimate the odds of developing postoperative ascites in the patient groups.The LLR group appeared to have a lower incidence of postoperative ascites(OR:0.32;95%CI:0.16-0.61;P = 0.0006) as compared with OLR patients.Similarly,fewer patients had liver failure in the LLR group than in the OLR group(OR:0.15;95%CI:0.02-0.95;P =0.04).However,no significant differences were found between the two approaches with regards to operation time [WMD:4.69 min;95%CI:-22.62-32 min;P = 0.74],bile leakage(OR:0.55;95%CI:0.10-3.12;P = 0.50),postoperative bleeding(OR:0.54;95%CI:0.20-1.45;P = 0.22),pulmonary complications(OR:0.43;95%CI:0.18-1.04;P = 0.06),intra-abdominal abscesses(OR:0.21;95%CI:0.01-4.53;P = 0.32),mortality(OR:0.46;95%CI:0.14-1.51;P = 0.20),presence of positive resection margins(OR:0.59;95%CI:0.21-1.62;P = 0.31) and tumor recurrence(OR:0.95;95%CI:0.62-1.46;P = 0.81).CONCLUSION:LLR appears to be a safe and feasible option for resection of HCC in selected patients based on current evidence.However,further appropriately designed randomized controlled trials should be undertaken to ascertain these findings.展开更多
To investigate the frost-heave properties of silty clay under the combination action of seasonal freezing and artificial freezing, and verify the feasibility of combined freezing, eight combined freezing experiments w...To investigate the frost-heave properties of silty clay under the combination action of seasonal freezing and artificial freezing, and verify the feasibility of combined freezing, eight combined freezing experiments were performed on silty clay with water content (mass fraction) of 23.5% and 28.0%, through developed frost-heave test apparatus, in closed or open system. Two sorts of freezing temperature models, namely, constant and sine models, were applied to artificial freezing. The experimental results indicate that the frost-heave degree in seasonal freezing stage accounts for over 90% of the total in open system and it is up to 95% in closed system; the change of artificial sine-freezing temperature has no influence on the frost-heave degree in closed system, however, slight influence in open system. It is found that the variation of temperature gradient of sine-freezing specimen lags behind that of sine-freezing temperature with half phase; sine-freezing temperature model can reduce frost-heave degree of soil. Brand new technology is proposed for the application of artificial ground freezing and new study field of artificial freezing is created.展开更多
Difficulties with soft coal seams having a high gas content and high stress levels can be addressed by a technology of pressure relief and permeability increase.Slotting the seam by auxiliary drilling with a water jet...Difficulties with soft coal seams having a high gas content and high stress levels can be addressed by a technology of pressure relief and permeability increase.Slotting the seam by auxiliary drilling with a water jet that breaks the coal and slots the coal seam during the process of retreat drilling achieves pressure relief and permeability increase.Improved efficiency of gas extraction from a field test,high gas coal seam was observed.Investigating the theory of pressure relief and permeability increase required analyzing the characteristics of the double power slotting process and the effects of coal pressure relief and permeability increase.The influence of confining pressure on coal physical properties was examined by using FLAC3D software code to simulate changes of coal stress within the tool destruction area.The double power joint drilling method was modeled.Field experiments were performed and the effects are analyzed.This research shows that there is an ''islanding effect'' in front of the joint double power drill and slotting equipment.The failure strength of the coal seam is substantially reduced within the tool destruction area.Drilling depths are increased by 72% and the diameter of the borehole is increased by 30%.The amount of powdered coal extracted from the drill head increases by 17 times when using the new method.A 30 day total flow measurement from the double power drilled and slotted bores showed that gas extraction increased by 1.3 times compared to the standard drilled bores.Gas concentrations increased from 30% to 60% and were more stable so the overall extraction efficiency increased by a factor of two times.展开更多
Water mist technology provides efficient firefighting performance while there is still room for improvement. So varieties of additives have been studied in recent years both at home and abroad. The self-made additives...Water mist technology provides efficient firefighting performance while there is still room for improvement. So varieties of additives have been studied in recent years both at home and abroad. The self-made additives are used to compare the firefighting performance of diesel and heptane fire in open space. By adjusting the concentration of substance in the additives and conducting the experiment under the pressure of 0.3 MPa,0.5 MPa and 0.7 MPa,extinguish time and temperature are measured in the experiment. Through the experiments using different fuels,it can be found when the fuel is heptane that has a lower ignition point and a higher evaporation rate, the water mist additive can still significantly improve the firefighting performance. According to the data based on different concentrations of fluorinated surfactants,we find that fluorinated surfactants are the main substance to improve the performances by changing physical property of water mist. Optimal proportion of the additives for firefighting performance is found by experiment results.展开更多
Flows through an open cross-flow-type nano-hydraulic turbine are numerically simulated to investigate the effects of the clearance Hc between the rotor and the ground on the turbine performance. A two-dimensional part...Flows through an open cross-flow-type nano-hydraulic turbine are numerically simulated to investigate the effects of the clearance Hc between the rotor and the ground on the turbine performance. A two-dimensional particle method is employed, which was successfully used for flow simulations of impulse-type and open cross-flow-type nano-hydraulic turbines in the authors' previous works. When the clearance Hc is smaller than a critical value, the simulated turbine performance decreases with decreasing Hc, in good agreement with the experiment. The simulations make it clear that such a reduction of turbine performance is attributable to an increase in the circumferential component of the water velocity at the rotor outlet. The simulations also demonstrate that the effect of the tip speed ratio of the rotor on the relation between Hc and turbine performance can be analyzed.展开更多
Wave group is important in ocean wave theory and applications. In the past, nonlinear interaction among wave groups has been studied on the basis of the nonlinear Sehrrdinger equation. Using this theoretical approach,...Wave group is important in ocean wave theory and applications. In the past, nonlinear interaction among wave groups has been studied on the basis of the nonlinear Sehrrdinger equation. Using this theoretical approach, we found that the nonlinear interaction among wave groups causes asymmetry in the shape of the wave envelope (steeper in the front of the curve of the envelope). An important consequence of this asymmetry is that the highest wave in a wave group appears one individual wave length ahead of the center of the wave group. Further results show that the degree of envelope asymmetry increases with increasing spectral width and the wave steepness. This theoretical analysis has been supplemented by a systematic experimental study of wind waves. Laboratory and some open sea wave data were analyzed. The results show that the shape of the wind wave envelope of wind waves has the same asymmetry predicted by the theoretical approach. The observed degree of deformation of the envelope also increases with increasing spectral width and the wave steepness as predicted by theory. These conclusions have important ramifications for practical applications of ocean wave theory.展开更多
Recently, Open Source Software (OSS) is so widely used not only by companies for development but also by common users instead of commercial software. However, the number of OSS is vast, and its quality varies from l...Recently, Open Source Software (OSS) is so widely used not only by companies for development but also by common users instead of commercial software. However, the number of OSS is vast, and its quality varies from low to high. So how people can evaluate OSS and ensta-e that it is reliable for use becomes necessary. This paper proposes a set of reliability evaluation metrics considering the states of OSS selected in the early stage. Understandability, Fault tolerance & Recoverability and Community Matmrity as sub-attributes of reliability are defined, and then several evaluation criteria for each of them are identified. A process of reliability evaluation in our study is proposed. For application, we select four OSS projects and evaluate them with our metrics. As a result of compadrison with other evaluation model for OSS, our research presents an easy, effective and trustworthy way for selecting a reliable OSS.展开更多
With the increasing requirement of a higher living quality and the growing awareness of energy saving, how to improve the indoor comfort level and to reduce the expenditure of energy and slow down the rate of natural ...With the increasing requirement of a higher living quality and the growing awareness of energy saving, how to improve the indoor comfort level and to reduce the expenditure of energy and slow down the rate of natural resource consumption is becoming increasingly important. The theory of open-plan housing is able to provide a more flexible and adaptive space for the users and bring sustainable and economic benefit in the way of making full use of construction materials. Sustainable architecture design, as a method to respond the phenomenon, is able to low down the building' s energy consumption and has enormous potentials in creation of sustainable living environment and a high-quality dwelling condition. The primary aim of this research is to create a new sustainable architecture design method for occupancy by integrating openplan housing theory and application of sustainable technologies. Numerical simulation by computer program is applied in order to investigate and evaluate the possibility of this method in teruas of improving indoor comfort level and energy-saving capacity.展开更多
It has been developed and implemented for use antiradiation mask "ARR-I" for use in the uranium industry. The outer layer is treated with a special solution with anti-gas composition, which holds the gaseous radioac...It has been developed and implemented for use antiradiation mask "ARR-I" for use in the uranium industry. The outer layer is treated with a special solution with anti-gas composition, which holds the gaseous radioactive isotopes.展开更多
Private clouds and public clouds are turning mutually into the open integrated cloud computing environment,which can aggregate and utilize WAN and LAN networks computing,storage,information and other hardware and soft...Private clouds and public clouds are turning mutually into the open integrated cloud computing environment,which can aggregate and utilize WAN and LAN networks computing,storage,information and other hardware and software resources sufficiently,but also bring a series of security,reliability and credibility problems.To solve these problems,a novel secure-agent-based trustworthy virtual private cloud model named SATVPC was proposed for the integrated and open cloud computing environment.Through the introduction of secure-agent technology,SATVPC provides an independent,safe and trustworthy computing virtual private platform for multi-tenant systems.In order to meet the needs of the credibility of SATVPC and mandate the trust relationship between each task execution agent and task executor node suitable for their security policies,a new dynamic composite credibility evaluation mechanism was presented,including the credit index computing algorithm and the credibility differentiation strategy.The experimental system shows that SATVPC and the credibility evaluation mechanism can ensure the security of open computing environments with feasibility.Experimental results and performance analysis also show that the credit indexes computing algorithm can evaluate the credibilities of task execution agents and task executor nodes quantitatively,correctly and operationally.展开更多
基金The National Natural Science Foundation of China(No60673128)
文摘In order to realize interoperability to a large number of autonomous and heterogeneous information sources with high efficiency, an agent-based multi-broker architecture (AMA)-HustEven, is constructed. A group of broker agents are designed to provide brokering services in a peer-to-peer (P2P) manner for the non- broker agents (user agents, resource agents, query agents). Thus, the scalability and robustness of the system are enhanced. Ontology is also used by the broker agents for facilitating interoperability among all the agents in HustEven. Unlike any other AMAs, an interdomain ontology is built in this system to represent the relationships among the common concepts in the innerdomain ontologies. Therefore, a broker forwards the queries only to the other related brokers according to the interdomain ontology and the communication overhead among the brokers is reduced. Obviously, the application of the interdomain ontology enables a broker to fully take advantage of the multi-broker architecture. The experimental results show that the HustEven performs more efficiently than any other existing systems.
基金supported by the National High-tech R&D Program of China grant 2015AA043302the Basic research project of Shenzhen grant JCYJ20140417115840236
文摘With rapid advances of solar blind ultraviolet LED and ultraviolet detecting technology in recent years, ultraviolet communication gradually becomes a research hotspot due to its inherent advantages: low solar background noise, non-line-of-sight(NLOS) and good secrecy. The strong scattering characteristics in atmospheric render ultraviolet waveband the ideal choice for achieving NLOS optical communication. This paper reviews the research history and status of ultraviolet communication both in China and abroad, and especially introduces three main issues of ultraviolet communication: channel model, system analysis and design, light sources and detectors. For each aspect, current open issues and prospective research directions are analyzed.
文摘AIM:To evaluate the main factors associated with mortality in patients undergoing surgery for perforated peptic ulcer referred to an academic department of general surgery in a large southern Italian city. METHODS:One hundred and forty-nine consecutive patients (M:F ratio=110:39,mean age 52 yrs,range 16-95) with peptic ulcer disease were investigated for clinical history (including age,sex,previous history of peptic ulcer,associated diseases,delayed abdominal surgery,ulcer site,operation type,shock on admission,postoperative general complications, and intra-abdominal and/or wound infections),serum analyses and radiological findings. RESULTS:The overall mortality rate was 4.0%.Among all factors,an age above 65 years,one or more associated diseases,delayed abdominal surgery,shock on admission, postoperative abdominal complications and/or wound infections,were significantly associated (x^2) with increased mortality in patients undergoing surgery (0.0001<P<0.03). CONCLUSION:Factors such as concomitant diseases,shock on admission,delayed surgery,and postoperative abdominal and wound infections are significantly associated with fatal outcomes and need careful evaluation within the general workup of patients admitted for perforated peptic ulcer.
文摘Small bowel strictures can be missed by current diagnostic methods. The Patency capsule is a new non-endoscopic dissolvable capsule which has as an objective of checking the patency of digestive tract, in a non-invasive manner. The available clinical trials have demonstrated that the Patency capsule is a good tool for assessment of the functional patency of the small bowel, and it allows identification of those patients who can safely undergo a capsule endoscopy, despite clinical and radiographic evidence of small-bowel obstruction. Some cases of intestinal occlusion have been reported with the Patency capsule, four of them needed surgery. So, a new capsule with two timer plugs (Agile capsule) has been recently developed in order to minimize the risk of occlusion. This new device stars its dissolution process earlier (30 h after ingestion) and its two timer plugs have been designed to begin the disintegration even when the device is blocked in a tight stricture.
文摘In this paper the results of skeletal traction and irrigation therapy (STIT) used for open fracture complicated with large-sized full-thickness skin-deficit and infection wounds (OFIW) were presented. Fourteen patients of OFIW were treated by the plaster cast and wound dressing (PCWD), and 30 patients of OFIW were treated by STIT. The results indicated that after one week of treatment, the white blood cell count in the STIT group, compared to 17. 6±l. 0×109/L from before treatment, returned to 8. 8±0. 8×109/L,and in contrast, the cell count of the PCWD group was about 13. 0±1. 4×109/L. All of wound exudate culture in the STIT group was negative, and those of 7 cases (7/14) in PCWD group were positive (P<0. 0l). The symptoms and signs such as pain, fever and septic exudate on the wound in the STIT group were much milder than those in the PCWD group. There were 5 cases (35. 7%) of toxicemia and septicemia, 2 cases (14. 3%) of osteomyelitis, 2 cases (14. 3 %) of amputation, 1 case (7. 1%) of delayed union and 3 cases (21. 4 %) of malunion in the PCWD group, and no complications in the STIT group.
基金provided by the independent research subject of State Key Laboratory of Coal Resources and Mine Safety of China University of Mining and Technology (No. SKLCRSM12X03)the Scientific Research and Innovation Project for College Graduates in Jiangsu (No. CXZZ13_0947)
文摘Aimed at determining the appropriate caving–mining ratio for fully mechanized mining of 20 m thick coal seam, this research investigated the effects of caving–mining ratio on the flow fields of coal and waste rocks, amount of cyclically caved coal and top coal loss by means of numerical modeling. The research was based on the geological conditions of panel 8102 in Tashan coal mine. The results indicated the loose coal and waste rocks formed an elliptical zone around the drawpoint. The ellipse enlarged with decreasing caving–mining ratio. And its long axis inclined to the gob gradually became vertical and facilitating the caving and recovery of top coal. The top coal loss showed a cyclical variation; and the loss cycle was shortened with the decreasing in caving–mining ratio. Moreover, the mean squared error(MSE) of the amount of cyclically caved coal went up with increasing caving–mining ratio, indicating a growing imbalance of amount of cyclically caved coal, which could impede the coordinated mining and caving operations. Finally it was found that a caving–mining ratio of 1:2.51 should be reasonable for the conditions.
基金Supported by Grants from the State Mecklenburg-Vorpommern and from Deutsche Krebshilfe,No.108446
文摘A substantial part of the human genome is derived from transposable elements;remnants of ancient retroviral infections.Conservative estimates set the percentage of human endogenous retroviruses(HERVs) in the genome at 8%.For the most part,the interplay between mutations,epigenetic mechanisms and posttranscriptional regulations silence HERVs in somatic cells.We first highlight mechanisms by which activation of members of several HERV families may be associated with tumor development before discussing the arising chances for both diagnosis and therapy.It has been shown that at least in some cases,tumor cells expressing HERV open reading frames(ORFs) thus gain tumor-promoting functions.However,since these proteins are not expressed in healthy tissues,they become prime target structures.Of potential pharmacological interest are the prevention of HERV transposition,the inhibition of HERV-encoded protein expression and the interference with these proteins' activities.Evidence from recent studies unequivocally proves that HERV ORFs represent a very interesting source of novel tumor-specific antigens with even the potential to surpass entity boundaries.The development of new tumor(immune-) therapies is a very active field and true tumor-specific targets are of outstanding interest since they minimize the risk of autoimmunity and could reduce side effects.Finally,we postulate on main future research streams in order to stimulate discussion on this hot topic.
基金the financial support received from the National Natural Science Foundation of China (No.51174078)Ph.D.Foundation of Henan Polytechnic University (No.60207004) of Chinathe Fostering Foundation of Henan Polytechnic University for the Excellent Ph.D.Dissertation of China (No.508063)
文摘The study analyzes the characteristics of roof movement in mining top coal of inclined coal seam,and establishes the mechanical model of support and surrounding-rock stability in inclined coal seam.Besides,this study carries out the numerical calculation and field observation of roof movement and support stability,and provides the critical control measures.The results show that the fracture firstly appears in middle-upper roof and extends upwards in top coal caving in inclined coal seam;regular and irregular caving zones appear in middle-upper stress concentration region,and the asymmetric caving arch is finally formed.Support load of middle-upper working face is larger than that of the middle-lower face;dynamic load coefficient of upper support is large,and the load on the front of support is larger than that on the rear of it,which leads to poor support stability.Stability of support and surrounding-rock system depends mainly on upper-support stability.
文摘In view of the situation of excavation of should carry out simulation studies for the numerical open coal mine for the underground water disaster, we value of the water lowering project and improve the accuracy and the level of the water lowering project. On the basis of the hydrological geological conditions of certain open mine digging, a more reasonable seepage numerical model was built according to MODFLOW. It was simulated in advance that the process of the confined water level descending with the time, and combining with the actual observations to test the correctness of the model. The calculation showed that the results coincided well with the results of actual measurement. Based on this, different water lowering numerical simulations were built for the open coal mine digging. It could be simulated and forecast that the changes of the groundwater level in drainage process within and outside the mine pit, and it was quantitatively assessed that the possible water lowering result of the opencast water drainage process, which provide an important basis for the actual water lowering project and the possible project disposal.
文摘AIM:To conduct a meta-analysis to determine the safety and efficacy of laparoscopic liver resection(LLR) and open liver resection(OLR) for hepatocellular carcinoma(HCC).METHODS:PubMed(Medline),EMBASE and Science Citation Index Expanded and Cochrane Central Register of Controlled Trials in the Cochrane Library were searched systematically to identify relevant comparative studies reporting outcomes for both LLR and OLR for HCC between January 1992 and February 2012.Two authors independently assessed the trials for inclusion and extracted the data.Meta-analysis was performed using Review Manager Version 5.0 software(The Cochrane Collaboration,Oxford,United Kingdom).Pooled odds ratios(OR) or weighted mean differences(WMD) with 95%CI were calculated using either fixed effects(Mantel-Haenszel method) or random effects models(DerSimonian and Laird method).Evaluated endpoints were operative outcomes(operation time,intraoperative blood loss,blood transfusion requirement),postoperative outcomes(liver failure,cirrhotic decompensation/ascites,bile leakage,postoperative bleeding,pulmonary complications,intraabdominal abscess,mortality,hospital stay and oncologic outcomes(positive resection margins and tumor recurrence).RESULTS:Fifteen eligible non-randomized studies were identified,out of which,9 high-quality studies involving 550 patients were included,with 234 patients in the LLR group and 316 patients in the OLR group.LLR was associated with significantly lower intraoperative blood loss,based on six studies with 333 patients [WMD:-129.48 mL;95%CI:-224.76-(-34.21) mL;P = 0.008].Seven studies involving 416 patients were included to assess blood transfusion requirement between the two groups.The LLR group had lower blood transfusion requirement(OR:0.49;95%CI:0.26-0.91;P = 0.02).While analyzing hospital stay,six studies with 333 patients were included.Patients in the LLR group were found to have shorter hospital stay [WMD:-3.19 d;95%CI:-4.09-(-2.28) d;P < 0.00001] than their OLR counterpart.Seven studies including 416 patients were pooled together to estimate the odds of developing postoperative ascites in the patient groups.The LLR group appeared to have a lower incidence of postoperative ascites(OR:0.32;95%CI:0.16-0.61;P = 0.0006) as compared with OLR patients.Similarly,fewer patients had liver failure in the LLR group than in the OLR group(OR:0.15;95%CI:0.02-0.95;P =0.04).However,no significant differences were found between the two approaches with regards to operation time [WMD:4.69 min;95%CI:-22.62-32 min;P = 0.74],bile leakage(OR:0.55;95%CI:0.10-3.12;P = 0.50),postoperative bleeding(OR:0.54;95%CI:0.20-1.45;P = 0.22),pulmonary complications(OR:0.43;95%CI:0.18-1.04;P = 0.06),intra-abdominal abscesses(OR:0.21;95%CI:0.01-4.53;P = 0.32),mortality(OR:0.46;95%CI:0.14-1.51;P = 0.20),presence of positive resection margins(OR:0.59;95%CI:0.21-1.62;P = 0.31) and tumor recurrence(OR:0.95;95%CI:0.62-1.46;P = 0.81).CONCLUSION:LLR appears to be a safe and feasible option for resection of HCC in selected patients based on current evidence.However,further appropriately designed randomized controlled trials should be undertaken to ascertain these findings.
基金Project(40571032) supported by the National Natural Science Foundation of ChinaProject(2006G011-B-3) supported by Science Studies and Development Plan Foundation of Railway Ministry
文摘To investigate the frost-heave properties of silty clay under the combination action of seasonal freezing and artificial freezing, and verify the feasibility of combined freezing, eight combined freezing experiments were performed on silty clay with water content (mass fraction) of 23.5% and 28.0%, through developed frost-heave test apparatus, in closed or open system. Two sorts of freezing temperature models, namely, constant and sine models, were applied to artificial freezing. The experimental results indicate that the frost-heave degree in seasonal freezing stage accounts for over 90% of the total in open system and it is up to 95% in closed system; the change of artificial sine-freezing temperature has no influence on the frost-heave degree in closed system, however, slight influence in open system. It is found that the variation of temperature gradient of sine-freezing specimen lags behind that of sine-freezing temperature with half phase; sine-freezing temperature model can reduce frost-heave degree of soil. Brand new technology is proposed for the application of artificial ground freezing and new study field of artificial freezing is created.
基金supports provided by the National Key Basic Research and Development Program of China (No. 2011CB201205)the National Natural Science Foundation of China (No. 51074161)the Independent research of State Key Laboratory of Coal Resources and Mine Safety of China University of Mining & Technology (No. SKLCRSM08X03)
文摘Difficulties with soft coal seams having a high gas content and high stress levels can be addressed by a technology of pressure relief and permeability increase.Slotting the seam by auxiliary drilling with a water jet that breaks the coal and slots the coal seam during the process of retreat drilling achieves pressure relief and permeability increase.Improved efficiency of gas extraction from a field test,high gas coal seam was observed.Investigating the theory of pressure relief and permeability increase required analyzing the characteristics of the double power slotting process and the effects of coal pressure relief and permeability increase.The influence of confining pressure on coal physical properties was examined by using FLAC3D software code to simulate changes of coal stress within the tool destruction area.The double power joint drilling method was modeled.Field experiments were performed and the effects are analyzed.This research shows that there is an ''islanding effect'' in front of the joint double power drill and slotting equipment.The failure strength of the coal seam is substantially reduced within the tool destruction area.Drilling depths are increased by 72% and the diameter of the borehole is increased by 30%.The amount of powdered coal extracted from the drill head increases by 17 times when using the new method.A 30 day total flow measurement from the double power drilled and slotted bores showed that gas extraction increased by 1.3 times compared to the standard drilled bores.Gas concentrations increased from 30% to 60% and were more stable so the overall extraction efficiency increased by a factor of two times.
基金Opening Fund of State Key Laboratory of Fire Science,University of Science and Technology of China(No.HZ2011-KF04)
文摘Water mist technology provides efficient firefighting performance while there is still room for improvement. So varieties of additives have been studied in recent years both at home and abroad. The self-made additives are used to compare the firefighting performance of diesel and heptane fire in open space. By adjusting the concentration of substance in the additives and conducting the experiment under the pressure of 0.3 MPa,0.5 MPa and 0.7 MPa,extinguish time and temperature are measured in the experiment. Through the experiments using different fuels,it can be found when the fuel is heptane that has a lower ignition point and a higher evaporation rate, the water mist additive can still significantly improve the firefighting performance. According to the data based on different concentrations of fluorinated surfactants,we find that fluorinated surfactants are the main substance to improve the performances by changing physical property of water mist. Optimal proportion of the additives for firefighting performance is found by experiment results.
文摘Flows through an open cross-flow-type nano-hydraulic turbine are numerically simulated to investigate the effects of the clearance Hc between the rotor and the ground on the turbine performance. A two-dimensional particle method is employed, which was successfully used for flow simulations of impulse-type and open cross-flow-type nano-hydraulic turbines in the authors' previous works. When the clearance Hc is smaller than a critical value, the simulated turbine performance decreases with decreasing Hc, in good agreement with the experiment. The simulations make it clear that such a reduction of turbine performance is attributable to an increase in the circumferential component of the water velocity at the rotor outlet. The simulations also demonstrate that the effect of the tip speed ratio of the rotor on the relation between Hc and turbine performance can be analyzed.
基金Supported by the National Science Foundation of China (No. 40576007)the New Century Excellent Talent Foundation from Education Ministry of China (No. NCET-08-0509)
文摘Wave group is important in ocean wave theory and applications. In the past, nonlinear interaction among wave groups has been studied on the basis of the nonlinear Sehrrdinger equation. Using this theoretical approach, we found that the nonlinear interaction among wave groups causes asymmetry in the shape of the wave envelope (steeper in the front of the curve of the envelope). An important consequence of this asymmetry is that the highest wave in a wave group appears one individual wave length ahead of the center of the wave group. Further results show that the degree of envelope asymmetry increases with increasing spectral width and the wave steepness. This theoretical analysis has been supplemented by a systematic experimental study of wind waves. Laboratory and some open sea wave data were analyzed. The results show that the shape of the wind wave envelope of wind waves has the same asymmetry predicted by the theoretical approach. The observed degree of deformation of the envelope also increases with increasing spectral width and the wave steepness as predicted by theory. These conclusions have important ramifications for practical applications of ocean wave theory.
文摘Recently, Open Source Software (OSS) is so widely used not only by companies for development but also by common users instead of commercial software. However, the number of OSS is vast, and its quality varies from low to high. So how people can evaluate OSS and ensta-e that it is reliable for use becomes necessary. This paper proposes a set of reliability evaluation metrics considering the states of OSS selected in the early stage. Understandability, Fault tolerance & Recoverability and Community Matmrity as sub-attributes of reliability are defined, and then several evaluation criteria for each of them are identified. A process of reliability evaluation in our study is proposed. For application, we select four OSS projects and evaluate them with our metrics. As a result of compadrison with other evaluation model for OSS, our research presents an easy, effective and trustworthy way for selecting a reliable OSS.
文摘With the increasing requirement of a higher living quality and the growing awareness of energy saving, how to improve the indoor comfort level and to reduce the expenditure of energy and slow down the rate of natural resource consumption is becoming increasingly important. The theory of open-plan housing is able to provide a more flexible and adaptive space for the users and bring sustainable and economic benefit in the way of making full use of construction materials. Sustainable architecture design, as a method to respond the phenomenon, is able to low down the building' s energy consumption and has enormous potentials in creation of sustainable living environment and a high-quality dwelling condition. The primary aim of this research is to create a new sustainable architecture design method for occupancy by integrating openplan housing theory and application of sustainable technologies. Numerical simulation by computer program is applied in order to investigate and evaluate the possibility of this method in teruas of improving indoor comfort level and energy-saving capacity.
文摘It has been developed and implemented for use antiradiation mask "ARR-I" for use in the uranium industry. The outer layer is treated with a special solution with anti-gas composition, which holds the gaseous radioactive isotopes.
基金Projects(61202004,61272084)supported by the National Natural Science Foundation of ChinaProjects(2011M500095,2012T50514)supported by the China Postdoctoral Science Foundation+2 种基金Projects(BK2011754,BK2009426)supported by the Natural Science Foundation of Jiangsu Province,ChinaProject(12KJB520007)supported by the Natural Science Fund of Higher Education of Jiangsu Province,ChinaProject(yx002001)supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions,China
文摘Private clouds and public clouds are turning mutually into the open integrated cloud computing environment,which can aggregate and utilize WAN and LAN networks computing,storage,information and other hardware and software resources sufficiently,but also bring a series of security,reliability and credibility problems.To solve these problems,a novel secure-agent-based trustworthy virtual private cloud model named SATVPC was proposed for the integrated and open cloud computing environment.Through the introduction of secure-agent technology,SATVPC provides an independent,safe and trustworthy computing virtual private platform for multi-tenant systems.In order to meet the needs of the credibility of SATVPC and mandate the trust relationship between each task execution agent and task executor node suitable for their security policies,a new dynamic composite credibility evaluation mechanism was presented,including the credit index computing algorithm and the credibility differentiation strategy.The experimental system shows that SATVPC and the credibility evaluation mechanism can ensure the security of open computing environments with feasibility.Experimental results and performance analysis also show that the credit indexes computing algorithm can evaluate the credibilities of task execution agents and task executor nodes quantitatively,correctly and operationally.