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“新解放、新跨越、新崛起”大讨论活动意见的调查
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作者 张旭光 曹璞 《中小企业管理与科技》 2009年第31期128-128,共1页
根据河南省公路局要求,监理咨询有限公司从8月15日开展了"新解放、新跨越、新崛起"大讨论活动。
关键词 监理公司 “新解放 新跨越 新崛起”活动调查
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Neoadjuvant chemoradiation therapy and pathological complete response in rectal cancer 被引量:5
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作者 Linda Ferrari Alessandro Fichera 《Gastroenterology Report》 SCIE EI 2015年第4期277-288,I0001,共13页
The management of rectal cancer has evolved significantly in the last few decades.Significant improvements in local disease control were achieved in the 1990s,with the introduction of total mesorectal excision and neo... The management of rectal cancer has evolved significantly in the last few decades.Significant improvements in local disease control were achieved in the 1990s,with the introduction of total mesorectal excision and neoadjuvant radiotherapy.Level 1 evidence has shown that,with neoadjuvant chemoradiation therapy(CRT)the rates of local recurrence can be lower than 6%and,as a result,neoadjuvant CRT currently represents the accepted standard of care.This approach has led to reliable tumor down-staging,with 15–27%patients with a pathological complete response(pCR)—defined as no residual cancer found on histological examination of the specimen.Patients who achieve pCR after CRT have better long-term outcomes,less risk of developing local or distal recurrence and improved survival.For all these reasons,sphincter-preserving procedures or organ-preserving options have been suggested,such as local excision of residual tumor or the omission of surgery altogether.Although local recurrence rate has been stable at 5–6%with this multidisciplinary management method,distal recurrence rates for locally-advanced rectal cancers remain in excess of 25%and represent the main cause of death in these patients.For this reason,more recent trials have been looking at the administration of full-dose systemic chemotherapy in the neoadjuvant setting(in order to offer early treatment of disseminated micrometastases,thus improving control of systemic disease)and selective use of radiotherapy only in non-responders or for low rectal tumors smaller than 5 cm. 展开更多
关键词 rectal cancer neoadjuvant chemoradiation therapy pathological complete response
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