缺血性心脏病作为心力衰竭的主要病因,具有患病人数多,再入院率和死亡率高的特点。近期研究发现,肠道菌群在心血管发病因素中发挥着重要的作用,肠道菌群失调时,肠道屏障功能发生障碍、肠道内有害菌如肠杆菌门、志贺氏菌和变形菌数量增加...缺血性心脏病作为心力衰竭的主要病因,具有患病人数多,再入院率和死亡率高的特点。近期研究发现,肠道菌群在心血管发病因素中发挥着重要的作用,肠道菌群失调时,肠道屏障功能发生障碍、肠道内有害菌如肠杆菌门、志贺氏菌和变形菌数量增加,厚壁菌门和乳酸杆菌门丰度减少,肠道内脂多糖、肿瘤坏死因子、干扰素γ增加,短链脂肪酸、白介素-10减少,加剧了全身炎症状态,可提高缺血性心肌病的发病率。因此重视肠道菌群在缺血性心肌病中的作用,通过及时调节肠道菌群,在心衰前期减少危险因素或在患心衰后防止病变加重,提高生活质量,这与中医“治未病”中未病先防,已病防传思想不谋而合,本文将从“治未病”角度探讨重视肠道菌群对缺血性心肌病的价值。As the main cause of heart failure, ischemic heart disease is characterized by a large number of patients, high readmission rates and high mortality. Recent studies have found that intestinal flora plays an important role in cardiovascular pathogenesis. When intestinal flora is disturbed, intestinal barrier function is impaired, the number of intestinal harmful bacteria such as Enterobacteria, Shigella and Proteobacteria increases, the abundance of firmicutes and Lactobacilli decreases, and intestinal lipopolysaccharides, tumor necrosis factor and interferon γ increase. The decrease of short-chain fatty acids and interleukin-10 can aggravate the systemic inflammatory state and increase the incidence of ischemic cardiomyopathy. Therefore, to pay attention to the role of intestinal flora in ischemic cardiomyopathy, through timely regulation of intestinal flora, reduce risk factors in the early stage of heart failure or prevent disease aggravation after heart failure, and improve the quality of life, which coincides with the idea of preventing disease before disease and preventing disease after disease in traditional Chinese medicine. This paper will discuss the value of paying attention to intestinal flora in ischemic cardiomyopathy from the perspective of “treating disease without disease”.展开更多
研究发现炎症与肿瘤的发生关系密切,炎症调节因子在慢性炎症的催化下形成炎症微环境,致使相关部位恶性肿瘤的发生、发展和恶化。根据相关流行病学调查显示,宫颈癌为女性常见的恶性肿瘤之一,相关实验证明慢性宫颈炎症的前期存在与宫颈癌...研究发现炎症与肿瘤的发生关系密切,炎症调节因子在慢性炎症的催化下形成炎症微环境,致使相关部位恶性肿瘤的发生、发展和恶化。根据相关流行病学调查显示,宫颈癌为女性常见的恶性肿瘤之一,相关实验证明慢性宫颈炎症的前期存在与宫颈癌的发病存在关联。本文基于“炎癌学说”探讨炎症与肿瘤存在联系的同时,也为宫颈慢性炎症与宫颈癌之间的相关性提供了依据,参考相关临床研究及实验观察发现中医药对宫颈慢性炎症的防治存在优势,符合中医“治未病”理论对疾病的防治理念,为进一步研究炎症与宫颈癌之间的转化通路提供了理论基础,也为临床防治宫颈癌提供了新思路。Studies have found that inflammation is closely related to the occurrence of tumors. Inflammation regulators form an inflammatory microenvironment under the catalysis of chronic inflammation, which leads to the occurrence, development and deterioration of malignant tumors in related areas. According to the relevant epidemiological survey, cervical cancer is one of the common malignant tumors in women, and relevant experiments have proved that the existence of chronic cervical inflammation in the early stage is related to the incidence of cervical cancer. Based on the theory of inflammation and cancer, this paper not only discusses the relationship between inflammation and tumor, but also provides a basis for the correlation between chronic cervical inflammation and cervical cancer. Referring to relevant clinical studies and experimental observations, it is found that traditional Chinese medicine has advantages in the prevention and treatment of chronic cervical inflammation, which is in line with the concept of disease prevention and treatment in the theory of traditional Chinese medicine. It provides a theoretical basis for further research on the transformation pathway between inflammation and cervical cancer, and also provides a new idea for clinical prevention and treatment of cervical cancer.展开更多
文摘缺血性心脏病作为心力衰竭的主要病因,具有患病人数多,再入院率和死亡率高的特点。近期研究发现,肠道菌群在心血管发病因素中发挥着重要的作用,肠道菌群失调时,肠道屏障功能发生障碍、肠道内有害菌如肠杆菌门、志贺氏菌和变形菌数量增加,厚壁菌门和乳酸杆菌门丰度减少,肠道内脂多糖、肿瘤坏死因子、干扰素γ增加,短链脂肪酸、白介素-10减少,加剧了全身炎症状态,可提高缺血性心肌病的发病率。因此重视肠道菌群在缺血性心肌病中的作用,通过及时调节肠道菌群,在心衰前期减少危险因素或在患心衰后防止病变加重,提高生活质量,这与中医“治未病”中未病先防,已病防传思想不谋而合,本文将从“治未病”角度探讨重视肠道菌群对缺血性心肌病的价值。As the main cause of heart failure, ischemic heart disease is characterized by a large number of patients, high readmission rates and high mortality. Recent studies have found that intestinal flora plays an important role in cardiovascular pathogenesis. When intestinal flora is disturbed, intestinal barrier function is impaired, the number of intestinal harmful bacteria such as Enterobacteria, Shigella and Proteobacteria increases, the abundance of firmicutes and Lactobacilli decreases, and intestinal lipopolysaccharides, tumor necrosis factor and interferon γ increase. The decrease of short-chain fatty acids and interleukin-10 can aggravate the systemic inflammatory state and increase the incidence of ischemic cardiomyopathy. Therefore, to pay attention to the role of intestinal flora in ischemic cardiomyopathy, through timely regulation of intestinal flora, reduce risk factors in the early stage of heart failure or prevent disease aggravation after heart failure, and improve the quality of life, which coincides with the idea of preventing disease before disease and preventing disease after disease in traditional Chinese medicine. This paper will discuss the value of paying attention to intestinal flora in ischemic cardiomyopathy from the perspective of “treating disease without disease”.
文摘研究发现炎症与肿瘤的发生关系密切,炎症调节因子在慢性炎症的催化下形成炎症微环境,致使相关部位恶性肿瘤的发生、发展和恶化。根据相关流行病学调查显示,宫颈癌为女性常见的恶性肿瘤之一,相关实验证明慢性宫颈炎症的前期存在与宫颈癌的发病存在关联。本文基于“炎癌学说”探讨炎症与肿瘤存在联系的同时,也为宫颈慢性炎症与宫颈癌之间的相关性提供了依据,参考相关临床研究及实验观察发现中医药对宫颈慢性炎症的防治存在优势,符合中医“治未病”理论对疾病的防治理念,为进一步研究炎症与宫颈癌之间的转化通路提供了理论基础,也为临床防治宫颈癌提供了新思路。Studies have found that inflammation is closely related to the occurrence of tumors. Inflammation regulators form an inflammatory microenvironment under the catalysis of chronic inflammation, which leads to the occurrence, development and deterioration of malignant tumors in related areas. According to the relevant epidemiological survey, cervical cancer is one of the common malignant tumors in women, and relevant experiments have proved that the existence of chronic cervical inflammation in the early stage is related to the incidence of cervical cancer. Based on the theory of inflammation and cancer, this paper not only discusses the relationship between inflammation and tumor, but also provides a basis for the correlation between chronic cervical inflammation and cervical cancer. Referring to relevant clinical studies and experimental observations, it is found that traditional Chinese medicine has advantages in the prevention and treatment of chronic cervical inflammation, which is in line with the concept of disease prevention and treatment in the theory of traditional Chinese medicine. It provides a theoretical basis for further research on the transformation pathway between inflammation and cervical cancer, and also provides a new idea for clinical prevention and treatment of cervical cancer.
