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角色扮演法在中学化学教学中的应用 被引量:3
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作者 王丽丽 王伟群 武春娟 《化学教学》 CAS 北大核心 2012年第3期4-7,共4页
角色扮演法在中学化学教学中具有独特价值,可以培养学生综合解决问题的能力,促使他们利用多元视角理解化学,帮助他们理解人的社会性。结合"氨的合成"的实践教学,介绍了依据5个步骤在化学课堂教学中设计角色扮演法:选定课题,角色分配... 角色扮演法在中学化学教学中具有独特价值,可以培养学生综合解决问题的能力,促使他们利用多元视角理解化学,帮助他们理解人的社会性。结合"氨的合成"的实践教学,介绍了依据5个步骤在化学课堂教学中设计角色扮演法:选定课题,角色分配,角色认知,角色扮演,角色融合。 展开更多
关键词 角色扮演法 中学化学 “氨的合成” 化学教学
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Synthesis of protected aminoalkyl sulfinyl dilactones from α-amino acids
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作者 付刚 邹晓民 +4 位作者 傅翌秋 牟科 马超 吕扬 徐萍 《Journal of Chinese Pharmaceutical Sciences》 CAS 2007年第2期119-124,共6页
Aim To synthesize protected aminoalkyl sulfinyl dilactones which were useful as the synthetic intermediates or the Cterminal pharmacophores of potential peptidomimetic proteasome inhibitors. Methods Organic reactions ... Aim To synthesize protected aminoalkyl sulfinyl dilactones which were useful as the synthetic intermediates or the Cterminal pharmacophores of potential peptidomimetic proteasome inhibitors. Methods Organic reactions such as reduction, oxidation, olcfmation, and dihydroxylation were used. Results A convenient synthetic procedure to afford a series of aminoalkyl sulfinyl.dilactones was presented, which would be useful in the synthesis of five- or six-member sulfmyl dilactones. Conclusion Four aminoalkyl sulfmyl dilactones connecting different α-amino acids were synthesized. 展开更多
关键词 Proteasome inhibitors Protected aminoalkyl sulfmyl dilactone Synthesis
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The reactive activities of natural amino acids: key principles of peptide-templated Au cluster synthesis 被引量:1
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作者 Xu Li Nan Li Lina Zhao 《Science Bulletin》 SCIE EI CAS CSCD 2016年第22期1732-1738,共7页
Coating of gold nanoclusters with peptides is an important targeting method in biomedical applications.However, their synthetic method highly influences their targeting ability. Current methods often use harsh reagent... Coating of gold nanoclusters with peptides is an important targeting method in biomedical applications.However, their synthetic method highly influences their targeting ability. Current methods often use harsh reagents and organic solvents to control morphology, which are not preferred for biomedical applications. Recently, several peptides with specific amino acid sequences have successfully been used to reduce Au ions and synthesize biocompatible peptide-covered gold particles in situ.However, the molecular mechanism of peptide-assisted nanocluster formation is yet unclear. Thus, reactive abilities of different amino acids should be studied to improve design of peptides with predetermined amino acid content and consequently, synthesize gold nanoclusters with improved performance. In this theoretical study, we have approximated the reactive abilities of 20 natural amino acids in their neutral state using density functional theory calculations, such as Fukui indices and HOMO/LUMO composition analysis. We have found that the top reducing agents are tryptophan, histidine, and tyrosine, and thestrongest binding can be expected from methionine and cysteine. Further study of the exact reactive sites in these high reactive amino acids provided the deep insight for the peptide design route for the targeted gold nanocluster formation. 展开更多
关键词 Reactive activity Amino acid Synthesis in situ Au nanocluster DFT calculation
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