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“差异的面纱”——早期马华小说“异族”想象方法的透视 被引量:2
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作者 马淑贞 《世界华文文学论坛》 2010年第2期50-54,共5页
"异族"题材向来是马华作家的一大取材方向,塑造"异族"形象是这类题材的中心任务。对于身为中国移民后裔的马华作家而言,塑造"异族"在某种程度上具有为华人构筑认同自身的镜子和参照系的意味,折射出了华... "异族"题材向来是马华作家的一大取材方向,塑造"异族"形象是这类题材的中心任务。对于身为中国移民后裔的马华作家而言,塑造"异族"在某种程度上具有为华人构筑认同自身的镜子和参照系的意味,折射出了华人主体对"自我"身份和对现实困境的反思。本文试图通过对马华早期小说文本中的"异族"想象方法的透视来剖析早期华人主体的"历史"心态。 展开更多
关键词 “异族” “魔化” 想象 认同
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Chalcogenide-based S-scheme heterojunction photocatalysts
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作者 Chunguang Chen Jinfeng Zhang +3 位作者 Hailiang Chu Lixian Sun Graham Dawson Kai Dai 《Chinese Journal of Catalysis》 SCIE CAS CSCD 2024年第8期81-108,共28页
The unique photocatalytic mechanism of S-scheme heterojunction can be used to study new and efficient photocatalysts.By carefully selecting semiconductors for S-scheme heterojunction photocatalysts,it is possible to r... The unique photocatalytic mechanism of S-scheme heterojunction can be used to study new and efficient photocatalysts.By carefully selecting semiconductors for S-scheme heterojunction photocatalysts,it is possible to reduce the rate of photogenerated carrier recombination and increase the conversion efficiency of light into energy.Chalcogenides are a group of compounds that include sulfides and selenides(e.g.,CdS,ZnS,Bi_(2)S_(3),MoS_(2),ZnSe,CdSe,and CuSe).Chalcogenides have attracted considerable attention as heterojunction photocatalysts owing to their narrow bandgap,wide light absorption range,and excellent photoreduction properties.This paper presents a thorough analysis of S-scheme heterojunction photocatalysts based on chalcogenides.Following an introduction to the fundamental characteristics and benefits of S-scheme heterojunction photocatalysts,various chalcogenide-based S-scheme heterojunction photocatalyst synthesis techniques are summarized.These photocatalysts are used in numerous significant photocatalytic reactions,in-cluding the reduction of carbon dioxide,synthesis of hydrogen peroxide,conversion of organic matter,generation of hydrogen from water,nitrogen fixation,degradation of organic pollutants,and sterilization.In addition,cutting-edge characterization techniques,including in situ characterization techniques,are discussed to validate the steady and transient states of photocatalysts with an S-scheme heterojunction.Finally,the design and challenges of chalcogenide-based S-scheme heterojunction photocatalysts are explored and recommended in light of state-of-the-art research. 展开更多
关键词 PHOTOCATALYSIS CHALCOGENIDE S-scheme heterojunction Charge separation Application
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Cloning of a MADS Box Gene(GhMADS3)from Cotton and Analysis of Its Homeotic Role in Transgenic Tobacco 被引量:8
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作者 郭余龙 祝钦泷 +1 位作者 郑尚永 李名扬 《Journal of Genetics and Genomics》 SCIE CAS CSCD 北大核心 2007年第6期527-535,共9页
A MADS box gene (GhMADS3) was cloned from cotton (Gossypium hirsutum L.) based on EST sequences. The predicted protein sequence of GhMADS3 showed 85%, 73%, and 62% identity with Theobroma cacao TcAG, Antirrhinum m... A MADS box gene (GhMADS3) was cloned from cotton (Gossypium hirsutum L.) based on EST sequences. The predicted protein sequence of GhMADS3 showed 85%, 73%, and 62% identity with Theobroma cacao TcAG, Antirrhinum majus FAR, and Arabidopsis thaliana AG, respectively, and was grouped with AG homologues when the full length sequences excluding N-extensions were compared. GhMADS3 expressed in the wild type cotton flower primarily in stamens and carpels, which was comparable to AG in Arabidopsis. However, it was not expressed in floral buds of a homeotic cotton variant chvl. Ectopic expression of GhMADS3 in tobacco (Nicotiana tabacum L.) resulted in flowers with sepal-to-carpel and petal-to-stamen transformation. The carpelloid first whorl organs, with stigmatic tissue on their upper edges, had a white appearance when compared with the dark green color of the wild type sepals. At times, long filaments were observed at the fusion site of the first carpelloid oranges. The second whorl organs in staminoid were usually smaller than the wild type and the color was changed from pink to white. These results suggest that GhMADS3 has a homeotic role in flower development. 展开更多
关键词 MADS-BOX AG subfamily homeotic role COTTON flower development
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Hydroxylation Polymorphisms of S─mephenytoin aDebrisoquin in Native Normal Chinese Zhuang MinorityVolunteers
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作者 匡唐永 罗其葵 +2 位作者 张家美 邹安庆 楼雅卿 《Journal of Chinese Pharmaceutical Sciences》 CAS 1995年第2期99-106,共8页
S─mephenytoin and debrisoquin hydroxylation abilities were investigated in 118 normal Chinese Zhuang minority volunteers after co─administration po 100 mg racemic mephenytoin(MP)and 10 mg debrisoquin (DB). The rat... S─mephenytoin and debrisoquin hydroxylation abilities were investigated in 118 normal Chinese Zhuang minority volunteers after co─administration po 100 mg racemic mephenytoin(MP)and 10 mg debrisoquin (DB). The ratio between S─and R─enantiomers of mephenytoin in urinewas determined by implication of GC─NPD and used as the measure of the drug hydroxylation. 2 ofthe 118 subjects had S/R ratios greater than 1.0 and were poor hydroxylators of S─mephenytoin. The frequency of S─mephenytoin poor metabolizers (PM) was 10.2%. No PM of debrisoquin was found in the volunteers. It indicated that there was no relationship between S─mephenytoin P(4′)─ hydroxylation and debrisoquin 4─hydroxylation polymorphisms in Chinese Zhuang Minority population. In addition, 16 of the 118 volunteers(4 PMs and 12 EMs of S-mephenytoin) were se─lected to conduct the elimination kinetic studies of racemic mephenytoin and debrisoquin in urine. The pharmacokinetic parameters of S─, R─mephenytoin, DB and 4─OH─DB were calculated. 展开更多
关键词 MEPHENYTOIN Debrisoquin HYDROXYLATION Inheritic polymorphism Pharma─cokinetics Gas chromatography
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A study of the genus Camptotylidea Wagner, 1957 (Hemiptera: Miridae: Phylinae) from China
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作者 李晓明 刘国卿 《Entomotaxonomia》 CSCD 北大核心 2014年第1期36-44,共9页
Four species of Camptotylidea Wagner are reported from China with Camptotylidea linzensis sp. nov. described as new to science. A key for identification of the Chinese species is given. Photographs of the dorsal habit... Four species of Camptotylidea Wagner are reported from China with Camptotylidea linzensis sp. nov. described as new to science. A key for identification of the Chinese species is given. Photographs of the dorsal habitus and figures of the male genitalia are provided. The type specimens are deposited in the Institute of Entomology, Nankai University, Tianjin, China. 展开更多
关键词 HETEROPTERA Miroidea Phylini TAXONOMY key
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Ulcerative colitis in a multiracial Asian country: Racial difference and clinical presentation among Malaysian patients 被引量:3
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作者 Khean-Lee Goh 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第37期5859-5862,共4页
AIM: To determine the prevalence of ulcerative colitis (UC) in Malaysian patients and to establish the spectrum of the disease seen in Malaysian patients. METHODS: Data were obtained retrospectively from a review ... AIM: To determine the prevalence of ulcerative colitis (UC) in Malaysian patients and to establish the spectrum of the disease seen in Malaysian patients. METHODS: Data were obtained retrospectively from a review of the medical records of in- and out-patients with a diagnosis of UC at the University Hospital, Kuala Lumpur between 1985 and 1998. RESULTS: There were 45 confirmed cases of UC, of which 3 were foreigners, who were excluded from analysis. Thirty new cases of UC were diagnosed during the study period. Their mean age at presentation was 33.0±10.0 years. The highest prevalence of UC was 17.9/100 000 hospital admissions in the Indians, followed by 11.2/100 000 hospital admissions in the Chinese. The lowest prevalence was 3.7/100 000 hospital admissions in the Malays. The prevalence of UC was significantly higher in the Indians and the Chinese when compared with the Malays with an OR of 4.89 (CI = 2.02-12.24; x^2 = 15.45, P〈0.001) and 3.06 (CI = 1.24-7.78; x^2= 6.30; P= 0.012) respectively. The extent of colonic disease Was similar in the Malay and Indian patients. In contrast, distal or left-sided colitis predominated in the Chinese with an OR of 8.17 (95%CI = 1.31-64.87; x^2 = 5.53, P = 0.02). Extraintestinal manifestations were uncommon (11.9%). CONCLUSION: UC is an uncommon disease in Malaysia, but racial differences exist. The Indians had the highest prevalence of UC with the Chinese demonstrating the least extensive disease. 展开更多
关键词 Ulcerative colitis Asian races Racial differences
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Demographic determinants of risk,colon distribution and density scores of diverticular disease 被引量:4
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作者 Mark Golder Irina Chis Ster +3 位作者 Pratusha Babu Amita Sharma Muhammad Bayat Abdulkadir Farah 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第8期1009-1017,共9页
AIM:To investigate associations between ethnicity,age and sex and the risk,colon distribution and density scores of diverticular disease(DD).METHODS:Barium enemas were examined in 1000 patients:410 male,590 female;760... AIM:To investigate associations between ethnicity,age and sex and the risk,colon distribution and density scores of diverticular disease(DD).METHODS:Barium enemas were examined in 1000 patients:410 male,590 female;760 whites,62 Asians,44 black africans(BAs),and 134 other blacks(OBs).Risks and diverticula density of left-sided DD(LSDD) and rightsided-component DD(RSCDD = right-sided DD + right and left DD + Pan-DD) were compared using logistic regression.RESULTS:Four hundred and forty-seven patients had DD(322 LSDD and 125 RSCDD).Adjusted risks:(1) LSDD:each year increase in age increased the odds by 6%(95% CI:5-8,SE:0.8%,P < 0.001);Asians:odds ratio(OR):0.23(95% CI:0.10-0.53,SE:0.1,P ≤ 0.001) and OBs:OR:0.25(95% CI:0.14-0.43,SE:0.07,P ≤ 0.001) appeared protected vs Whites;(2) RSCDD:each year increase in age increased the odds by 4%(95% CI:2-6,SE:1%,P < 0.001);females were 0.60 times(95% CI:0.40-0.90,SE:0.12,P = 0.01) less likely than males to have RSCDD;BAs were 3.51 times(95% CI:1.70-7.24,SE:1.30,P < 0.001) more likely than Whites to have RSCDD;and(3) DD density scores:each year increase in age increased the odds of highdensity scores by 4%(95% CI:1-6,SE:1%,P < 0.001);RSCDD was 2.77 times(95% CI:1.39-3.32,SE:0.67,P < 0.001) more likely to be of high density than LSDD.No further signif icant differences were found in the adjusted models.CONCLUSION:Right colonic DD might be more common and has higher diverticula density in the west than previously reported.BAs appear predisposed to DD,whereas other ethnic differences appear conserved following migration. 展开更多
关键词 Diverticular disease Migration Barium enema ETHNICITY Colon distribution RISK
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英语怪异纵横谈
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作者 江船漂 《宁德师专学报(哲学社会科学版)》 2004年第4期64-67,共4页
以词汇变化为主要特征的语言中的细微变化往往不被使用它的本族人察觉,以"异族敏感论"的角度说,以重意合的汉语看重音合的英语,可以更敏锐地发现英语独有的许多"怪异"现象。
关键词 英语 “怪异”现象 “异族敏感论” 词汇 汉语 文化差异 语言文字
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A study of the genus Xylotrechus Chevrolat(Coleoptera:Cerambycidae)from Beijing,China 被引量:1
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作者 Meiying LIN Siqin GE Nengwen XIAO 《Entomotaxonomia》 CSCD 2021年第3期205-224,共20页
Ten species of the genus Xylotrechus Chevrolat,1860 from Beijing are studied.Xylotrechus pekingensis Pic,1939 is reinstated from synonym of Xylotrechus yanoi Gressitt,1934,and newly recorded from Hebei and Shaanxi Pro... Ten species of the genus Xylotrechus Chevrolat,1860 from Beijing are studied.Xylotrechus pekingensis Pic,1939 is reinstated from synonym of Xylotrechus yanoi Gressitt,1934,and newly recorded from Hebei and Shaanxi Provinces.Xylotrechus bifenestratus Pic,1916 is proposed as a new junior synonym of Xylotrechus polyzonus(Fairmaire,1888),both were described from Beijing,China.Three species,X.ibex(Gebler,1825),X.pyrrhoderus Bates,1873,and X.robusticollis(Pic,1936),are reported from Beijing for the first time.Several new localities are added to the related species based on specimens examined.A key to the ten species of Xylotrechus Chevrolat,1860 from Beijing is provided. 展开更多
关键词 CERAMBYCINAE Clytini TAXONOMY new synonym new record
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Sino-Western Regional Differences and Translation
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作者 ZHAO You-bin 《Journal of Literature and Art Studies》 2016年第4期441-444,共4页
Cultuare difference always exists in many aspects. Due to the national characters, regionalism, and times, translation can not be in a position when we try to translate without considering the language culture. Cultur... Cultuare difference always exists in many aspects. Due to the national characters, regionalism, and times, translation can not be in a position when we try to translate without considering the language culture. Cultural difference between English and Chinese, determines the different features between English and Chinese. 展开更多
关键词 Sino-Western cultures regional culture TRANSLATION
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Study on the Policy of Embodying Language Difference between Chinese and Western Culture
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作者 LI Yan 《International English Education Research》 2016年第1期69-70,共2页
For centuries, cross-cultural exchange activities throughout history, language and culture from the communication is an integral part of the contact. For the entire human history, cross-cultural communication is not s... For centuries, cross-cultural exchange activities throughout history, language and culture from the communication is an integral part of the contact. For the entire human history, cross-cultural communication is not strange. It plays an important role in studying different languages. Language is the carrier of culture and the main manifestation of culture. Language is developing with the development of a nation, it is an integral part of national culture, history, customs and local customs and practices, the nation's culture and social customs are also in the national language to show. The different historical background and development process leads to great difference exists in Western languages. With mutual understanding and deepen, the conflict in western culture are increasing. Language is the primary from of communication. And the use of language and culture are closely related. So "differences between Chinese culture and Western culture in English language" has become the important topic of intercultural communication. 展开更多
关键词 cultural difference the policy of embodiment mode of thinking
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A Study on the Cultural Meanings of Qiang’s Traditional Dress and Adornment
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作者 SU Yan-fei 《Cultural and Religious Studies》 2018年第5期285-293,共9页
Since 2008 when the Wenchuan earthquake occurred, media from different countries and regions across the world reported the earthquake so that a less well-known ethnic group of China, the Qiang ethnic minority, has att... Since 2008 when the Wenchuan earthquake occurred, media from different countries and regions across the world reported the earthquake so that a less well-known ethnic group of China, the Qiang ethnic minority, has attracted attention around the world. The Qiang ethnic minority could be dated back to the Shang Dynasty (ca. 1600-1046BC). The long-standing Qiang culture is an important part of those brilliant Chinese cultures. The Qiang’s traditional dress and adornment is an integral part of the Qiang culture, appreciating unique ethnic characteristics and cultural meanings. Being against the backdrop of promoting cultural diversity nowadays, this paper makes a brief introduction to the Qiang’s traditional dress and adornment and gives an explanation of their rich unique cultural meanings so as to present the Qiang’s traditional dress and adornment to the world, facilitate their going out to the world and communication with other cultures in the world, and enrich the world’s ethnic cultures. 展开更多
关键词 The Qiang ethnic minority the Qiang's traditional dress and adornment cultural meanings
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Cultural Disjunction in B. Mukherjee's Wife
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作者 Stefanovici Smaranda 《Journal of Literature and Art Studies》 2013年第1期9-15,共7页
After experiencing racism in Canada, where multiculturalism emphasized ethnic differences and fixed identities rather than allowing for cultural interaction and hybridity, the author, B. Mukherjee, moves to the USA wh... After experiencing racism in Canada, where multiculturalism emphasized ethnic differences and fixed identities rather than allowing for cultural interaction and hybridity, the author, B. Mukherjee, moves to the USA whose biculturalism favors cultural interactions and fluid identities. Here she experiences the transformative powers of cultural interactions and frees herself and her work from the static power of cultural disjunction. Her personal experience highlights the need of immigrant characters to connect to the mainstream and not to be isolated from it The paper explores the problem of cultural adaptability and integration as experienced by Dimple, the main character in Mukherjee's novel Wife (1975). Based upon contemporary research on cultural and social identity formation, the paper analyses Dimple's inner struggle of identity in the context of her immigrant status, and it relates her ultimately tragic response to loneliness and alienation resulting in cultural disjunction, non-adaptability, and non-assimilation. 展开更多
关键词 enculturation/acculturation multiculturalism/biculturalism cultural disjunction/cultural interaction static/transformative dialogic confrontation/hybridity
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Associations between interleukin-1 polymorphisms and gastric cancers among three ethnicities 被引量:6
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作者 Jiu-Da Zhao Pai-Li Geng +10 位作者 Zhan-Quan Li Sen Cui Jun-Hui Zhao Li-Juan Wang Jin-Zhang Li Fa-Xiang Ji Guo-Yuan Li Guo-Shuang Shen Ming-Zhe Lin Cun-Fang Shen Cheng-Zhu Cao 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第47期7093-7099,共7页
AIM:To investigate the associations between interleukin(IL)-1B and IL-1RN polymorphisms and gastric cancers among the Tibet,Hui and Han ethnicities.METHODS:Genomic DNA was extracted from peripheral blood of 210,205,an... AIM:To investigate the associations between interleukin(IL)-1B and IL-1RN polymorphisms and gastric cancers among the Tibet,Hui and Han ethnicities.METHODS:Genomic DNA was extracted from peripheral blood of 210,205,and 202 healthy volunteers and from 155,158,and 197 gastric cancer patients from the Tibet,Hui,and Han populations,respectively.Polymorphisms in IL-1B and IL-1RN were analyzed by denaturing high-performance liquid chromatography.RESULTS:Carriers of the IL-1B-31 CC genotype had an increased risk of intestinal type gastric cancer [odds ratio(OR) = 2.17,P = 0.037] in the Tibet ethnicity.Carriers of the IL-1B 2/L genotype had an increased risk of both intestinal and diffuse types of gastric cancer(OR = 2.08,2.31,P = 0.007,0.016,respectively) in the Hui ethnicity.In the Han population,carriers of the IL-1B-31 CC,IL-1B-511CT,TT genotypes had increased risk of intestinal type gastric cancer(OR = 2.51,2.74,5.66,P = 0.005,0.002,0.000,respectively).CONCLUSION:IL-1B and IL-RN genotypes may differentially contribute to gastric cancer among the Tibet,Hui,and Han ethnicities in the Qinghai area of China. 展开更多
关键词 Gastric cancer INTERLEUKIN-1B Interleukin1RN POLYMORPHISM Risk of gastric cancer
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Genetic variations of beta 2-adrenergic receptor gene are associated with essential hypertension in Xinjiang Kazakans
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作者 Zhi-Tao Yan Nan-Fang Li Jin Yang Ling Zhou Hui Liu Qin Luo 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2010年第1期52-57,共6页
Objective The aims of the present study were to investigate the associations of 46 A〉G, 79 C〉G, 491 C〉T and 659 C〉G genetic variants of the human beta 2-adrenergic receptor (β2-AR), ADRB2, gene with essential h... Objective The aims of the present study were to investigate the associations of 46 A〉G, 79 C〉G, 491 C〉T and 659 C〉G genetic variants of the human beta 2-adrenergic receptor (β2-AR), ADRB2, gene with essential hypertension (EH) in Xinjiang Kazakans population.Methods A gender-matched case-control (271 hypertensive cases and 267 normotensive controls) study was used to investigate the associations of the four variations in the coding region of ADRB2 with EH. The genotypes of the variants were identified by the polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) methods. Results 46 A〉G, 79 C〉G and 659 C〉G polymorphisms were common in the Kazakan population, but 491 C〉T was a mutation (frequency ofT allele was only 0.003) and only found in EH group. The fxequency distributions of genotypes and alleles for 659 C〉G between the EH and control groups was significantly different (P〈0.05), while those for 46 A〉G and 79 C〉G polymorphisms were not statistically different. Logistic regression analysis suggested that the G allele of 659 C〉G polymorphism was a risk factor for hypertension (minor allele vs common homo; odds ratio, 13.240, 95% CI, 4.052-43.274; P〈0.05). Covariance analysis showed that systolic and diastolic blood pressure levels in GG+CG group of 659 C〉G were significantly higher than those in the CC group, but no significant difference of blood pressure were found between common homo and minor allele for 46 A〉G and 79C〉G polymorphisms. Haplotype analysis showed that two hyplotypes, HI: 46A-79C-491C-523C(48%)and H5:46A-79C-491C-659G, were associated with EH.Conelusion ADRB2 genetic variants may play independent roles in the molecular genetic mechanism of EH in Xinjiang Kazakans population (d Geriatr Cardio12010; 7:52-57). 展开更多
关键词 β2-adrenergic receptor gene variant essential hypertension HAPLOTYPE Xinjiang Kazakan
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Involvement of two glycoside hydrolase family 19 members in colony morphotype and virulence in Flavobacterium columnare
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作者 张晓林 李楠 +2 位作者 秦婷 黄贝 聂品 《Chinese Journal of Oceanology and Limnology》 SCIE CAS CSCD 2017年第6期1511-1523,共13页
Flavobacterium columnare is the pathogenic agent of columnaris disease in aquaculture. Using a recently developed gene deletion strategy, two genes that encode the Glyco hydro_19 domain (GH19 domain) containing prot... Flavobacterium columnare is the pathogenic agent of columnaris disease in aquaculture. Using a recently developed gene deletion strategy, two genes that encode the Glyco hydro_19 domain (GH19 domain) containing proteins, ghd-1 and ghd-2, were deleted separately and together from the F. columnare G4 wild type strain. Surprisingly, the single-, Aghd-1 and Aghd-2, and double-gene mutants, Aghd-1 Aghd-2, all had rhizoid and non-rhizoid colony morphotypes, which we named Aghd-1, Aghd-2, Aghd-1 Aghd-2, and NAghd-1, NAghd-2, and NAghd-1 Aghd-2. However, chitin utilization was not detected in either these mutants or in the wild type. Instead, skimmed milk degradation was observed for the mutants and the wild type; the non-rhizoid strain NAghd-2 exhibited higher degradation activity as revealed by the larger transparent circle on the skimmed milk plate. Using zebrafish as the model organism, we found that non-rhizoid mutants had higher LDs0 values and were less virulent because zebrafish infected with these survived longer. Transcriptome analysis between the non-rhizoid and rhizoid colony morphotypes of each mutant, i.e., NAghd-1 versus (vs) Aghd-1, NAghd-2 vs Aghd-2, and NAghd-1 Aghd-2 vs Aghd-1 Aghd-2, revealed a large number of differentially expressed genes, among which 39 genes were common in three of the pairs compared. Although most of these genes encode hypothetical proteins, a few molecules such as phage tail protein, rhs element Vgr protein, thiol-activated cytolysin, and TonB-dependent outer membrane receptor precursor, expression of which was down-regulated in non-rhizoid mutants but up-regulated in rhizoid mutants, may play a role F. columnare virulence. 展开更多
关键词 Flavobacterium columnare GH 19 domain gene deletion rhizoid colony non-rhizoid colony
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Relationship between β3-AR Gene and Obesity, Type 2 Diabetes, Insulin Resistance in Chinese Han Population
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作者 HEWei MAXiang-hua SHENJie 《Journal of Nanjing Medical University》 2004年第4期211-214,共4页
Objective: To explore the relationship between the β 3-adrenergic receptor(β 3-AR)gene and obesity, T2DM, insulin resistance in Chinese Han population. Methods: Fifty-three healthy subjects, 105 subjects with simp... Objective: To explore the relationship between the β 3-adrenergic receptor(β 3-AR)gene and obesity, T2DM, insulin resistance in Chinese Han population. Methods: Fifty-three healthy subjects, 105 subjects with simple obesity, 63 type 2 diabetic patients without obesity, and 114 type 2 diabetic patients with obesity were studied with the technique of PCR-RFLP in codon 64 of the exon region of β 3-AR gene representing the variation Trp/Arg. Results: Compared with the subjects of Trp homozygous group, the individuals with Arg allele were more elevated in WHR,MBP,SBP,DBP,FBS,PBS,FINS,PINS,FCP,PCP and lower in ISI. Frequency of Arg allele was higher in HINS subgroup without T2DM. Conclusion: The results indicate that the Trp/Arg variation might lead to insulin resistance, obesity and T2DM.β 3-AR gene is supposed to be the candidate gene of insulin resistance, obesity and T2DM in Chinese Han population. 展开更多
关键词 adrenergic receptor gene OBESITY type 2 diabetes mellitus insulin resistance
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Theoretical Study on the Stable Structures and Aromaticities for Pnictogen Dianionic Sb4^2-, Bi4^2-, and (SbBi)2^2- Clusters
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作者 Xing-bao Wang Xian-xing Chi 《Chinese Journal of Chemical Physics》 SCIE CAS CSCD 2009年第1期75-81,共7页
Through the theoretical calculation of structural optimization, vibrational frequencies and atomization energies with one method of density functional theory (B3LYP) and two post- Hartree-Fock approaches (MP2, CCSD... Through the theoretical calculation of structural optimization, vibrational frequencies and atomization energies with one method of density functional theory (B3LYP) and two post- Hartree-Fock approaches (MP2, CCSD(T)), several stable isomers for new three pnictogen dianionic Sb4^2-, Bi4^2-, and (SbBi)2^2- species were determined. For two homoatomic Sb4^2- and Bi4^2- species, there are three stable isomers: square (D4h), roof-shaped (C2v-1), and C2v-2 structure with the square isomer being the ground state. For the heteroatomic dian- ionic (SbBi)2^2- species, there are also three stable isomers: rhombus (D2h), roof-shaped (C1), and C2v structures with the rhombic isomer being the ground state. The calculated NICS values show that nucleus-independent chemical shifts (NICS) values of roof-shaped isomers for Sb4^2-, Bi4^2-, and (SbBi)2^2- species are all negative, consequently indicating that these roof-shaped isomers possess aromaticities. NICS values for the planar ring isomers are all positive, suggesting that these three planar ring isomers have antiaromatic characters. The aromaticity for the two stable roof-shaped and square isomers are preliminarily explained and discussed with MO analysis. 展开更多
关键词 Pnictogen cluster Ab initio AROMATICITY Nucleus-independent chemical shift
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Germline MLH1 and MSH2 mutational spectrum including frequent large genomic aberrations in Hungarian hereditary non-polyposis colorectal cancer families:Implications for genetic testing 被引量:9
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作者 Janos Papp Marietta E Kovacs Edith Olah 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第19期2727-2732,共6页
AIM: To analyze the prevalence of germline MLH1 and MSH2 gene mutations and evaluate the clinical characteristics of Hungarian hereditary non-polyposis colorectal cancer (HNPCC) families. METHODS: Thirty-six kindreds ... AIM: To analyze the prevalence of germline MLH1 and MSH2 gene mutations and evaluate the clinical characteristics of Hungarian hereditary non-polyposis colorectal cancer (HNPCC) families. METHODS: Thirty-six kindreds were tested for mutations using conformation sensitive gel electrophoreses, direct sequencing and also screening for genomic rearrangements applying multiplex ligation-dependent probe amplifi cation (MLPA). RESULTS: Eighteen germline mutations (50%) were identifi ed, 9 in MLH1 and 9 in MSH2. Sixteen of these sequence alterations were considered pathogenic, the remaining two were non-conservative missense alterations occurring at highly conserved functional motifs. The majority of the defi nite pathogenic mutations (81%, 13/16) were found in families fulfilling the stringent Amsterdam Ⅰ/Ⅱ criteria, including three rearrangements revealed by MLPA (two in MSH2 and one in MLH1). However, in three out of sixteen HNPCC-suspected families (19%), a disease-causing alteration could be revealed. Furthermore, nine mutations described here are novel, and none of the sequence changes were found in more than one family.CONCLUSION: Our study describes for the f irst time the prevalence and spectrum of germline mismatch repair gene mutations in Hungarian HNPCC and suspected-HNPCC families. The results presented here suggest that clinical selection criteria should be relaxed and detection of genomic rearrangements should be included in genetic screening in this population. 展开更多
关键词 Germline mutation Hereditary non-polyposis colorectal cancer MLH1 MSH2 REARRANGEMENT
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Parasites of Anisakidae Family--Geographical Distribution and Threat to Human Health
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作者 Ewa Bilska-Zajac Mirostaw Rozycki Ewa Chmurzynska Jacek Karamon Jacek Sroka Maciej Kochanowski Pawet Kusyk Tomasz Cencek 《Journal of Agricultural Science and Technology(A)》 2015年第2期146-152,共7页
Nematodes of the Anisakidae family are important parasites that can cause anisakiasis--human parasitic infection of gastrointestinal tract. Allergic symptoms can arise as secondary immune response after infection by l... Nematodes of the Anisakidae family are important parasites that can cause anisakiasis--human parasitic infection of gastrointestinal tract. Allergic symptoms can arise as secondary immune response after infection by living parasite. In the life cycle of these parasites, intermediate, definitive and paratenic hosts (fish) might occur. In most cases, human anisakiasis is caused by consumption of fish which are infected with the larvae of the Anisakidae family. The purpose of the article was to assess the definitive host, the geographical spread of the parasites and the risk associated with consumption of raw fish and fishery products. Furthermore, this article describes symptoms and treatment of anisakiasis and kinds of preventive measures that can be taken to prevent anisakiasis. 展开更多
关键词 Larvae of Anisakidae family ANISAKIS Pseudoterranova decipiens anisakiasis.
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