Objective: To investigate the relationship between peroxisomeproliferators-activated receptor-gamma (PPAR-γ) and clinical pathology of lung cancer, and to studythe inhibitory effect of PPAR-γ activators on lung canc...Objective: To investigate the relationship between peroxisomeproliferators-activated receptor-gamma (PPAR-γ) and clinical pathology of lung cancer, and to studythe inhibitory effect of PPAR-γ activators on lung cancer growth and the mechanism of inducingapoptosis of lung cancer. Methods: Expression of PPAR-γ in 15 cases of non-cancerous lung tissuesand 64 cases of lung cancer tissues was detected by using immunohistochemistry. The average A valueswere measured by using image analysis. The expression of PPAR-γ in lung cancer cells was detectedby using RT-PCR. After being treated with PPAR-γ activators, apoptosis was detected by using flowcytometry, and meanwhile, the change in caspase-3 activity was detected by caspase-3 kits. Results:Expression levels of PPAR-γ in cancerous tissues were higher than those in non-cancerous lungtissues. In four types of lung cancer, the sequence of PPAR-γ expression from high to low levelswas small-cell lung cancer, squamous carcinom, large-cell lung cancer, adenocarcinoma in turns. Theexpression of PPAR-γ was correlated with differentiation and postoperative TNM staging of lungcancer tissues, but not with lymph node metastasis. PPAR-γ expressed in two lung cancer cell lines,which could induce apoptosis of lung cancer cells after being treated with PPAR-γ activators, andcaspase-3 activity in cells treated with PPAR-γ activators was significantly increased. Conclusion:PPAR-γ is correlated with clinical pathology and apoptosis of lung cancer closely, and activatedPPAR-γ can increase caspase-3 activity to induce cells apoptosis. PPAR-γ will be able to become anew target for therapy of lung cancer in the future.展开更多
The differences between two sequences of nonnegative independent and identically distributed random variables with sub-exponential tails and the random index are studied. The random index is a strictly stationary rene...The differences between two sequences of nonnegative independent and identically distributed random variables with sub-exponential tails and the random index are studied. The random index is a strictly stationary renewal counting process generated by some negatively associated random variables. Using a revised large deviation result of partial sums, the elementary renewal theorem and the central limit theorem of negatively associated random variables, a precise large deviation result is derived for the random sums. The result is applied to the customer-arrival-based insurance risk model. Some uniform asymptotics for the ruin probabilities of an insurance company are obtained as the number of customers or the time tends to infinity.展开更多
Objective To explore the expression change of stem cell-derived neural stem/progenitor cell supporting factor （SDNSF） gene in the injuried spinal cord tissues of rats, and the relation between the expressions of SDN...Objective To explore the expression change of stem cell-derived neural stem/progenitor cell supporting factor （SDNSF） gene in the injuried spinal cord tissues of rats, and the relation between the expressions of SDNSF and nestin. Methods The spinal cord contusion model of rat was established according to Allen＇s falling strike method. The expression of SDNSF was studied by RT-PCR and in situ hybridization （ISH）, and the expression of nestin was detected by immunochemistry. Results RT-PCR revealed that SDNSF mRNA was upregulated on day 4 after injury, peaked on day 8-12, and decreased to the sham operation level on day 16. ISH revealed that SDNSF mRNA was mainly expressed in the gray matter cells, probably neurons, of spinal cord. The immunohistochemistry showed that accompanied with SDNSF mRNA upregulation, the nestin-positive cells showed erupted roots, migrated peripherad and proliferation on the 8-day slice. However, the distribution pattern of these new cells was different from that of SDNSF-positive cells. Conclusion （1） SDNSF is expressed in the gray matter of spinal cord. The expression of SDNSF mRNA in the spinal cord varies with injured time. （2） The nestin-positive cells proliferate accompanied with spinal cord injury repair, but do not secrete SDNSF.展开更多
As a huge,intense,and elevated atmospheric heat source(AHS) approaching the mid-troposphere in spring and summer,the Tibetan Plateau(TP) thermal forcing is perceived as an important factor contributing to the formatio...As a huge,intense,and elevated atmospheric heat source(AHS) approaching the mid-troposphere in spring and summer,the Tibetan Plateau(TP) thermal forcing is perceived as an important factor contributing to the formation and variation of the Asian summer monsoon.Despite numerous studies devoted to determine the strength and change of the thermal forcing of the TP on the basis of various data sources and methods,uncertainties remain in quantitative estimation of the AHS and will persist for the following reasons:(1) Routine meteorological stations cover only limited regions and show remarkable spatial inhomogeneity with most distributed in the central and eastern plateau.Moreover,all of these stations are situated at an altitude below 5000 m.Thus,the large area above that elevation is not included in the data.(2) Direct observations on heat fluxes do not exist at most stations,and the sensible heat flux(SHF) is calculated by the bulk formula,in which the drag coefficient for heat is often treated as an empirical constant without considering atmospheric stability and thermal roughness length.(3) Radiation flux derived by satellite remote sensing shows a large discrepancy in the algorithm in data inversion and complex terrain.(4) In reanalysis data,besides the rare observational records employed for data assimilation,model bias in physical processes induces visible errors in producing the diabatic heating fields.展开更多
This paper deals with the properties of the solution to a class of nonlocal degenerate reaction-diffusion equation with nonlocal source,subject to the null Dirichlet boundary condition.We first give sufficient conditi...This paper deals with the properties of the solution to a class of nonlocal degenerate reaction-diffusion equation with nonlocal source,subject to the null Dirichlet boundary condition.We first give sufficient conditions for that the solution exists globally or blows up in the finite time.Then the blow-up time is also given.At last,we obtain a property differing from the local source which the blow-up set is the entire interval.展开更多
An adaptive joint source channel bit allocation method for video communications over error-prone channel is proposed.To protect the bit-streams from the channel bit errors,the rate compatible punctured convolution(RCP...An adaptive joint source channel bit allocation method for video communications over error-prone channel is proposed.To protect the bit-streams from the channel bit errors,the rate compatible punctured convolution(RCPC)code is used to produce coding rates varying from 4/5 to 1/2 using the same encoder and the Viterbi decoder.An expected end-to-end distortion model was presented to estimate the distortion introduced in compressed source coding due to quantization and channel bit errors jointly.Based on the proposed end-to-end distortion model,an adaptive joint source-channel bit allocation method was proposed under time-varying error-prone channel conditions.Simulated results show that the proposed methods could utilize the available channel capacity more efficiently and achieve better video quality than the other fixed coding-based bit allocation methods when transmitting over error-prone channels.展开更多
Atmospheric carbon dioxide concentration [CO2],incoming solar radiation and sea ice coverage are among the most important factors that control the global climate.By applying the simple cell-to-cell mapping technique t...Atmospheric carbon dioxide concentration [CO2],incoming solar radiation and sea ice coverage are among the most important factors that control the global climate.By applying the simple cell-to-cell mapping technique to a simplified atmosphere-ocean-sea ice feedback climate model,effects of these factors on the stability of the climatic system are studied.The current climatic system is found to be stable but highly nonlinear.The resiliency of stability increases with [CO2] to a summit when [CO2] reaches 290 μL/L which is comparable to the pre-industrial level,suggesting carbon dioxide is essential to the stability of the global climate.With [CO2] rising further,the global climate stability decreases,the mean ocean temperature goes up and the sea ice coverage shrinks in the polar region.When the incoming solar radiation is intensified,the ice coverage gradually diminishes,but the mean ocean temperature remains relatively constant.Overall,our analysis suggests that at the current levels of three external factors the stability of global climate is highly resilient.However,there exists a possibility of extreme states of climate,such as a snow-ball earth and an ice-free earth.展开更多
The induced polarization （IP） in rocks and minerals is of significance to the marine controlled-source electromagnetic （CSEM） field. We propose an adaptive finite-element algorithm for the 2.5D frequency-domain fo...The induced polarization （IP） in rocks and minerals is of significance to the marine controlled-source electromagnetic （CSEM） field. We propose an adaptive finite-element algorithm for the 2.5D frequency-domain forward modeling of marine CSEM that considers the induced polarization. The geoelectrical model is discretized using an unstructured triangular elemental grid that accommodates the complex topography and geoelectrical structures. We use the Cole-Cole model to describe the IP and develop a complex resistivity forward modeling algorithm. We compare the simulation results with published 1D model results and subsequently calculate the electromagnetic field for variable azimuth sources, IP parameters, and topography. Finally, we analyze the IP effect on the marine CSEM field and show that IP of oil reservoirs and topography affects the marine CSEM electromagnetic field.展开更多
The effect of ground properties with heat conduction between soil and ground loop heat exchangers(GLHEs)has been analyzed.A finite line source model proposed by Cui,Yang,and Fang is used.Far field radius is defined.Th...The effect of ground properties with heat conduction between soil and ground loop heat exchangers(GLHEs)has been analyzed.A finite line source model proposed by Cui,Yang,and Fang is used.Far field radius is defined.The analyses for a 1.5m borehole line source in three kinds of soil conditions:damp and breeze(D.B.),damp and heavy(D.H.),and saturated and heavy(S.H.)are carried out.The results of the comparisons show that in the condition of continuous operation,the variation of the far field radius is related to soil thermal conductivity.The rate of heat transfer will decrease after long time operation.And then soil condition will not influence the far field radius obviously.展开更多
Due to low carrying capacity and short life of current ring reducer,we proposed a new planetary gearing with internal gear ring,which consisted of two stages.One was an involute planetary drive and the other was an N-...Due to low carrying capacity and short life of current ring reducer,we proposed a new planetary gearing with internal gear ring,which consisted of two stages.One was an involute planetary drive and the other was an N-type planetary drive with small teeth difference.The kinematic calculation was conducted based on the analysis of structural composition and working principle.Formulas of backlash calculation for the new planetary gearing were derived by using probabilistic theory and the analytical model was created at the same time.Then,main factors that affect the systematic backlash were introduced and the effects of manufacture error,misaligments and roller bearing parameters on the distribution of backlash were presented.The influence of gear backlash on systematic return difference was performed based on the backlash mathematic model proposed.The results show that the backlash is a little large,of which the backlash of bearing takes a greater part than two gearing stages.So we presented some practical methods to reduce the systematic backlash.展开更多
The hybrid slip model used to generate a finite fault model for near-field ground motion estimation and seismic hazard assessment was improved to express the uncertainty of the source form of a future earthquake.In th...The hybrid slip model used to generate a finite fault model for near-field ground motion estimation and seismic hazard assessment was improved to express the uncertainty of the source form of a future earthquake.In this process, source parameters were treated as normal random variables, and the Fortran code of hybrid slip model was modified by adding a random number generator so that the code could generate many finite fault models with different dimensions and slip distributions for a given magnitude.Furth...展开更多
文摘Objective: To investigate the relationship between peroxisomeproliferators-activated receptor-gamma (PPAR-γ) and clinical pathology of lung cancer, and to studythe inhibitory effect of PPAR-γ activators on lung cancer growth and the mechanism of inducingapoptosis of lung cancer. Methods: Expression of PPAR-γ in 15 cases of non-cancerous lung tissuesand 64 cases of lung cancer tissues was detected by using immunohistochemistry. The average A valueswere measured by using image analysis. The expression of PPAR-γ in lung cancer cells was detectedby using RT-PCR. After being treated with PPAR-γ activators, apoptosis was detected by using flowcytometry, and meanwhile, the change in caspase-3 activity was detected by caspase-3 kits. Results:Expression levels of PPAR-γ in cancerous tissues were higher than those in non-cancerous lungtissues. In four types of lung cancer, the sequence of PPAR-γ expression from high to low levelswas small-cell lung cancer, squamous carcinom, large-cell lung cancer, adenocarcinoma in turns. Theexpression of PPAR-γ was correlated with differentiation and postoperative TNM staging of lungcancer tissues, but not with lymph node metastasis. PPAR-γ expressed in two lung cancer cell lines,which could induce apoptosis of lung cancer cells after being treated with PPAR-γ activators, andcaspase-3 activity in cells treated with PPAR-γ activators was significantly increased. Conclusion:PPAR-γ is correlated with clinical pathology and apoptosis of lung cancer closely, and activatedPPAR-γ can increase caspase-3 activity to induce cells apoptosis. PPAR-γ will be able to become anew target for therapy of lung cancer in the future.
基金The National Natural Science Foundation of China (No.10671139,11001052)the Natural Science Foundation of Jiangsu Province(No. BK2008284 )+2 种基金China Postdoctoral Science Foundation ( No.20100471365)the Natural Science Foundation of Higher Education Institutions of Jiangsu Province (No. 09KJD110003)Postdoctoral Research Program of Jiangsu Province (No.0901029C)
文摘The differences between two sequences of nonnegative independent and identically distributed random variables with sub-exponential tails and the random index are studied. The random index is a strictly stationary renewal counting process generated by some negatively associated random variables. Using a revised large deviation result of partial sums, the elementary renewal theorem and the central limit theorem of negatively associated random variables, a precise large deviation result is derived for the random sums. The result is applied to the customer-arrival-based insurance risk model. Some uniform asymptotics for the ruin probabilities of an insurance company are obtained as the number of customers or the time tends to infinity.
文摘Objective To explore the expression change of stem cell-derived neural stem/progenitor cell supporting factor （SDNSF） gene in the injuried spinal cord tissues of rats, and the relation between the expressions of SDNSF and nestin. Methods The spinal cord contusion model of rat was established according to Allen＇s falling strike method. The expression of SDNSF was studied by RT-PCR and in situ hybridization （ISH）, and the expression of nestin was detected by immunochemistry. Results RT-PCR revealed that SDNSF mRNA was upregulated on day 4 after injury, peaked on day 8-12, and decreased to the sham operation level on day 16. ISH revealed that SDNSF mRNA was mainly expressed in the gray matter cells, probably neurons, of spinal cord. The immunohistochemistry showed that accompanied with SDNSF mRNA upregulation, the nestin-positive cells showed erupted roots, migrated peripherad and proliferation on the 8-day slice. However, the distribution pattern of these new cells was different from that of SDNSF-positive cells. Conclusion （1） SDNSF is expressed in the gray matter of spinal cord. The expression of SDNSF mRNA in the spinal cord varies with injured time. （2） The nestin-positive cells proliferate accompanied with spinal cord injury repair, but do not secrete SDNSF.
基金supported by the the National Natural Science Foundation of China (Grants 91337216 and 41175070)and the Open Project of the Key Laboratory of Meteorological Disaster of Ministry of Education (Grant KLME1309)
文摘As a huge,intense,and elevated atmospheric heat source(AHS) approaching the mid-troposphere in spring and summer,the Tibetan Plateau(TP) thermal forcing is perceived as an important factor contributing to the formation and variation of the Asian summer monsoon.Despite numerous studies devoted to determine the strength and change of the thermal forcing of the TP on the basis of various data sources and methods,uncertainties remain in quantitative estimation of the AHS and will persist for the following reasons:(1) Routine meteorological stations cover only limited regions and show remarkable spatial inhomogeneity with most distributed in the central and eastern plateau.Moreover,all of these stations are situated at an altitude below 5000 m.Thus,the large area above that elevation is not included in the data.(2) Direct observations on heat fluxes do not exist at most stations,and the sensible heat flux(SHF) is calculated by the bulk formula,in which the drag coefficient for heat is often treated as an empirical constant without considering atmospheric stability and thermal roughness length.(3) Radiation flux derived by satellite remote sensing shows a large discrepancy in the algorithm in data inversion and complex terrain.(4) In reanalysis data,besides the rare observational records employed for data assimilation,model bias in physical processes induces visible errors in producing the diabatic heating fields.
基金Supported by the National Natural Science Foundation of China（10571024）
文摘This paper deals with the properties of the solution to a class of nonlocal degenerate reaction-diffusion equation with nonlocal source,subject to the null Dirichlet boundary condition.We first give sufficient conditions for that the solution exists globally or blows up in the finite time.Then the blow-up time is also given.At last,we obtain a property differing from the local source which the blow-up set is the entire interval.
基金National High-Tech Research and Development Plan of China(No.2003AA1Z2130)Science and Technology Project of Zhejiang Province,China(No.2006C11200)
文摘An adaptive joint source channel bit allocation method for video communications over error-prone channel is proposed.To protect the bit-streams from the channel bit errors,the rate compatible punctured convolution(RCPC)code is used to produce coding rates varying from 4/5 to 1/2 using the same encoder and the Viterbi decoder.An expected end-to-end distortion model was presented to estimate the distortion introduced in compressed source coding due to quantization and channel bit errors jointly.Based on the proposed end-to-end distortion model,an adaptive joint source-channel bit allocation method was proposed under time-varying error-prone channel conditions.Simulated results show that the proposed methods could utilize the available channel capacity more efficiently and achieve better video quality than the other fixed coding-based bit allocation methods when transmitting over error-prone channels.
基金Funded by the National Natural Science Foundation of China(No.20877105)
文摘Atmospheric carbon dioxide concentration [CO2],incoming solar radiation and sea ice coverage are among the most important factors that control the global climate.By applying the simple cell-to-cell mapping technique to a simplified atmosphere-ocean-sea ice feedback climate model,effects of these factors on the stability of the climatic system are studied.The current climatic system is found to be stable but highly nonlinear.The resiliency of stability increases with [CO2] to a summit when [CO2] reaches 290 μL/L which is comparable to the pre-industrial level,suggesting carbon dioxide is essential to the stability of the global climate.With [CO2] rising further,the global climate stability decreases,the mean ocean temperature goes up and the sea ice coverage shrinks in the polar region.When the incoming solar radiation is intensified,the ice coverage gradually diminishes,but the mean ocean temperature remains relatively constant.Overall,our analysis suggests that at the current levels of three external factors the stability of global climate is highly resilient.However,there exists a possibility of extreme states of climate,such as a snow-ball earth and an ice-free earth.
基金This work was supported by the National Natural Science Foundation of China （No. 41304094） and the National High Technology Research and Development Program of China （863 Program） （No. 2012AA09A20107）.
文摘The induced polarization （IP） in rocks and minerals is of significance to the marine controlled-source electromagnetic （CSEM） field. We propose an adaptive finite-element algorithm for the 2.5D frequency-domain forward modeling of marine CSEM that considers the induced polarization. The geoelectrical model is discretized using an unstructured triangular elemental grid that accommodates the complex topography and geoelectrical structures. We use the Cole-Cole model to describe the IP and develop a complex resistivity forward modeling algorithm. We compare the simulation results with published 1D model results and subsequently calculate the electromagnetic field for variable azimuth sources, IP parameters, and topography. Finally, we analyze the IP effect on the marine CSEM field and show that IP of oil reservoirs and topography affects the marine CSEM electromagnetic field.
基金Key Discipline Program of Donghua University,China
文摘The effect of ground properties with heat conduction between soil and ground loop heat exchangers(GLHEs)has been analyzed.A finite line source model proposed by Cui,Yang,and Fang is used.Far field radius is defined.The analyses for a 1.5m borehole line source in three kinds of soil conditions:damp and breeze(D.B.),damp and heavy(D.H.),and saturated and heavy(S.H.)are carried out.The results of the comparisons show that in the condition of continuous operation,the variation of the far field radius is related to soil thermal conductivity.The rate of heat transfer will decrease after long time operation.And then soil condition will not influence the far field radius obviously.
基金Funded by Key Technology R&D Program of Chongqing(No. 2008AC3087)Science & Technology Project of Chongqing Education Committee(No. KJ091414)
文摘Due to low carrying capacity and short life of current ring reducer,we proposed a new planetary gearing with internal gear ring,which consisted of two stages.One was an involute planetary drive and the other was an N-type planetary drive with small teeth difference.The kinematic calculation was conducted based on the analysis of structural composition and working principle.Formulas of backlash calculation for the new planetary gearing were derived by using probabilistic theory and the analytical model was created at the same time.Then,main factors that affect the systematic backlash were introduced and the effects of manufacture error,misaligments and roller bearing parameters on the distribution of backlash were presented.The influence of gear backlash on systematic return difference was performed based on the backlash mathematic model proposed.The results show that the backlash is a little large,of which the backlash of bearing takes a greater part than two gearing stages.So we presented some practical methods to reduce the systematic backlash.
基金Supported by National Natural Science Foundation of China (No. 50778058 and No. 90715038)National Key Technology Research and Development Program of China (No. 2006BAC13B02)Major State Basic Research Development Program of China ("973" Program, No. 2008CB425802)
文摘The hybrid slip model used to generate a finite fault model for near-field ground motion estimation and seismic hazard assessment was improved to express the uncertainty of the source form of a future earthquake.In this process, source parameters were treated as normal random variables, and the Fortran code of hybrid slip model was modified by adding a random number generator so that the code could generate many finite fault models with different dimensions and slip distributions for a given magnitude.Furth...
