从一般艺术学视角审视赵孟頫的“活精神”

宋末元初,艺术家赵孟頫于诗、书、画、印诸艺术领域均能开宗立派而留名青史。从一般艺术学视角审视,赵孟頫的艺术创作之所以取得辉煌成就,这是艺术的"自律"与"他律"综合作用的结果。在蒙元时期,赵孟頫的人生以及他的艺术创作成就都体现出他特有的一种艺术"活精神",具体体现在他的艺术创造精神以及他在当时的历史处境中把汉文化的艺术精神发扬光大上。只有充分认识到赵孟頫的这种"活精神",我们才能以正确的史学观与艺术观来看待赵孟頫的艺术成就以及他对中国艺术的贡献。

Caregiver burden:A concept analysis

Objective:Caregiver burden is used frequently within the nursing literature.It has not yet been clearly defined as there are different opinions regarding this concept.The purpose of this paper is to provide clarity surrounding the concept caregiver burden.Methods:An electronic search of MEDLINE,CINAHL,Health Source Nursing/Academic Edition and Academic Search Complete(ASC)of EBSCO,China National Knowledge Infrastructure(CNKI)and Google Scholar were searched with a limit of 10 years and published in the English or Chinese language.The paper adopted the framework by Walker and Avant.The attributes,antecedents,consequences and uses of the concept were identified.Results:At total of 33 articles were included.The three attributes of caregiver burden were identified as self-perception,multifaceted strain,and over time.The antecedents included insufficient financial resources,multiple responsibility conflict,lack of social activities.The consequences of caregiver burden resulted in negative change which included decreased care provision,decrease in quality of life,physical and psychological health deterioration.Conclusion:A definition of caregiver burden was developed.Tools to measure caregiver burden were identified.The findings from this analysis can be used in nursing practice,nursing education,research and administration.

Ezra Pound＇s Conversion to Confucianism

The paper aims to explore Pound＇s early discovery of Confucianism and his conversion to Confucianism. Pound＇s interest in Confucianism coincided with the time when Christianity, already ＂contaminated＂ by ＂historical diseases＂ in Pound＇s view, could not offer a valid vision by which to guide the spiritual life, resulting in losing self in a modem society. Pound discovers three main deficiencies of Christianity： lack of respect for individuality, the decline of ethics, and open attack upon nature, which could not provide solutions to Western problems. Pound turned to Confucianism to search the existence of modem man in the face of society, and nature, which results in Pound＇s Confucian medicine to cure Western moral obtuseness.

Martin Luther on Marriage and Family

This paper describes and analyzes Martin Luther＇s views on marriage and family primarily from his own writings. Luther elevated marriage and family life to a place of respect and honor in the church and society at a time when singleness and celibacy were celebrated as ways of reaching a higher state of spirituality. Martin Luther＇s teachings were so radically different from the traditional Catholic views of his days that the church became furious with him and tried almost everything in their power to silence him. Although Luther is known primarily for his views on Justification, but it is his teachings on marriage and family that has been more consequential. Many in the West who have never heard the name of Martin Luther, today enjoy a more biblical view on marriage and family because of his influence. He advocated divorce according to biblical principles, at a time when divorce was almost impossible; he encouraged priests to marry by showing that there was no conflict between their calling and marriage; he denounced celibacy, blaming it for encouraging lust rather than aiding chastity; he restored marriage and family life back to the arena of spirituality and respectability in society. Luther lived out his own advice by getting married and living an exemplary married life. What made Luther so effective was the passionate intensity with which he advocated these reforms. He wrote and spoke with such power and backed up his words with such a bold and courageous life, although living in the shadow of constant threats, that centuries after his death, the power and conviction of his ideas still resonate.

On Sustainable Civil Rights

The tide of reform and opening up promotes the rapid development of science and technology in our society, and citizens have not only wimessed great improvement in basic material living conditions, but also have lived a fulfilled spiritual life. Material wealth stimulates self- awareness of rights protection of the citizens, and that＇s the issue of civil rights that we need to carry out in-depth studies on. As important rights of citizens, how can civil rights gain effective legal protection and how citizens themselves fully and effectively exercise the rights are problems asking for attention in the study of civil rights. Civil rights are not only the issue of inherence and existence, and we should also pay attention to its development or whether there is sustainable development. Moreover, how long this sustainability could last is also the issue of sustainable civil rights this thesis is going to discuss.

An Analysis of the Tragedy in The Catcher in the Rye

Jerome David Salinger is a famous American novelist. His famous novel The Catcher in the Rye, vividly shows us imagination of a teenage after the Second World War. In this novel, the writer put contradiction between American teenager material life and the lack of spiritual life after the World War II, reflected on the protagonist Holden. In the novel, Amanda Louise Holden hated the adult hypocritical world and he wanted to escape from the reality, but his weakness decided that he finally ended in failure and the collapse of the spirit. Holden is a victim of the era and the tragedy of the times. This paper tries to make a detailed and deep analysis on the tragedy of Holden in the novel

Contribution of spinal glia activation to mechanical hyperalgesia induced by spared nerve injury in rats

Objective: To investigate the role of spinal glial cells activation in neuropathic pain in a recently developed spared nerve injury (SNI) animal model by Decosterd and Woolf. Methods: A lesion was made to two of the three terminal branches of the sciatic nerve of rats (tibial and common peroneal nerves) leaving the sural nerve intact. Continuous intrathe-cal administration of propentofylline, a glial modulating agent, 1 d before and 5 d after operation, was performed to disrupt spinal cord glia function. The vehicle was intrathecally administrated as control. The paw withdrawal threshold to mechanical stimulation (paw withdrawal mechaical threshold PWMT), body mass and motor function were determined pre- and post-surgery. Results: It produced a prolonged mechanical allodynia in the medial and lateral part of the ipsilateral hind paw in SNL models. The treatment with propentofylline significantly prevented the development of mechanical allodynia located in either medial or lateral plantar surface. Rats in two groups showed normal motor function and body weight increase. Conclusion: SNI model can be applied as a useful method with little variance in searching the mechanism of neuropathic pain. These study suggest that spinal glia activation may contribute to mechanical allodynia induced by SNI.

Popular Catholicism Based on Sensory Engagement and Corporeal Perception

Pat Mora＇s House of Houses is a collection of memories about a Southwestern Mexican immigrant family. She develops multilayered meanings of the house in terms of psychological, spiritual, and sensory influences on both her private and communal life. She deploys sensory signiflers to portray religious and spiritual memories in a picturesque or performative way. The book reveals that the primacy of the senses as a perceptual device transforms the habitual religious rituals of popular Catholicism into the unconscious. This book shows how sensory perception is engaged in appropriating mystical space/time and interiorizing spiritual objects of family life. Thus, the paper investigates how the sensory agencies contribute to exploring culturally plural ways of experiencing the divine. It also illustrates how Mora＇s deployment of corporeality is related to her reassessment of femaleness and understanding of a meaning of the divine, which is distinctively embodied through 1o cotidiano. In effect, it focuses on Mora＇s treatment of the sensible body in connection with spiritual and religious connotations.

Soul, Spirit, Breath, and Life in the Book of Job

The terms ＂soul,＂ ＂spirit,＂ ＂breath,＂ and ＂life＂ occur several times each in the Book of Job. A proper understanding of these terms in Scripture, especially ＂soul＂ and ＂spirit＂ is integral to understanding the state of the dead, among others. These terms are used in diverse contexts with interchangeable nuances in the Book of Job. A living （＂life＂） person （＂soul＂） consists of the body/flesh plus the life principle （＂spirit＂） of which ＂breath＂ is a concrete expression. In poetic contexts, the terminologies denote the physical （＂soul＂/＂life＂）, appetitive （＂soul＂/＂life＂）, psychical （＂spirit＂/＂breath＂）, and emotional （＂soul＂/＂spirit＂） characteristics of the human being. While ＂soul＂ and ＂life＂ tend towards physieality and therefore can be used synonymously for the whole person, ＂spirit＂ and ＂breath＂ tend towards non-physicality and express such phenomena as intellection and wind. A study of these terminologies in other poetic texts in the Hebrew Bible may evince similar semantic configurations as found in the Book of Job.

Sexual Ethics; A Need Indeed, Buddhist Ethics as a Model

According to Psychological theories of motivation, sexuality is a biological need which urges to satisfy sexual desire. Though it is not essential for the survival of an individual, it plays a major role in the growth, development, adjustment and well-being. Therefore, sexuality is a common aspect in the existence and it should not be neglected. However, in many religious ethical issues, sexuality had been treated negatively and identified as a barrier for an advanced spiritual life. Even in tribal societies there were some sexual taboos that controlled man＇s sexual behavior to some extent. Among religious ethical codes, one may find that it had been placed an important position for controlling or completely eliminating sexual behaviors. In modem world, what is evident is that this so called sexual need has been used for many commercial and marketing purposes. Even in advertising field, sexual desire of man is used as a mean of attracting public. Phonograph has become a very profitable illegal professional today. Sexual medicines, drugs and tools are available everywhere in the society. Though sexual education had been included into the curriculum in schools and higher education institutions, the awareness of sexuality among people seems to be in a low level. While biologically man is compelled to fulfill sexual desire internally, it is motivated externally by many social factors. So that not only misconceptions of sexuality, but also misbehaviors of sexuality can be observed in the society today. By examining these current situations of man＇s sexual behaviors, there is a big need to formulate a sexual ethical code--a code of law with the help of religious teachings. Otherwise these various sexual behaviors may create more and more social and world problems. In this paper, my aim is to examine Buddhist ethics in order to formulate a sexual ethical code.

A Family of Origin Scale in Mothers of Children with Autistic Spectrum Disorder-Preliminary Report

The influence of the family of origin is often described in the aetiology of different psychiatric disorders. The majority of papers concerning the families of autistic children concentrate on the quality of their lives. The aim of our study was to compare the experiences from the family of origin of mothers of children with Autistic Spectrum Disorders （ASD） and from mothers of healthy children. In our study a Family of Origin Scale （FOS） was used. This scale consists of l0 constructs： clarity of expression, responsibility, respect for others, openness to others, acceptance of separation/loss, range of feelings, mood and tone, conflict resolution, empathy and trust. It was a pilot study. The examined group consisted of 9 mothers of children with ASD, the control group-7 mothers of healthy children. We found that both groups differed in a statistically significant way as for the construct called responsibility. Our research was a pilot study and it required further investigations.

Physical Activity Stares of Civil Servants and Their Health- Related Research

Since the 1980s, people＇ s material and spiritual life are constantly enriched and improved. People＇ s values are constantly changing, more and more people realize that participate in physical exercise for their own importance in sports. The status of people＇ s lives has been greatly improved, for most residents; they participate in physical activity and have gradually become a richer cultural life, and they enhance the basic needs of physical, mental lifelong sports have gradually deep heart. While people continue to enhance the sports consciousness exercise, we also see some potential problems, such as the rapid development of science and technology is to bring more and more problems to people. As people, enjoy the level of automation in the material aspects of life. They gradually have cars, telephones, washing machines, refrigerators, microwave ovens, rice cookers. And the household products go into our lives, we enjoy the material on those by making more and more people gradually reduce the daily activities. And the most prominent is the elevators and cars, reducing active time and the amount of activity, a lot of heat stored in the human body is causing various diseases, from the results of medical research over the past decade. Various diseases associated with obesity have been become the most important factor in human deaths worldwide, the rapid emergence of this disease and the rapid development of social science and technology form a clear lack of coordination, for which many experts at home and abroad for such issues of deep study and research.

Pharmaceutical Care of the Patients Suffering from Depression

Depression is the most present mental disorders with a very expensive treatment costs. Due to the high prevalence of depression in Bosnia and Herzegovina and high work load of psychiatrists, patients that suffer from depression are often marginalised, stigmatised and inadequately treated. Therefore, a pharmacist can influence an adequate selection of a therapy through an interdisciplinary approach and pharmaceutical care and alos provide patient monitoring, counselling about side effects and interactions of the prescribed drugs, which will in the end improve the quality of life for patients that suffer from depression. The aim of this work was to establish the influence of pharmaceutical care on the outcome of the quality of life and the pharmacological treatment of patients suffering from depression. Results showed that the involvement of pharmacist in a multidisciplinary approach to the treatment of depression lead to improvement of the effect of therapy and increased quality of life.

Interaction of antipsychotic drug with novel surfactants: Micellization and binding studies

The interaction of cationic gemini surfactants(alkanediyl-α,ω-bis(alkyl dimethylammonium bromide)) with an antipsychotic drug(chlorpromazine hydrochloride(CPZ)) has been investigated. Various micellar and interfacial parameters have been deliberated by surface tension measurement to report the nature of interactions between drug and novel surfactant mixtures. The behavior of mixed systems, their compositions and activities of components have been analyzed in the light of Rubingh's theory. The results indicate synergism in the binary mixtures.The binding study between CPZ and surfactants has been done by spectroscopic techniques such as UV–visible and fluorescence. The results are discussed in the light of the use of gemini surfactants as promising drug delivery agents for phenothiazine drugs, and hence, improve their bioavailability.

EFFECT OF ELECTRO-SCALP ACUPUNCTURE ON GLUCOSE METABOLISM OF THE CEREBRAL REGIONS INVOLVING MENTAL ACTIVITY IN HEALTHY PEOPLE

Objective: To observe the effect of electro-scalp acupuncture on glucose metabolism of cerebral regions involving mental activity in healthy people. Methods: A total of 6 cases of volunteer healthy subjects (3 males and 3 females) ranging in age from 22 to 36 years were subjected to this study. Changes of cerebral glucose metabolism before and after electro-scalp acupuncture were observed by using positron emission tomography (PET) and semi-quantifying analysis method. Electro-scalp acupuncture stimulation (50 Hz, 2 mA) of Middle Line of Vertex (Ding zhongxian,顶中线,MS5), Middle Line of Forehead (Ezhongxian, 额中线,MS1) and bilateral Lateral Line 1 of Forehead (Epangyixian,额旁一线,MS2) was administered for 30 minutes. Then cerebral regions of interest (ROIs) were chosen and their average glucose metabolism levels (radioactivity of 18 fluorine deoxyglucose) were analyzed. Results: After administration of electro-scalp acupuncture, the glucose metabolism levels in bilateral frontal lobes and bilateral caudate nuclei, left cingulate gyrus and right cerebellum increased significantly in comparison with those of pre stimulation (P<0.05). Conclusion: Electro-scalp acupuncture of MSI, MS2 and MS5 can increase the glucose metabolism of certain cerebral regions involving mental activity in healthy subjects.

Observation on clinical effect of tuina plus Western medication for functional dyspepsia due to liver qi stagnation and spleen deficiency

Objective：To observe the clinical effects of tuina plus Western medication for functional dyspepsia （FD） due to liver qi stagnation and spleen deficiency.Methods：A total of 72 patients in conformity with the inclusion criteria of FD were randomly divided into an observation group and a control group based upon the random number table,36 cases in each group.The control group was treated with mosapride citrate dispersible tablets,and the observation group was treated with the same tablets plus tuina.Before the treatment and 4 weeks after the treatment,the clinical symptoms,quality of life （QOL） and depression severity were observed by the scale,and were followed up two months later after the treatment for assessment of the clinical effects.Results：After the treatment and at the follow-up,the symptom scores of FD and the sores of Hamilton depression rating scale （HAMD） in both groups decreased,and the scores in Chinese version of quality of life questionnaire for functional digestive disorders （Chin-FDDQL） increased,with statistically significant differences in comparison with the same group before the treatment （all P〈0.05）.In comparison between the two groups at the same time point after the treatment,the scores of FD symptoms,HAMD and Chin-FDDQL were improved better in the observation group than those in the control group,with statistically significant differences （all P〈0.05）.The total effective rates at the follow-up were 91.7% in the observation group and 75.0% in the control group,without statistical difference between the two groups （P〉0.05）.The rate of clinical cure and remarkable effect was 66.7% in the observation group,higher than 41.7% in the control group,it is higher in the observation group than that in the control group,with a statistically significant difference between the two groups （P〈0.05）.Conclusion：Tuina plus Western medication is precise in the therapeutic effects for FD due to liver qi stagnation and spleen deficiency and can effectively relieve clinical symptoms,elevate the QOL and alleviate depression severity of the patients.Moreover,it＇s better than the treatment by Western medication alone in the long-term therapeutic effects.

Therapeutic efficacy and mechanism of heat-sensitive moxibustion for adjuvant treatment of depression in Parkinson disease

Objective:To observe the clinical efficacy of heat-sensitive moxibustion for adjuvant treatment of depression in Parkinson disease and explore its mechanism.Methods:A total of 80 patients with Parkinson disease coupled with depression were randomized into an observation group and a control group,with 40 cases in each group.The control group was treated with levodopa and benserazide hydrochloride tablets and paroxetine tablets,while the observation group was treated with heat-sensitive moxibustion on the basis of the medications in the control group.The treatment course was 2 months.The Hamilton depression scale-17(HAMD-17),unified Parkinson's disease rating scale(UPDRS)and Parkinson's disease quality of life questionnaire-39(PDQ-39)were scored before and after the treatment,and the efficacy was evaluated after treatment.Levels of patients'serum dopamine(DA),5-hydroxytryptamine(5-HT),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)were detected before and after the treatment.Results:After treatment,the total effective rate of the observation group was higher than that of the control group(P<0.05).The HAMD-17 scores in the two groups decreased significantly after treatment(both P<0.05),and the score in the observation group was obviously lower than that in the control group(P<0.05).The component scores and total scores of UPDRS in both groups decreased significantly(all P<0.05),and the scores in the observation group were lower than those in the control group(all P<0.05).The score of PDQ-39 in the observation group decreased significantly(P<0.05),and was lower than that in the control group(P<0.05).After treatment,the serum DA and 5-HT levels in the observation group increased significantly(both P<0.05)and the TNF-αand IL-6 levels decreased significantly(both P<0.05),which were statistically different from those in the control group(all P<0.05).Conclusion:Heat-sensitive moxibustion has certain auxiliary effect in treating depression in Parkinson disease,significantly improving clinical symptoms and the quality of life,which may be related to the up-regulation of DA and 5-HT levels and down-regulation of TNF-αand IL-6 levels.

A cross-sectional study of irritable bowel syndrome in nurses in China: prevalence and associated psychological and lifestyle factors

The prevalence of irritable bowel syndrome （IBS） and associated factors, especially psychological and lifestyle factors, in nurses in China have not been investigated previously. The aims of this study were to assess the prevalence of IBS in nurses, to evaluate whether factors, such as psychological disorders, are associated with IBS, and to determine whether psychological disorders can influence the severity of symptoms of IBS and quality of life （QOL）. A cross-sectional study was conducted for Chinese nurses from November 2012 to February 2013. Partici- pants were asked to complete questionnaires. The prevalence of IBS was 17.4%. The revised symptom checklist 90 （SCL-90-R） scores were significantly higher for nurses with IBS than for those without IBS （P〈0.001）, and no difference in scores between IBS subtypes was found （F=1.893, P=-0.142）. The scores of QOL for nurses with and without IBS were 77.18±21.93 and 88.44±11.89 （P〈0.001）, respectively. Psychological disorders did not show statistically significant correlations with severity of symptoms of IBS or QOL. Alcohol consumption, low level of exercise, and psychological disorders were risk factors for IBS. In summary, nurses in China show a high prevalence of IBS. Psy- chological disorders and some related lifestyle factors are probably responsible for the development of IBS in nurses.

Therapeutic efficacy and mechanism of heat-sensitive moxibustion for vascular dementia

Objective:To observe the clinical efficacy of heat-sensitive moxibustion for vascular dementia and explore its mechanism.Methods:A total of 70 patients with vascular dementia were randomized into an observation group and a control group,with 35 cases in each group.The control group was treated with piracetam,and the observation group was treated with heat-sensitive moxibustion on the basis of the treatment of the control group.The treatment lasted for 8 weeks.Before and after the treatment,the mini-mental state examination(MMSE),activity of daily living(ADL)and traditional Chinese medicine(TCM)symptom scores were assessed,and the levels of acetyl choline(Ach)and homocysteine(Hcy)were measured.The efficacy was evaluated after treatment.Results:The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).After treatment,the MMSE and ADL scores in the observation group decreased significantly,and were lower than those in the control group(all P<0.05);the TCM symptom score of the observation group decreased significantly(P<0.05),while that of the control group had no significant change(P>0.05);the plasma Ach level in the observation group increased significantly(P<0.05),and the Hcy level decreased significantly(P<0.05),which were statistically different from those in the control group(both P<0.05).Conclusion:Heat-sensitive moxibustion plus piracetam is effective in treating vascular dementia.It can significantly improve dementia symptoms and ADL,which may be related to the correction of plasma Ach and Hcy levels.

Dysbindin promotes progression of pancreatic Juctal adenocarcinoma via direct activation of PI3

Pancreatic ductal adenocarcinoma （PDAC） represents a biggest challenge in clinic oncology due to its invasiveness and lack of tar- geted therapeutics. Our recent study showed that schizophrenia susceptibility factor dysbindin exhibited significant higher level in serum of PDAC patients. However, the functional relevance of dysbindin in PDAC is still unclear. Here, we show that dysbindin pro- motes tumor growth both in vitro and in vivo by accelerating the G1/S phase transition in cell cycle via PI3K/AKT signaling path- way. Mechanistically, dysbindin interacts with PI3K and stimulates the kinase activity of PI3K. Moreover, overexpression of dysbindin in PDAC is correlated with clinicopathological characteristics significantly, such as histological differentiation （P = 0.011） and tumor size （P = 0.007）. Kaplan-Meier survival curves show that patients with high dysbindin expression exhibit poorer overall survival, compared to those with low dysbindin expression （P 〈 0.001）. Multivariate analysis reveals that dysbindin is an independ- ent prognostic factor for pancreatic ductal adenocarcinoma （P = 0.001）. Thus, our findings reveal that dysbindin is a novel PI3K acti- vator and promotes PDAC progression via stimulation of PI3K/AKT. Dysbindin therefore represents a potential target for prognosis and therapy of PDAC.