党风廉政建设和反腐败斗争应加大“治本”的力度

党风廉政建设和反腐败斗争取得了举世瞩目的成就,但令人深思的是,为什么在反腐高压之下,一些干部还继续贪腐?一些干部仍能继续被"带病"提拔?这能否说明:反腐力度大、富有成效,而防止、根除干部腐败的体制、机制尚未形成?因此当务之急,必须坚持标本兼治,适时加大"治本"的力度。"治本"的目的,是形成干部不能腐的制度环境。完善党内制度体系是"治本"的总要求。建立健全科学规范的干部选拔任用和管理制度是"治本"的核心。加强决策与权力运行监督是"治本"的关键。摆脱"运动式"管党治党的影响是"治本"的重要保障。

刑事诉讼法学“治本”教学模式探索

刑事诉讼法学理论是从现实的司法世界中抽象出来的理论共识与规律,是"外在实践活动"向"内在理性结构"的转化。"治本"教学模式是与传统理论讲授为主的教学模式相对应的范畴,它强调"法律伦理"的植入与"法律思维"的养成,旨在从根本上促进学生对法学知识的深刻体悟与理解,激发其作为"法律学人"乃至"法律人"的使命感与责任感,促使其进行真正有生命力的学习与研讨。"真实卷宗研判""模拟法庭训练"等实践性教学方法的采用,能够有效帮助法科学生摆脱"确证偏见"的束缚、纠正"认知偏差"、养成正确的"法律思维",这对于面向社会、面向司法实务部门培养和输送真正合格的法律人才具有重要意义。

试析滇池水环境“治本”问题

滇池水环境是一个生态系统,单一的措施只能缓解一时的、局部的污染问题,根本措施应该是解决污染源问题。滇池污染源有周边城镇废弃物、流域农业面源、流域工业园区、底泥排放等污染。针对滇池的以上"病因",各级政府应关注"治本",整合资源重点实施城镇废弃物资源化利用、农业面源污染综合整治、工业园区污染源治理、滇池底泥疏浚及资源化利用等工程项目。

“治本安全观”视域下监狱执法文书的规范化思考

监狱执法文书是监狱行使职能的重要工具,承载了监狱刑罚执行、狱政管理、教育改造等大量功能,体现着监狱执法的水平和能力。司法部提出"治本安全观",明确要求监狱民警要注意提升执法的公信力,而作为监狱工作基础载体的监狱执法文书,是反映监狱工作时代性的重要尺度,是引导罪犯积极改造的教育手段,也是对监狱工作进行评估的重要材料,因此,进一步规范监狱执法文书十分必要。

“治本安全观”语境下应对未成年人网络犯罪问题研究——以百余件未成年人网络犯罪案件为例

信息化时代带来的网络风险成为未成年人网络犯罪的主要诱因,面对网络风险社会,网络犯罪未成年人具有双重属性,既是犯罪人,又是受害者。采取"分类+分级"的模式对未成年人网络犯罪予以划分,制定个性化未成年人矫正方案,构建"小政府+大社会"的社区矫正工作机制,对预防未成年人犯罪,避免未成年人重新犯罪,贯彻落实新时代"治本安全观"有重要意义。

基于“治本安全观”视角的司法警官类院校实践教学新模式的研究思路——以江西司法警官职业学院刑执专业运用的“现场教学法”为例

"治本安全观"是当前加快推进司法体制改革、深化监狱工作改革形势下新的任务要求,也是监狱坚持根本宗旨与实现社会功能的客观需要。在此背景下,江西司法警官职业学院大力推进新的教学方法在刑执专业特色课程中的应用。这种变革既是保证司法类高职院校教学质量的关键,也是高职教育的特色所在,更是"治本安全观"的实践教学体现。

On Some Fundamental Theorems in Stability Theory

This paper gives several fundamental theorems for the stability, uniform stability, asymptotic stability and uniform asymptotic stability. Those theorems allow the derivative of Lyapunov functions to be positive on certain sets,relax the restriction about the rate of change of state variable in a system to be bounded in Marachkov's theorem and extend the related results in [4—7].

Surgical treatment of ulcerative colitis in the biologic therapy era

Recently introduced in the treatment algorithms and guidelines for the treatment of ulcerative colitis,biological therapy is an effective treatment option for patients with an acute severe flare not responsive to conventional treatments and for patients with steroid dependent disease.The reduction in hospitalization and surgical intervention for patients affected by ulcerative colitis after the introduction of biologic treatment remains to be proven.Furthermore,these agents seem to be associated with increase in cost of treatment and risk for serious postoperative complications.Restorative proctocolectomy with ileal pouch-anal anastomosis is the surgical treatment of choice in ulcerative colitis patients.Surgery is traditionally recommended as salvage therapy when medical management fails,and,despite advances in medical therapy,colectomy rates remain unchanged between 20% and 30%.To overcome the reported increase in postoperative complications in patients on biologic therapies,several surgical strategies have been developed to maintain long-term pouch failure rate around 10%,as previously reported.Surgical staging along with the development of minimally invasive surgery are among the most promising advances in this field.

Mechanisms of Dihuang(Rehmanniae Radix)in treating diabetic nephropathy complicated with depression based on network pharmacology

Objective To predict the molecular mechanism of Dihuang(Rehmanniae Radix)in the treatment of diabetic nephropathy(DN)complicated with depression based on network pharmacology.Methods The components of Dihuang(Rehmanniae Radix)were identified from the Integrated Pharmacology-based Research Platform of Traditional Chinese Medicine(TCMIP),Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP),and relevant literature.The component targets were detected by combining the SwissTargetPrediction and Pub Chem databases.Disease targets were collected from the Therapeutic Target Database(TTD),Dis Ge NET,and Ensembl databases with“diabetic nephropathy”and“depression”as keywords.The disease-component targets were mapped using Venny 2.1.0 to obtain potential targets.A protein-protein interaction(PPI)network was constructed using the Search Tool for the Retrieval of Interacting Genes/Proteins(STRING)database and Cytoscape 3.7.2.The co-expression genes of the key targets were collected based on the COXPRESdb 7.3.Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis were performed for potential targets using R language.Target-component docking was verified and evaluated using Discovery Studio 4.5.Results According to the databases and literature reports,Dihuang(Rehmanniae Radix)contained 65 active components,and had 155 related targets for the treatment of DN complicated with depression.PPI screening showed that the key targets included serine/threonine protein kinase 1(AKT1),signal transducer and activator transcription 3(STAT3),interleukin 6(IL-6),mitogen-activated protein kinase 1(MAPK1),and vascular endothelial growth factor A(VEGFA),etc.GO enrichment analysis mainly involved biological processes,such as lipid metabolism,protein secretion regulation,cell homeostasis,and phosphatidylinositol 3 kinase activity.KEGG pathway enrichment analysis included the role of the AGE-RAGE signaling pathway in diabetic complements,insulin resistance(IR),neurotrophin signal path,Toll-like receptor signaling pathway,relaxin signaling pathway,epidermal growth factor receptor tyrosine kinase inhibitors(EGFR-TKIs),etc.Molecular docking showed that the target had high affinity for stachyose,manninotriose,verbascose,nigerose,etc.Conclusion Based on network parmacology,this study preliminarily predict the effects of Dihuang(Rehmanniae Radix)in treating DN complicated with depression by regulating inflammation,glucose metabolism,nution nerve,etc.

Medical malpractice litigation related to gastrointestinal endoscopy in Japan:A two-decade review of civil court cases

AIM: To examine the allegations in malpractice litigations related to gastrointestinal endoscopy in Japan. METHODS: A retrospective review of cases tried in the civil court system during the 21-year period from 1985 to 2005, identified in a computerized legal database, was undertaken. RESULTS: Eighteen malpractice litigations and a total of 30 allegations were identified. Of the 18 (44%) malpractice litigations, 8 (44%) were related to eso- phagogastroduodenoscopy, 4 (22%) to colonoscopy, 4 (22%) to endoscopic sphincterotomy, and 2 (11%) to endoscopic retrograde cholangiopancreatography. Seventeen (94%) cases pertained to complications, and the remaining (6%) case pertained to misdiagnosis. In 10 cases, the patient died of the complications. Allegations were categorized as: (1) performance error during the endoscopic procedure (n = 12, 40%); (2) lack of informed consent (n = 9, 30%); (3) performance error during the treatment after the endoscopic procedure (n = 4, 13%); (4) premedication error (n = 3, 10%); (5) diagnostic error (n = 1, 3%); and (6) indication error for the endoscopic procedure (n = 1, 3%). CONCLUSION: These data may aid in the design of risk prevention strategies to be used by gastrointestinal endoscopists.

Interferon alpha plus ribavirin combination treatment of Japanese chronic hepatitis C patients with HCV genotype 2:A project of the Kyushu University Liver Disease Study Group

AIM： To determine the efficacy of an interferon alpha and ribavirin combination treatment for Japanese patients infected with hepatitis C virus （HCV） of genotype 2, a multi-center study was retrospectively analyzed. METHODS： In total, 173 patients with HCV genotype 2 started to receive interferon-alpha subcutaneously thrice a week and 600-800 mg of ribavirin daily for 24 wk. RESULTS： The overall sustained virological response （SVR）, defined as undetectable HCV RNA in serum, 24 wk after the end of treatment, was remarkably high by 84.4%, （146/173） by an intention-to-treat analysis. A significant difference in SVR was found between patients with and without the discontinuation of ribavirin （46.9% vs 92.9 %）, but no difference was found between those with and without a dose reduction of ribavirin. A significant difference in SVR was also found between patients with less than 16 wk and patients with 16 or more weeks of ribavirin treatment （34.8 % vs 92.0 %）. CONCLUSION： The 24-wk interferon and ribavirin treatment is highly effective for Japanese patients with HCV genotype 2. The significant predictor of SVR is continuation of the ribavirin treatment for up to 16

遗传算法优化BP神经网络在中医按摩机器人中的应用

针对中医按摩设备的临床需求,研制了一种基于多种按摩手法的中医按摩机器人系统。同时,为了提高中医按摩机器人穴位寻找行为规划的精度,提出了一种基于遗传算法优化BP神经网络的中医按摩机器人穴位坐标预测方法,利用遗传算法弥补BP神经网络的缺陷,提高神经网络的预测精度,求解出最优解,保证了中医按摩机器人对患者做出精确的按摩治疗行为决策。并对上述方法进行了实现与仿真,结果表明,该方法对中医按摩机器人寻找患者穴位坐标具有较好的精度和较高的预测准确性。

Long-term effects of lamivudine treatment in Japanese chronic hepatitis B patients

AIM： To analyze the association between the emergence of tyrosine-methionine-asparatate-asparatate （YMDD） mutants （reverse transcription; rtM204I/V） and deterioration of liver function during long-term lamivudine treatment of Japanese patients with chronic hepatitis B virus （HBV） infection. METHODS： The data of 61 consecutive Japanese pa- tients with chronic hepatitis B who underwent continu- ous lamivudine treatment for more than 24 mo and had a virological response were analyzed. Analysis of YMDD mutants was done by real-time polymerase chain reaction with LightCycler probe hybridization assay for up to 90 mo （mean, 50.8 too; range, 24-90 too）.RESULTS： A mixed mutant-type （YMDD ＋ tyrosine-iso- leucine-asparatate-asparatate： YIDD or tyrosine-valineasparatate-asparatate： YVDD） or a mutant-type （YIDD or YVDD） were found in 57.4% of 61 patients at i year, 78.7% of 61 patients at 2 years, 79.6% of 49 patients at 3 years, 70.5% of 34 patients at 4 years, 68.4% of 19 patients at 5 years, 57.1% of 14 patients at 6 years, and 33.3% of 6 patients at 7 years. Of the 61 patients, 56 （92%） had mixed mutant- or a mutant-type. Only 5 （8%） had no mutants at each observation point. Vi- rological breakthrough was found in 26 （46.4%） of 56 patients with YMDD mutants, 20 of whom had a hepa- titis flare-up： the remaining 30 （53.6%） had neither a virological breakthrough nor a flare-up. All 20 patients who developed a hepatitis flare-up had a biochemical and virological response after adefovir was added to the lamivudine treatment. CONCLUSION： Our results suggest that it is possible to continue lamivudine treatment, even after the emergence of YMDD mutants, up to the time that the patients develop a hepatitis flare-up.

Efficacy of endoluminal gastroplication in Japanese patients with proton pump inhibitor-resistant,non-erosive esophagitis

AIM： To evaluate the efficacy, safety, and long-term outcomes of endoluminal gastroplication （ELGP） in pa- tients with proton pump inhibitor （PPI）-resistant, non- erosive reflux disease （NERD）. METHODS： The subjects were NERD patients, diag- nosed by upper endoscopy before PPI use, who had symptoms such as heartburn or reflux sensations two or more times a week even after 8 wk of full-dose PPI treatment. Prior to ELGP, while continuing full-dose PPImedication, patients＇ symptoms and quality of life （QOL） were assessed using the questionnaire for the diagno- sis of reflux disease, the frequency scale for symptoms of gastro-esophageal reflux disease （FSSG）, gastroin- testinal symptoms rating scale, a 36-item short-form. In addition, 24-h esophageal pH monitoring or 24-h in- traesophageal pH/impedance （MII-pH） monitoring was performed. The Bard EndoCinchTM was used for ELGP, and 2 or 3 plications were made. After ELGP, all acid reducers were temporarily discontinued, and medica- tion was resumed depending on the development and severity of symptoms. Three mo after ELGP, symptoms, QOL, pH or MII-pH monitoring, number of plications, and PPI medication were evaluated. Further, symptoms, number of plications, and PPI medication were evalu- ated 12 mo after ELGP to investigate long-term effects. RESULTS： The mean FSSG score decreased signifi- cantly from before ELGP to 3 and 12 mo after ELGP （19.1 ：k 10.5 to 10.3 ＋ 7.4 and 9.3 ＋ 9.9, P 〈 0.05, respectively）. The total number of plications decreased gradually at 3 and 12 mo after ELGP （2.4 ＋ 0.8 to 1.2 ：l： 0.8 and 0.8 ：l： 1.0, P 〈 0.05, respectively）. The FSSG scores in cases with no remaining plications and in cases with one or more remaining plications were 4.4 and 2.7, respectively, after 3 too, and 2.0 and 2.8, respectively, after 12 mo, showing no correlation to plication loss. On pH monitoring, there was no differ- ence in the percent time pH 〈 4 from before ELGP to 3 mo after. Impedance monitoring revealed no changes in the number of reflux episodes or the symptom index for reflux events from before ELGP to 3 mo after, but the symptom sensitivity index decreased significantly 3 mo after ELGP （16.1：1：12.9 to 3.9 ~ 8.3, P 〈 0.01）. At 3 mo after ELGP, 6 patients （31.6%） had reduced their PPI medication by 50% or more, and 11 patients （57.9%） were able to discontinue PPI medication alto- gether. After 12 mo, 3 patients （16.7%） were able toreduce the amount of PPI medication by 50% or more, and 22 patients （66.7%） were able to discontinue PPI medication altogether. A high percentage of cases with remaining plications had discontinued PPIs medication after 3 mo, but there was no difference after 12 mo. No serious complications were observed in this study. CONCLUSION： ELGP was safe, resulted in significant improvement in subjective symptoms, and allowed less medication to be used over the long term in patients with PPI-refractory NERD.

Biological Autonomy

We argue that genuine biological autonomy, or described at human level as free will, requires taking into account quantum vacuum processes in the context of biological teleology. One faces at least three basic problems of genuine biological autonomy： （1） if biological autonomy is not physical, where does it come from？ （2） Is there a room for biological causes？ And （3） how to obtain a workable model of biological teleology？ It is shown here that the solution of all these three problems is related to the quantum vacuum. We present a short review of how this basic aspect of the fundamentals of quantum theory, although it had not been addressed for nearly 100 years, actually it was suggested by Bohr, Heisenberg, and others. Realizing that the quantum mechanical measurement problem associated with the ＂collapse＂ of the wave function is related, in the Copenhagen Interpretation of quantum mechanics, to a process between self-consciousness and the external physical environment, we are extending the issue for an explanation of the different processes occurring between living organisms and their internal environment. Definitions of genuine biological autonomy, biological aim, and biological spontaneity are presented. We propose to improve the popular two-stage model of decisions with a biological model suitable to obtain a deeper look at the nature of the mind-body problem. In the newly emerging picture biological autonomy emerges as a new, fundamental and inevitable element of the scientific worldview.

Notes on soil predatory mites: the genus Lasioseius with a newly recorded species and key from China(Acari: Mesostigmata: Blattisociidae)

This paper presents a new record of Lasioseius Berlese in China, Lasioseius japonicas Ehara, with descriptions of the female. Specimens of L. japonicus were collected from the laboratory culture of Athetis lepigone Moschler (Lepidoptera: Noctuidae) in Shandong Agricultural University and deposited in the Laboratory of Systematic and Applied Acarology, Shandong Agricultural University (SDAU). L. japonicus has shown promise of being a biological control agent of Bradysia odoriphaga in laborat ory observations. A key to the females of Lasioseius species from China is provided.

Cost of treating chronic hepatitis B:Comparison of current treatment guidelines

AIM:To compare program costs of chronic hepatitis B(CHB) screening and treatment using Australian and other published CHB treatment guidelines.METHODS:Economic modeling demonstrated that in Australia a strategy of hepatocellular cancer(HCC) prevention in patients with CHB is more cost-effective than current standard care,or HCC screening.Based upon this model,we developed the B positive program to optimize CHB management of Australians born in countries of high CHB prevalence.We estimated CHB program costs using the B positive program algorithm and compared them to estimated costs of using the CHB treatment guidelines published by the AsianPacific,American and European Associations for the Study of Liver Disease(APASL,AASLD,EASL) and those suggested by an independent United States hepatology panel.We used a Markov model that factored in the costs of CHB screening and treatment,individualized by viral load and alanine aminotransferase levels,and calculated the relative costs of program components.Costs were discounted by 5% and calculated in Australian dollars(AUD).RESULTS:Using the B positive algorithm,total program costs amount to 13 979 224 AUD,or 9634 AUD per patient.The least costly strategy is based upon using the AASLD guidelines,which would cost 34% less than our B positive algorithm.Using the EASL and the United States Expert Group guidelines would increase program costs by 46%.The largest expenditure relates to the cost of drug treatment(66.9% of total program costs).The contribution of CHB surveillance(20.2%) and HCC screening and surveillance(6.6%) is small-and together they represent only approximately a quarter of the total program costs.CONCLUSION:The significant cost variations in CHB screening and treatment using different guidelines are relevant for clinicians and policy makers involved in designing population-based disease control programs.

Basic Structures and Political Implications of a Sustainable Welfare Model

A synopsis of political welfare concepts, which are currently discussed under labels such as ＂green growth＂, ＂zero growth＂ and ＂degrowth＂, has identified fundamental shortcomings concerning the informational bases of the complex links between ecological, social and economic systems, which were taken into account in the creation of the concept. In the development of a concept for political action, a rationally acting environmental policy cannot neglect reflecting on which economic, ecological and social contexts have to be taken into account and on which normative statements its decisions should be grounded. The proposed sustainable welfare model consists of a positive impact and a normative decision model. The positive model provides a description of the ＂world＂ with which the effects of the various options for action on the environmental, social and the economic systems can be assessed. The normative model is a tool for selecting and assessing the options for action in pursuing the desired goal of sustainable welfare development. Principally the key environmental goals are prearranged to socio-economic goals. The model at hand provides the reference points for the development of a sustainable welfare concept, which can be used as a political action plan in the context of environmental policy.

AIDS Treatments Efficiency Analysis Based on Cost Efficiency Data Envelopment Analysis Model

Three data envelopment analysis (DEA) models were used to analyse the relative efficiencies of four AIDS treatments in AIDS Clinical Trial Group (ACTG) Study 193A(1 309 patients in total, classified into 4 age groups). Results from the output-oriented BCC model show that Treatment 4 ( 600 mg of zidovudine plus 400 mg of didanosine plus 400 mg of nevirapine) is particularly efficient for age group 14—25, but not efficient for the older age groups; Treatment 1 (600 mg of zidovudine alternating monthly with 400 mg of didanosine)and Treatment 2 (600 mg of zidovudine plus 2.25 mg of zalcitabine) are efficient for the age groups 35—45 and 45— ; age group 25—35 does not have a particularly efficient treatment, but Treatments 1 and 2 are relatively good. The cost efficiency BCC model, which takes the treatment cost into account, gives similar results as the output-oriented model. Results from the indirect output-oriented BCC model, which allows the replacement among medicines, show that the efficiency of Treatment 2 has greatly decreased compared with that of the output-oriented model, and a set of optimal medicine amounts for different age groups is obtained.