Wearable devices have great application potential in the next generation of smart portable electronics,especially in the fields of medical monitoring,soft robotics,artificial intelligence,and human-machine interfaces....Wearable devices have great application potential in the next generation of smart portable electronics,especially in the fields of medical monitoring,soft robotics,artificial intelligence,and human-machine interfaces.Piezoelectric flexible strain sensors are key components of wearable devices.However,existing piezoelectric flexible strain sensors have certain limitations in weak signal monitoring due to their large modulus and low sensitivity.To solve this problem,the concept of Kirigami(paper-cutting)was introduced in this study to design the sensor structure.By comparing the Kirigami structures of different basic structures,the serpentine structure was determined as the basic configuration of the sensor.The serpentine structure not only provides excellent tensile properties,but also significantly improves the sensitivity of the sensor,which performs well in monitoring weak signals.On this basis,the adhesion properties of the flexible sensor were analyzed and tested,and the optimal ratio of the substrate was selected for preparation.In addition,a low-cost and rapid prototyping process for stretchable patches was established in this study.Using this technology,we prepared the sensor device and tested its performance.Finally,we successfully developed a flexible sensor with a sensitivity of 0.128 mV/μɛand verified its feasibility for wrist joint motion monitoring applications.This result opens up new avenues for the recovery care of tenosynovitis patients after surgery.展开更多
The aim of the experiment was to explore the feasibility of discarded nutrient medium of Cordyceps militaris as feed in the production of laying hens. 100 g/kg, 200 g/kg, 300 g/kg of discarded nutrient medium of Cordy...The aim of the experiment was to explore the feasibility of discarded nutrient medium of Cordyceps militaris as feed in the production of laying hens. 100 g/kg, 200 g/kg, 300 g/kg of discarded nutrient medium of Cordyceps militaris were added to the basal diet of laying hens. The results showed that the optimal addition of discarded nutrient medium of Cordyceps militaris in the diet of laying hens was 10%. According to the results of measuring the conventional indicators of eggs, the weight of eggs produced by laying hens fed with discarded nutrient medium of Cordyceps militaris was higher than that of laying hens fed with ordinary laying hens. The content of interleukin-1(IL-1) in the experimental group was significantly higher than that in the control group, and the concentration of IL-1 increased by 141.5 pg/mL, which indicated that the application of discarded nutrient medium of Cordyceps militaris effectively improved the immunity of laying hens. The high-throughput analysis of the intestinal contents of the two groups of laying hens showed that the microbial population abundance of the intestinal tract of the experimental group was greater than that of control group, and the application of discarded nutrient medium of Cordyceps militaris increased the diversity of bacteria in the intestinal tract of laying hens. In addition, the sensitivity of some pathogenic bacteria in the intestinal tract of chickens to drugs was also increased, thereby reducing the use of antibiotics. The secondary utilization of discarded nutrient medium of Cordyceps militaris has great development and utilization prospects, which provided a scientific reference and basic theoretical basis for the development of discarded nutrient medium of Cordyceps militaris as feed in the production of laying hens.展开更多
Understanding the steady mechanism of biomass smoldering plays a great role in the utilization of smoldering technology.In this study numerical analysis of steady smoldering of biomass rods was performed.A two-dimensi...Understanding the steady mechanism of biomass smoldering plays a great role in the utilization of smoldering technology.In this study numerical analysis of steady smoldering of biomass rods was performed.A two-dimensional(2D)steady model taking into account both char oxidation and pyrolysis was developed on the basis of a calculated propagation velocity according to empirical correlation.The model was validated against the smoldering experiment of biomass rods under natural conditions,and the maximum error was smaller than 31%.Parameter sensitivity analysis found that propagation velocity decreases significantly while oxidation area and pyrolysis zone increase significantly with the increasing diameter of rod fuel.展开更多
The combustion and explosion characteristics of lithium-ion battery vent gas is a key factor in determining the fire hazard of lithium-ion batteries.Investigating the combustion and explosion hazards of lithium-ion ba...The combustion and explosion characteristics of lithium-ion battery vent gas is a key factor in determining the fire hazard of lithium-ion batteries.Investigating the combustion and explosion hazards of lithium-ion batteries vent gas can provide guidance for rescue and protection in explosion accidents in energy storage stations and new energy vehicles,thereby promoting the application and development of lithium-ion batteries.Based on this understanding and combined with previous research on gas production from lithium-ion batteries,this article conducted a study on the combustion and explosion risks of vent gas from thermal runaway of 18650 LFP batteries with different states of charge(SOCs).The explosion limit of mixed gases affected by carbon dioxide inert gas is calculated through the“elimination”method,and the Chemkin-Pro software is used to numerically simulate the laminar flame speed and adiabatic flame temperature of the battery vent gas.And the concentration of free radicals and sensitivity coefficients of major elementary reactions in the system are analyzed to comprehensively evaluate the combustion explosion hazard of battery vent gas.The study found that the 100%SOC battery has the lowest explosion limit of the vent gas.The inhibitory elementary reaction sensitivity coefficient in the reaction system is lower and the concentration of free radicals is higher.Therefore,it has the maximum laminar flame speed and adiabatic flame temperature.The combustion and explosion hazard of battery vent gas increases with the increase of SOC,and the risk of explosion is the greatest and most harmful when SOC reaches 100%.However,the related hazards decrease to varying degrees with overcharging of the battery.This article provides a feasible method for analyzing the combustion mechanism of vent gas from lithium-ion batteries,revealing the impact of SOC on the hazardousness of battery vent gas.It provides references for the safety of storage and transportation of lithium-ion batteries,safety protection of energy storage stations,and the selection of related fire extinguishing agents.展开更多
Objective Triple-negative breast cancer(TNBC)is the breast cancer subtype with the worst prognosis,and lacks effective therapeutic targets.Colony stimulating factors(CSFs)are cytokines that can regulate the production...Objective Triple-negative breast cancer(TNBC)is the breast cancer subtype with the worst prognosis,and lacks effective therapeutic targets.Colony stimulating factors(CSFs)are cytokines that can regulate the production of blood cells and stimulate the growth and development of immune cells,playing an important role in the malignant progression of TNBC.This article aims to construct a novel prognostic model based on the expression of colony stimulating factors-related genes(CRGs),and analyze the sensitivity of TNBC patients to immunotherapy and drug therapy.Methods We downloaded CRGs from public databases and screened for differentially expressed CRGs between normal and TNBC tissues in the TCGA-BRCA database.Through LASSO Cox regression analysis,we constructed a prognostic model and stratified TNBC patients into high-risk and low-risk groups based on the colony stimulating factors-related genes risk score(CRRS).We further analyzed the correlation between CRRS and patient prognosis,clinical features,tumor microenvironment(TME)in both high-risk and low-risk groups,and evaluated the relationship between CRRS and sensitivity to immunotherapy and drug therapy.Results We identified 842 differentially expressed CRGs in breast cancer tissues of TNBC patients and selected 13 CRGs for constructing the prognostic model.Kaplan-Meier survival curves,time-dependent receiver operating characteristic curves,and other analyses confirmed that TNBC patients with high CRRS had shorter overall survival,and the predictive ability of CRRS prognostic model was further validated using the GEO dataset.Nomogram combining clinical features confirmed that CRRS was an independent factor for the prognosis of TNBC patients.Moreover,patients in the high-risk group had lower levels of immune infiltration in the TME and were sensitive to chemotherapeutic drugs such as 5-fluorouracil,ipatasertib,and paclitaxel.Conclusion We have developed a CRRS-based prognostic model composed of 13 differentially expressed CRGs,which may serve as a useful tool for predicting the prognosis of TNBC patients and guiding clinical treatment.Moreover,the key genes within this model may represent potential molecular targets for future therapies of TNBC.展开更多
Group testing is a method that can be used to estimate the prevalence of rare infectious diseases,which can effectively save time and reduce costs compared to the method of random sampling.However,previous literature ...Group testing is a method that can be used to estimate the prevalence of rare infectious diseases,which can effectively save time and reduce costs compared to the method of random sampling.However,previous literature only demonstrated the optimality of group testing strategy while estimating prevalence under some strong assumptions.This article weakens the assumption of misclassification rate in the previous literature,considers the misclassification rate of the infected samples as a differentiable function of the pool size,and explores some optimal properties of group testing for estimating prevalence in the presence of differential misclassification conforming to this assumption.This article theoretically demonstrates that the group testing strategy performs better than the sample by sample procedure in estimating disease prevalence when the total number of sample pools is given or the size of the test population is determined.Numerical simulation experiments were conducted to evaluate the performance of group tests in estimating prevalence in the presence of dilution effect.展开更多
The method of cloud model with entropy weight was adopted for the prediction of rock burst classification. Some main factors of rock burst including the uniaxial compressive strength （σc）, the tensile strength （σ...The method of cloud model with entropy weight was adopted for the prediction of rock burst classification. Some main factors of rock burst including the uniaxial compressive strength （σc）, the tensile strength （σt）, the tangential stress （σθ）, the rock brittleness coefficient （σc/σt）, the stress coefficient （σθ /σc） and the elastic energy index （Wet） are chosen to establish evaluation index system. The entropy？cloud model and criterion are obtained through 209 sets of rock burst samples from underground rock projects. The sensitivity of indicators is analyzed and 209 sets of rock burst samples are discriminated by this model. The discriminant results of the entropy-cloud model are compared with those of Bayes, KNN and RF methods. The results show that the sensitivity order of those factors from high to low is σ_θ /σ_c, σ_θ, W_（ct）, σ_c/σ_t, σ_t, σ_c, and the entropy-cloud model has higher accuracy than Bayes, K-Nearest Neighbor algorithm （KNN） and Random Forest （RF） methods.展开更多
基金supported by National Natural Science Foundation of China(Nos.62301509,62304209)Key Research and Development Program of Shanxi Province(No.202302030201001)Fundamental Research Program of Shanxi Province(Nos.202203021222079,0210302123203,202103021223185).
文摘Wearable devices have great application potential in the next generation of smart portable electronics,especially in the fields of medical monitoring,soft robotics,artificial intelligence,and human-machine interfaces.Piezoelectric flexible strain sensors are key components of wearable devices.However,existing piezoelectric flexible strain sensors have certain limitations in weak signal monitoring due to their large modulus and low sensitivity.To solve this problem,the concept of Kirigami(paper-cutting)was introduced in this study to design the sensor structure.By comparing the Kirigami structures of different basic structures,the serpentine structure was determined as the basic configuration of the sensor.The serpentine structure not only provides excellent tensile properties,but also significantly improves the sensitivity of the sensor,which performs well in monitoring weak signals.On this basis,the adhesion properties of the flexible sensor were analyzed and tested,and the optimal ratio of the substrate was selected for preparation.In addition,a low-cost and rapid prototyping process for stretchable patches was established in this study.Using this technology,we prepared the sensor device and tested its performance.Finally,we successfully developed a flexible sensor with a sensitivity of 0.128 mV/μɛand verified its feasibility for wrist joint motion monitoring applications.This result opens up new avenues for the recovery care of tenosynovitis patients after surgery.
基金Project supported by Key Project of Education Department of Liaoning Province(LJKZZ20220116)Surface Project of Science and Technology Department of Liaoning Province(2023-MS-251).
文摘The aim of the experiment was to explore the feasibility of discarded nutrient medium of Cordyceps militaris as feed in the production of laying hens. 100 g/kg, 200 g/kg, 300 g/kg of discarded nutrient medium of Cordyceps militaris were added to the basal diet of laying hens. The results showed that the optimal addition of discarded nutrient medium of Cordyceps militaris in the diet of laying hens was 10%. According to the results of measuring the conventional indicators of eggs, the weight of eggs produced by laying hens fed with discarded nutrient medium of Cordyceps militaris was higher than that of laying hens fed with ordinary laying hens. The content of interleukin-1(IL-1) in the experimental group was significantly higher than that in the control group, and the concentration of IL-1 increased by 141.5 pg/mL, which indicated that the application of discarded nutrient medium of Cordyceps militaris effectively improved the immunity of laying hens. The high-throughput analysis of the intestinal contents of the two groups of laying hens showed that the microbial population abundance of the intestinal tract of the experimental group was greater than that of control group, and the application of discarded nutrient medium of Cordyceps militaris increased the diversity of bacteria in the intestinal tract of laying hens. In addition, the sensitivity of some pathogenic bacteria in the intestinal tract of chickens to drugs was also increased, thereby reducing the use of antibiotics. The secondary utilization of discarded nutrient medium of Cordyceps militaris has great development and utilization prospects, which provided a scientific reference and basic theoretical basis for the development of discarded nutrient medium of Cordyceps militaris as feed in the production of laying hens.
文摘Understanding the steady mechanism of biomass smoldering plays a great role in the utilization of smoldering technology.In this study numerical analysis of steady smoldering of biomass rods was performed.A two-dimensional(2D)steady model taking into account both char oxidation and pyrolysis was developed on the basis of a calculated propagation velocity according to empirical correlation.The model was validated against the smoldering experiment of biomass rods under natural conditions,and the maximum error was smaller than 31%.Parameter sensitivity analysis found that propagation velocity decreases significantly while oxidation area and pyrolysis zone increase significantly with the increasing diameter of rod fuel.
基金supported by the National Natural Science Foundation of China(52106284)the Natural Science Foundation of Hebei Province(B2021507001)support of Project to Promote Innovation in Doctoral Research at CPPU(BSKY202302).
文摘The combustion and explosion characteristics of lithium-ion battery vent gas is a key factor in determining the fire hazard of lithium-ion batteries.Investigating the combustion and explosion hazards of lithium-ion batteries vent gas can provide guidance for rescue and protection in explosion accidents in energy storage stations and new energy vehicles,thereby promoting the application and development of lithium-ion batteries.Based on this understanding and combined with previous research on gas production from lithium-ion batteries,this article conducted a study on the combustion and explosion risks of vent gas from thermal runaway of 18650 LFP batteries with different states of charge(SOCs).The explosion limit of mixed gases affected by carbon dioxide inert gas is calculated through the“elimination”method,and the Chemkin-Pro software is used to numerically simulate the laminar flame speed and adiabatic flame temperature of the battery vent gas.And the concentration of free radicals and sensitivity coefficients of major elementary reactions in the system are analyzed to comprehensively evaluate the combustion explosion hazard of battery vent gas.The study found that the 100%SOC battery has the lowest explosion limit of the vent gas.The inhibitory elementary reaction sensitivity coefficient in the reaction system is lower and the concentration of free radicals is higher.Therefore,it has the maximum laminar flame speed and adiabatic flame temperature.The combustion and explosion hazard of battery vent gas increases with the increase of SOC,and the risk of explosion is the greatest and most harmful when SOC reaches 100%.However,the related hazards decrease to varying degrees with overcharging of the battery.This article provides a feasible method for analyzing the combustion mechanism of vent gas from lithium-ion batteries,revealing the impact of SOC on the hazardousness of battery vent gas.It provides references for the safety of storage and transportation of lithium-ion batteries,safety protection of energy storage stations,and the selection of related fire extinguishing agents.
基金supported by grants from The National Natural Science Foundation of China(82303126,82303069,82173374,82103342)Natural Science Foundation of Hunan Province(2024JJ6325,2024JJ5287)Natural Science Foundation of Fujian Province(2023J05038)。
文摘Objective Triple-negative breast cancer(TNBC)is the breast cancer subtype with the worst prognosis,and lacks effective therapeutic targets.Colony stimulating factors(CSFs)are cytokines that can regulate the production of blood cells and stimulate the growth and development of immune cells,playing an important role in the malignant progression of TNBC.This article aims to construct a novel prognostic model based on the expression of colony stimulating factors-related genes(CRGs),and analyze the sensitivity of TNBC patients to immunotherapy and drug therapy.Methods We downloaded CRGs from public databases and screened for differentially expressed CRGs between normal and TNBC tissues in the TCGA-BRCA database.Through LASSO Cox regression analysis,we constructed a prognostic model and stratified TNBC patients into high-risk and low-risk groups based on the colony stimulating factors-related genes risk score(CRRS).We further analyzed the correlation between CRRS and patient prognosis,clinical features,tumor microenvironment(TME)in both high-risk and low-risk groups,and evaluated the relationship between CRRS and sensitivity to immunotherapy and drug therapy.Results We identified 842 differentially expressed CRGs in breast cancer tissues of TNBC patients and selected 13 CRGs for constructing the prognostic model.Kaplan-Meier survival curves,time-dependent receiver operating characteristic curves,and other analyses confirmed that TNBC patients with high CRRS had shorter overall survival,and the predictive ability of CRRS prognostic model was further validated using the GEO dataset.Nomogram combining clinical features confirmed that CRRS was an independent factor for the prognosis of TNBC patients.Moreover,patients in the high-risk group had lower levels of immune infiltration in the TME and were sensitive to chemotherapeutic drugs such as 5-fluorouracil,ipatasertib,and paclitaxel.Conclusion We have developed a CRRS-based prognostic model composed of 13 differentially expressed CRGs,which may serve as a useful tool for predicting the prognosis of TNBC patients and guiding clinical treatment.Moreover,the key genes within this model may represent potential molecular targets for future therapies of TNBC.
基金supported by the National Natural Science Foundation of China(Grant No.72091212).
文摘Group testing is a method that can be used to estimate the prevalence of rare infectious diseases,which can effectively save time and reduce costs compared to the method of random sampling.However,previous literature only demonstrated the optimality of group testing strategy while estimating prevalence under some strong assumptions.This article weakens the assumption of misclassification rate in the previous literature,considers the misclassification rate of the infected samples as a differentiable function of the pool size,and explores some optimal properties of group testing for estimating prevalence in the presence of differential misclassification conforming to this assumption.This article theoretically demonstrates that the group testing strategy performs better than the sample by sample procedure in estimating disease prevalence when the total number of sample pools is given or the size of the test population is determined.Numerical simulation experiments were conducted to evaluate the performance of group tests in estimating prevalence in the presence of dilution effect.
基金Projects(51474252,51274253)supported by the National Natural Science Foundation of ChinaProject(2015CX005)supported by the Innovation Driven Plan of Central South University,ChinaProject(2016zzts095)supported by the Fundamental Research Funds for the Central Universities,China
文摘The method of cloud model with entropy weight was adopted for the prediction of rock burst classification. Some main factors of rock burst including the uniaxial compressive strength （σc）, the tensile strength （σt）, the tangential stress （σθ）, the rock brittleness coefficient （σc/σt）, the stress coefficient （σθ /σc） and the elastic energy index （Wet） are chosen to establish evaluation index system. The entropy？cloud model and criterion are obtained through 209 sets of rock burst samples from underground rock projects. The sensitivity of indicators is analyzed and 209 sets of rock burst samples are discriminated by this model. The discriminant results of the entropy-cloud model are compared with those of Bayes, KNN and RF methods. The results show that the sensitivity order of those factors from high to low is σ_θ /σ_c, σ_θ, W_（ct）, σ_c/σ_t, σ_t, σ_c, and the entropy-cloud model has higher accuracy than Bayes, K-Nearest Neighbor algorithm （KNN） and Random Forest （RF） methods.
