This paper deals with I new genus and I new species from Fujian Province, China, viz: Evallocotaphis Zhang, gen. nov., Evallocotaphis lutescens Zhang et Qiao, sp. nov.. All the type specimens are deposited in the Ins...This paper deals with I new genus and I new species from Fujian Province, China, viz: Evallocotaphis Zhang, gen. nov., Evallocotaphis lutescens Zhang et Qiao, sp. nov.. All the type specimens are deposited in the Institute of Zoology, Academia Sinica.展开更多
In the last two decades, great efforts have been made in the treatment of metastatic colorectal cancer(m CRC) due to the approval of new target agents for cytotoxic drugs. Unfortunately, a large percentage of patients...In the last two decades, great efforts have been made in the treatment of metastatic colorectal cancer(m CRC) due to the approval of new target agents for cytotoxic drugs. Unfortunately, a large percentage of patients present with metastasis at the time of diagnosis or relapse after a few months. The complex molecular heterogeneity of this disease is not completely understood; to date, there is a lack of predictive biomarkers that can be used to select subsets of patients who may respond to target drugs. Only the RAS-mutation status is used to predict resistance to anti-epidermal growth factor receptor agents in patients with m CRC. In this review, we describe approved targeted therapies for the management of metastatic m CRC and discuss new candidate targets on the horizon.展开更多
Thromboembolic complications represent a substantial problem in patients with atrial fibrillation （AF）. The prevalence of AF burden and associated arterial and venous thrombosis progressively increases with age. At ...Thromboembolic complications represent a substantial problem in patients with atrial fibrillation （AF）. The prevalence of AF burden and associated arterial and venous thrombosis progressively increases with age. At the same time, representative national data regarding stroke incidence in AF patients aged 80 and older are limited.展开更多
Atrial fibrillation and venous thromboembolism （VTE） are common disorders associated with maleficent thrombotic events, particularly in the elderly patients. Polypharmacy, co-morbidities, and altered pharmacokinetic...Atrial fibrillation and venous thromboembolism （VTE） are common disorders associated with maleficent thrombotic events, particularly in the elderly patients. Polypharmacy, co-morbidities, and altered pharmacokinetics, often present in these patients, render the use of antico-agulants quite challenging. Novel oral anticoagulants （NOACs） have recently emerged as alternatives to Vitamin K Antagonists （VKAs） and are gradually increasing their popularity mainly because of their fewer drug and food interactions and ease of use. Their effectiveness and safety has been weU-established in the general population but the balance between benefit and harm in the elderly is still unclear. Routine use in these patients is uncommon. Accumulating data have shown that the benefit of NOACs is consistent among all age groups, featuring equal or greater efficacy in preventing thrombotic events. Excess bleedings were lower with NOACs in comparison to VKAs, but bleeding patterns were disparate among them and head to head comparison is not available. The present review highlights on the efficacy and safety of novel anticoagulants in the elderly population.展开更多
To investigated the usefulness of a novel slim type ball-tipped FlushKnife (FlushKnife-BTS) over ball-tipped FlushKnife (FlushKnife-BT) in functional experiments and clinical practice.METHODSIn order to evaluate the f...To investigated the usefulness of a novel slim type ball-tipped FlushKnife (FlushKnife-BTS) over ball-tipped FlushKnife (FlushKnife-BT) in functional experiments and clinical practice.METHODSIn order to evaluate the functionality of FlushKnife-BTS, water aspiration speed, resistance to knife insertion through the scope, and waterjet flushing speed were compared between FlushKnife-BTS and BT. In clinical practice, esophageal endoscopic submucosal dissection (ESD) performed using FlushKnife-BTS or BT by an experienced endoscopist between October 2015 and January 2016 were retrospectively reviewed. The treatment speed and frequency of removing and reinserting the knife to aspirate fluid and air during ESD sessions were analyzed.RESULTSFunctional experiments revealed that water aspiration speed by the endoscope equipped with a 2.8-mm working channel with FlushKnife-BTS was 7.7-fold faster than that with conventional FlushKnife-BT. Resistance to knife insertion inside the scope with a 2.8-mm working channel was reduced by 40% with FlushKnife-BTS. The waterjet flushing speed was faster with the use of FlushKnife-BT. In clinical practice, a comparison of 6 and 7 ESD using FlushKnife-BT and BTS, respectively, revealed that the median treatment speed was 25.5 mm<sup>2</sup>/min (range 19.6-30.3) in the BT group and 44.2 mm<sup>2</sup>/min (range 15.5-55.4) in the BTS group (P = 0.0633). However, the median treatment speed was significantly faster with FlushKnife-BTS when the resection size was larger than 1000 m<sup>2</sup> (n = 4, median 24.2 mm<sup>2</sup>/min, range 19.6-27.7 vs n = 4, median 47.4 mm<sup>2</sup>/min, range 44.2-55.4, P = 0.0209). The frequency of knife replacement was less in the BTS group (median 1.76 times in one hour, range 0-5.45) than in the BT group (7.02 times in one hour, range 4.23-15) (P = 0.0065).CONCLUSIONOur results indicate that FlushKnife-BTS enhances the performance of ESD, particularly for large lesions, by improving air and fluid aspiration and knife insertion during ESD and reducing the frequency of knife removal and reinsertion.展开更多
A new species in the Oriental delphacid genus Miranus Chen et Ding, M. serrulatus sp. nov. is described and illustrated. A key to all species of this genus is presented. The specimens examined are deposited in the Ent...A new species in the Oriental delphacid genus Miranus Chen et Ding, M. serrulatus sp. nov. is described and illustrated. A key to all species of this genus is presented. The specimens examined are deposited in the Entomological Museum, Northwest A ＆ F University （NWAFU）. The terminology used in this paper follows that of Ding （2006）.展开更多
Polyketides have been widely used clinically due to their significant biological activities, but the needed structural and functional diversity cannot be achieved by common chemical synthetic methods. The tool of comb...Polyketides have been widely used clinically due to their significant biological activities, but the needed structural and functional diversity cannot be achieved by common chemical synthetic methods. The tool of combinatorial biosynthesis provides the possibility to produce "unnatural" natural drugs, which has achieved initial success. This paper provides an overview for the strategies of combinatorial biosynthesis in producing the structural and functional diversity of polyketides, including the redesign of metabolic flow, polyketide synthase(PKS) engineering, and PKS post-translational modification. Although encouraging progress has been made in the last decade, challenges still exist regarding the rational combinatorial biosynthesis of polyketides. In this review, the perspectives of polyketide combinatorial biosynthesis are also discussed.展开更多
The effect of verapamil on Ca2+ influx across the myocardial plasma membrane and coxsackie virus B3 ( CVB3)-RNA replication in cultured neonatal rat heart cells infected with CVB3 was investigated. It was found that t...The effect of verapamil on Ca2+ influx across the myocardial plasma membrane and coxsackie virus B3 ( CVB3)-RNA replication in cultured neonatal rat heart cells infected with CVB3 was investigated. It was found that the Ca2+ influx could be inhibited significantly (P<O. 01) by verapamil (1 μmol/L) after infection of heart cells for 48h. However, when the cultured heart cells infected with CVB3 and treated with verapamil (Iμmol/L and 10 nmo/L) at the same time for 48h, the amounts of CVB3-RNA in myocytes were significantly higher than that in infected control group (P<O. 05). These phenomena suggest that the increase of Ca2+ influx of cultured heart cells infected with CVB3 could be inhibited by some calcium antagonists, e. g. verapamil at the early stage. On the other hand, verapamil might accelerate viral replication in myocardium. Thus, although verapamil could be beneficial for decreasing the secondary Ca2+ damages and improve the myocardial electric activity, it isn’t a sensible choice for therapy in early stage of virus infection with cardiac symptoms.展开更多
A straight, non-sporulating, Gram-variable bacillus (HKU24T) was recovered from the blood culture of a patient with metastatic breast carcinoma. After repeated subculturing in BACTEC Plus Anaerobic/F blood culture bro...A straight, non-sporulating, Gram-variable bacillus (HKU24T) was recovered from the blood culture of a patient with metastatic breast carcinoma. After repeated subculturing in BACTEC Plus Anaerobic/F blood culture broth, HKU24T grew on brucella agar as non-hemolytic, pinpoint colonies after 96 h of incubation at 37 °C in an anaerobic environment and aerobic environment with 5% CO2. Growth was enhanced with a streak of Staphylococcus aureus. HKU24T was non-motile and catalase-negative, but positive for alkaline phosphatase, β-glucosidase, and α-glucosidase. It hydrolyzed phenylphosphonate and reduced resazurin. 16S rRNA, groEL, gyrB, recA, and rpoB sequencing showed that HKU24T occupies a distinct phylogenetic position among the Leptotrichia species, being most closely related to Leptotrichia trevisanii. Using HKU24T groEL, gyrB, recA, and rpoB gene-specific primers, fragments of these genes were amplified from one of 20 oral specimens. Based on phenotypic and genotypic characteristics, we propose a new species, Leptotrichia hongkongensis sp. nov., to describe this bacterium.展开更多
This paper describes new fossils of Equus huanghoensis from an Early Pleistocene bed in Nihewan, Hebei Province, which confirms the classification of E. huanghoensis by Chinese researchers. The new fossils include a r...This paper describes new fossils of Equus huanghoensis from an Early Pleistocene bed in Nihewan, Hebei Province, which confirms the classification of E. huanghoensis by Chinese researchers. The new fossils include a relatively complete male skull and mandible with all upper and lower dentition, a broken female skull with fragment of mandible and a broken Mc III of Equus sp. The fossils were collected from the Yangshuizhan site of Nihewan. The age of the formation is about 1.6 Ma. The new materials verify some classification characteristics based on teeth published in previous descriptions. These characteristics include large teeth size, short protocone, and tilted protoloph and metaloph. We have added to these characteristics of large skull size, a developed protuberantia supramagna, pentagonal nuchal side, weak Pli cabaline, simple enamel plications; a series of new characteristics strikingly different from the other Equus horses. The broken Mc III is similar to Equus qingyangensis from Qingyang, Gansu.展开更多
The elements in the periodic table are the building blocks used to form substances with different compositions. Nevertheless, it is the properties of substances that are decisive for their existence and practical appl...The elements in the periodic table are the building blocks used to form substances with different compositions. Nevertheless, it is the properties of substances that are decisive for their existence and practical applications. Searching for new class of materials with exotic properties has always been challenging because of the complexity of both the theoretical and the experimental approaches developed so far. Here, we propose that the three ubiquitous and paramount attributes of all existing matter charge(Q), spin(S) or rotational motion, and linear motion(K) can be used to account for the formation of different types of matter/materials and their properties that have been or will be known to us. The three attributes or original codes can produce six primary codes which can further produce another sixty codes. The physical meanings represented by each code are unlocked. The table consisting of the 60 codes is introduced as the table of properties of codes of matter. We demonstrate that these codes can be used as building blocks to form new properties and new materials. Many new types of quasiparticles and new classes of materials with exotic properties of Q, S and K are predicted. Their possible experimental realizations are proposed. The possible applications of the codes of matter in other fields such as elementary particles, photonics and chemistry are briefly discussed. We know that there should be more new materials and new electronic, spin and photonic states to be discovered, but we do not know what they are. The codes of matter clearly reveal to us how many and what they are and how easily we can recognize what they are. Experimental and theoretical exploration for new forms of matter, new quasiparticles, or new electronic and spin states, or new states of photon or properties of light, as well as macroscopic entities with exotic properties represented by the codes of matter, is imminent.展开更多
China has experienced spectacular economic growth during the past three decades and seen some parts of the country, in particular the Yangzi Delta, swiftly converging with the developed countries in the level of econo...China has experienced spectacular economic growth during the past three decades and seen some parts of the country, in particular the Yangzi Delta, swiftly converging with the developed countries in the level of economic development. This unprecedented growth has been seen as the greatest economic miracle in world history. This miracle is based on the economic performance of the Yangzi Delta in the long run of centuries. It is impossible to achieve a better understanding of the economic miracle of the delta without a better understanding of the basis created by the delta＇s economy during its long historical development, in particular in the centuries before the modern West arrived in the mid- nineteenth century. To achieve this objective, we must break free of the West-centric straightjacket and study China＇s early modern economy from a new perspective, which will be crucial to improve our knowledge of Chinese economic performance prior to the arrival of the West.展开更多
文摘This paper deals with I new genus and I new species from Fujian Province, China, viz: Evallocotaphis Zhang, gen. nov., Evallocotaphis lutescens Zhang et Qiao, sp. nov.. All the type specimens are deposited in the Institute of Zoology, Academia Sinica.
文摘In the last two decades, great efforts have been made in the treatment of metastatic colorectal cancer(m CRC) due to the approval of new target agents for cytotoxic drugs. Unfortunately, a large percentage of patients present with metastasis at the time of diagnosis or relapse after a few months. The complex molecular heterogeneity of this disease is not completely understood; to date, there is a lack of predictive biomarkers that can be used to select subsets of patients who may respond to target drugs. Only the RAS-mutation status is used to predict resistance to anti-epidermal growth factor receptor agents in patients with m CRC. In this review, we describe approved targeted therapies for the management of metastatic m CRC and discuss new candidate targets on the horizon.
文摘Thromboembolic complications represent a substantial problem in patients with atrial fibrillation （AF）. The prevalence of AF burden and associated arterial and venous thrombosis progressively increases with age. At the same time, representative national data regarding stroke incidence in AF patients aged 80 and older are limited.
文摘Atrial fibrillation and venous thromboembolism （VTE） are common disorders associated with maleficent thrombotic events, particularly in the elderly patients. Polypharmacy, co-morbidities, and altered pharmacokinetics, often present in these patients, render the use of antico-agulants quite challenging. Novel oral anticoagulants （NOACs） have recently emerged as alternatives to Vitamin K Antagonists （VKAs） and are gradually increasing their popularity mainly because of their fewer drug and food interactions and ease of use. Their effectiveness and safety has been weU-established in the general population but the balance between benefit and harm in the elderly is still unclear. Routine use in these patients is uncommon. Accumulating data have shown that the benefit of NOACs is consistent among all age groups, featuring equal or greater efficacy in preventing thrombotic events. Excess bleedings were lower with NOACs in comparison to VKAs, but bleeding patterns were disparate among them and head to head comparison is not available. The present review highlights on the efficacy and safety of novel anticoagulants in the elderly population.
文摘To investigated the usefulness of a novel slim type ball-tipped FlushKnife (FlushKnife-BTS) over ball-tipped FlushKnife (FlushKnife-BT) in functional experiments and clinical practice.METHODSIn order to evaluate the functionality of FlushKnife-BTS, water aspiration speed, resistance to knife insertion through the scope, and waterjet flushing speed were compared between FlushKnife-BTS and BT. In clinical practice, esophageal endoscopic submucosal dissection (ESD) performed using FlushKnife-BTS or BT by an experienced endoscopist between October 2015 and January 2016 were retrospectively reviewed. The treatment speed and frequency of removing and reinserting the knife to aspirate fluid and air during ESD sessions were analyzed.RESULTSFunctional experiments revealed that water aspiration speed by the endoscope equipped with a 2.8-mm working channel with FlushKnife-BTS was 7.7-fold faster than that with conventional FlushKnife-BT. Resistance to knife insertion inside the scope with a 2.8-mm working channel was reduced by 40% with FlushKnife-BTS. The waterjet flushing speed was faster with the use of FlushKnife-BT. In clinical practice, a comparison of 6 and 7 ESD using FlushKnife-BT and BTS, respectively, revealed that the median treatment speed was 25.5 mm<sup>2</sup>/min (range 19.6-30.3) in the BT group and 44.2 mm<sup>2</sup>/min (range 15.5-55.4) in the BTS group (P = 0.0633). However, the median treatment speed was significantly faster with FlushKnife-BTS when the resection size was larger than 1000 m<sup>2</sup> (n = 4, median 24.2 mm<sup>2</sup>/min, range 19.6-27.7 vs n = 4, median 47.4 mm<sup>2</sup>/min, range 44.2-55.4, P = 0.0209). The frequency of knife replacement was less in the BTS group (median 1.76 times in one hour, range 0-5.45) than in the BT group (7.02 times in one hour, range 4.23-15) (P = 0.0065).CONCLUSIONOur results indicate that FlushKnife-BTS enhances the performance of ESD, particularly for large lesions, by improving air and fluid aspiration and knife insertion during ESD and reducing the frequency of knife removal and reinsertion.
基金supported by the grants from the National Science Foundation of China(Nos.30970387 and 31172126)
文摘A new species in the Oriental delphacid genus Miranus Chen et Ding, M. serrulatus sp. nov. is described and illustrated. A key to all species of this genus is presented. The specimens examined are deposited in the Entomological Museum, Northwest A ＆ F University （NWAFU）. The terminology used in this paper follows that of Ding （2006）.
基金supported by the Major Research Plan of Tianjin(No.16YFXTSF00460)
文摘Polyketides have been widely used clinically due to their significant biological activities, but the needed structural and functional diversity cannot be achieved by common chemical synthetic methods. The tool of combinatorial biosynthesis provides the possibility to produce "unnatural" natural drugs, which has achieved initial success. This paper provides an overview for the strategies of combinatorial biosynthesis in producing the structural and functional diversity of polyketides, including the redesign of metabolic flow, polyketide synthase(PKS) engineering, and PKS post-translational modification. Although encouraging progress has been made in the last decade, challenges still exist regarding the rational combinatorial biosynthesis of polyketides. In this review, the perspectives of polyketide combinatorial biosynthesis are also discussed.
文摘The effect of verapamil on Ca2+ influx across the myocardial plasma membrane and coxsackie virus B3 ( CVB3)-RNA replication in cultured neonatal rat heart cells infected with CVB3 was investigated. It was found that the Ca2+ influx could be inhibited significantly (P<O. 01) by verapamil (1 μmol/L) after infection of heart cells for 48h. However, when the cultured heart cells infected with CVB3 and treated with verapamil (Iμmol/L and 10 nmo/L) at the same time for 48h, the amounts of CVB3-RNA in myocytes were significantly higher than that in infected control group (P<O. 05). These phenomena suggest that the increase of Ca2+ influx of cultured heart cells infected with CVB3 could be inhibited by some calcium antagonists, e. g. verapamil at the early stage. On the other hand, verapamil might accelerate viral replication in myocardium. Thus, although verapamil could be beneficial for decreasing the secondary Ca2+ damages and improve the myocardial electric activity, it isn’t a sensible choice for therapy in early stage of virus infection with cardiac symptoms.
基金supported by the Consultancy Service for Enhancing Laboratory Surveillance of Emerging Infectious Disease for Department of Health of the Hong Kong Special Administrative Region of China,the Research Grant Council Grant,the University Development Fund,the Outstanding Young Researcher Award,and the Committee for Research and Conference Grant and The University of Hong Kong,China
文摘A straight, non-sporulating, Gram-variable bacillus (HKU24T) was recovered from the blood culture of a patient with metastatic breast carcinoma. After repeated subculturing in BACTEC Plus Anaerobic/F blood culture broth, HKU24T grew on brucella agar as non-hemolytic, pinpoint colonies after 96 h of incubation at 37 °C in an anaerobic environment and aerobic environment with 5% CO2. Growth was enhanced with a streak of Staphylococcus aureus. HKU24T was non-motile and catalase-negative, but positive for alkaline phosphatase, β-glucosidase, and α-glucosidase. It hydrolyzed phenylphosphonate and reduced resazurin. 16S rRNA, groEL, gyrB, recA, and rpoB sequencing showed that HKU24T occupies a distinct phylogenetic position among the Leptotrichia species, being most closely related to Leptotrichia trevisanii. Using HKU24T groEL, gyrB, recA, and rpoB gene-specific primers, fragments of these genes were amplified from one of 20 oral specimens. Based on phenotypic and genotypic characteristics, we propose a new species, Leptotrichia hongkongensis sp. nov., to describe this bacterium.
基金National Natural Science Foundation of China(Grant Nos.41290253,41174057)the National Basic Research Program of China(Grant No.2013CB955901)
文摘This paper describes new fossils of Equus huanghoensis from an Early Pleistocene bed in Nihewan, Hebei Province, which confirms the classification of E. huanghoensis by Chinese researchers. The new fossils include a relatively complete male skull and mandible with all upper and lower dentition, a broken female skull with fragment of mandible and a broken Mc III of Equus sp. The fossils were collected from the Yangshuizhan site of Nihewan. The age of the formation is about 1.6 Ma. The new materials verify some classification characteristics based on teeth published in previous descriptions. These characteristics include large teeth size, short protocone, and tilted protoloph and metaloph. We have added to these characteristics of large skull size, a developed protuberantia supramagna, pentagonal nuchal side, weak Pli cabaline, simple enamel plications; a series of new characteristics strikingly different from the other Equus horses. The broken Mc III is similar to Equus qingyangensis from Qingyang, Gansu.
基金supported by the Australian Research Council Future Fellowship(Professorial)Program(FT130100778)
文摘The elements in the periodic table are the building blocks used to form substances with different compositions. Nevertheless, it is the properties of substances that are decisive for their existence and practical applications. Searching for new class of materials with exotic properties has always been challenging because of the complexity of both the theoretical and the experimental approaches developed so far. Here, we propose that the three ubiquitous and paramount attributes of all existing matter charge(Q), spin(S) or rotational motion, and linear motion(K) can be used to account for the formation of different types of matter/materials and their properties that have been or will be known to us. The three attributes or original codes can produce six primary codes which can further produce another sixty codes. The physical meanings represented by each code are unlocked. The table consisting of the 60 codes is introduced as the table of properties of codes of matter. We demonstrate that these codes can be used as building blocks to form new properties and new materials. Many new types of quasiparticles and new classes of materials with exotic properties of Q, S and K are predicted. Their possible experimental realizations are proposed. The possible applications of the codes of matter in other fields such as elementary particles, photonics and chemistry are briefly discussed. We know that there should be more new materials and new electronic, spin and photonic states to be discovered, but we do not know what they are. The codes of matter clearly reveal to us how many and what they are and how easily we can recognize what they are. Experimental and theoretical exploration for new forms of matter, new quasiparticles, or new electronic and spin states, or new states of photon or properties of light, as well as macroscopic entities with exotic properties represented by the codes of matter, is imminent.
文摘China has experienced spectacular economic growth during the past three decades and seen some parts of the country, in particular the Yangzi Delta, swiftly converging with the developed countries in the level of economic development. This unprecedented growth has been seen as the greatest economic miracle in world history. This miracle is based on the economic performance of the Yangzi Delta in the long run of centuries. It is impossible to achieve a better understanding of the economic miracle of the delta without a better understanding of the basis created by the delta＇s economy during its long historical development, in particular in the centuries before the modern West arrived in the mid- nineteenth century. To achieve this objective, we must break free of the West-centric straightjacket and study China＇s early modern economy from a new perspective, which will be crucial to improve our knowledge of Chinese economic performance prior to the arrival of the West.
