目的:探讨润燥灵对免疫诱导性干燥综合征(SS)模型小鼠外周血辅助性T细胞17(Th17)和调节性T细胞(Treg)的影响。方法:将90只C57bl/6j小鼠随机分成为正常组、模型组、润燥灵36g/kg组、润燥灵18g/kg组、润燥灵9g/kg组和泼尼松0.2g/kg组,每...目的:探讨润燥灵对免疫诱导性干燥综合征(SS)模型小鼠外周血辅助性T细胞17(Th17)和调节性T细胞(Treg)的影响。方法:将90只C57bl/6j小鼠随机分成为正常组、模型组、润燥灵36g/kg组、润燥灵18g/kg组、润燥灵9g/kg组和泼尼松0.2g/kg组,每组15只,除正常组外,其余各小鼠采用免疫诱导法建立SS模型,造模第5 w开始灌胃给药,每周测量小鼠饮水量,给药4 w后眼球取血,断颈处死,分离颌下腺,HE梁色后病理检测,PCR检测颌下视黄醇类核内受体(RORγt)和转录因子叉头框蛋白3(Fox P3)的表达,流式细胞术检测Thl7细胞和CD4^+CD25^+T细胞的含量。结果:与模型组比较,润燥灵36g/kg组和润燥灵18g/kg组小鼠饮水量增加,颌下腺淋巴细胞浸润减少。PCR法结果显示,与正常组比较,模型组RORγt m RNA和Fox P3 m RNA表达量升高;与模型组比较,润燥灵36gkg、润燥灵18g/kg和泼尼松0.2g/kg组RORγt m RNA和Fox P3 m RNA表达量降低。流式细胞术结果显示,与模型组比较,润燥灵36gkg组和泼尼松0.2g/kg组CD4^+/CD4^+CD25^+T比值降低。结论:润燥灵能够抑制SS模型小鼠RORγt m RNA和Fox P3 m RNA表达量,调节Thl7/Treg细胞平衡作用。展开更多
Using monthly precipitation and monthly mean temperature, a surface humid index was proposed. According to the index, the distributed characteristics of extreme dryness has been fully analyzed. The results indicated t...Using monthly precipitation and monthly mean temperature, a surface humid index was proposed. According to the index, the distributed characteristics of extreme dryness has been fully analyzed. The results indicated that there is an obvious increasing trend of extreme dryness in the central part of northern China and northeastern China in the last 10 years, which shows a high frequency period of extreme dryness; while a low frequency period in the regions during the last 100 years. Compared with variation trend of the temperature in these regions, the region of high frequent extreme dryness is consistent with the warming trend in the same region.展开更多
The behaviors of inorganic nitrogen species in three types of bioretention columns under an intermittently wetting regime were investigated. The mean NH+4—N, NO-3—N and total N(TN) removal efficiencies for the conve...The behaviors of inorganic nitrogen species in three types of bioretention columns under an intermittently wetting regime were investigated. The mean NH+4—N, NO-3—N and total N(TN) removal efficiencies for the conventional bioretention column(Col. T1) are 71%, 1% and 41%, for layered bioretention column with less permeable soil layer(Col. T2) the efficiencies are 83%, 84% and 82%, and for the bioretention column with submerged zone(Col. T3) the values are 63%, 31% and 53%, respectively. The best nitrogen removal is obtained using Col. T2 with relatively low infiltration rate. Adsorption during runoff dosing and nitrification during the drying period are the primary NH+4—N removal pathways. Less permeable soil and the elevated outlet promote the formation of anoxic conditions. 30%–70% of NO-3—N applied to columns in a single repetition is denitrified during the draining period, suggesting that the draining period is an important timeframe for the removal of NO-3—N. Infiltration rate controls the contact time with media during the draining periods, greatly influencing the NO-3—N removal effects. Bioretention systems with infiltration rate ranging from 3 to 7 cm/h have a great potential to remove NO-3—N.展开更多
Cost, the effect on the environment, and health issues are relevant when considering the choice of a lubricant and application system in a modern metal cutting process. This paper provided a general introduction to me...Cost, the effect on the environment, and health issues are relevant when considering the choice of a lubricant and application system in a modern metal cutting process. This paper provided a general introduction to metalworking fluids, reviewed the benefits and negative effects attributed to the production of mist during cutting processes. Due to the increasing concern over workers exposed to cutting fluid mist, and to achieve the recommended exposure limit, much attention was focused on how to minimize or prevent the mist formation. Different proposed techniques were analyzed, each of them has its advantages and limitations. Finally, the benefits of minimum quantity of lubrication (MQL) technique over all other techniques were studied.展开更多
In the present study,we discussed the drug-induced liver injury caused by Chinese patent medicines containing Polygonum multiflorum to provide a reference for clinical rational drug use of Polygonum multiflorum and it...In the present study,we discussed the drug-induced liver injury caused by Chinese patent medicines containing Polygonum multiflorum to provide a reference for clinical rational drug use of Polygonum multiflorum and its preparations.One case of long-term taking Jingwu capsule and Huolisu oral liquid,which led to the drug-induced liver injury,was reported.The other case took Runzaozhiyang capsule for a long time,which also led to drug-induced liver injury.Jingwu capsule,Huolisu oral liquid,and Runzaozhiyang capsule all contained Polygonum multiflorum,which could result in liver injury when used long-term.Moreover,we explored the clinical features and toxicity of liver damage induced by Polygonum multiflorum.Liver damage in serum transaminase was significantly increased,and the increasing rate of ALT was more than that of AST.Jaundice appeared obviously.The liver damage mechanisms included drug metabolism,immune response,physical fitness,and many other reasons.Corresponding suggestions on rational use of Polygonum multiflorum and its preparations were presented.The dosage and period should be regulated.The index of liver function should be monitored during the medication periods.Collectively,patients with a history of liver disease or a history of allergies should pay more attention when using the above-mentioned drugs.展开更多
文摘目的:探讨润燥灵对免疫诱导性干燥综合征(SS)模型小鼠外周血辅助性T细胞17(Th17)和调节性T细胞(Treg)的影响。方法:将90只C57bl/6j小鼠随机分成为正常组、模型组、润燥灵36g/kg组、润燥灵18g/kg组、润燥灵9g/kg组和泼尼松0.2g/kg组,每组15只,除正常组外,其余各小鼠采用免疫诱导法建立SS模型,造模第5 w开始灌胃给药,每周测量小鼠饮水量,给药4 w后眼球取血,断颈处死,分离颌下腺,HE梁色后病理检测,PCR检测颌下视黄醇类核内受体(RORγt)和转录因子叉头框蛋白3(Fox P3)的表达,流式细胞术检测Thl7细胞和CD4^+CD25^+T细胞的含量。结果:与模型组比较,润燥灵36g/kg组和润燥灵18g/kg组小鼠饮水量增加,颌下腺淋巴细胞浸润减少。PCR法结果显示,与正常组比较,模型组RORγt m RNA和Fox P3 m RNA表达量升高;与模型组比较,润燥灵36gkg、润燥灵18g/kg和泼尼松0.2g/kg组RORγt m RNA和Fox P3 m RNA表达量降低。流式细胞术结果显示,与模型组比较,润燥灵36gkg组和泼尼松0.2g/kg组CD4^+/CD4^+CD25^+T比值降低。结论:润燥灵能够抑制SS模型小鼠RORγt m RNA和Fox P3 m RNA表达量,调节Thl7/Treg细胞平衡作用。
基金Major State Basic Research Development Program of China No.G1999043400+1 种基金 National Natural Science Foundation of China No.40375028
文摘Using monthly precipitation and monthly mean temperature, a surface humid index was proposed. According to the index, the distributed characteristics of extreme dryness has been fully analyzed. The results indicated that there is an obvious increasing trend of extreme dryness in the central part of northern China and northeastern China in the last 10 years, which shows a high frequency period of extreme dryness; while a low frequency period in the regions during the last 100 years. Compared with variation trend of the temperature in these regions, the region of high frequent extreme dryness is consistent with the warming trend in the same region.
基金Project(2011ZX07303-002)supported by National Water Pollution Control and Management Technology Major Program,China
文摘The behaviors of inorganic nitrogen species in three types of bioretention columns under an intermittently wetting regime were investigated. The mean NH+4—N, NO-3—N and total N(TN) removal efficiencies for the conventional bioretention column(Col. T1) are 71%, 1% and 41%, for layered bioretention column with less permeable soil layer(Col. T2) the efficiencies are 83%, 84% and 82%, and for the bioretention column with submerged zone(Col. T3) the values are 63%, 31% and 53%, respectively. The best nitrogen removal is obtained using Col. T2 with relatively low infiltration rate. Adsorption during runoff dosing and nitrification during the drying period are the primary NH+4—N removal pathways. Less permeable soil and the elevated outlet promote the formation of anoxic conditions. 30%–70% of NO-3—N applied to columns in a single repetition is denitrified during the draining period, suggesting that the draining period is an important timeframe for the removal of NO-3—N. Infiltration rate controls the contact time with media during the draining periods, greatly influencing the NO-3—N removal effects. Bioretention systems with infiltration rate ranging from 3 to 7 cm/h have a great potential to remove NO-3—N.
文摘Cost, the effect on the environment, and health issues are relevant when considering the choice of a lubricant and application system in a modern metal cutting process. This paper provided a general introduction to metalworking fluids, reviewed the benefits and negative effects attributed to the production of mist during cutting processes. Due to the increasing concern over workers exposed to cutting fluid mist, and to achieve the recommended exposure limit, much attention was focused on how to minimize or prevent the mist formation. Different proposed techniques were analyzed, each of them has its advantages and limitations. Finally, the benefits of minimum quantity of lubrication (MQL) technique over all other techniques were studied.
基金Traditional Chinese Medical Science and Technology Projects of Zhejiang Province(Grant No.2016ZQ017 and 2015ZB044)Clinical pharmacy of TCM in the 13th five years plan of Zhejiang Administration of traditional Chinese Medicine(Zhejiang health office TCM(2019)No.1)the Clinical Pharmacy Research Fund of Chinese Integrative Medicine Association of Zhejiang Province(Grant No.2013LYSX018)。
文摘In the present study,we discussed the drug-induced liver injury caused by Chinese patent medicines containing Polygonum multiflorum to provide a reference for clinical rational drug use of Polygonum multiflorum and its preparations.One case of long-term taking Jingwu capsule and Huolisu oral liquid,which led to the drug-induced liver injury,was reported.The other case took Runzaozhiyang capsule for a long time,which also led to drug-induced liver injury.Jingwu capsule,Huolisu oral liquid,and Runzaozhiyang capsule all contained Polygonum multiflorum,which could result in liver injury when used long-term.Moreover,we explored the clinical features and toxicity of liver damage induced by Polygonum multiflorum.Liver damage in serum transaminase was significantly increased,and the increasing rate of ALT was more than that of AST.Jaundice appeared obviously.The liver damage mechanisms included drug metabolism,immune response,physical fitness,and many other reasons.Corresponding suggestions on rational use of Polygonum multiflorum and its preparations were presented.The dosage and period should be regulated.The index of liver function should be monitored during the medication periods.Collectively,patients with a history of liver disease or a history of allergies should pay more attention when using the above-mentioned drugs.
