康德作为两种现代性理论的源头——从“物自体”看现代性及其初始可能

康德"物自体"范畴的两个维度以及理论理性与实践理性的二分法所喻示的是现代性的初步分裂,《判断力批判》则体现了弥补现代性分裂的初步尝试,提供了第一个包含张力的现代性解决方案。三大批判共同构成了现代性得以支撑的先验的批判性母体,也标志着社会关系进入哲学的视野。这使得康德成为现代性的思想家。审视现代性及其流变,可以确知,康德的"物自体"理论及其审美解决方案成为日后两种现代性理论的源头。

“物自体”抑或“意义质点”?——略论感性的对象与感性认识

当我们在感性论中引入了"意义质点"的概念时,"物自体"这一概念的悖谬就显得一目了然了。所谓意义质点,就是根据认识和实践的目的不需要再分割的感性直观的最小单元。感性对象———现象,就是直观中的意义质点及它们之间的感性关系与认识主体相互作用的总和。它既有客观性又有主观性。感性认识的意义就在于把握意义质点之间的感性关系,而意义质点本身却从来都不是感性认识的对象。

康德“物自体”概念的实践维度

为了克服理性哲学发展过程中的矛盾和弊端,康德提出了“物自体”概念,以此实现对理性和形而上学的救赎。“物自体”在康德批判哲学体系中,具有感性表象的来源和始基础、意志的范导等三个方面的含义。康德以“物自体”概念为拱顶石的批判哲学开启了一个批判的时代,但是也存在一些无法自洽的逻辑矛盾。

开放的康德哲学——重读“物自体”

“物自体”是康德哲学的基础性概念。它不仅是理论理性的知识论概念 ,更是实践理性的本体性概念 ,二者之间构成了内在张力 ,贯穿于康德哲学的整个体系之中。康德哲学是可知论与不可知论的结合 ,是理性与非理性 (或超理性 )的矛盾统一 ,正是这种张力 ,推动着康德哲学体系的运转 ,而“物自体”是其轴心。康德对“物自体”的设定在于批判先验实在论 ,使人回到现实的经验世界 ,同时启迪人们从经验世界走向理想。而这都必须在实践中达成。康德哲学由此实现了知识与人文价值的结合 ,知识向人文价值的转化和生成 ;从而端正了西方智力思维的运思路径 ,为人类的实践活动和营造人性的生活世界指明了方向。

金融危机解读:康德哲学的魅力再现

金融危机的爆发,是金融市场内部矛盾的凸显和激化,表明了以实体经济为基础的经济学理论去指导虚拟经济的匮乏与不足。经济学理论的理性指导与现实虚拟经济中非理性的冲突,显现出超越特定认知领域后认识的不可知性,让人不禁再次感叹康德哲学的魅力所在,现象与"物自体"的划分、"二律背反"为解释当前金融危机提供了新的角度和新的方法。

Molecular Biology of Self and Non-self Pollen Recognition in Flowering Plants

Fertilization in flowering plants is completed through several recognitionevents, and the first of which is the recognition of pollen by pistil of female reproductivetissue. Self-incompatibility (SI) is an intraspecific reproductive barrier to prevent selfferitilization and widely distributed in flowering plants. In many species, SI shows simplegenetics and is controlled by a single multi-allelic locus, called the S locus. In gametophyticSI (GSI) exemplified by the Solanaceae, Scrophulariaceae and Rosaceae, a class ofribonucleases, called S RNases, have been shown to mediate the stylar expression of SI butnot the pollen expression of SI. The latter appears to be determined by a gene differentfrom those encoding S RNases, often referred to as pollen S gene. The pollen S gene is thecrucial missing part in understanding the biochemical and molecular mechanisms of self andnon-self pollen recognition in flowering plants. Recent genetic analysis of mutationsaffecting the pollen expression of SI has suggested a possible model of how the pollen S geneinteracts with S RNases to achieve self and non-self pollen recognition. Furthermore, wewill present two approaches, S-locus directed transposon tagging and map-based cloning, forcloning the pollen S in Antirrhinum.

Self-adapting extraction of matrix mineral bulk modulus and verification of fluid substitution

Gassmann＇s equations are commonly used for predicting seismic wave velocity in rock physics research.However the input matrix mineral bulk modulus parameters are not accurate,which greatly influences the prediction reliability.In this paper,combining the Russell fluid factor with the Gassman-Biot-Geertsma equation and introducing the dry-rock Poisson＇s ratio,we propose an effective matrix mineral bulk modulus extraction method.This method can adaptively invert the equivalent matrix mineral bulk modulus to apply the Gassmann equation to fluid substitution of complex carbonate reservoirs and increase the fluid prediction reliability.The verification of the actual material fluid substitution also shows that this method is reliable,efficient,and adaptable.

Effect of Cistanoside Compounds on Oxidative Stress and Immunity

Cistanoside compounds were studied as the scavengers of hydroxyl and superoxide anion free radicals with spin trapping ESR method in vitro. Low-temperature ESR technique, experimental technique of immunotoxicology and biochemical method were used to detect the level of reactive oxygen radicals in kidney tissue of rats and SOD level and GSH-Px activity in rat serum. The results indicated that cistanoside compounds could inhibit reactive oxygen free radicals in vitro and prevent and repair the free radical damages for diabetic nephropathy. The experimental data of 揷arbon-particle detection in mouse serum?showed that cistanoside compounds could improve the phagocytotis index of macrophages (Mj) in mice blood and increase the weights of immune organs of mice.

Overview of macroautophagy regulation in mammalian cells

Macroautophagy is a multistep, vacuolar, degradation pathway terminating in the lysosomal compartment, and it is of fundamental importance in tissue homeostasis. In this review, we consider macroautophagy in the light of recent advances in our understanding of the formation of autophagosomes, which are double-membrane-bound vacuoles that sequester cytoplasmic cargos and deliver them to lysosomes. In most cases, this final step is preceded by a maturation step during which autophagosomes interact with the endocytic pathway. The discovery of AuTophaGyrelated genes has greatly increased our knowledge about the mechanism responsible for antophagosome formation, and there has also been progress in the understanding of molecular aspects of autophagosome maturation. Finally, the regulation of autophagy is now better understood because of the discovery that the activity of Atg complexes is targeted by protein kinases, and owing to the importance of nuclear regulation via transcription factors in regulating the expression of autophagy genes.

Investigation of the biological roles of autophagy in appressorium morphogenesis in Magnaporthe oryzae

Magnaporthe oryzae has been used as a primary model organism for investigating fungus-plant interaction. Many researches focused on molecular mechanisms of appressorium formation to restrain this fungal pathogen. Autophagy is a very high conserved process in eukaryotic cells. Recently, autophagy has been considered as a key process in development and differentia-tion in M. oryzae. In this report, we present and discuss the current state of our knowledge on gene expression in appressorium formation and the progress in autophagy of rice blast fungi.

Paste-like self-flowing transportation backfilling technology based on coal gangue

A paste-like self-flowing pipeline transportation backfilling technology with coal gangue as aggregate is proposed to remove the potential damage caused by coal gangue piles. As well, the difficult problems of recovering high quality safety coal pillars and deep mining of the Suncun Coal Mine （SCM）, Xinwen Coal Group, Shandong are resolved. The physical-chemical properties of coal gangue, optimized proportion of materials, backfilling system and craft in the SCM were studied in the laboratory and then an industrial test was carried out on high quality coal pillars under a town. The results show that finely crushed kaolinized and fresh gangue with granularity less than 5 mm can be used as aggregate with fly ash to replace part of the cement and a composite water reducer as an additive, accounting for 1.0%-1.5% of the total amount of cement and fly ash. The recommended proportion is l（cement）：4（fly ash）： 15（coal gangue）, with a mass fraction of 72%-75%, rheoiogical paste-like properties and a strength of more than 0.7 MPa at 7 d. The sequence of adding cement, fly ash, water reducer and then coal gangue ensures that the suspended state of the slurry, reducing the wear and jam of pipelines. The working face is advancing continuously by the alternating craft of building block walls with coal gangue and backfilling mined-out gobs with paste-like slurry. The recovery rate is as high as 90% with a backfilling cost of 36.9 YuarffL good utilization of coal gangue and no subsidence on the surface. This technology provides a good theoretical basis and application experience for coal mines, cement backfilling with paste-like slurry.

Revascularization for Iliac-femoral Artery Pseudoaneurysm with Greater Saphenous Vein

Objective To investigate the role of revascularization procedures with autologous greater saphenous vein in surgical management of iliac-femoral artery pseudoaneurysm in parenteral drug abusers. Methods Twenty-one patients with iliac-femoral artery pseudoaneurysm caused by parenteral drug abuse from 2004 to 2007 were enrolled. Among them,15 patients were male and 6 were female; their average age was 31.3 years. The size of pseudoaneurysms ranged from 3.0 cm to 7.5 cm. Common femoral artery and distal external iliac artery were often involved. We performed arterial reconstruction on these patients with autologous greater saphenous vein as a graft after excising iliac-femoral artery pseudoaneurysm through a single curved inguinal incision. All patients were followed up,and the complications were recorded. Results The surgical procedures were finished without intraoperative mortality or perioperative complications. All patients were free of claudication symptoms after the surgery except one case with preoperative popliteal artery stenosis. One case of infection and wound tissue fistula was found later. One case had inguinal incisional hematoma and another complained of numbness in thigh skin. Conclusions The use of autologous greater saphenous venous grafts for arterial reconstruction after pseudoaneurysm excision in drug abusers is safe and effective. This technique offers more advantages than arterial ligation alone without revascularization. An optimal greater saphenous venous graft is a prerequisite for revascularization.

Conscious Entities in Superluminal Parallel Universe

Tachyons are theoretical superluminal particles, i.e., faster than light particles. The idea of existence of tachyons comes from Arnold Sommerfeld. Bilaniuk and Sudarshan （1969） published the article ＂Particles beyond the Light Barrier＂ in Physics Today magazine where they analyze the theoretical properties of tachyons. From the tachyon idea I have hypothesized the existence of a Superluminal Parallel Universe constituted by Superluminal Conscious Entities that, like the theoretical tachyons, only can exist at speeds greater than the speed of light. This hypothesis should be subject to scientific inquiry but also to philosophical speculation or spiritual imagination. Later I imagine that the Superluminal Parallel Universe is the Spiritual World thought by theologians and idealistic philosophers. I relate the Superluminal Conscious Entities with Spirits and the Superluminal Parallel Universe comprising infinity of Superluminal Conscious Entities with God, the Universal Spirit, thus being simultaneously Unity and Infinity given that superluminal speed implies non-local, instantaneous connections. I imagine that the material Universe might have emerged from that God, assuming that many Spirits could lose superluminality generating the two classes of substances of the Universe： the class of subluminal particles of matter and the class of luminal particles, like photons. I imagine a Soul as a quasi superluminal entity dropped from a Spirit to animate material entities. The substances of both Universes would have evolved in parallel, with life arising and evolving from the subluminal substance driven by companion Souls. Let＇s also imagine that the natural way of being of Spirits and free Souls is a state similar to conscious dreaming. In this imagination, we all, Souls, would have been a part of God and we all might be again. We all are makers of the Universe. We all might get connected with the Spirits in God to beg for and to receive inspiration.

Preparation and in vitro Studies of Stealth PEGylated PLGA Nanoparticles as Carriers for Arsenic Trioxide

The aim of this study was to prepare arsenic trioxide （ATO）-loaded stealth PEGylated PLGA nanoparticles （PEG-PLGA-NPs） and to assess the merits of PEG-PLGA-NPs as drug carriers for ATO delivery. PEG-PLGA copolymer was synthesized with methoxypolyethyleneglycol （Mw=5000）, D, L-lactide, and glycolide by the ring-opening polymerization method. Amorphous ATO was transformed into cubic crystal form to increase its solu-bility in the organic solvent. ATO-loaded PEG-PLGA-NPs were prepared by the modified spontaneous emulsification solvent diffusion （SESD） method, and the main experimental factors influencing the characteristics of nanopar- ticles were investigated, to optimize the preparation. To confirm the escape of PEG-PLGA-NPs from phagocytosis by phagocytes, PEG-PLGA-NPs labeled rhodamine B uptake by murine peritoneal macrophages （MPM） were analyzed by flow cytometry. The results showed that the physicochemical characteristics of PEG-PLGA-NPs were affected by the type and concentration of the emulsifiers, polymer concentration, and drug concentration. ATO-loaded PEG-PLGA-NPs, with particle size of 120.8nm, zeta potential of-10.73mV, encapsulation efficiency of 73.6%, and drug loading of 1.36%, were prepared under optimal conditions. The images of transmission electron micros-copy （TEM） indicated that the optimized nanoparticles were near spherical and without aggregation or adhesion. The release experiments in vitro showed the ATO release from PEG-PLGA-NPs exhibited consequently sustained release for more than 26d, which was in accordance with Higuchi equation. The uptake of PEG-PLGA-NPs by MPM was found to decrease markedly compared to PLGA-NPs. The experimental results showed that PEG-PLGA-NPs were potential nano drug delivery carriers for ATO.

Potential efficacy of ginger as a natural supplement for nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease(NAFLD) is one of the most common liver diseases and its prevalence is likely to reach epidemic proportions.According to the"two-stage hypothesis"proposed for the pathophysiology of NAFLD,insulin resistance,oxidative stress and pro-inflammatory cytokines are among the key promoters of the disease. Here,ginger has been hypothesized to prevent NAFLD or blunt its progression via several mechanisms,such as sensitizing insulin effects,activating peroxisome proliferator-activated receptorγwhich induces adiponectin and down-regulates pro-inflammatory cytokines,changing the balance between adiponectin and tumor necrosis factor-αin favor of adiponectin,promoting considerable antioxidant effects and antidyslipidemic properties,and reducing hepatic triglyceride content which can prevent steatosis.The aforementioned mechanisms imply that ginger possesses interesting potentials for serving as a natural supplement for the prevention and treatment of NAFLD.Therefore,conducting trials to explore its benefits in clinical practice is greatly recommended.

Dual function of Arabidopsis A TAF1 in abiotic and biotic stress responses

NAC family genes encode plant-specific transcription factors involved in diverse biological processes. In this study, the Arabidopsis NAC gene ATAF1 was found to be induced by drought, high-salinity, abscisic acid （ABA）, methyl jasmonate, mechanical wounding, and Botrytis cinerea infection. Significant induction of ATAF1 was found in an ABA-deficient mutant aba2 subjected to drought or high salinity, revealing an ABA-independent mechanism of expression. Arabidopsis ATAFl-overexpression lines displayed many altered phenotypes, including dwarfism and short primary roots. Furthermore, in vivo experiments indicate that ATAF1 is a bonafide regulator modulating plant responses to many abiotic stresses and necrotrophic-pathogen infection. Overexpression of ATAF1 in Arabidopsis increased plant sensitivity to ABA, salt, and oxidative stresses. Especially, ATAF1 overexpression plants, but not mutant lines, showed remarkably enhanced plant tolerance to drought. Additionally, ATAF1 overexpression enhanced plant susceptibility to the necrotrophic pathogen B. cinerea, but did not alter disease symptoms caused by avirulent or virulent strains of P. syringae pv tomato DC3000. Transgenic plants overexpressing ATAF1 were hypersensitive to oxidative stress, suggesting that reactive oxygen intermediates may be related to ATAFl-mediated signaling in response to both pathogen and abiotic stresses.

Autoantibodies against MMP-7 as a novel diagnostic biomarker in esophageal squamous cell carcinoma

AIM： To evaluate the diagnostic values of serum autoan tibodies against matrix metalloproteinase-7 （MMP-7） in patients with esophageal squamous cell carcinoma （ESCC）. METHODS： The MMP-7 cDNA was cloned from ESCC tissues, and MMP-7 was expressed and purified from a prokaryotic system. MMP-7 autoanUbodies were then measured in sera from 50 patients with primary ESCC and 58 risk-matched controls, using a reverse capture enzyme-linked immunosorbent assay （ELISA） in which autoantibodies to MMP-7 bound to the purified MMP-7 proteins. In addition, MMP-7 autoantibody levels in sera from 38 gastric cancer patients and from control serum samples were also tested. RESULTS： The optimum conditions for recombinant MMP-7 protein expression were determined as 0.04 mmol/L Isopropyl-13-D-Thiogalactopyranoside （IPTG）induction at 37℃ for four hours. The levels of serum autoantibodies against MMP-7 were significantly higher in patients with ESCC than in the matched-control samples （OD450 = 1.69 ±0.08 vs OD450 = 1.55 ± 0.10, P 〈 0.001）. The area under the receiver operating character- istic （ROC） curve was 0.87. The sensitivity and specificity for detection of ESCC were 78.0% and 81.0%, respectively, when the OD450 value was greater than 1.65. Although the levels of autoantibodies against MMP-7 were also significantly higher in patients with gastric cancer compared to control samples （OD450 = 1.62± 0.06 vs OD450 = 1.55±0.10, P 〈 0.001）, the diagnostic accuracy was less significant than in ESCC patients. The area of ROC curve was 0.75, whereas the sensitivity and specificity were 60.5% and 71.7%, respectively, when the cut-off value of OD450 was set at 1.60. CONCLUSION： Serum autoantibody levels of MMP-7 may be a good diagnostic biomarker for esophageal squamous cell carcinoma,

Determination of phagocytic functions of macrophages, vascular density and NPY-nerve within autotransplanted splenic tissue in adult rats

Objective: To estimate directly phagocytic functions of the macrophages because of the importance in innate immunity, determine blood vessel density and re-innervation density which are basis of function. Methods: Eighty adult Wistar rats were randonjy divided into experimental and control groups.The formers underwent splenotomy and a half splenie slice was transplanted into greater omentum. The latter only moved. After 6 months, examination was made as follows: ① After injection of 0.4% carbon particles by vein, spleme tissues were taken out at different times for estimating phagocytosis by light microscope. ② When splenic tissues had been intubated into left ventricle under total anesthesia, animals were perfused by formalin and India ink mixture suspension. Splenic tissues were taken out for making sections for measurement of area density of blood vessels.③ Immunohistochemical procedure was used for detecting neuropeptide Y(NPY). Results: Phagocytie functions had no difference between two groups, hut the area density of blood vessels and NPY-positive fibers re-dued (P<0.01) in experimental group. Conclusion:Autotransplanted splenic tissues show good innate immunity though regeneration of blood vessels and nerves do not reach normal level.

Collective Excitations in Spin-2 Bose-Einstein Condensates

The Green＇s functions and the correlation functions in spin-2 Bose-Einstein condensates at finite temperature are defined and the generalized Dyson-Beliaev equations are introduced. We discuss the spin conservation in z direction and decouple the Green＇s functions and the generalized Dyson-Beliaev equations according to different spin conservations in z direction. The anomalous vertex functions are introduced and the self-energies are separated into the proper self-energies and the improper self-energies. The generalized Dyson-Beliaev equations are decoupled according to separation of the self-energies. We calculate the Green＇s functions step by step in the Bogoliubov approximation and discuss the collective excitations in spin-2 Bose-Einstein condensates in the polar, ferromagnetic, and cyclic cases, respectively.

Sharing Culture and Belonging Through Cross-Cultural Collaborative Painting

The topic of this paper is animals in painting and the investigative process undertaken by the artist Vanessa Barbay during her practice--led Ph.D.. Her aim was to discover a way to present deceased animals that retained their agency as individuals by challenging the objectifying nature of representation. The foundation of this method was the collaboration between artist and dead animal subjects through harnessing the natural decomposition of the subject in order to generate their image. A related stream of Barbay＇s research was learning about the art and culture of Kunwinjku speaking artists living in Kunbarlanja Western Amhem Land where artists have painted images of animals on rock shelters and on bark from ancient through to contemporary times. The significance of their form of animal representation is a mythopoeic relationship between locally found pigments and animal bodies. Paintings are considered as collaboration between matter, subject, and artist, which Barbay extends in her current work centred on collaborative painting involving more than one artist.