“测量”活动方案的设计

作者发挥备课组的集体智慧,使"测量"活动的设计在教材基础上进行创新,很成功,对培养学生的科学探究能力很有价值。本刊欢迎这一类的稿件。

Safety and efficacy of Profermin~to induce remission in ulcerative colitis

AIM:To test the efficacy and safety of Profermin in inducing remission in patients with active ulcerative colitis(UC).METHODS:The study included 39 patients with mild to moderate UC defined as a Simple Clinical Colitis Activity Index(SCCAI)>4 and<12(median:7.5),who were treated open-label with Profermintwice daily for 24 wk.Daily SCCAI was reported observer blinded via the Internet.RESULTS:In an intention to treat(ITT)analysis,the mean reduction in SCCAI score was 56.5%.Of the 39 patients,24(62%)reached the primary endpoint,which was proportion of patients with≥50%reduction in SCCAI.Our secondary endpoint,the proportion of patients in remission defined as SCCAI≤2.5,was in ITT analysis reached in 18 of the 39 patients(46%).In a repeated-measure regression analysis,the estimated mean reduction in score was 5.0 points(95%CI:4.1-5.9,P<0.001)and the estimated mean time taken to obtain half the reduction in score was 28 d(95%CI:26-30).There were no serious adverse events(AEs)or withdrawals due to AEs.Profermin was generally well tolerated.CONCLUSION:Profermin is safe and may be effective in inducing remission of active UC.

Considerations when using the activPAL monitor in field-based research with adult populations

Research indicates that high levels of sedentary behavior(sitting or lying with low energy expenditure) are adversely associated with health. A key factor in improving our understanding of the impact of sedentary behavior(and patterns of sedentary time accumulation) on health is the use of objective measurement tools that collect date and time-stamped activity information. One such tool is the activP AL monitor. This thigh-worn device uses accelerometer-derived information about thigh position to determine the start and end of each period spent sitting/lying, standing, and stepping, as well as stepping speed, step counts, and postural transitions. The activP AL is increasingly being used within field-based research for its ability to measure sitting/lying via posture. We summarise key issues to consider when using the activP AL in physical activity and sedentary behavior field-based research with adult populations. It is intended that the findings and discussion points be informative for researchers who are currently using activP AL monitors or are intending to use them. Pre-data collection decisions, monitor preparation and distribution, data collection considerations, and manual and automated data processing possibilities are presented using examples from current literature and experiences from 2 research groups from the UK and Australia.

A Modified Method for Measuring Root Iron Reductase Activity Under Normal Laboratory Conditions

Based on the strong chelating property of bathophenanthroline disulfonic acid (BPDS) with root chelate reductase activity is usually measured with a spectrophotometer using MES (2-morpholinoethanesulfonic acid) or HEPES (2-(4-(2-Hydroxyethyl)-1-piperazinyl) ethanesulfonic acid) buffer in the dark because of high autoreduction rate of in the presence of light. However, the exclusion of light is inconvenient, especially when analyzing a large number of samples. The objective of this study was to develop a new method for determination of root reductase activity under normal laboratory conditions using a suitable buffer composition and concentration to eliminate the autoreduction of A modified method using a Tris (2-amino-2-hydroxymethyl-1,3-propanediol) buffer at pH 7.5 instead of MES or HEPES buffer and a decreased FeEDTA (Fe ethylene diamine tetraacetic acid) concentration of 50 μmol L-1 was developed. The autoreduction of using the Tris buffer was undetectable for temperatures at 4 and 28 °C and was also much lower than that using the other buffers even with sunlight during measurement of reduction. Furthermore, the differences in reductase activity among 5 plant species and 14 red clover cultivars (Trifolium pratense L.) could be easily detected with the modified method. The method developed in this study to measure root Fe chelate reductase activity was not only effective and reliable but also easily managed under normal laboratory light conditions.

The upper-ocean response to typhoons as measured at a moored acoustic Doppler current profiler

A moored acoustic Doppler current profiler(ADCP) data,satellite-derived sea surface wind data,and the chlorophyll-a concentration were used to examine the influence of typhoon events on the upper ocean in the central Luzon Strait. The data were collected between August 27 and October 6,2011. Large changes in ocean dynamics and marine life were recorded in the upper layers over the short term during the transit of each of the three violent typhoons that passed over the region during the study period. The geostrophic flow during the period of ADCP monitoring was comparable to the Ekman flow,recently shown to be prominent in the upper layer. Based on the influence of the three typhoon events that swept the Luzon Strait or traversed Luzon Island on their way to the South China Sea,we postulated a typhoon-induced upwelling around the ADCP and found that upward isothermal displacements reached 11.8–39.0 m,which was confirmed by the sea-level anomaly data recorded at the same time. This variability in the upper ocean may play an important role in biological activity,especially in offshore deep-sea regions.

Implementation of Vibrancy Awaking Pressure Measuring Instrument for Single Hydraulic Prop

An instnmaent awakened by means of vibration for single hydraulic prop pressame measuring is described in this paper. The principle and implementation of this metlmd are introduced in detail. The instnznent uses the hgh-perftmnance single chip C8051F310 as its MCU and vibration sensor as its awaking device. It has such advantages as small vohane and low power consmnption, and moreover it could resolve the problem that traditional pressure measming instrument on single hydraulic prop can＇t be used in coal mine.

GPS Rapid Static and Kinematic Positioning Based on GPS Active Network

This paper presents a data processing strategy for GPS kinematic positioning by using a GPS active network to model the GPS errors in double difference observable.Firstly,the double difference residuals are estimated between the reference stations in the active network.Then the errors at a user station are predicted as the network corrections to user measurements,based on the location of the user.Finally conventional kinematic positioning algorithms can be applied to determine the position of the user station.As an example,continuous 24_hour GPS data in March 2001 has been processed by this method.It clearly demonstrates that,after applying these corrections to a user within the network,both the success rate for ambiguity resolution and the positioning accuracy have been significantly improved.

Use of SAR interferometry for monitoring illegal mining activities: A case study at Xishimen Iron Ore Mine

The development and application of the ''digital mine'' concept in China depends heavily upon the use of remote sensing data as well as domestic expertise and awareness. Illegal mining of mineral resources has been a serious long term problem frustrating the Xishimen Iron Ore Mine management. This mine is located in Wu'an county in Hebei province, China. Illegal activities have led to enormous economic losses by interfering with the normal operation of the Xishimen mine and have ruined the surrounding environ- ment and the stability of the Mahe riverbed the crosses the mined area. This paper is based on field recon- naissance taken over many years around the mine area. The ground survey data are integrated with Differential Synthetic Aperture Radar Interferometry (D-InSAR) results from ALOS/PALSAR data to pin- point mining locations. By investigating the relationship between the resulting interferometric deforma- tion pattern and the mining schedule, which is known a priori, areas affected by illegal mining activities are identified. To some extent these areas indicate the location of the illegal site. The results clearly dem- onstrate D-InSAR's ability to cost-effectively monitor illegal mining activities.

Late Quaternary Activity and Paleoearthquakes along the Nanyukou Segment of the Northern Piedmont Fault of Wutai Mountain

The northern piedmont fault of Wutai Mountain is located at the north of the Shanxi Graben system, which is the dominating fault of the south boundary of the Fanshi-Daixian depression. This paper discusses the fault activity and paleoearthquakes around the Nanyukou segment of the northern piedmont fault of Wutai Mountain during the late Quaternary through field investigation along the fault, measuring geomorphic deformation and excavating trenches at some important sites. From Nanyukou to the southwest of Shanhui, we find obviously dislocated alluvial fans, with strong neotectonic movement at these sites. Since nearly 20ka, the vertical average slip rate is 1.55mm/a to 2.0mm/a. However,since nearly 6ka,it has reached as high as 2.3mm/a, which is twice that on other segments. 2 trenches were excavated around Nanyukou with 6 events discovered. The referenced ages of the events are before 7600a, 6700a - 7600a, 5321a - 5575a, 4400a - 5400a,420Oa-4400a and after 1600a B.P. with approximate recurrence interval 1400a. The latest event is likely to be the earthquake occurring at 512 A. D. ,so it is necessary to do further work to verify this in the future.

Electrical conductivity of hydrous silicate melts and aqueous fluids: Measurement and applications

The combination of magnetotelluric survey and laboratory measurements of electrical conductivity is a powerful approach for exploring the conditions of Earth's deep interior. Electrical conductivity of hydrous silicate melts and aqueous fluids is sensitive to composition, temperature, and pressure, making it useful for understanding partial melting and fluid activity at great depths. This study presents a review on the experimental studies of electrical conductivity of silicate melts and aqueous fluids, and introduces some important applications of experimental results. For silicate melts, electrical conductivity increases with increasing temperature but decreases with pressure. With a similar Na^+ concentration, along the calc-alkaline series electrical conductivity generally increases from basaltic to rhyolitic melt, accompanied by a decreasing activation enthalpy. Electrical conductivity of silicate melts is strongly enhanced with the incorporation of water due to promoted cation mobility. For aqueous fluids, research is focused on dilute electrolyte solutions. Electrical conductivity typically first increases and then decreases with increasing temperature, and increases with pressure before approaching a plateau value. The dissociation constant of electrolyte can be derived from conductivity data. To develop generally applicable quantitative models of electrical conductivity of melt/fluid addressing the dependences on temperature, pressure, and composition, it requires more electrical conductivity measurements of representative systems to be implemented in an extensive P-T range using up-to-date methods.

Altered relationship between thickness and intrinsic activity amplitude in generalized tonic–clonic seizures

A thinner cortex has higher potential for binding GABA receptor A which is associated with larger amplitudes of intrinsic brain activity(i BA). However, the relationship between cortical thickness and i BA is unknown in intact and epileptic brains. To this end, we investigated the relationship between cortical thickness measured by highresolution MRI and surface-based i BA derived from resting-state functional MRI in normal controls(n = 82) andpatients with generalized tonic–clonic seizures(GTCS)only(n = 82). We demonstrated that the spatial distribution of cortical thickness negatively correlated with surface-based i BA amplitude at both whole-brain and within independent brain functional networks. In GTCS patients,spatial coupling between thickness and i BA amplitude decreased in the default mode, dorsal attention, and somatomotor networks. In addition, the vertex-wise acrosssubject thickness–i BA amplitude correspondence altered in the frontal and temporal lobes as well as in the precuneus in GTCS patients. The relationship between these two modalities can serve as a brain-based marker for detecting epileptogenic changes.

Ionospheric absorption and planetary wave activity in East Asia sector

In this paper, we focus on ionospheric absorption in the East Asia sector, and look for manifestations of atmospheric influences in this area. First, a 4-year historical record of absorption measurement at Beijing is presented. This record was obtained by a sweep frequency technique, in which 27-days periodic variation of the absorption level was found to be dominant, appearing in most seasons except winters. Instead, unusual enhancements of the absorption level appeared in winters (winter anomaly), at the meantime the level varied with periods mainly in the range of 8-12 days. Comparing to 27-days period from the Sun, the shorter period oscillations should be related to planetary wave activities in lower atmosphere. Second, fmin data from 5 mid-latitude ionosondes in Japan were used as an indirect but long-term measurement. With the fmin data covering two solar cycles, disturbances with various periods were found to be active around solar maximum years, but the 8-12 days oscillations always existed in winter, showing seasonal dependence instead of connection to solar activity. These results given in this paper demonstrate seasonal and solar cycle-dependent features of the ionospheric absorption in East Asia sector, and confirm the existence of influence from atmosphere-ionosphere coupling in this area, as well as the relationship between ionospheric winter anomaly and planetary wave activity.

Therapeutic observation of Fu's subcutaneous needling for scapulohumeral periarthritis

Objective： To observe the therapeutic efficacy of Fu＇s subcutaneous needling（FSN） in treating scapulohumeral periarthritis（SP）.Methods： Eighty patients with SP were randomly divided into an observation group and a control group, 40 cases in each group. Patients in the observation group received FSN treatment while those in the control group received conventional acupuncture treatment. Visual analogue scale（VAS） and range of motion（ROM） were observed before and after the treatment, and the therapeutic efficacy was also evaluated.Results： After the treatment, the VAS scores decreased significantly in the two groups, and the VAS score in the observation group was significantly lower than that in the control group（P〈0.01）. After the treatment, the ROM increased significantly in both groups（both P〈0.01）, and the ROM in the observation group was significantly higher than that in the control group（P〈0.01）. The recovery rate and the total effective rate in the observation group were respectively 40.0% and 95.0%,significantly higher than 12.5% and 77.5% in the control group（P〈0.01, P〈0.05）.Conclusion： FSN can effectively relieve pain and improve the joint motion in treating SP, thus offering a novel option to the treatment of this kind of musculoskeletal disorder.