基于“消”法理论的中药联合前列安栓治疗ⅢB型前列腺炎的疗效观察

目的探讨基于"消"法理论的中药联合前列安栓治疗ⅢB型前列腺炎的疗效观察。方法选取我院收的ⅢB型前列腺炎118例,按随机分组法分成观察组40例、对照1组39例、对照2组39例。观察组给予"消"法理论的中药汤剂联合前列安栓塞肛治疗;对照1组单纯给予中药汤剂治疗;对照2组单纯给予前列安栓塞肛治疗,疗程均为4周。对比三组治疗前后的肛门指检评分、中医症状评分、前列腺常规检测评分以及NIH-CPSI总评分。结果治疗后,三组前列腺常规检测评分比较,差异无统计学意义(P>0.05);治疗后,观察组的肛门指检评分、中医症状评分以及NIH-CPSI总评分降低明显优于对照1组、对照2组,且对照1组肛门指检评分、中医症状评分以及NIH-CPSI总评分优于对照2组,差异均有统计学意义(P<0.05);观察组治疗总有效率高于对照1组、对照2组,差异有统计学意义(P<0.05)。结论基于"消"法理论的中药汤剂联合前列安栓能改善ⅢB型CP的肛门指检症状、中医症状评分以及NIH-CPSI总评分,进而改善ⅢB型前列腺炎患者的症状,疗效可靠,安全。

基于“消托补”法思辨治疗复发性尿路感染

中医将复发性尿路感染归属于“劳淋”范畴。因其反复发作,迁延难愈,一直是困扰患者和医务人员的难题。“消、托、补”三法是对中医外科疾病所应用的内治法总纲。由于复发性尿路感染的发生和常见的中医外科疾病在病机方面存在高度相似性,故笔者将“消、托、补”三法应用于对复发性尿路感染的中医组方治疗中,取得较好疗效。

“消生”法巧算多平衡体系的化学平衡常数

2022年全国高考甲卷理综化学试题28题对化学平衡常数的计算有了更高的思维要求,在课堂实际教学中,学生对于化学平衡常数的计算由单一平衡体系转向两个或者两个反应平衡体系以上存在思维断层.通过“消生”法巧算多反应平衡体系的化学平衡常数,助力学生学科思维养成.

Effect of Different Disinfection Methods on Calluses of Amorphophallus albus P.Y.Liu&J.F.Chen

This study aimed to examine the effect of different disinfection methods on the callus of Amorphophallus albus in the tissue culture and rapid propagation system.The calluses induced from buds of A.albus were disinfected with benzalkonium bromide,mercury bichloride,sodium hypochlorite,and ethanol,respectively,for different time periods.The growth of calluses was compared between different treatments and observed in detail by dissection.The results showed that the disinfection with 0.1% mercury bichloride for 5 min and 75% ethanol for 5 s had mild effect on the callus,with the lowest browning rates of 16.32% and 15.46% and the lowest vitrification rates of 3.24% and 9.72%,respectively,after 20 d.The disinfection with benzalkonium bromide and sodium hypochlorite had strong effect on the callus cells,with the lowest browning rate of 50.69% and 25.12% and the lowest vitrification rates of 28.47% and 28.43%,respectively.The cytological observation result showed that the calluses disinfected with ethanol and mercury bichloride showcased compact structures,while those disinfected with sodium hypochlorite and benzalkonium bromide exhibited loose structures.To sum up,it is recommended that 75% ethanol or 0.1% mercury bichloride can be used for disinfection in the tissue culture and rapid propagation of A.albus,while the use of benzalkonium bromide and sodium hypochlorite should be avoided as much as possible.

The Determination of Heavy Metal Elements in Honey by MWD-ICP-AES

In order to build method for measuring of elements in honey, the contents of Ba, Cu, Pb, Cd, As, Hg, Cr, Mn, Se had been determined by microwave diges- tion （MWD） and actively coupled plasma atomic emission spectrometry （ICP-AES）. The results show that, the range of heavy metal elements were in the range of 0- 10.0 mg/L, with good linear relationship. In addition, all correlation coefficients kept higher than 0.999, and the recovery rate of ample added with standard solution was in 94.1%-110%. By comparison with the result of chemical experiment, the method was quickly accessible and convenient, widely used in the measurement of elements in honey, with satisfactory results.

Application of Image Fusion Methods to Cell Imaging Processing

Aim To fuse the fluorescence image and transmission image of a cell into a single image containing more information than any of the individual image. Methods Image fusion technology was applied to biological cell imaging processing. It could match the images and improve the confidence and spatial resolution of the images. Using two algorithms, double thresholds algorithm and denoising algorithm based on wavelet transform,the fluorescence image and transmission image of a Cell were merged into a composite image. Results and Conclusion The position of fluorescence and the structure of cell can be displyed in the composite image. The signal-to-noise ratio of the exultant image is improved to a large extent. The algorithms are not only useful to investigate the fluorescence and transmission images, but also suitable to observing two or more fluoascent label proes in a single cell.

The Determination of Heavy Metal Elements in Sipunculs nudus by MWD-ICP-AES

In order to develop a method for measuring of elements in Sipunculus nudus, the contents of Cu, Pb, Cd, Cr, Mn, As, Hg and Ba were determined by actively coupled plasma atomic emission spectrometry （MWD） and microwave digestion （ICP-AES）. The results showed that correlation coefficients al kept higher than 0.999 and the recovery rates of sample added standard solutions were in 98%-114%. The results indicated that the contents of Cu, Pb, Cd, Cr, Mn, As, Hg and Ba were 17.119, 3.781, 0.695, 7.351, 1997.982, 0.620, 0.144, 4.249 mg/kg respectively. The contents of Mn exceeded national limit by hundredfold, Cd sevenfold, Pd fourfold, Cd three-and-a-half-fold, and As onefold. Sipunculs nudus became seriously pol uted. Therefore, it is necessary to formulate robust policies to fol ow closely and pay close attention to coastal areas pol ution around Dongfang City.

New seismic attribute:Fractal scaling exponent based on gray detrended fluctuation analysis

Seismic attributes have been widely used in oil and gas exploration and development. However, owing to the complexity of seismic wave propagation in subsurface media, the limitations of the seismic data acquisition system, and noise interference, seismic attributes for seismic data interpretation have uncertainties. Especially, the antinoise ability of seismic attributes directly affects the reliability of seismic interpretations. Gray system theory is used in time series to minimize data randomness and increase data regularity. Detrended fluctuation analysis （DFA） can effectively reduce extrinsic data tendencies. In this study, by combining gray system theory and DFA, we propose a new method called gray detrended fluctuation analysis （GDFA） for calculating the fractal scaling exponent. We consider nonlinear time series generated by the Weierstrass function and add random noise to actual seismic data. Moreover, we discuss the antinoise ability of the fractal scaling exponent based on GDFA. The results suggest that the fractal scaling exponent calculated using the proposed method has good antinoise ability. We apply the proposed method to 3D poststack migration seismic data from southern China and compare fractal scaling exponents calculated using DFA and GDFA. The results suggest that the use of the GDFA-calculated fractal scaling exponent as a seismic attribute can match the known distribution of sedimentary facies.

Construction of Value Models of Consumer Creation for Agricultural Products Based on the Analytic Hierarchy Process(AHP)

With the increased competition of modern economy and globalization,consumer creation which based on the analysis of consumer behavior was more and more attentioned and respected by business.Based on the meaning and characteristics of agricultural product consumer creation,index system of value model of agricultural product consumer creation was put forward through analytical hierarchy process（AHP）.The weights of the indicators and related indicators of impact on the value were analyzed,and value models of agricultural product consumer creation were constructed to provide ideas for development of agricultural product consumer market and research of consumer value.Consumer creation was constructed to provide ideas for development of agricultural product consumer market and research of consumer value.

PRESENT SITUATION OF STUDY AND VIEW ON FUNCTIONAL DYSPEPSIA TREATED WITH SPECIFIC ACUPOINTS IN ACUPUNCTURE

Acupuncture plays a dominant role in treating functional dyspepsia （FD）. By reviewing and e- valuating clinical ROT and fundamental research with high quality in the past 17 years, it is found that specific acupoints are the chief in the treatment of FD; additionally, there are differences between specific acupoints and non-specific acupoints in therapeutic effect, explaining that the specificity of meridian points plays an im- portant role in treatment. However, because of inadequate high-quality researches in clinics, the specificity of acupoints can＇t be proved until the researches of clinical effect and mechanism of therapeutic difference are intensified.

RESEARCH OF THE PARAMETRIC ASSEMBLY METHOD

The parametric part assembly generation method is presented. Based on the parametric part generated by means of constructive-element, through interactively inputting the relationships of the location and the assembly, and by compiling operations like movement and rotation, the assembly drawing is created so as to implement the occurrence of the parameterizations of the assembly and the part drawing. The data structure of the assembly part and the key technologies of hidden line removal in the implementation of assembly process, etc. , are described in detail.

Accelerated Recursive Feature Elimination Based on Support Vector Machine for Key Variable Identification

Key variable identification for classifications is related to many trouble-shooting problems in process indus-tries. Recursive feature elimination based on support vector machine (SVM-RFE) has been proposed recently in applica-tion for feature selection in cancer diagnosis. In this paper, SVM-RFE is used to the key variable selection in fault diag-nosis, and an accelerated SVM-RFE procedure based on heuristic criterion is proposed. The data from Tennessee East-man process (TEP) simulator is used to evaluate the effectiveness of the key variable selection using accelerated SVM-RFE (A-SVM-RFE). A-SVM-RFE integrates computational rate and algorithm effectiveness into a consistent framework. It not only can correctly identify the key variables, but also has very good computational rate. In comparison with contribution charts combined with principal component aralysis (PCA) and other two SVM-RFE algorithms, A-SVM-RFE performs better. It is more fitting for industrial application.

Capsule endoscopy in neoplastic diseases

Until recently, diagnosis and management of small-bowel tumors were delayed by the diffi culty of access to the small bowel and the poor diagnostic capabilities of the available diagnostic techniques. An array of new methods has recently been developed, increasing the possibility of detecting these tumors at an earlier stage. Capsule endoscopy (CE) appears to be an ideal tool to recognize the presence of neoplastic lesions along this organ, since it is non-invasive and enables the entire small bowel to be visualized. High- quality images of the small-bowel mucosa may be captured and small and ? at lesions recognized, without exposure to radiation. Recent studies on a large population of patients undergoing CE have reported small-bowel tumor frequency only slightly above that reported in previous surgical series (range, 1.6%-2.4%) and have also confirmed that the main clinical indication to CE in patients with small-bowel tumors is obscure gastrointestinal (GI) bleeding. The majority of tumors identified by CE are malignant; many were unsuspected and not found by other methods. However, it remains difficult to identify pathology and tumor type based on the lesion’s endoscopic appearance. Despite its limitations, CE provides crucial information leading in most cases to changes in subsequent patient management. Whether the use of CE in combination with other new diagnostic (MRI or multidetector CT enterography) and therapeutic (Push- and-pull enteroscopy) techniques will lead to earlier diagnosis and treatment of these neoplasms, ultimately resulting in a survival advantage and in cost savings,remains to be determined through carefully-designed studies.

Capsule endoscopy in non-steroidal anti-inflammatory drugs-enteropathy and miscellaneous,rare intestinal diseases

Despite significant advances over the last decade, mucosal lesions of the small bowel are poorly detected by imaging studies such as CT scan, MRI-enteroclysis and contrast-enhanced abdominal ultrasound. Capsule endoscopy (CE) has dramatically changed the diagnostic approach to intestinal diseases. Moreover, the use of CE can be extended to include other conditions. However, it is diffi cult to assess the positive influence of CE on patient outcomes in conditions involving a small number of patients, or in critically ill and diff icult to examine patients. CE has the advantage of diagnosing intestinal lesions and of directing the use of double balloon enteroscopy (DBE) in order to obtain biopsy specimens. Moreover, CE allows repeated assessment in chronic conditions, especially to detect relapse of an infectious disease.

A anorectal fistula treatment with acellular extracellular matrix: A new technique

AIM: To investigate a new technique of the anorectal fistula treatment with acellular extracellular matrix (AEM). METHODS: Thirty patients with anorectal fistula were treated with AEM. All fistula tracts and primary openings were identified using conventional fistula probe. All tracts were curetted with curet and irrigated with hydrogen peroxide and metronidazole. The AEM was pulled into the fistula tract from secondary to primary opening. The material was secured at the level of the primary opening. The excess AEM was trimmed at skin level at the secondary opening. RESULTS: All of the 30 patients had successful closure of their fistula after a 7-14 d follow-up. The healing rate of anal fistula in treatment group was 100%. The ache time, healing time and anal deformation of treatment group were obviously superior to traditional surgical methods. CONCLUSION: Using AEM anal fistula plug in treatment that causes the anorectal fistula is safe and successful in 100% of patients. It can reduce pain, shorten disease course and protect anal function.

Estimating model for urban carrying capacity on bike-sharing

As the demand for bike-sharing has been increasing,the oversupply problem of bike-sharing has occurred,which leads to the waste of resources and disturbance of the urban environment.In order to regulate the supply volume of bike-sharing reasonably,an estimating model was proposed to quantify the urban carrying capacity(UCC)for bike-sharing through the demand data.In this way,the maximum supply volume of bike-sharing that a city can accommodate can be obtained.The UCC on bike-sharing is reflected in the road network carrying capacity(RNCC)and parking facilities’carrying capacity(PFCC).The space-time consumption method and density-based spatial clustering of application with noise(DBSCAN)algorithm were used to explore the RNCC and PFCC for bike-sharing.Combined with the users’demand,the urban load ratio on bike-sharing can be evaluated to judge whether the UCC can meet users’demand,so that the supply volume of bike-sharing and distribution of the related facilities can be adjusted accordingly.The application of the model was carried out by estimating the UCC and load ratio of each traffic analysis zone in Nanjing,China.Compared with the field survey data,the effect of the proposed algorithm was verified.

Selection of optimal antisense accessible sites of survivin and its application in treatment of gastric cancer

AIM: To select the optimal antisense accessible sites of survivin, a highly expressed gene in tumor tissues, in order to explore a novel approach to improve biological therapy of gastric cancer. METHODS: The 20 mer random oligonucleotide library was synthesized, hybridized with in vitro transcribed total survivin cRNA, then digested by RNase H. After primer extension and autoradiography, the antisense accessible sites (AAS) of survivin were selected. Then RNADraw software was used to analyze and choose the AAS with obvious stem-loop structures, according to which the complementary antisense oligonucleotides (AS-ODNs) were synthesized and transferred into survivin highly- expressing gastric cancer cell line MKN-45. Survivin expression was detected by RT-PCR and Western Blotting. Cellular growth activities were assayed by tetrazolium bromide (MTT) colorimetry. Cellular ultrastructure was observed by electronic microscopy, while apoptosis was detected by annexin V-FITC and propidium iodide staining flow cytometry. RESULTS: Thirteen AAS of survivin were selected In vitro. Four AAS with stem-loop structures were chosen, locating at 207-226 bp, 187-206 bp, 126-145 bp and 44-63 bp of survivin cDNA respectively. When compared with non-tranfection controls, their corresponding AS-ODNs (AS-ODN1, AS-ODN2, AS-ODN3 and AS-ODN4) could reduce Survivin mRNA levels in MKN-45 cells by 54.3±±1.1% (t= 6.12, P<0.01), 86.1±±1.0% (t= 5.27, P<0.01), 32.2±±1.3% (t= 7.34, P<0.01) and 56.2±±0.9% (t = 6.45, P<0.01) respectively, while survivin protein levels were decreased by 42.2±±2.5% (t = 6.26, P<0.01), 75.4±±3.1% (t= 7.11, P<0.01), 28.3±±2.0% (t= 6.04, P<0.01) and 45.8±±1.2% (t = 6.38,P<0.01) respectively. After transfection with 600 nmol/L AS-ODN1-AS-ODN4for 24 h, cell growth was inhibited by 28.12±±1.54% (t= 7.62, P<0.01), 38.42±±3.12% (t= 7.75, P<0.01), 21.46±±2.63% (t= 5.94, P<0.01) and 32.12±1.77% (t = 6.17, P<0.01) respectively. Partial cancer cells presented the characteristic morphological changes of apoptosis, with apoptotic rates being 19.31±1.16% (t= 7.16,P<0.01), 29.24±1.94% (t = 8.15,P<0.01), 11.87±0.68% (t = 6.68, P<0.01) and 21.68±2.14% (t = 7.53, P<0.01) respectively. CONCLUSION: The MS of survivin could be effectively selected in vitro by random oligonucleotide library/RNase H cleavage method combined with computer software analysis, this has important reference values for further studying survivin-targeted therapy strategies for gastric cancer.

Patency and agile capsules

Small bowel strictures can be missed by current diagnostic methods. The Patency capsule is a new non-endoscopic dissolvable capsule which has as an objective of checking the patency of digestive tract, in a non-invasive manner. The available clinical trials have demonstrated that the Patency capsule is a good tool for assessment of the functional patency of the small bowel, and it allows identification of those patients who can safely undergo a capsule endoscopy, despite clinical and radiographic evidence of small-bowel obstruction. Some cases of intestinal occlusion have been reported with the Patency capsule, four of them needed surgery. So, a new capsule with two timer plugs (Agile capsule) has been recently developed in order to minimize the risk of occlusion. This new device stars its dissolution process earlier (30 h after ingestion) and its two timer plugs have been designed to begin the disintegration even when the device is blocked in a tight stricture.

Long-term results of endoscopic balloon dilatation of lower gastrointestinal tract strictures in Crohn's disease:A prospective study

AIM:To examine the long-term results of endoscopic treatment in a prospective study conducted over a period of 10 years,1997 to January 2007.METHODS:A total of 25 patients(20 female and five male:aged 18-75 years),with at least one symptom of stricture not passable with the standard colonoscope and with a confirmed scarred Crohn's stricture of the lower gastrointestinal tract,were included in the study.The main symptom was abdominal pain.The endoscopic balloon dilatation was performed with an 18 mm balloon under endoscopic and radiological control.RESULTS:Eleven strictures were located in the colon,13 at the anastomosis after ileocecal resection,three at the Bauhin valve and four in the ileum.Four patients had two strictures and one patient had three strictures.Of the 31 strictures,in 30 was balloon dilatation successful in a single endoscopic session,so that eventually the strictures could be passed easily with the standard colonoscope.In one patient with a long stricture of the ileum involving the Bauhin valve and an additional stricture of the ileum which were 15 cm apart,sufficient dilatation was not possible.This patient therefore required surgery.Improvement of abdominal symptoms was achieved in all cases which had technically successful balloon dilatation,althoughin one case perforation occurred after dilatation of a recurrent stricture.Available follow-up was in the range of 54-118 mo(mean of 81 mo).The relapse rate over this period was 46%,but 64% of relapsing strictures could be successfully dilated again.Only in four patients was surgery required during this follow-up period.CONCLUSION:We conclude from these initial results that endoscopic balloon dilatation,especially for short strictures in Crohn's disease,can be performed with reliable success.Perforation is a rare complication.It is our opinion that in the long-term,the relapse rate is probably higher than after surgery,but usually a second endoscopic treatment can be performed successfully,leading to a considerable success rate of the endoscopic procedure.

Colon capsule endoscopy

Wireless capsule endoscopy has become the first imaging tool for small bowel examination. Recently, new capsule endoscopy applications have been developed, such as esophageal capsule endoscopy and colon capsule endoscopy. Clinical trials results have shown that colon capsule endoscopy is feasible, accurate and safe in patients suffering from colonic diseases. It could be a good alternative in patients refusing conventional colonoscopy or when it is contraindicated. Upcoming studies are needed to demonstrate its utility for colon cancer screening and other indications such us ulcerative colitis. Comparative studies including both conventional and virtual colonoscopy are also required.