Joyce began his literary career with strong discontent with his social condition. Ulysses is Joyce＇s optimum work, which takes 3 Dublin characters＇ experience in one day as the main line to show the paralysation and...Joyce began his literary career with strong discontent with his social condition. Ulysses is Joyce＇s optimum work, which takes 3 Dublin characters＇ experience in one day as the main line to show the paralysation and crisis of the whole Western society, people＇s emptiness on their minds, loneliness on their feelings and labefaction on their spirits, also, it showed the inextricable perplexity. To treat the theme of inextricable perplexity, this paper is trying to set about the inextricable Catholic Church and identity problems, with the ideas of Alick West-the outstanding English Marxist literary critic of the 20th century.展开更多
Mammalian AlkB homologue 2(ALKBH2)is the primary housekeeping DNA demethylase,effectively repairing endogenously formed methylated lesions in double-stranded DNA.Our previous studies demonstrated that a hydrophobicβ-...Mammalian AlkB homologue 2(ALKBH2)is the primary housekeeping DNA demethylase,effectively repairing endogenously formed methylated lesions in double-stranded DNA.Our previous studies demonstrated that a hydrophobicβ-hairpin motif of ALKBH2 could play crucial roles in base-pair stability interrogation and damaged base flipping.Using chemical cross-linking strategy,we obtained two crystal structures of human ALKBH2 mutant bound to duplex DNA.The structural analysis suggests that theβ-hairpin motif is flexible in conformation and is likely to slide along the DNA duplex in local regions to search for damaged base.This study provides a new mechanistic insight into DNA damage detection by ALKBH2.展开更多
文摘Joyce began his literary career with strong discontent with his social condition. Ulysses is Joyce＇s optimum work, which takes 3 Dublin characters＇ experience in one day as the main line to show the paralysation and crisis of the whole Western society, people＇s emptiness on their minds, loneliness on their feelings and labefaction on their spirits, also, it showed the inextricable perplexity. To treat the theme of inextricable perplexity, this paper is trying to set about the inextricable Catholic Church and identity problems, with the ideas of Alick West-the outstanding English Marxist literary critic of the 20th century.
基金financially supported by the Hundred Talents Program of the Chinese Academy of Sciences,Key Project of Chinese National Programs for Fundamental Research and Development(2009CB918502)
文摘Mammalian AlkB homologue 2(ALKBH2)is the primary housekeeping DNA demethylase,effectively repairing endogenously formed methylated lesions in double-stranded DNA.Our previous studies demonstrated that a hydrophobicβ-hairpin motif of ALKBH2 could play crucial roles in base-pair stability interrogation and damaged base flipping.Using chemical cross-linking strategy,we obtained two crystal structures of human ALKBH2 mutant bound to duplex DNA.The structural analysis suggests that theβ-hairpin motif is flexible in conformation and is likely to slide along the DNA duplex in local regions to search for damaged base.This study provides a new mechanistic insight into DNA damage detection by ALKBH2.
