白癜风胶囊对白癜风患者的临床效果研究

目的:观察研究白癜风胶囊对比常规西药治疗白癜风疾病临床效果。方法:纳入2014年1月至2015年6月我科室收诊治疗的诊断为白癜风的患者80例,按随机数字表法分为观察组及对照组各40例,观察组给予白癜风胶囊治疗,对照组患者给予常规西药进行治疗,记录并分析治疗后两组患者相关指标的对比情况。结果:观察组治疗后全血粘度、红细胞沉降率、红细胞压积值分别为(5.36±1.02mP a/s、7.34±0.71nm/h、38.46±3.92%),均明显优于对照组(6.01±1.12mP a/s、6.52±0.91nm/h、45.53±3.63%);观察组治疗后血清IL-2、IL-6、IL-10的测定结果分别为(1.75±0.16mg/L、132.6±11.6ng/L、21.63±2.03ng/L),均明显优于对照组(2.79±0.14mg/L、171.4±10.9ng/L、26.43±2.63ng/L);观察组治疗前后血清细胞因子TNF-α和TGF-β的水平分别为(1.03±0.16ug/L、483.6±52.4pg/ml),均明显优于对照组(1.41±0.18ug/L、415.2±54.9pg/ml);(4)观察组治疗后临床总显效率达75.0%,明显高于对照组40.0%;(5)观察组治疗前后白癜风的病变面积为(99.6±18.5)cm2,明显优于对照组(131.4±22.5)cm2。结论:白癜风胶囊对白癜风疾病患者的临床效果优于单独应用常规西药,且无明显副作用,值得临床进一步研究和应用。

Study of neuropeptide Y in the plasma and skin tissue of patients with vitiligo

Objective: To study the role of neuropeptide Y (NPY) in the pathogenesis of vitiligo. Methods: The levels of NPY in the plasma from patients with vitiligo and healthy volunteers were measured by 125I RIA Kit. The expression of NPY in normal skin tissues, uninvolved tissues and lesional tissues of vitiligo was detected by immunohistochemistry. Results: The levels of NPY in the patients with vitiligo of all types were significantly higher than that in the normal controls. In all types, the levels in active stage were significantly higher than those in stable stage. The expression of NPY was upregulated in lesions of patients with active vitiligo (P<0.01) compared with those in normal skin tissues and uninvolved tissues. There was significant difference of NPY expression between active stage and stable stage (P<0.01). Conclusion: These findings support the concept of neuropeptide involvement in vitiligo, especially in active vitiligo, and suggest that NPY may play a role in the pathogenesis of this disease.