回归“正”治:当代中国哲学研究的发展路向

近代中国社会的巨大变迁是导致传统文化及其理论形态--中国哲学--受到贬抑的重要根源。百多年来,中国哲学研究者努力探索传统理论现代转型的路径。他们从现实的事功需要出发,以西方哲学的思辨框架对中国哲学进行批判和改造。然而这种努力却在一定程度上抑制了中国哲学发展的内生动力,使中国哲学丧失了自身的活力和特色。中国哲学具有观察问题的独特视角、认知世界的独特思维模式、处理现实问题的独特价值立场,具体表现为对"道"的皈依立场和以道之"正"治世之"不正"的理论旨趣。只有重新回到这一本质和根基,确立以"道"为价值根据、以"正"治现实问题为学术立场的哲学发展思路,构建"中国特色"的哲学理论体系、学科体系、话语体系,重建中国哲学面向现实的自然、自由、自主发展机制,才能真正实现中国哲学的现代转型。

Distalization of maxillary molars for Class Ⅱ malocclusion with Chinese Ni-Ti coil-springs appliance

Objective: To evaluate the effects of the Chinese Ni-Ti coil-springs appliance on distalization of maxillary molars and the reciprocal effects on the anchorage teeth. Methods:Twenty-four adolescent patients(12 boys,12 girls) with Class Ⅱ malocclusion were selected and the coil-springs appliance was used during the treatment. Pre- and postdistalization lateral cephalometric radiographs were analyzed and compared. Results: The average time for the correction of Class Ⅱ molar relationship was 4.6 months. And the mean distance of molar distalization was 4.4 mm. The Chinese Ni-Ti coil-springs also demostrated less tipping and better bodily movement of maxillary molars. Conclusion: This study suggests that the Chinese Ni-Ti coil-springs appliance distalizes the upper molar significantly, while there is no remarkable loss of anchorage because of patients’ wearing headgear with J hooks at night and Class Ⅱ elastics in the day time.

Non-classical phenotypes of autoimmune hepatitis and advances in diagnosis and treatment

Non-classical manifestations of autoimmune hepatitis can delay diagnosis and treatment. Our aims were to describe the clinical phenotypes that can confound the diagnosis, detail scoring systems that can ensure their recognition, and outline advances in treatment that can improve their outcome. Prime source and review articles in English were selected throuqh Medline from 1970-2008 and assimilated into personal libraries spanning 32 years. Acute severe or asymptomatic presentations and atypical histological findings,including centrilobular zone 3 necrosis and concurrent bile duct changes, are compatible with the diagnosis. Cholangiographic abnormalities may be present in children and adults with the disease, and autoimmune hepatitis must be considered in patients without autoantibodies or with antimitochondrial antibodies and no other cholestatic features. Asymptomatic patients frequently become symptomatic; mild disease can progress; and there are no confident indices that justify withholding treatment. Two diagnostic scoring systems with complementary virtues have been developed to evaluate patients with confusing features. Normal liver tests and tissue constitute the optimal end point of treatment, and the first relapse is an indication for long- term azathioprine therapy. Cyclosporine, tacrolimus and mycophenolate mofetil are promising salvage therapies,and budesonide with azathioprine may be a superior frontline treatment. We conclude that the non-classical phenotypes of autoimmune hepatitis can be recognized promptly, diagnosed accurately, and treated effectively.

Is ERCP really necessary in case of suspected spontaneous passage of bile duct stones?

AIM:To investigate the usefulness of magnetic resonance cholangiopancreatography (MRCP) and the need for endoscopic retrograde cholangiopancreatography (ERCP) in cases of suspected spontaneous passage of stones into the common bile duct.METHODS:Thirty-six patients with gallbladder stones were clinically suspected of spontaneous passage of stones into the common bile duct because they presented with clinical symptoms such as abdominal pain and fever,and showed signs of inflammatory reaction and marked rise of hepatobiliary enzymes.These symptoms resolved and they showed normalized values of blood biochemical parameters after conservative treatment without evidence of stones in the common bile duct on MRCP.All these patients were subjected to ERCP within 3 d of MRCP to check for the presence of stones.RESULTS:No stones were detected by ERCP in any patient,confi rming the results of MRCP.CONCLUSION:When clinical symptoms improve,blood biochemical parameters have normalized,and MRCP shows there are no stones in the common bile duct,it can be considered the stone has spontaneously passed and thus ERCP is not necessary.

Tumor budding as a potential histopathological biomarker in colorectal cancer:Hype or hope?

Colorectal cancer （CRC）, the third most commonly di- agnosed type of cancer in men and women worldwide is recognized as a complex multi-pathway disease, an observation sustained by the fact that histologically identical tumors may have different outcome, including various response to therapy. Therefore, particularly in early and intermediate stage （stages Ⅱ and Ⅲ, respec- tively） CRC, there is a compelling need for biomarkers helpful of selecting patients with aggressive disease that might benefit from adjuvant and targeted therapy. Histopathological examination shows that likely other solid tumors the development and progression of hu- man CRC is not only determined by genetically abnor- mal cells, but also by intricate interactions between malignant cells and the surrounding microenvironment. This has led to reconsider the features of tumor mi- croenvironment as potential predictive and prognostic biomarkers. Among the histopathological biomarkers, tumor budding （i.e., the presence of individual cells and small clusters of tumor cells at the tumor invasive front）has received much recent attention, particularly in the setting of CRC. Although its acceptance as a reportable factor has been held back by a lack of uniformity with respect to qualitative and quantitative aspects, tumor budding is now considered as an independent adverse prognostic factor in CRC that may allow for stratifica- tion of patients into risk categories more meaningful than those defined by tumor-node-metastasis staging alone, and also potentially guide treatment decisions, especially in T2-T3 NO （stage Ⅱ） CRCs.

Clinical Effects of Shenqi Fuzheng Injection in the Neoadjuvant Chemotherapy for Local Advanced Breast Cancer and the Effects on T-lymphocyte Subsets

Objective： To evaluate clinical effects of Shenqi Fuzheng Injection （参芪抉正注射液） in the neoadjuvant chemotherapy for local advanced breast cancer and the effects on T-lymphocyte subsets. Methods： During the period from 2000 to 2005, 126 patients with local advanced breast cancer were treated with the neoadjuvant chemotherapy. They were randomly divided into the following two groups： a control group of 61 cases treated by chemotherapy alone and a study group of 65 cases treated by chemotherapy plus Shenqi Fuzheng Injection, All the cases of both groups were given the CEF （CTX 500 mg/m^2, d1, 8; EP140 mg/m^2, d1, 8; and 5-Fu 500 mg/m^2, d1,8） regimen. The clinical effects, the effects on T-lymphocyte subgroup and NK cells, and the toxic side effects were observed. Results： All the patients completed two cycles of the chemotherapy, and the efficacy and the toxic side effects were evaluated. For the primary tumor in the breast, the total effective rate was 69.2% （45/65） in the study group and 49.2% （30/61） in the control group with a statistically significant difference in the intergroup comparison （x^2=5.251, P=0.022, 〈 0.05）. There was no progression of the disease in both the groups, and there were no grade IV toxic side effects in the two groups. The major toxic responses were myelosuppression and gastrointestinal reaction, which were milder in the study group than the control group, and with a shorter recovery course in the former than the latter. Besides, an obvious rise of the T-lymphocyte subgroup and NK cells was found in the study group after the neoadjuvant chemotherapy, with a very significant difference from the controls （P〈0.01）. Conclusions： Shenqi Fuzheng Injection can improve and regulate immune function of the patients with local advanced breast cancer given the neoadjuvant chemotherapy, and therefore it can enhance the curative effect and reduce the side effect as well.

Metastases of esophageal carcinoma to skeletal muscle:Single center experience

Metastases of esophageal carcinoma to the skeletal muscle are rare,but the incidence may be increasing because of better diagnosis resulting from widespread use of positron emission tomography/computed tomography(PET/CT).A cohort of 205 patients with esophageal carcinoma treated at our center who had PET/CT between 2006 and 2010 was retrospectively evaluated for the presence of skeletal muscle metastases.Four patients had skeletal muscle metastases of esophageal carcinoma,including two patients with squamous cell carcinoma.In another patient with squamous cell carcinoma of the esophagus and synchronous skeletal muscle metastases,muscle metastases were subsequently shown to be related to second primary pancreatic adenocarcinoma.In all cases,skeletal muscle metastases were the first manifestation of systemic disease.In three patients palliation was obtained with the combination of external beam radiation therapy,systemic chemotherapy or surgical resection.Skeletal muscle metastases are a rare complication of esophageal carcinoma.

Existence of positive solutions in a delay logistic difference equation

The author studied the existence of positive solutions of the delay logistic difference equation Δ y n=p ny n(1-y τ(n) ), n =0,1,2,.... where { p n } is a sequence of positive real numbers, { τ(n) } is a nondecreasing sequence of integers, τ(n)<n and lim n →∞ τ(n) =∞. A sufficient condition for the existence of positive solutions of the equation was given.

The Relationship between Serum VEGF Expression and PET/CT Images in TNM-staging of Lung Carcinoma

OBJECTIVE To analyze the relationship between the characteristics of PET/CT images for lung carcinoma(LC)TNM staging and the expression of serum VEGF protein. METHODS PET/CT examinations were performed before treatment of 53 patients with LC.The expression of serum VEGF protein was examined using a quantitative sandwich enzyme-linked immunosorbent assay(ELISA R and D system).The relationship was analyzed between PET/CT images for LC T-staging and metastasis(lymph nodes and distance)and serum VEGF expression. RESULTS Based on PET/CT images for LC T-staging,11 cases were staged as T1,9 as T2,18 as T3 and 15 as T4.Mediastinal nodal metastases were found in 22 patients,and distance metastasis in 9.The serum VEGF level in the LC patients was(378.02±180.79)ng/L,showing that there was a significant difference between the patients and healthy subjects(P<0.05). There was no significant difference in the level of serum VEGF between different low T-staged(T1,T2)patients.However,the level of serum VEGF was significantly different between the low T-staged(T1,T2)and high T-staged (T3,T4)patients(P<0.05).The level of the serum VEGF protein in the patients with mediastinal nodal metastasis was(561.50±104.55)ng/L,and indicating that there was a statistical significance(t=12.21,P<0.05)compared to those in the non-metastatic group.The level of serum VEGF in the patients with distance metastasis was(614.11±158.81)ng/L,demonstrating that there was a significant difference(t=5.30,P<0.05)compared to those in the nondistant metastatic group. CONCLUSION ① There is a high level of serum VEGF expression in LC patients.②There is a correlation between metastases(lymph nodes and distance)and the level of serum VEGF. ③ With an upgrade of the TNM-stage,the level of serum VEGF protein is elevated.

Oscillation in a Variable Delay Logistic Difference Equation

Consider the nonautonomous delay logistic equation △yn=pnyn（1-yn-ln/k）,n≥0, where {Pn}n≥0 is a sequence of nonnegative real numbers, {In}n≥0 is a sequence of positive integers satisfying n→∞lim（n-ln）=∞, and k is a positive constant. Only solutions which are positive for n ≥ 0 are considered. We obtain a new sufficient for all positive solutions of （1） to oscillate about k which contains the corresponding result in [2] when i = 1.

Schmitt, Kant, and the Theory of International Relations： Reflecting the Problems of Just War, Unipolarism, and Political Realism

Concerning international relations theory, the work of Immanuel Kant was hitherto reflected in terms of the liberal paradigm, particularly of the democratic peace, whereas Carl Schmitt was predominantly associated with the assumptions of political realism or--at least for a short period Nazi imperialism. However, these differences seem to have taken a back seat since both thinkers have been adopted to legitimate the convictions of imperial liberalism. In contrast, this article will show that Schmitt and Kant have essentially more in common than generally assumed but do precisely argue against just war theory, humanitarian interventions, and a unipolar world. On the other hand, Kant＇s liberal and Schmitt＇s illiberal theory do not apply to the classical paradigms of intemational relations. Instead, Schmitt＇s Political Theology and Kant＇s Political Philosophy will be compared along with the antagonistic logic （and ethics） of political existentialism and a peaceful interdependence between states and nations. Considering the contemporary crisis of world order, it should be even plausible that the two dominating paradigms of future international relations might be formed by Kantian and Schmittian premises. Thus, the aim of this paper is not to match Kant and Schmitt once again with the usual approaches in international relations theory but to stretch its theoretical and conceptual spectrum by extracting the inventive contribution both thinkers made to important topics of IR.

Ectopic papilla of Vater in the pylorus

The major papilla of Vater is usually located in the second portion of the duodenum, to the posterior medial wall. Sometimes the mouth of the biliary duct is located in other areas. Drainage of the common bile duct into the pylorus is extremely rare. A 73-year old man, with a history of duodenal ulcer, was admitted to hospital with the diagnosis of cholangitis. Dilatation of the extrahepatic biliary duct was observed by abdominal ultrasonography, and endoscopic retrograde cholangiopancreatography （ERCP） was performed. No area suggesting the presence of the papilla of Vater was found within the second duodenal portion. Finally the major papilla was located in the theoretical pyloric duct. Cholangiography was performed and choledocholithiasis was found in the biliary tree. The patient underwent dilatation of the papilla with a balloon tyre and removal of a 7 mm stone using a Dormia basket, which solved the problem without further complications. This anomaly increased the difficulty of performing therapeutic interventions during ERCR This alteration in anatomy may increase the risk of complications during papillotomy, with a theoretically higher risk of perforation. Dilatation using a balloon was the chosen therapeutic technique both in our case and in the literature, due to its low rate of complications.

Heroin Narratives： Normalisation and Demonisation of Heroin Use at a Swedish Online Message Board

Heroin is considered potent and addictive and users are often stigmatised as the other. On the internet, however, hegemonic ideas about drugs can be resisted. This study elucidates how efforts to uormalise and demonise heroin meet at a Swedish online message board （Flashback Forum）. The study aims at analysing how heroin use is given meaning by discussants in a thread called ＂I will start with heroin＂. The data were perceived and structured as a collaborative, overarching narrative about when, why, and for whom heroin use can make sense. Discussants used stories about pleasure-seekers, miserable junkies, and self-medicating addicts to depict the activity as unproblematic and rational, problematic and irrational, or as problematic and rational. No stories about heroin use departed from the plot-lines of pleasure maximisation and pain minimisation. Results elucidate a discursive battle in which： （1） heroin use as minimisation of pain ＂wins＂ over heroin use as maximisation of pleasure; and （2） there is a general agreement that heroin use cannot be irrational and unproblematic at the same time. It is suggested that these features are central to contemporary drug discourse, and that they probably hinder public understanding of why people use heroin and therefore contribute to keep users stigmatised.

Desire, Discipline, and Happiness

This paper develops an Augustinian response to political problems diagnosed by Michel Foucault＇s analysis of modem power. Foucault argues that power in the modem age is not repressive but creative. Instead of prohibiting acts, political power disciplines and normalizes subjects. Foucault＇s alternative consists in practices of aesthetic self-creation not linked to transcendent or natural order. Within Augustine＇s account of the purposive nature of love and desire, however, lies an implicit critique of Foucault＇s ethic of aesthetic self-creation. Augustine＇s eudaimonism allows him to resist the process of normalization. Augustine provides an alternative to both modem political practice and a Foucauldian practice of aesthetic self-creation.

Corporate Governance and the Financial Value of Financially Distressed Listed Companies

The article combines the background of Chinese system, theoretically derivates the relationship between corporate governance and their financial value, selects a sample of loss listed companies from 2003 to 2009, and studies how the level of corporate governance affects the value of listed company losses. Research results show that, among corporate governance factors, the largest shareholder and the market for corporate control have obvious positive effects on the financial value of loss listed companies; the proportion of state-owned shares, the type of audit opinion, and corporate govemance factors have obvious negative effects on the financial value of loss listed companies; and managerial ownership, the proportion of independent directors, and the size of the board have no obvious driving effect on the financial value of loss listed companies.

The role and status of fuzheng in cancer prevention and treatment

Traditional Chinese medicine(TCM) treatment of cancer has a long history, and is an important part of cancer prevention and control in China. Fuzheng, also called reinforcing healthy qi and supplementing the root, is the most fundamental principle of TCM in cancer prevention and control. In recent decades, this treatment has been thoroughly studied and widely applied, and played a crucial role in cancer prevention and treatment. With regard to the treatment of malignant tumors, Chinese medicine is mainly used in the following areas: improving symptoms, enhancing the quality of life, reducing postoperative recurrence and metastasis, increasing efficacy and decreasing toxicity together with radiotherapy and chemotherapy treatments, and to some extent prolonging the survival of advanced tumors.

Relativistic Treatment of Massive Klein-Gordon Particle by Modified Generalized Hulthen Potential

Approximate bound state solutions of spinless particles with a special case of equal scalar and vector modified generalized Hulthen potential has been obtained under the massive Klein-Gordon equation. The energy eigenvalues and the corresponding wave functions expressed in terms of a Jacobi polynomial are also obtained using the parametric generalization of the Nikiforov-Uvarov （NU） method. Under limiting cases our result are in agreement with the existing literature. Our results could be used to study the interactions and binding energies of the central potential for diatomic molecules in the relativistic framework which have many applications in physics and some others related disciplines.

Transvenous injection of n-Butyl cyanoacrylate combined with placement of coils in cavernous sinus for treatment of cavernous dural arteriovenous fistulae

Objective： To evaluate the technical aspects, efficacy and safety in the treatment of cavernous dural arteriovenous fistulae （DAVF） by transvenous liquid n-Butyl cyanoacrylate （NBCA） injection combined with coils placement in the cavemous sinus. Methods： Eight patients with cavernous DAVF, treated by transvenous embolization with combination of detachable coils and glue between February 2006 and February 2009 in our hospital, were retrospectively analyzed, including the clinical presentations, patterns of angioarchitecture, methods of treatment and the results of follow-up. Results： In all 8 patients, 9 transvenous and 1 transarterial interventions were carried out. A single endovascular procedure was performed in 6 patients and 2 patients had to be treated twice. Of the nine transvenous approaches, eight approaches were performed via inferior petrosal sinus （IPS） and 1 via the facial vein. Complete angiographic obliteration was achieved in all patients immediately after the embolization. There was no procedure-related morbidity except for mild headache for one to seven days after the embolization. Clinical cure was achieved in all cases during the clinical follow-up periods, ranging from 8 months to 3 years. The follow-up angiography periods averaged 6.6 months with a range of 5-9 months, in which no recurrence was observed. Conclusion： In this small series, embolization with combination of glue and detachable coils by transvenous approaches was a safe, effective and economical method for the treatment of part of symptomatic patients presenting with complex cavernous DAVE

Surgical resection of a solitary para-aortic lymph node metastasis from hepatocellular carcinoma

Lymph node (LN) metastases from hepatocellular carcinoma (HCC) are considered uncommon. We describe the surgical resection of a solitary para-aortic LN metastasis from HCC. A 65-year-old Japanese man with B-type liver cirrhosis was admitted for the evaluation of a liver tumor. He had already undergone radiofrequency ablation, transcatheter arterial chemoembolization, and percutaneous ethanol injection therapy for HCC. Despite treatment, viable regions remained in segments 4 and 8. We performed a right paramedian sectionectomy with partial resection of the left paramedian section of the liver. Six months later, serum concentrations of alpha-fetoprotein (189 ng/mL) and PIVKA-2 (507 mAU/mL) increased. Enhanced com- puted tomography of the abdomen revealed a tumor (20 mm in diameter) on the right side of the abdominal aorta. Fluorine-18 fluorodeoxyglucose positron emission tomography revealed an increased standard uptake value. There was no evidence of recurrence in other regions. Esophagogastroduodenoscopy and colonoscopy revealed no malignant tumor in the gastrointestinal tract. Para-aortic LN metastasis from HCC was thus diagnosed. We performed lymphadenectomy. Histopathological examination revealed that the tumor was largely necrotic, with poorly differentiated HCC on its surface, which confirmed the suspected diagnosis. After 6 mo tumor marker levels were normal, with no evidence of recurrence. Our experience suggests that a solitary para-aortic LN metastasis from HCC can be treated surgically.

Current trends in staging rectal cancer

Management of rectal cancer has evolved over the years. In this condition preoperative investigations assist in deciding the optimal treatment. The relation of the tumor edge to the circumferential margin (CRM) is an important factor in deciding the need for neoadjuvant treatment and determines the prognosis. Those with threatened or involved margins are offered long course chemoradiation to enable R0 surgical resection. Endoanal ultrasound (EUS) is useful for tumor (T) staging; hence EUS is a useful imaging modality for early rectal cancer. Magnetic resonance imaging (MRI) is useful for assessing the mesorectum and the mesorectal fascia which has useful prognostic significance and for early identification of local recurrence. Computerized tomography (CT) of the chest, abdomen and pelvis is used to rule out distant metastasis. Identification of the malignant nodes using EUS, CT and MRI is based on the size, morphology and internal characteristics but has drawbacks. Most of the common imaging techniques are suboptimal for imaging following chemoradiation as they struggle to differentiate fibrotic changes and tumor. In this situation, EUS and MRI may provide complementary information to decide further treatment. Functional imaging using positron emission tomography (PET) is useful, particularly PET/CT fusion scans to identify areas of the functionally hot spots. In the current state, imaging has enabled the multidisciplinary team of surgeons, oncologists, radiologists and pathologists to decide on the patient centered management of rectal cancer. In future, functional imaging may play an active role in identifying patients with lymph node metastasis and those with residual and recurrent disease following neoadjuvant chemoradiotherapy.