远程监管在药品监管和企业管理的作用与实践

当前,信息技术与监管业务不断融合,数字化监管、移动化监管等创新监管方式的作用不断凸显。远程监管能够通过智能分析风险点准确制定监管策略,从而提高监管效率并确保药品安全。云南省药品监督管理局“以点带面”,推行“药监慧眼”工程试点,实现药品生产安全远程监管。在试点过程中,云南白药集团及其子公司通过“技术先行”“数据赋能”解决了信息化程度不同企业的数据收集、上传、预警问题,为探索药品生产智慧监管提供了新思路。“药监慧眼”工程试点的实施不但促进了企业自身信息化建设,推进质量管理系统的整合,更重要的是将生产过程可识别化,为智慧监管打通了关键一环,是药品全生命周期风险管控的有效手段。本研究总结试点项目的实施和成效,并对实现药品生产全过程可追溯、推进药品生产企业信息化建设、构建监管大数据的应用场景进行了思考,建议通过鼓励医药产业信息化、打通中药原料的追溯和监管、建立信息安全防护体系、构建智能化数据分析等措施,推动药品安全治理的网络化、智慧化、高效化。

Application of MODIS data in monitoring suspended sediment of Taihu Lake,China

Application of MODIS in ocean color is mainly based on bands 8-16 with the spatial resolution of 1 000 m.This spatial resolution,however,can not meet the application demand of inland waters where the areas are relatively small.With the assumption of the black water at shortwave infrared(SWIR) wavelengths(>1 000 nm),we first propose an atmospheric correction method for bands 1 and 2 with their spatial resolution of 250 m,and we then establish a quantitative retrieval model for suspended sediment concentration retrieval using the in-situ data collected in Taihu Lake.We also use MODIS data to retrieve the suspended sediment concentration of Taihu Lake with the retrieval model.The comparison between the retrieved and measured suspended sediment concentrations confirms that our algorithm can provide reliable data for monitoring the suspended sediment in Taihu Lake.

Application of MOS-1b/MESSR data to flood monitoring of Dongting Lake

Taking Dongting Lake district as the studying area and utilizing multi-temporal MOS-lb/MESSR data as remote sensing info source, by the combination operation and ratio transform processing and the image, spectrum and histogram comparison of the MESSR image data of all bands for the flood season and dry season with the ER-DAS IMAGINE system, a classification model was established, which can be used to acquire the spatial distributing information of water bodies. Meanwhile a water depth index model was derived and built, and then a model for detecting the depth of water body based on the non-linear recursive analysis was presented. By the overlay analysis of the classification thematic images based on the model for extracting flood information, the flooding area and distributing information were acquired.

Evaluation of the retrieval of total suspended matter concentration in Taihu Lake,China from CBERS-02B CCD

Remote sensing techniques is used to quantify the total suspended matter concentration （CTSM）. In this study, we used remotely sensed data to retrieve the CTSM for the Taihu Lake, China, and developed an atmospheric correction algorithm especially for CBERS-02B CCD data. We simulated the remote sensing reflectance （Rr~） of CCD bands using in-situ observations made in a cruise over the Taihu Lake in autumn 2004, from which a retrieval model is established with simulated Rrs（830） and measured CTSM. In addition, we applied the atmospheric correction algorithm and retrieval model to process the CCD data over the lake in 2008 and to retrieve the CTSM. The RMS relative error between the CTSM retrieved from MODIS and from the CCD images is about 42.9%, indicating that algorithms described in this paper can be used for the application of CCD data in monitoring the CTSM distribution in the Taihu Lake.

Cities Make Life Better:Hukou and Household Satisfaction about Life

This paper examines the relationship between a change of hukou and househoM satisfaction about life based on large-sample China Family Panel Studies （CFPS） data. As horizontally shown by cross-section data, significant hukou identity differences exist in the subjective happiness of households reflected in life satisfaction. However, the traditional view that ＂rural residents are subjectively happier than urban residents＂ is not verified in this study. From a vertical perspective of tracing data, the estimation results of the DID model and the PSM model indicate that a change of hukou identity for rural residents has a significantly positive effect on their subjective happiness, lending credence to the saying that ＂cities make life better＂.

Danger of GLOFs in the Mountain Areas of Kazakhstan

The presentation describes the methods and shows the results of GLOFs＇ danger estimation in lie and Zhetysu Alatau ranges （Kazakhstan）. The catalogues of glacial lakes were made following the results of satellite images processing. The catalogue contains the data of 186 glacial lakes in lle Alatau and 577 lakes in Zhetysu Alatau. According to the bathymetric data of 35 glacial lakes the dependences of volume on lake＇s area for proglacial and moraine lakes were developed and lake＇s volumes were calculated. There are 32 lakes in Ile Alatau and 110 lakes in Zhetysu Alatau with water volume more than 100,000 m3. The most hazardous lakes have the following characteristics： 1） the lake volume exceeds 100,000 m3, （2） the lake is proglacial, （3） the dam is a young moraine with an ice core, （4） there are sites with the steep of more than 15° spreading for more than 500 m down the valley, and （5） there are important non-protected objects in the mudflows affected area. There are 14 the most hazardous glacial lakes with very high level of GLOF danger： 6 lakes in lie Alatau and 8 lakes in Zhetysu Alatau.

Construction of lake bathymetry from MODIS satellite data and GIS from 2003 to 2011

In recent years, sedimentation conditions in Dongting Lake have varied greatly because of signifi cant changes in runoff and sediment load in the Changjiang(Yangtze) River following the construction of Three Gorges Dam. The topography of the lake bottom has changed rapidly because of the intense exchange of water and sediment between the lake and the Changjiang River. However, time series information on lake-bottom topographic change is lacking. In this study, we introduced a method that combines remote sensing data and in situ water level data to extract a record of Dongting Lake bottom topography from 2003 to 2011. Multi-temporal lake land/water boundaries were extracted from MODIS images using the linear spectral mixture model method. The elevation of water/land boundary points were calculated using water level data and spatial interpolation techniques. Digital elevation models of Dongting Lake bottom topography in different periods were then constructed with the multiple heighted waterlines. The mean root-mean-square error of the linear spectral mixture model was 0.036, and the mean predicted error for elevation interpolation was-0.19 m. Compared with fi eld measurement data and sediment load data, the method has proven to be most applicable. The results show that the topography of the bottom of Dongting Lake has exhibited uneven erosion and deposition in terms of time and space over the last nine years. Moreover, lake-bottom topography has undergone a slight erosion trend within this period, with 58.2% and 41.8% of the lake-bottom area being eroded and deposited, respectively.

Determining whether Qinghai–Tibet Plateau waterbodies have acted like carbon sinks or sources over the past 20 years

Half of all of China’s lakes are on the Qinghai–Tibet Plateau(QTP),which are mainly distributed at altitudes above 4000 m asl.Being under conditions of progressively intensifying anthropogenic activities and climate change,the debate on whether QTP lakes act as carbon(C)sinks or sources remains unresolved.This study explores QTP lake C exchange processes and characteristics over the past two decades through field monitoring and data integration.Results reveal high lake carbon dioxide(CO_(2))exchange flux distribution patterns in its western and southern regions and correspondingly low values in its eastern and northern regions.Lake CO_(2)exchange flux rates also show significant temporal differences where those in the 2000s and 2010s were significantly higher compared to the 2020s.Annual total CO_(2)emission flux from QTP lakes has increased from 1.60 Tg Ca^(-1)in the 2000s to 6.87 Tg Ca^(-1)in the 2010s before decreasing to 1.16 Tg Ca^(-1)in the 2020s.However,QTP lakes have generally acted as C sinks when annual ice-cover periods are included in the estimation of annual C budgets.Consequently,QTP lakes are gradually evolving towards C sinks.Some small-sized freshwater lakes on the QTP exhibit C sequestration characteristics while low-mid altitude saltwater lakes also act as C sinks.Therefore,owing to the high uncertainties in the estimation of C exchange flux,the QTP lake C sink capacity has been largely underestimated.

Lake geochemistry reveals marked environmental change in Southwest China during the Mid Miocene Climatic Optimum

The Mid-Miocene Climatic Optimum （MMCO; 15-17 Ma） was one of the short-term climatic warm events that punctuated the Cenozoic long-term cooling trend. Because there are very few terrestrial records of this event, most of our understanding comes from marine cores. In this report, we first present new palaeomagnetic data that revises the dating of our 400 m-thick lacustrine section in Wenshan （Yunnan）, previously thought to be Late Mio- cene. These new data suggest an older age, ca. 15.2-16.5 Ma, coinciding with the MMCO. We measured δ13C on bulk organic matter （3 Corg）, total organic carbon （TOC）, total nitrogen （TN） and C/N ratios at a high sample resolution to： （1） reconstruct the palaeoenvironmental changes in the lake catchment area, and （2） infer mechanisms responsible for these changes. Our results show that all four geochemical parameters demonstrate that a strong environmental change occurred around the middle of the section, shortly after the C5Cn/C5Br geomagnetic reversal and the Early/Middle Miocene boundary at 15.97 Ma. We propose that the environmental shift may be due to a combination of a change in climate, which became cooler, together with a change in organic matter cycling within the lake. This study provides a new insight into the MMCO and demonstrates that although the MMCO was generally a warm event, it was also a time of climatic instability and abrupt environmental changes.