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基于蛋白质相互作用“热点”区域的小分子药物设计研究进展
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作者 杨晓敏 李英伦 《生物物理学报》 CAS CSCD 北大核心 2015年第2期90-104,共15页
蛋白质为行使其生物学功能,通常与其它蛋白质发生相互作用,而这些相互作用的区域被称为"热点"区域,某些异常的相互作用可能会导致一些疾病的产生,而某些特定结构的小分子药物可以抑制这些相互作用,进而达到治疗疾病的目的。... 蛋白质为行使其生物学功能,通常与其它蛋白质发生相互作用,而这些相互作用的区域被称为"热点"区域,某些异常的相互作用可能会导致一些疾病的产生,而某些特定结构的小分子药物可以抑制这些相互作用,进而达到治疗疾病的目的。文章综述了蛋白质-蛋白质相互作用(protein-protein interactions,PPIs)中"热点"区域的构成、"热点"区域的变异与疾病之间的关系、"热点"区域的预测,以及几个"热点"区域与药物小分子的相互作用,为开发调节PPIs的小分子药物提供参考依据。 展开更多
关键词 蛋白质-蛋白质相互作用 “热点”区域 小分子药物
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基于最小费用路径(LCP)的偷采者路线模拟与防范——以广西防城金花茶国家级自然保护区为例 被引量:4
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作者 张钦 张昆 《林业调查规划》 2018年第5期25-29,共5页
因广西防城金花茶国家级自然保护区面临着金花茶Camellia chrysanthoides被偷采、滥挖的风险,文中应用GIS中的最小费用路径(LCP)模型,以土地覆盖、坡度、距离为因子,模拟了偷采者可能的潜入路线。共选取了65个金花茶分布点,40个保护区... 因广西防城金花茶国家级自然保护区面临着金花茶Camellia chrysanthoides被偷采、滥挖的风险,文中应用GIS中的最小费用路径(LCP)模型,以土地覆盖、坡度、距离为因子,模拟了偷采者可能的潜入路线。共选取了65个金花茶分布点,40个保护区入口点,模拟出2600条最小费用路径。用自然断点分类法找出了重叠度高的"热点"区域。基于"热点区域"提出了一种视频监控点布局方案,规划了7个视频监控点,目的是覆盖偷采者最可能的潜入路径,更好地保护稀有的金花茶。 展开更多
关键词 最小费用路径(LCP) 金花茶 视频监控点 “热点”区域 自然断点分类法
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A Neuro-Fuzzy Based Adaptive Set-Point Heat Exchanger Control Scheme in District Heating System
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作者 Liang Huang Zaiyi Liao Zhao Lian 《Journal of Civil Engineering and Architecture》 2012年第11期1584-1588,共5页
The control of heat exchange stations in district heating system is critical for the overall energy efficiency and can be very difficult due to high level of complexity. A conventional method is to control the equipme... The control of heat exchange stations in district heating system is critical for the overall energy efficiency and can be very difficult due to high level of complexity. A conventional method is to control the equipment such that the temperature of hot water supply is maintained at a set-point that may be a fixed value or be compensated against the external temperature. This paper presents a novel scheme that can determine the optimal set-point of hot water supply that maximizes the energy efficiency whilst providing sufficient heating capacity to the load. This scheme is based on Adaptive Neuro-Fuzzy Inferential System. The aim of this study is to improve the overall performance of district heating systems. 展开更多
关键词 District heating system NEURO-FUZZY inferential sensor energy efficiency CONTROL
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Extraction and Dynamic Spatial-Temporal Changes of Grassland Deterioration Research Hot Regions in China 被引量:4
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作者 胡云锋 韩月琪 +1 位作者 张云芝 庄园 《Journal of Resources and Ecology》 CSCD 2017年第4期352-358,共7页
The authors use a web crawler to retrieve all periodical articles from CNKI between the 1950 s and 2016 and then parse the abstracts of 293368 articles about grassland deterioration by word segmentation, location matc... The authors use a web crawler to retrieve all periodical articles from CNKI between the 1950 s and 2016 and then parse the abstracts of 293368 articles about grassland deterioration by word segmentation, location matching and other methods. The authors also construct a research hot regions extraction model of grassland deterioration in China based on a comprehensive research hot regions index of toponyms and then analyze the spatial pattern and dynamic change in research hot regions of grassland deterioration in China. The research shows the following:(1) The spatial heterogeneity of grassland deterioration in China can be effectively described by a model of grassland deterioration based on the comprehensive research hot regions index.(2) The research hot regions of grassland deterioration are mainly distributed in most regions of Inner Mongolia, Xinjiang, Qinghai, Tibet, Gansu and other provinces. The northeastern region of Inner Mongolia(such as Hulunbeier) and the eastern region of Inner Mongolia(such as Xilin Gol, Chifeng and Wulanchabu) are significant hot regions in the study of grassland deterioration.(3) The number of high research hot regions increases from 81 in the 1950 s to 99 in the 2000s; the area increases from 1.038 million km2 to 1.146 million km2. The degree of hot for grassland deterioration research in 197 counties showed an upward trend. This paper also discusses the relationship between the region of research hot regions and the region of grassland deterioration and then indicates the differences between them in time matching, space matching and concept matching. 展开更多
关键词 knowledge engine hot regions analysis grassland deterioration region extraction spatial distribution dynamic change
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Warming-driven migration of core microbiota indicates soil property changes at continental scale 被引量:1
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作者 Shang Wang Xuelian Bao +23 位作者 Kai Feng Ye Deng Wenjun Zhou Pengshuai Shao Tiantian Zheng Fei Yao Shan Yang Shengen Liu Rongjiu Shi Zhen Bai Hongtu Xie Jinghua Yu Ying Zhang Yiping Zhang Liqing Sha Qinghai Song Yuntong Liu Jizhong Zhou Yuguang Zhang Hui Li Qingkui Wang Xingguo Han Yongguan Zhu Chao Liang 《Science Bulletin》 SCIE EI CSCD 2021年第19期2025-2035,M0004,共12页
Terrestrial species are predicted to migrate northward under global warming conditions,yet little is known about the direction and magnitude of change in microbial distribution patterns.In this continental-scale study... Terrestrial species are predicted to migrate northward under global warming conditions,yet little is known about the direction and magnitude of change in microbial distribution patterns.In this continental-scale study with more than 1600 forest soil samples,we verify the existence of core microbiota and lump them into a manageable number of eco-clusters based on microbial habitat preferences.By projecting the abundance differences of eco-clusters between future and current climatic conditions,we observed the potential warming-driven migration of the core microbiota under warming,partially verified by a field warming experiment at Southwest China.Specifically,the species that favor low p H are potentially expanding and moving northward to medium-latitudes(25°–45°N),potentially implying that warm temperate forest would be under threat of soil acidification with warming.The eco-cluster of high-p H with high-annual mean temperature(AMT)experienced significant abundance increases at middle-(35°–45°N)to high-latitudes(>45°N),especially under Representative Concentration Pathway(RCP)8.5,likely resulting in northward expansion.Furthermore,the eco-cluster that favors low-soil organic carbon(SOC)was projected to increase under warming scenarios at low-latitudes(<25°N),potentially an indicator of SOC storage accumulation in warmer areas.Meanwhile,at high-latitudes(>45°N)the changes in relative abundance of this eco-cluster is inversely related with the temperature variation trends,suggesting microbes-mediated soil organic carbon changes are more responsive to temperature variation in colder areas.These results have vital implications for the migration direction of microbial communities and its potential ecological consequences in future warming scenarios. 展开更多
关键词 Climate change Microbial biogeography Climate projection Latitudinal pattern
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