蒙医“粘”性脑刺痛发热证期转化与炎性因子的相关性实验研究

目的:探讨蒙医"粘"性脑刺痛未熟热期转化成熟热期与炎性因子的相关性。方法:采用大肠埃希菌小脑延髓池注射法造模。在造模前、造模后1.5h、8h分别采集脑脊液和外周血,测脑脊液和外周血白细胞数、IL-1、IL-6、TNF-α与外周血C反应蛋白(CRP)含量。结果:造模后体温开始上升,约2h达高峰,高热持续约7～9h后体温开始逐渐下降。与空白组和造模前比较,模型组未熟热期、成熟热期脑脊液白细胞数、IL-1、IL-6、TNF-α,外周血IL-1、TNF-α含量显著升高,差异有统计学意义(P<0.05);与未熟热期比较,模型组成熟热期脑脊液白细胞数、TNF-α与外周血CRP含量显著升高,差异有统计学意义(P<0.05)。结论:模型组发热过程和症状符合蒙医未熟热期和成熟热期的演变过程。蒙医"粘"性脑刺痛未熟热期转化成熟热期证的病机变化与相关的炎性因子具有一定的相关性。

内毒素致家兔蒙医“粘”性脑刺痛未熟热与成熟热期模型的研究

建立家兔蒙医“粘”性脑刺痛病未熟热与成熟热期模型。方法：模型组于家兔小脑延髓池内分别注射0．05μg／kg（A）、0.075μg/kg（B）、0.1μg/kg（C）、0.25μg/kg（D）大肠埃希菌内毒素，空白组于家兔小脑延髓池注射等量的生理盐水，连续测量体温，观察证侯表现。

大肠埃希菌致家兔蒙医“粘”性腹刺痛未成熟热期、成熟热期动物模型的研究

目的:建立大肠埃希菌致家兔蒙医"粘"性腹刺痛症未成熟热期与成熟热期实验模型,为蒙医"粘"性腹刺痛症及未熟热证、成熟热证相关研究提供疾病模型.方法:取16只家兔随机分为实验组8只,空白组8只,实验组采用大肠埃希菌3×108、1ml腹腔4个点注射法造模,空白组注入生理盐水,两组连续测量体温、对照观察一般情况、症候表现.结果:实验组造模后70分钟体温迅速上升,约80分钟达高热,高热持续约240分钟,380分钟后体温开始缓慢下降至基础体温水平.发热过程中出现精神状况、活动、发热、寒战、毛被、呼吸、心跳、耳及耳缘血管、眼、鼻、舌、进食进水、尿色、尿气味、粪便的色味与软硬度等方面出现了规律性变化.其体温上升期出现的症候表现符合蒙医疫因性温病未熟热阶段的表现,高热平台期症候符合蒙医疫因性温病成熟热阶段表现.两组比较具有显著性差异.结论:大肠埃希菌腹腔注射诱发家兔发热模型符合蒙医疫因性温病未熟热期和成熟热期的症候表现,可用于蒙医"粘"性腹刺痛未熟热期、成熟热期相关的实验研究.

蒙西医结合治疗“粘”性脑刺痛临床疗效观察

目的:观察蒙西医结合治疗"粘"性脑刺痛的临床疗效。方法:选取40例"粘"性脑刺痛患者为研究对象,随机分为观察组和对照组各20例。观察组患者采用蒙医辨证治疗加西医常规治疗,对照组患者采用西医常规治疗,比较两组患者的临床疗效。结果:经过治疗,观察组患者总有效率为90.0%,明显优于对照组的75.0%,差异具有统计学意义(P<0.05)。结论:蒙西医结合治疗蒙医"粘"性脑刺痛疗效显著,具有疗效快、时间短、后遗症少等特点。

Quantifying the Effects of Near-Surface Viscosity on Seismic Acquisition Geometry: A case study from Chepaizi Exploration Area, Junggar Basin (NW China)

The Chepaizi Exploration Area,Junggar Basin(NW China)holds substantial importance for seismic exploration endeavors,yet it poses notable challenges due to the intricate nature of its subsurface and near-surface conditions.To address these challenges,we introduce a novel and comprehensive workflow tailored to evaluate and optimize seismic acquisition geometries while considering the impacts of near-surface viscosity.By integrating geological knowledge,historical seismic data,and subsurface modeling,we conduct simulations employing the visco-acoustic wave equation and reverse-time migration to produce detailed subsurface images.The quality of these images is quantitatively evaluated using a local similarity metric,a pivotal tool for evaluating the accuracy of seismic imaging.The culmination of this workflow results in an automated optimization strategy for acquisition geometries that enhances subsurface exploration.Our proposed methodology underscores the importance of incorporating near-surface viscosity effects in seismic imaging,offering a robust framework for improving the accuracy of subsurface imaging.Herein,we aim to contribute to the advancement of seismic imaging methodologies by providing valuable insights for achieving high-quality seismic exploration outcomes in regions characterized by complex subsurface and near-surface conditions.

Local existence and uniqueness of solutions to the evolutionary model for magnetoviscoelasticity

In this paper,we prove the local existence and uniqueness of solutions to the evolutionary model for magnetoviscoelasticity in R^(2),R^(3).This model consists of an incompressible Navier-Stokes,a regularized system for the evolution of the deformation gradient and the Landau-Lifshitz-Gilbert system for the dynamics of the mag-netization.Our approach depends on approximating the system with a sequence of perturbed systems.

Polyetherketoneketone/carbon fiber composites with an amorphous interface prepared by solution impregnation

Interfacial adhesion between carbon fibers(CF)and polyetherketoneketone(PEKK)is a key factor that affects the mechanical performances of their composites.It is therefore of great importance to impregnate the CF bundles with PEKK as effi-ciently as possible.We report that PEKK with a good dispersion in a mixed solution of 4-chlorophenol and 1,2-dichloroethane can be introduced onto CF surfaces by solution impregnation and curing at 280,320,340 and 360℃.The excellent wettability or infiltra-tion of the PEKK solution guarantees a full covering and its tight binding to CFs,making it possible to evaluate the interfacial shear strength(IFSS)with the microdroplet method.The interior of the CF bundles is completely and uniformly filled with PEKK by solu-tion impregnation,leading to a high interlaminar shear strength(ILSS).The maximum IFSS and ILSS reached 107.8 and 99.3 MPa,respectively.Such superior shear properties are ascribed to the formation of amorphous PEKK in the small spaces between CFs.

A generalized viscoelastic Biot/squirt model for clay-bearing sandstones in a wide range of permeabilities

To simultaneously take into account the Biot-flow mechanism, the squirt-flow mechanism, and the frame-viscoelasticity mechanism, a generalized viscoelastic BISQ （Biot/squirt） model is developed for wave propagation in clay-bearing sandstones based on Dvorkin＇s elastic BISQ model. The present model is extended to a wide range of permeabilities （k 〉 0.05 mD） by introducing a dimensionless correction factor for viscoelastic parameters, defined as a function of the permeability and the clay content. We describe the frame＇s stress-strain relationship of the clay-bearing sandstones by the differential constitutive equations of generalized viscoelasticity and then derive the viscoelastic-wave dynamic equations. With the assumption of a plane-wave solution, we finally yield the phase velocities and the attenuation coefficients by solving the dynamic wave equations in the frequency and wave number domain. The comparison of numerical results and experimental data shows that the generalized viscoelastic BISQ model is applicable for modeling the wave propagation in most of the sandstones mainly bearing kaolinite clay.

Study on the Fermentation Conditions of a Mucopolysaccharide-producing Bacterium LV-1

bacterium LV-1 which isolated from soil sample were studied bacterium was isolated by serial dilution method, the effects of carbon source, nitrogen source, the initial pH and temperature on producing polysaccharide by it were discussed to confirm the optimum fermentation conditions. [ Result] The physicochemical properties showed that the polysaccharide was water-soluble, but insoluble in organic solvents including ethanol, butanol, and chloroform. It was neutral polysaccharide with negative charge and without reducing terminal. The pH of its solution was pH =7.5. There were no protein, fructose, uronic acid, sulphate and starch-like structure included in po/ysacchadde molecules. The optimum fermentation conditions for po/ysaccharide produc- tion were 3% mannitol as carbon source, 0.25% yeast extract as nitrogen source, culture temperature 28 ~（3 and pH =7.5. [Coadu^en] The re- search could provide basis for development and utilization of LV-1 and industrialized production of mucopolysaccharide.

Determination of undrained shear strength using piezocone penetration test in clayey soil for bridge foundation

In order to obtain the reasonable undrained shear strength Su for geotechnical analyses of bridge foundations in Yangtze River floodplain clayey soils, a site-specific study is conducted using the imported piezocone penetration test （CPTu） with dissipation phases at the Fourth Nanjing Yangtze River Bridge construction sites. Taking the values of Su from laboratory tests as references, several existing Su-predicted methods based on CPTu are compared and evaluated. To verify the presented cone factor Nk, additional test sites are selected and examined. The results show that the values of cone factors such as Nkt, Nke, and Nau, depend on the shear test mode and disturbance. Generally, the values of Nke show more scattering than those of Nkt and N△u. For the stratified and layered sediments of the Yangtze River floodplain, it is recommended using the net cone resistance qT to estimate Su and the preliminary cone factor values Nkt are from 7 to 16, with an average of 11. It is also confirmed that the CPTu test, as a new technique in site characterization, can present reasonable parameters for bridge foundations.

Review on the Development of Oil and Gas Flow in Underground Porous Media

Through reviewing the flow theory’s birth and development history in underground porous media and contrasting the mechanics of underground fluids and mechanics of viscous fluids, this paper points out the main factors, which affect the development of the theory on oil and gas porous flow. The development law and development route of the mechanics of fluids in porous media are also summarized in this paper.

Microstructure,mechanical properties and dry wear resistance of β-type Ti-15Mo-xNb alloys for biomedical applications

In order to study the effect of element Nb on the microstructure and properties of the biomedical β-type Ti-Mo based alloys,Ti-15Mo-xNb（x=5,10,15 and 20 in %） alloys were investigated.The dry wear resistance of β-type Ti-15Mo-xNb alloys against Gr15 ball was investigated on CJS111A ball-disk wear instrument.Experimental results indicate that crystal structure and morphology of the Ti-15Mo-xNb alloys are sensitive to their Nb contents.Ti-15Mo-xNb alloys match those for β phase peaks and no any phases are found.The Vickers hardness values of all the Ti-15Mo-xNb alloys are higher than HV200.The compression yield strength of the Ti-15Mo-5Nb alloy is the lowest and that of the Ti-15Mo-10Nb alloy is the highest.For all the Ti-15Mo-xNb alloys,the friction coefficient is not constant but takes a higher value.In dry condition,SEM study reveals deep parallel scars on the wear surfaces of all the Ti-15Mo-xNb alloys under different loads.The friction coefficient of the Ti-15Mo-5Nb alloy under 1 N is the lowest.The wear principal mechanism for Ti-15Mo-xNb alloys is adhesive wear.

FEM tire model oriented to virtual experiment of off-road vehicle trafficability

In order to estimate the trafficability of off-road vehicles, the linear relationships between the pressure and the stiffness of the tire and the action of the vertical tire force with the viscoelasticity are analyzed. The method to improve the precision of the model by the coefficients is presented. The constitutive equation of the three-parameter linear model and the stiffness matrix of four-node isoparametric elements are derived to construct the FEM （finite element method） tire model in plan stress. A demarcation and verification system is designed based on the six-dimensional wheel force transducer and the vertical tire force is measured under different velocities. The results show that the model and the method proposed are reasonable.

Analytical Solution for Laminar Viscous Flow inthe Gap Between Two Parallel Rotary Disks

Aim To get the analytical for laminar viscous flow in the gap of two parallel rotating disks. Methods By estimating the order of magnitude of each term in the Navier-Stokes equations to drop small terms and achieve the required simplified differential equations, and by integrating the equations to obtain the solution for theflow between two rotary disks. Results Parameters related to the laminar viscous flow in the gap between two parallel rotary disks, such as the velocity, the pressure, the flowrate, the force, the shearing stress, the torque and the power derived. Conclusion The result provides a theoretical basis and an effective method for the designs of the devices connected with the laminar viscous flow in the gap between two parallel rotary disks.

N-S EQUATION CALCULATIONS ON MULTI-ELEMENT AIRFOILS WITH ZONAL PATCHED GRIDS

For a complex flow about multi-element airfoils a mixed grid method is set up. C-type grids are produced on each element′s body and in their wakes at first, O-type grids are given in the outmost area, and H-type grids are used in middle additional areas. An algebra method is used to produce the initial grids in each area. And the girds are optimized by elliptical differential equation method. Then C-O-H zonal patched grids around multi-element airfoils are produced automatically and efficiently. A time accurate finite-volume integration method is used to solve the compressible laminar and turbulent Navier-Stokes (N-S) equations on the grids. Computational results prove the method to be effective.

Determination of interfacial adhesive properties for polymeric film by blister test

The interfacial adhesive properties ofpolypropylene/stainless steel were studied by the blister test. The polypropylene film with a squared free-standing window was pressured by oil from one side of film. The corresponding deformation field was observed by a digital speckle correlation method. The experimental results show that the squared film deforms and debonds from stainless steel with the increase of pressure. The debonding of the squared film in initiates from the center of edge and extends to the comer, and then the deformation of film evolves from square to circle shape. The interfacial adhesive energy of polypropylene/stainless steel is （22.60±1.55） J/m2, which is in agreement with that measured by film with a circular window.

BISQ model based on a Kelvin-Voigt viscoelastic frame in a partially saturated porous medium

Taking into account three important porous media mechanisms during wave propagation （the Biot-flow, squirt-flow, and solid-skeleton viscoelastic mechanisms）, we introduce water saturation into the dynamic governing equations of wave propagation by analyzing the effective medium theory and then providing a viscoelastic Biot/squirt （BISQ） model which can analyze the wave propagation problems in a partially viscous pore fluid saturated porous media. In this model, the effects of pore fluid distribution patterns on the effective bulk modulus at different frequencies are considered. Then we derive the wave dynamic equations in the time-space domain. The phase velocity and the attenuation coefficient equations of the viscoelatic BISQ model in the frequency-wavenumber domain are deduced through a set of plane harmonic solution assumptions. Finally, by means of numerical simulations, we investigate the effects of water saturation, permeability, and frequency on compressional wave velocity and attenuation. Based on tight sandstone and carbonate experimental observed data, the compressional wave velocities of partially saturated reservoir rocks are calculated. The compressional wave velocity in carbonate reservoirs is more sensitive to gas saturation than in sandstone reservoirs.

Viscoplastic friction and microstructural evolution behavior of laser-clad Co-Cr-Ni-Mo coating

The viscoplastic friction and nanostructure formation mechanism of laser-clad Co-based coating were studied by rotary friction between laser-clad Co-Cr-Ni-Mo coating and WC-Co rod.The friction coefficient,friction interface temperature and axial displacement—time curves during rotary friction process were measured.The results showed that all the curves firstly experienced rising stage and then steady stage.The rising stage corresponded to sliding friction while the steady stage corresponded to viscoplastic friction.After viscoplastic friction processing,three typical zones of viscoplastic deformation zone,thermo-mechanically affected zone,and original laser-clad zone can be observed successively from the friction surface to the interior.The viscoplastic deformation significantly crushed the network M23C7 phase in original laser-clad zone and made it dispersively distributed with equiaxial shape and in nano-scale.The viscoplastic zone,in width of 37-131 μm,is mainly characterized by refined M23C7 and α-Co phase with grain size bellow 50 nm,and even a small quantity of amorphous.Thus,the hardness of viscoplastic zone about HV997 was improved compared with the hardness of original laser-clad zone about HV600.