At present, the technology of biomass fuel composite molding technique is relatively lagging in China, which brings several negative influences, such as high energy consumption, short service life of the equipment. Th...At present, the technology of biomass fuel composite molding technique is relatively lagging in China, which brings several negative influences, such as high energy consumption, short service life of the equipment. The current situation of the biomass pellet fuel molding technology at home and abroad was introduced, and the development direction in China was put forward, which was of great significance for enhancing the level of pellet fuel molding technology in China.展开更多
This paper presents an improved unstructured grid immersed boundary method.The advantages of both immersed boundary method and body fitted grids which are generated by unstructured grid technology are used to enhance ...This paper presents an improved unstructured grid immersed boundary method.The advantages of both immersed boundary method and body fitted grids which are generated by unstructured grid technology are used to enhance the computation efficiency of fluid structure interaction in complex domain.The Navier-Stokes equation was discretized spacially with collocated finite volume method and Euler implicit method in time domain.The rigid body motion was simulated by immersed boundary method in which the fluid and rigid body interface interaction was dealt with VOS(volume of solid) method.A new VOS calculation method based on graph was presented in which both immersed boundary points and cross points were collected in arbitrary order to form a graph.The method is verified with flow past oscillating cylinder.展开更多
Practical techniques for smooth geodesic patterning of membrane structures were investigated.For the geodesic search,adjustment of the subplane of the extracted elements series was proposed,and various spline approxim...Practical techniques for smooth geodesic patterning of membrane structures were investigated.For the geodesic search,adjustment of the subplane of the extracted elements series was proposed,and various spline approximation methods were used to flatten the strip for the generation of a smooth pattern.This search approach is very simple,and the geodesic line could be easily attained by the proposed method without the need for a difficult computation method.Smooth cutting patterning can also be generated by spline approximation without the noise in discrete nodal information.Additionally,the geodesic cutting pattern saved about 21%of the required area for the catenary model due to the reduction of the curvature of the planar pattern seam line.展开更多
A new (2+1)-dimensional KdV equation is constructed by using Lax pair generating technique. Exact solutions of the new equation are studied by means of the singular manifold method. Bgcklund transformation in terms...A new (2+1)-dimensional KdV equation is constructed by using Lax pair generating technique. Exact solutions of the new equation are studied by means of the singular manifold method. Bgcklund transformation in terms of the singular manifold is obtained. And localized structures are also investigated.展开更多
The chemical synthesis of Guanine arabinoside (ara-G) is extremely complex, time-consuming, and seriously polluted. A two-step enzymatic synthesis process was developed to acquire ara-G easily. 2,6-Diaminopurine ara...The chemical synthesis of Guanine arabinoside (ara-G) is extremely complex, time-consuming, and seriously polluted. A two-step enzymatic synthesis process was developed to acquire ara-G easily. 2,6-Diaminopurine arabinoside (ara-DA) was first synthesized with purine nucleoside phosphorylase and pyrimidine nucleoside phosphorylase produced by Enterobacter aerogenes DGW-07. The conversion yield of ara-DA could reach above 90% when the reaction liquid contained 30 mmol·L^-1 uracil arabinoside as arabinose donor, 10 mmol·L^- 1 2,6-diaminopurine as arabinose acceptor in pH 7.0 20 mmol·L^-1 phosphate buffer, and reacted at 60℃ for 48h. Then, ara-DA was effectively transformed into ara-G with adenylate deaminase produced by Aspergillus oryzae DAW-01. The total process had no complex separation and purification.展开更多
In order to evaluate the effects of mesh generation techniques and grid convergence on pump performance in centrifugal pump model, three widely used mesh styles including structured hexahedral, unstructured tetrahedra...In order to evaluate the effects of mesh generation techniques and grid convergence on pump performance in centrifugal pump model, three widely used mesh styles including structured hexahedral, unstructured tetrahedral and hybrid prismatic/tetrahedral meshes were generated for a centrifugal pump model. And quantitative grid convergence was assessed based on a grid convergence index(GCI), which accounts for the degree of grid refinement. The structured, unstructured or hybrid meshes are found to have certain difference for velocity distributions in impeller with the change of grid cell number. And the simulation results have errors to different degrees compared with experimental data. The GCI-value for structured meshes calculated is lower than that for the unstructured and hybrid meshes. Meanwhile, the structured meshes are observed to get more vortexes in impeller passage.Nevertheless, the hybrid meshes are found to have larger low-velocity area at outlet and more secondary vortexes at a specified location than structured meshes and unstructured meshes.展开更多
This paper proposes a new method that can access tion of the data report in LabWindows/CVI. It can produce the testing system by programming. This helps improve the increase the efficiency greatly. the Microsoft Excel...This paper proposes a new method that can access tion of the data report in LabWindows/CVI. It can produce the testing system by programming. This helps improve the increase the efficiency greatly. the Microsoft Excel 2003 by ActiveX to make up for the limita- a required data report and draw up a data chart automatically in flexibility and universality when producing the data report and展开更多
Various methods for production of polysilicon have been proposed for lowering the production cost andenergy consumption, and enhancing productivity, which are critical for industrial applications. The fluidized bed ch...Various methods for production of polysilicon have been proposed for lowering the production cost andenergy consumption, and enhancing productivity, which are critical for industrial applications. The fluidized bed chemical vapor deposition (FBCVD) method is a most promising alternative to conventional ones, but the homogeneous reaction of silane in FBCVD results in unwanted formation of fines, which will affect the product qualityand output. There are some other problems, such as heating degeneration due to undesired polysilicon deposition on the walls of the reactor and the heater. This article mainly reviews the technological development on FBCVD of polycrystalline silicon and the research status for solving the above problems. It also identifies a number of challenges to tackle and principles should be followed in the design ofa FBCVD reactor.展开更多
The study of cyclic codes over rings has generated a lot of public interest.In this paper,we study cyclic codes and their dual codes over the ring Z P2 of length pe,and find a set of generators for these codes.The ran...The study of cyclic codes over rings has generated a lot of public interest.In this paper,we study cyclic codes and their dual codes over the ring Z P2 of length pe,and find a set of generators for these codes.The ranks and minimal generator sets of these codes are studied as well,which play an important role in decoding and determining the distance distribution of codes.展开更多
Rising worldwide cancer incidence and resistance to current anti-cancer drugs necessitate the need for new pharmaceutical compounds and drug delivery system. Malfunction of the immune system, particularly in the tumor...Rising worldwide cancer incidence and resistance to current anti-cancer drugs necessitate the need for new pharmaceutical compounds and drug delivery system. Malfunction of the immune system, particularly in the tumor microenvironment, causes tumor growth and enhances tumor progression. Thus, cancer immunotherapy can be an appropriate approach to provoke the systemic immune system to combat tumor expansion. Texosomesj which are endogenous nanovesicles released by all tumor cells, contribute to cell-cell communication and modify the phenotypic features of recipient cells due to the texosomes' ability to transport biological components. For this reason, texosome-based delivery system can be a valuable strategy for therapeutic purposes. To improve the pharmaceutical behavior of this system and to facilitate its use in medical applications, biotechnology approaches and mimetic techniques have been utilized. In this review, we present the development history oftexosome-based delivery systems and discuss the advantages and disadvantages of each system.展开更多
This paper presents examples of field data of extreme seiche waves measured at Coffs Harbour by MHL and describes the generation and measuring methodology to detect and reduce seiche agitation in the Coifs Harbour boa...This paper presents examples of field data of extreme seiche waves measured at Coffs Harbour by MHL and describes the generation and measuring methodology to detect and reduce seiche agitation in the Coifs Harbour boat ramp using a 3D physical model. The paper also discusses the techniques in investigating a short wave problem of stability in the same model where a long wave is simulated. Waves offshore of Coffs Harbour at 80 m depth have been recorded by MHL for a period of over 30 years. Long waves have been simultaneously measured in the harbour over a period of a decade. These data enabled the model to be verified on two dates (4/6/12, 5/9/14) when high long waves were recorded at the boat ramp harbour under storm and non-storm conditions. Long waves are generated in harbours due to group bounded long wave and surf beat or edge waves. The paper presents methodologies of generating long waves both numerically and by using physical models, and discusses the advantages and disadvantages of these generation techniques. Numerical modelling carried out using long period regular waves in a previous investigation predicted reductions up to 50% due to change of planform of the boat ramp harbour where an area next to the boat ramp was excavated and roughness elements introduced to dampen long periods. The 3D physical model simulated a 25% decrease in the long wave energy in the boat ramp when a suitable change in the planform was made. A 3D undistorted model of scale 1:58 was used in the investigation.展开更多
Cancer is a major threat to public health in the 21st century because it is one of the leading causes of death worldwide.The mechanisms of carcinogenesis,cancer invasion,and metastasis remain unclear.Thus,the developm...Cancer is a major threat to public health in the 21st century because it is one of the leading causes of death worldwide.The mechanisms of carcinogenesis,cancer invasion,and metastasis remain unclear.Thus,the development of a novel approach for cancer detection is urgent,and real-time monitoring is crucial in revealing its underlying biological mechanisms.With the optical and chemical advantages of quantum dots(QDs),QD-based nanotechnology is helpful in constructing a biomedical imaging platform for cancer behavior study.This review mainly focuses on the application of QD-based nanotechnology in cancer cell imaging and tumor microenvironment studies both in vivo and in vitro,as well as the remaining issues and future perspectives.展开更多
Quantum communications helps us to enhance the security and efficiency of communications and to deepen our understanding of quantum physics. Its rapid development in recent years has attracted the interest of research...Quantum communications helps us to enhance the security and efficiency of communications and to deepen our understanding of quantum physics. Its rapid development in recent years has attracted the interest of researchers from diverse fields such as physics, mathematics, and computer science. We review the background and current state of quantum communications technology, with an emphasis on quantum key distribution, quantum random number generation, and a relatively hot topic: device independent protocols.展开更多
Several bacterial strains of Actinomycetes belonging to Streptomyces and Arthrobacter genera for the first time were used to study the biotechnology of synthesis of gold and silver nanoparticles. The experimental cond...Several bacterial strains of Actinomycetes belonging to Streptomyces and Arthrobacter genera for the first time were used to study the biotechnology of synthesis of gold and silver nanoparticles. The experimental conditions of gold and silver nanoparticles production by the cells of studied strains in aqueous chloroauric acid (HAuCIq) and in silver nitrate (AgNO3) solutions, respectively, were determined. Concentration and time-dependences of nanoparticle formation were investigated. The complex of optical and analytical methods was used for testing the gold and silver nanoparticles in the bacterial biomass. The TEM (Transmission Electron Microscopy) and XRD (X-ray Diffraction) data in all cases demonstrated the presence of crystals with fcc (face centered cubic) structure. The results obtained show that the Actinomycetes are capable of producing gold and silver nanoparticles of spherical shape extracellularly when exposed to suitable compounds. The particle size distribution shows that the sizes of nanoparticles are in the range of 5 nm to 80 nm. The biomass obtained may be used for industrial as well as medical and pharmaceutical purposes.展开更多
The pilot-scale process for preparing 2-amino-6-chloro-9-(2',3',5'-tri-O-acetyl-Dq3-ribofuranosyl)-purine and 2-chloroadenosine has been developed with a total yield of the desired compounds 73% and 44.5%, respec...The pilot-scale process for preparing 2-amino-6-chloro-9-(2',3',5'-tri-O-acetyl-Dq3-ribofuranosyl)-purine and 2-chloroadenosine has been developed with a total yield of the desired compounds 73% and 44.5%, respectively. These compounds are useful intermediates for enzymatic synthesis of active pharmaceutical ingredients Nelarabine and Cladribine. The starting material--commercially avaliable guanosine--was acetylated with acetic anhydride, yielding 2,3,5-tri-O-acetylguanosine, which was further deoxyhalogenated with phosphorous oxychloride in presence of tetraethylammonia chloride. Diazotization of the resulting intermediate with tert-butylnitrite leads to the corresponding ribofuranosyl-substituted 2,6-dichloropurine, which was converted to 6-chloroadenosine by reaction with methanolic ammonia.展开更多
Visualization of tumor angiogenesis can facilitate noninvasive evaluation of tumor vascular characteristics to supplement the conventional diagnostic imaging goals of depicting tumor location,size,and morphology.Hybri...Visualization of tumor angiogenesis can facilitate noninvasive evaluation of tumor vascular characteristics to supplement the conventional diagnostic imaging goals of depicting tumor location,size,and morphology.Hybrid imaging techniques combine anatomic [ultrasound,computed tomography(CT),and/or magnetic resonance imaging(MRI)] and molecular(single photon emission CT and positron emission tomography) imaging modalities.One example is real-time virtual sonography,which combines ultrasound(grayscale,colour Doppler,or dynamic contrast harmonic imaging) with contrast-enhanced CT/MRI.The benefits of fusion imaging include an increased diagnostic confidence,direct comparison of the lesions using different imaging modalities,more precise monitoring of interventional procedures,and reduced radiation exposure.展开更多
Metallurgical sector plays an important role in the economy of each country because steel products present essential raw material for basic industries. Changes in the sectors of iron, steel and non-ferrous metals and ...Metallurgical sector plays an important role in the economy of each country because steel products present essential raw material for basic industries. Changes in the sectors of iron, steel and non-ferrous metals and the current development of technology forces the steel mills increased productivity, reduce production costs while ensuring to obtain a product with the required properties and to improve the competitiveness of enterprises in the global market. Currently, the most popular in meeting these requirements, enjoys a method of integration which combines individual operations into one integrated whole. The use of modem, perfectly designed, fully automated design of mechanical, hydraulic and measurement allowed us to achieve an innovative line of production. This article presents the general characteristics of the steel industry and a description of the latest integrated technology currently used in foundries and rolling mills. It also presents examples of the use of integrated technologies in metallurgy and the effects of economic, environmental and quality resulting from their use on an industrial scale.展开更多
Angiogenesis has a critical role in primary tumor growth and the development of metastases.Several angiogenesis inhibitors were recently developed,being a very attractive target for digestive tumor therapy.However,ind...Angiogenesis has a critical role in primary tumor growth and the development of metastases.Several angiogenesis inhibitors were recently developed,being a very attractive target for digestive tumor therapy.However,individualized therapy should not only be based on the pre-treatment imaging evaluation,but also on sensitive monitoring of microvascular changes during treatment.State-of-theart imaging techniques have the potential to visualize and characterize angiogenesis,although the technology and methodologies employed are recent and need further validation.The aim of this series of reviews was to analyze and enhance current knowledge and future perspectives about the real-time assessment of angiogenesis in digestive cancers,used for the longitudinal monitoring of the effects of chemo-radiotherapy(including anti-angiogenic therapies),as well as for the precise targeting of drugs through molecular-based drug-delivery systems.展开更多
On June 16,2016 the technical achievement of the Shaanxi Yanchang Oil Group relating to "the integrated process technology for comprehensive utilization of coal,oil and gas and their commercial application" has pass...On June 16,2016 the technical achievement of the Shaanxi Yanchang Oil Group relating to "the integrated process technology for comprehensive utilization of coal,oil and gas and their commercial application" has passed the experts’appraisal in Beijing.It is said that this achievement has shattered the traditional precedent and engineering paradigm of using coal or natural gas to simplistically manufacture methanol and has carved out a new mode for comprehensive utilization of coal, oil and gas resources, featuring apparent emissions reduction ef-fects with innovative nature to command a leading posi-tion internationally.展开更多
基金Supported by the Special Fund for Agro-Scientific Research in the Public Interest(201003063)the Key Technology R&D Program of Jiangsu Province(BE2013412)the Fund for Independent Innovation of Agricultural Sciences in Jiangsu Province(XC(13)3030)~~
文摘At present, the technology of biomass fuel composite molding technique is relatively lagging in China, which brings several negative influences, such as high energy consumption, short service life of the equipment. The current situation of the biomass pellet fuel molding technology at home and abroad was introduced, and the development direction in China was put forward, which was of great significance for enhancing the level of pellet fuel molding technology in China.
文摘This paper presents an improved unstructured grid immersed boundary method.The advantages of both immersed boundary method and body fitted grids which are generated by unstructured grid technology are used to enhance the computation efficiency of fluid structure interaction in complex domain.The Navier-Stokes equation was discretized spacially with collocated finite volume method and Euler implicit method in time domain.The rigid body motion was simulated by immersed boundary method in which the fluid and rigid body interface interaction was dealt with VOS(volume of solid) method.A new VOS calculation method based on graph was presented in which both immersed boundary points and cross points were collected in arbitrary order to form a graph.The method is verified with flow past oscillating cylinder.
基金Project(12 High-tech Urban C22)supported by High-tech Urban Development Program,Ministry of Land,Transport and Moritime Affairs of Korea
文摘Practical techniques for smooth geodesic patterning of membrane structures were investigated.For the geodesic search,adjustment of the subplane of the extracted elements series was proposed,and various spline approximation methods were used to flatten the strip for the generation of a smooth pattern.This search approach is very simple,and the geodesic line could be easily attained by the proposed method without the need for a difficult computation method.Smooth cutting patterning can also be generated by spline approximation without the noise in discrete nodal information.Additionally,the geodesic cutting pattern saved about 21%of the required area for the catenary model due to the reduction of the curvature of the planar pattern seam line.
基金Supported by Research Fund for the Doctoral Program of Higher Education of China under Grant No.20070486094
文摘A new (2+1)-dimensional KdV equation is constructed by using Lax pair generating technique. Exact solutions of the new equation are studied by means of the singular manifold method. Bgcklund transformation in terms of the singular manifold is obtained. And localized structures are also investigated.
基金Supported by the Innovation Fund for Technology Based Firms from Ministry of Science and Technology of China(07C26213101283)
文摘The chemical synthesis of Guanine arabinoside (ara-G) is extremely complex, time-consuming, and seriously polluted. A two-step enzymatic synthesis process was developed to acquire ara-G easily. 2,6-Diaminopurine arabinoside (ara-DA) was first synthesized with purine nucleoside phosphorylase and pyrimidine nucleoside phosphorylase produced by Enterobacter aerogenes DGW-07. The conversion yield of ara-DA could reach above 90% when the reaction liquid contained 30 mmol·L^-1 uracil arabinoside as arabinose donor, 10 mmol·L^- 1 2,6-diaminopurine as arabinose acceptor in pH 7.0 20 mmol·L^-1 phosphate buffer, and reacted at 60℃ for 48h. Then, ara-DA was effectively transformed into ara-G with adenylate deaminase produced by Aspergillus oryzae DAW-01. The total process had no complex separation and purification.
基金Projects(51109095,51179075,51309119)supported by the National Natural Science Foundation of ChinaProject(BE2012131)supported by Science and Technology Support Program of Jiangsu Province,China
文摘In order to evaluate the effects of mesh generation techniques and grid convergence on pump performance in centrifugal pump model, three widely used mesh styles including structured hexahedral, unstructured tetrahedral and hybrid prismatic/tetrahedral meshes were generated for a centrifugal pump model. And quantitative grid convergence was assessed based on a grid convergence index(GCI), which accounts for the degree of grid refinement. The structured, unstructured or hybrid meshes are found to have certain difference for velocity distributions in impeller with the change of grid cell number. And the simulation results have errors to different degrees compared with experimental data. The GCI-value for structured meshes calculated is lower than that for the unstructured and hybrid meshes. Meanwhile, the structured meshes are observed to get more vortexes in impeller passage.Nevertheless, the hybrid meshes are found to have larger low-velocity area at outlet and more secondary vortexes at a specified location than structured meshes and unstructured meshes.
文摘This paper proposes a new method that can access tion of the data report in LabWindows/CVI. It can produce the testing system by programming. This helps improve the increase the efficiency greatly. the Microsoft Excel 2003 by ActiveX to make up for the limita- a required data report and draw up a data chart automatically in flexibility and universality when producing the data report and
基金Supported by the Natural Science Foundation of Shandong Province of China (ZR2009BM011) and the Doctor Foundation of Shandong Province of China (BS2010NJ005).
文摘Various methods for production of polysilicon have been proposed for lowering the production cost andenergy consumption, and enhancing productivity, which are critical for industrial applications. The fluidized bed chemical vapor deposition (FBCVD) method is a most promising alternative to conventional ones, but the homogeneous reaction of silane in FBCVD results in unwanted formation of fines, which will affect the product qualityand output. There are some other problems, such as heating degeneration due to undesired polysilicon deposition on the walls of the reactor and the heater. This article mainly reviews the technological development on FBCVD of polycrystalline silicon and the research status for solving the above problems. It also identifies a number of challenges to tackle and principles should be followed in the design ofa FBCVD reactor.
基金the National Natural Science Foundation of China(No.60673074)the Key Project of Ministry of Education Science and Technology’s Research(107065)
文摘The study of cyclic codes over rings has generated a lot of public interest.In this paper,we study cyclic codes and their dual codes over the ring Z P2 of length pe,and find a set of generators for these codes.The ranks and minimal generator sets of these codes are studied as well,which play an important role in decoding and determining the distance distribution of codes.
文摘Rising worldwide cancer incidence and resistance to current anti-cancer drugs necessitate the need for new pharmaceutical compounds and drug delivery system. Malfunction of the immune system, particularly in the tumor microenvironment, causes tumor growth and enhances tumor progression. Thus, cancer immunotherapy can be an appropriate approach to provoke the systemic immune system to combat tumor expansion. Texosomesj which are endogenous nanovesicles released by all tumor cells, contribute to cell-cell communication and modify the phenotypic features of recipient cells due to the texosomes' ability to transport biological components. For this reason, texosome-based delivery system can be a valuable strategy for therapeutic purposes. To improve the pharmaceutical behavior of this system and to facilitate its use in medical applications, biotechnology approaches and mimetic techniques have been utilized. In this review, we present the development history oftexosome-based delivery systems and discuss the advantages and disadvantages of each system.
文摘This paper presents examples of field data of extreme seiche waves measured at Coffs Harbour by MHL and describes the generation and measuring methodology to detect and reduce seiche agitation in the Coifs Harbour boat ramp using a 3D physical model. The paper also discusses the techniques in investigating a short wave problem of stability in the same model where a long wave is simulated. Waves offshore of Coffs Harbour at 80 m depth have been recorded by MHL for a period of over 30 years. Long waves have been simultaneously measured in the harbour over a period of a decade. These data enabled the model to be verified on two dates (4/6/12, 5/9/14) when high long waves were recorded at the boat ramp harbour under storm and non-storm conditions. Long waves are generated in harbours due to group bounded long wave and surf beat or edge waves. The paper presents methodologies of generating long waves both numerically and by using physical models, and discusses the advantages and disadvantages of these generation techniques. Numerical modelling carried out using long period regular waves in a previous investigation predicted reductions up to 50% due to change of planform of the boat ramp harbour where an area next to the boat ramp was excavated and roughness elements introduced to dampen long periods. The 3D physical model simulated a 25% decrease in the long wave energy in the boat ramp when a suitable change in the planform was made. A 3D undistorted model of scale 1:58 was used in the investigation.
基金supported by the Academic Award for Excellent Ph.D.Candidates Funded by the Ministry of Education of China(No.5052011303014)the National Natural Science Foundation of China(No.81171396)+1 种基金the Science Fund for Creative Research Groups of the National Natural Science Foundation of China(Nos.20621502 and 20921062)the Fundamental Research Funds for the Central Universities of Ministry of Education of China(No.4103005).
文摘Cancer is a major threat to public health in the 21st century because it is one of the leading causes of death worldwide.The mechanisms of carcinogenesis,cancer invasion,and metastasis remain unclear.Thus,the development of a novel approach for cancer detection is urgent,and real-time monitoring is crucial in revealing its underlying biological mechanisms.With the optical and chemical advantages of quantum dots(QDs),QD-based nanotechnology is helpful in constructing a biomedical imaging platform for cancer behavior study.This review mainly focuses on the application of QD-based nanotechnology in cancer cell imaging and tumor microenvironment studies both in vivo and in vitro,as well as the remaining issues and future perspectives.
基金supported by the National Basic Research Program of China under Grants No. 2011CBA00200 No. 2011CB921200+2 种基金National Natural Science Foundation of China under Grants No. 60921091 No. 61101137 No. 61201239
文摘Quantum communications helps us to enhance the security and efficiency of communications and to deepen our understanding of quantum physics. Its rapid development in recent years has attracted the interest of researchers from diverse fields such as physics, mathematics, and computer science. We review the background and current state of quantum communications technology, with an emphasis on quantum key distribution, quantum random number generation, and a relatively hot topic: device independent protocols.
文摘Several bacterial strains of Actinomycetes belonging to Streptomyces and Arthrobacter genera for the first time were used to study the biotechnology of synthesis of gold and silver nanoparticles. The experimental conditions of gold and silver nanoparticles production by the cells of studied strains in aqueous chloroauric acid (HAuCIq) and in silver nitrate (AgNO3) solutions, respectively, were determined. Concentration and time-dependences of nanoparticle formation were investigated. The complex of optical and analytical methods was used for testing the gold and silver nanoparticles in the bacterial biomass. The TEM (Transmission Electron Microscopy) and XRD (X-ray Diffraction) data in all cases demonstrated the presence of crystals with fcc (face centered cubic) structure. The results obtained show that the Actinomycetes are capable of producing gold and silver nanoparticles of spherical shape extracellularly when exposed to suitable compounds. The particle size distribution shows that the sizes of nanoparticles are in the range of 5 nm to 80 nm. The biomass obtained may be used for industrial as well as medical and pharmaceutical purposes.
文摘The pilot-scale process for preparing 2-amino-6-chloro-9-(2',3',5'-tri-O-acetyl-Dq3-ribofuranosyl)-purine and 2-chloroadenosine has been developed with a total yield of the desired compounds 73% and 44.5%, respectively. These compounds are useful intermediates for enzymatic synthesis of active pharmaceutical ingredients Nelarabine and Cladribine. The starting material--commercially avaliable guanosine--was acetylated with acetic anhydride, yielding 2,3,5-tri-O-acetylguanosine, which was further deoxyhalogenated with phosphorous oxychloride in presence of tetraethylammonia chloride. Diazotization of the resulting intermediate with tert-butylnitrite leads to the corresponding ribofuranosyl-substituted 2,6-dichloropurine, which was converted to 6-chloroadenosine by reaction with methanolic ammonia.
基金Supported by Research Grant No. 570/2008,Entitled "Integrative Prediction Model of Malignant Transformation of Regeneration Lesions in Cirrhotic Liver Using Noninvasive Imaging Techniques,Immunohistochemical and Molecular Genetic Methods"Financed by the Romanian Ministry of EducationResearch-National Authority for Scientific Research (PN2-ID-PCE)
文摘Visualization of tumor angiogenesis can facilitate noninvasive evaluation of tumor vascular characteristics to supplement the conventional diagnostic imaging goals of depicting tumor location,size,and morphology.Hybrid imaging techniques combine anatomic [ultrasound,computed tomography(CT),and/or magnetic resonance imaging(MRI)] and molecular(single photon emission CT and positron emission tomography) imaging modalities.One example is real-time virtual sonography,which combines ultrasound(grayscale,colour Doppler,or dynamic contrast harmonic imaging) with contrast-enhanced CT/MRI.The benefits of fusion imaging include an increased diagnostic confidence,direct comparison of the lesions using different imaging modalities,more precise monitoring of interventional procedures,and reduced radiation exposure.
文摘Metallurgical sector plays an important role in the economy of each country because steel products present essential raw material for basic industries. Changes in the sectors of iron, steel and non-ferrous metals and the current development of technology forces the steel mills increased productivity, reduce production costs while ensuring to obtain a product with the required properties and to improve the competitiveness of enterprises in the global market. Currently, the most popular in meeting these requirements, enjoys a method of integration which combines individual operations into one integrated whole. The use of modem, perfectly designed, fully automated design of mechanical, hydraulic and measurement allowed us to achieve an innovative line of production. This article presents the general characteristics of the steel industry and a description of the latest integrated technology currently used in foundries and rolling mills. It also presents examples of the use of integrated technologies in metallurgy and the effects of economic, environmental and quality resulting from their use on an industrial scale.
文摘Angiogenesis has a critical role in primary tumor growth and the development of metastases.Several angiogenesis inhibitors were recently developed,being a very attractive target for digestive tumor therapy.However,individualized therapy should not only be based on the pre-treatment imaging evaluation,but also on sensitive monitoring of microvascular changes during treatment.State-of-theart imaging techniques have the potential to visualize and characterize angiogenesis,although the technology and methodologies employed are recent and need further validation.The aim of this series of reviews was to analyze and enhance current knowledge and future perspectives about the real-time assessment of angiogenesis in digestive cancers,used for the longitudinal monitoring of the effects of chemo-radiotherapy(including anti-angiogenic therapies),as well as for the precise targeting of drugs through molecular-based drug-delivery systems.
文摘On June 16,2016 the technical achievement of the Shaanxi Yanchang Oil Group relating to "the integrated process technology for comprehensive utilization of coal,oil and gas and their commercial application" has passed the experts’appraisal in Beijing.It is said that this achievement has shattered the traditional precedent and engineering paradigm of using coal or natural gas to simplistically manufacture methanol and has carved out a new mode for comprehensive utilization of coal, oil and gas resources, featuring apparent emissions reduction ef-fects with innovative nature to command a leading posi-tion internationally.