高压氧结合“知信行”护理模式干预对脑卒中后患者康复影响

探讨高压氧(HBO)疗法结合“知信行”模式护理干预对脑卒中患者后期康复产生的影响影响。方法 研究所选择的对象均为2023年2月至2024年2月柳州市柳铁中心医院高压氧科收治的脑卒中患者,通过分层随机的方式抽选符合条件的患者74例,所有患者均进行常规治疗护理及高压氧HBO治疗,研究组在此基础上结合“知信行”护理模式进行干预。结果 经过各项数据的对比后发现,研究组上下肢的运动功能评分与参照组差异明显,数据显示P<0.05;研究组护理前后的自我管理行为评分改善更显著,护理后的评分结果与参照组差异显著P<0.05;研究组患者在接受干预后的知信行评分显著提高,结果与参照组比较显示P<0.05;研究组患者对护理满意度的评价更好,差异显著P<0.05,有统计学意义。结论 在脑卒中患者护理中采取临床护理路径,能够让患者的整体治疗效果得到有效提升,可以减少患者并发症发生的情况,并让护理满意度得到显著提高,可推广运用。

“知行研”相结合:职前英语教师教育模式构建

本文研究探索"知行研"相结合的职前英语教师教育模式。该模式将教学理论学习(知)、实践运用(行)、研究反思(研)有机结合,能有效地促进职前英语教师专业知识的掌握和语言教学与研究能力的提高,为职后的专业可持续发展奠定坚实的基础。

“知行合一”思想对小学语文德育教育的启发与优化

新时代下,只有不断提升小学生的道德素质水平,传承社会主义核心价值观,才能使其更好地适应新时代的发展,为学生的未来成长打下坚实的教育基础。为此,我国便在“立德树人”背景下形成了“全学科育人”的新口号。其中,语文本身就同时兼具工具性、人文性相统一的特点,蕴含着丰富的德育思想,所以语文教师便要遵循王阳明心学理念中的“知行结合”思想去组织德育教育实践活动,为提升学生的素质水平做好充足准备。本文将思考并阐述“知行结合”思想下小学语文教师应该如何组织德育教育活动。

Discussion of the promising effect of electroacupuncture on cognitive improvement in D-galactose-induced aging rats based on NLRP3-ASC-Caspase-1 signaling pathway

Objective:To investigate the effect of electroacupuncture(EA)on cognitive function in D-galactose(D-gal)-induced aging rats,and the correlation between the effect and nucleotide-binding oligomerization domain(NOD)-like receptor protein 3(NLRP3)-ASC-Caspase-1 signaling pathway.Methods:Forty-six male Sprague-Dawley(SD)rats were randomly divided into a control group(n=10),a model group(n=12),an EA-7 d group(n=12)and an EA-21 d group(n=12).Except the control group,the other three groups received 42 consecutive days of intraperitoneal injection of D-gal to establish aging rat models with cognitive dysfunction.The control group received the same amount of normal saline via intraperitoneal injection.Two EA groups were given EA therapy for 21 consecutive days(began from the 22nd day of modeling)or 7 consecutive days(began from the 36th day of modeling)accordingly at Dazhui(GV 14),Baihui(GV 20),Shenshu(BL 23)and Zusanli(ST 36).After modeling/intervention,all four groups received behavioral evaluations by Morris water maze(MWM)test,novel object recognition(NOR)test and step-down passive avoidance(SDPA)test followed by the Western blot(WB)detection of the expression levels of hippocampal NLRP3 inflammasome-associated proteins NLRP3,ASC and Caspase-1.Results:MWM(place navigation test,PNT)results showed that the escape latency in the model group was significantly longer than that in the other three groups(P<0.05),and there was no significant difference among the other three groups on the 1st day of the test(P>0.05).From the 2nd day to the 4th day of the test,there was no significant difference between the EA-21 d group and the control group(P>0.05)in the escape latency;the escape latency was significantly shorter in the EA-21 d group than in the model group and the EA-7 d group(P<0.05).MWM(spatial probe test,SPT)results showed that the time spent in the target quadrant was significantly shorter and platform crossover number was significantly lower in the model group than in the other three groups(P<0.05).The time spent in the target quadrant was longer in the EA-7 d group than in the model group(P<0.05),but was shorter than that in the control group and the EA-21 d group(P<0.05).There was no significant difference in the swimming speed among the four groups(P>0.05).NOR results showed that there was no significant difference in the recognition ratio between the EA-7 d group and the EA-21 d group(P>0.05),and the recognition ratio was significantly higher in the two EA groups than in the model group(P<0.05),but was lower than in the control group(P<0.05).SDPA results showed that the electric shock number was higher in the model group than in the other three groups(P<0.05),and the differences among the other three groups were statistically insignificant(P>0.05).The model group had the shortest step-down latency,followed by the EA-7 d group,the EA-21 d group and the control group in order(P<0.05).The WB results indicated that the expression level of NLRP3 was significantly lower in the control group and the EA-21 d group than in the model group and the EA-7 d group(P<0.05).The expression levels of ASC and Caspase-1 were significantly higher in the model group than in the other three groups(P<0.05),and there was no significant difference among these three groups(P>0.05).Conclusion:NLRP3 inflammasome may be involved in the development of cognitive decline in aging rats;7 consecutive days of EA intervention can partially improve the cognitive impairment in aging rats though the effect is rather limited;21 consecutive days of EA intervention may improve the learning and memory abilities in aging rats via downregulating the expression levels of NLRP3 inflammasome-associated proteins in hippocampus.