AIMTo determine the sensitivity of macroscopic appearance for predicting histological diagnosis at sites other than duodenum in pediatric celiac disease (CD).METHODSEndoscopic and histologic findings in pediatric pati...AIMTo determine the sensitivity of macroscopic appearance for predicting histological diagnosis at sites other than duodenum in pediatric celiac disease (CD).METHODSEndoscopic and histologic findings in pediatric patients undergoing upper endoscopy for first-time diagnosis of CD at Stollery Children’s Hospital from 2010-2012 were retrospectively reviewed.RESULTSClinical charts from 140 patients were reviewed. Esophageal and gastric biopsies were taken in 54.3% and 77.9% of patients, respectively. Endoscopic appearance was normal in the esophagus and stomach in 75% and 86.2%. Endoscopic esophageal diagnoses were eosinophilic esophagitis (EE) (11.8%), esophagitis (7.9%), glycogenic acanthosis (1.3%) and non-specific abnormalities (3.9%). Endoscopic gastric diagnoses were gastritis (8.3%), pancreatic rest (0.9%), and non-specific abnormalities (4.6%). Histology was normal in 76.3% of esophageal and 87.2% of gastric specimens. Abnormal esophageal histology was EE (10.5%), esophagitis (10.5%), glycogenic acanthosis (1.3%) and non-specific (1.3%). Gastritis was reported in 12.8% of specimens. Sensitivity and specificity of normal endoscopy for predicting normal esophageal histology was 86.2% and 61.1%, and for normal gastric histology was 87.4% and 21.4%.CONCLUSIONIn the absence of macroscopic abnormalities, routine esophageal and gastric biopsy during endoscopy for pediatric CD does not identify major pathologies. These findings have cost and time saving implications for clinical practice.展开更多
There are more and more research on active control in the application of civil structure.However,some problems such as the drive levers design,optimization and control law problems restricted its application developme...There are more and more research on active control in the application of civil structure.However,some problems such as the drive levers design,optimization and control law problems restricted its application development.In this work,we presented a kind of piezoelectric drive lever to convert pulling force to pressure without flexural moments based on characteristics of the piezoelectric pile,using the genetic algorithm to optimize the layout of the driving lever,which greatly improved the efficiency.Then an active control experiment on a three-layer intelligence space structure was carried out.The experimental data show that the intelligent structures can produce through active control greatly inhibitive effects on the correspondingly controlled modal displacement and acceleration.Spectral analysis shows that the corresponding modal damping coefficient can be improved to different degrees.展开更多
基金Supported by Women and Children’s Health Research Institute
文摘AIMTo determine the sensitivity of macroscopic appearance for predicting histological diagnosis at sites other than duodenum in pediatric celiac disease (CD).METHODSEndoscopic and histologic findings in pediatric patients undergoing upper endoscopy for first-time diagnosis of CD at Stollery Children’s Hospital from 2010-2012 were retrospectively reviewed.RESULTSClinical charts from 140 patients were reviewed. Esophageal and gastric biopsies were taken in 54.3% and 77.9% of patients, respectively. Endoscopic appearance was normal in the esophagus and stomach in 75% and 86.2%. Endoscopic esophageal diagnoses were eosinophilic esophagitis (EE) (11.8%), esophagitis (7.9%), glycogenic acanthosis (1.3%) and non-specific abnormalities (3.9%). Endoscopic gastric diagnoses were gastritis (8.3%), pancreatic rest (0.9%), and non-specific abnormalities (4.6%). Histology was normal in 76.3% of esophageal and 87.2% of gastric specimens. Abnormal esophageal histology was EE (10.5%), esophagitis (10.5%), glycogenic acanthosis (1.3%) and non-specific (1.3%). Gastritis was reported in 12.8% of specimens. Sensitivity and specificity of normal endoscopy for predicting normal esophageal histology was 86.2% and 61.1%, and for normal gastric histology was 87.4% and 21.4%.CONCLUSIONIn the absence of macroscopic abnormalities, routine esophageal and gastric biopsy during endoscopy for pediatric CD does not identify major pathologies. These findings have cost and time saving implications for clinical practice.
基金Funded by General Planned Research Program of the National Natural Science Foundation of China (No. 90715003)Key Science and Technology Program of the Ministry of Education of China (No. 209124)+6 种基金Ph.D. Programs Foundation of the Ministry of Education of China (No. 200807030002)Shaanxi Key Industry Research Project (No. 2008K07-31)Shaanxi Natural Science Foundation Research Fund (No. 2007E205)Shaanxi Key Laboratory Project (No. 08JZ35)National Key Laboratory Open Project (No. 08KF02)Shaanxi Provincial Key Laboratory Research Project (No. 09JS022)Key Laboratory Project of Shaanxi Department of Education (No. 09JS023),Key Laboratory Project of Shaanxi Department of Education by Visiting Scholars (No. 09JS024)
文摘There are more and more research on active control in the application of civil structure.However,some problems such as the drive levers design,optimization and control law problems restricted its application development.In this work,we presented a kind of piezoelectric drive lever to convert pulling force to pressure without flexural moments based on characteristics of the piezoelectric pile,using the genetic algorithm to optimize the layout of the driving lever,which greatly improved the efficiency.Then an active control experiment on a three-layer intelligence space structure was carried out.The experimental data show that the intelligent structures can produce through active control greatly inhibitive effects on the correspondingly controlled modal displacement and acceleration.Spectral analysis shows that the corresponding modal damping coefficient can be improved to different degrees.
