This paper studies the preparation method of As_2O_3 nanoparticles and theirantitumor effect on human liver cancer cells. As_2O_3 nanoparticles were prepared by sol-gel method.As_2O_3 nanoparticles were characterized ...This paper studies the preparation method of As_2O_3 nanoparticles and theirantitumor effect on human liver cancer cells. As_2O_3 nanoparticles were prepared by sol-gel method.As_2O_3 nanoparticles were characterized by transmission electron microscope ( TEM), energydispersive spectrometer ( EDS) and computer color magic image analysis system (CMIAS). A methylthiazolyl tetrazolium (MTT) assay and a flow cytometry (FCM) assay were performed to examine theantitumor effect of As_2O_3 nanoparticlesat various concentrations(1, 2, 5, 10 mumol/L). We alsocompared the antitumor effect of As_2O_3 nanoparticles with that of As_2O_3 solution. The averagediameters of two kinds of As_2O_3 nanoparticles prepared were about 80 nm and 40 nm. It wasidentified that the prepared nanoparticles were As_2O_3 and there were no other components by EDS.After 48 h of treatment with As_2O_3 nanoparticles, the survival ratio of cells was significantlylower than that of the As2O3 solution with the same concentration(P < 0. 05). Experimental resultsdemonstrate that by sol-gel method As_2O_3 can be prepared into nanoparticles. As_2O_3 nanoparticlescan produce a better cytotoxic effect on tumor cells than the As_2O_3 solution.展开更多
In the fabrication of Bi nanowire array thermoelectric materials,electrodeposition technology has been used to deposit bismuth into the nanopores of anodic alumina porous films.The experiments show that the temperatur...In the fabrication of Bi nanowire array thermoelectric materials,electrodeposition technology has been used to deposit bismuth into the nanopores of anodic alumina porous films.The experiments show that the temperature significantly affects the electrodepositing process,and the simple form of Bi 3+ in the solutions is helpful to the deposition of metal Bi.The pulse plating technique is necessary for the electrodeposition because of the diffusive difficulty of Bi 3+ into the nanopores of the films.The XRD analysis indicates that Bi nanowire arrays have been manufactured by this technology.展开更多
We describe the fabrication of metal nanogaps of sub-20nm in feature size using the proximity effect in electron beam lithography (EBL). The proximity effect is extended to develop a flexible and practical method fo...We describe the fabrication of metal nanogaps of sub-20nm in feature size using the proximity effect in electron beam lithography (EBL). The proximity effect is extended to develop a flexible and practical method for preparing metal (e. g. Au or Ag) nanogaps and arrays in combination with a transfer process (e. g., deposition/lift-off). Different from the direct gap-writing process,the nanogap precursor structures (nanoconnections) were designed by GDSII software and then written by electron beam. Following a deposition and lift-off process, the metal nanogaps were obtained and the nanogap size can be lowered to -10nm by controlling the exposure dose in EBL.展开更多
Recently, the study on one-dimensional thermoelectric materials is getting more and more attention. For those one-dimensional thermoelectric materials with nanowire array structure fabricated with alumina film as temp...Recently, the study on one-dimensional thermoelectric materials is getting more and more attention. For those one-dimensional thermoelectric materials with nanowire array structure fabricated with alumina film as template, its thickness is often in the range of 10 to several tens micrometers, and the conventional measurement cannot be used. The key difficulties of the thermoelectric performance measurement for nanowire array materials include two aspects: 1) How to heat the two sides of the specimen uniformly and keep the temperature difference constantly at the same time; 2) How to measure the temperature of the two sides of the specimen with the thickness of 10 to several tens micrometers. A new type heating and temperature measuring technology has been used, and it can be simply described as liquid heating and separate temperature measurement. According to this principle, a thermoelectric performance measurement system has been established.展开更多
Inflammatory bowel diseases (IBDs) such as Crohn's disease are highly debilitating. There are inconsistencies in response to and side effects in the current conventional medications, failures in adequate drug deli...Inflammatory bowel diseases (IBDs) such as Crohn's disease are highly debilitating. There are inconsistencies in response to and side effects in the current conventional medications, failures in adequate drug delivery, and the lack of therapeutics to offer complete remission in the presently available treatments of IBD. This suggests the need to explore beyond the horizons of conventional approaches in IBD therapeutics. This review examines the arena of the evolving IBD nanomedicine, studied so far in animal and in vitro models, before comprehensive clinical testing in humans. The investigations carried out so far in IBD models have provided substantial evidence of the nanotherapeutic approach as having the potential to overcome some of the current drawbacks to conventional IBD therapy. We analyze the pros and cons of nanotechnology in IBD therapies studied in different models, aimed at different targets and mechanisms of IBD pathogenesis, in an attempt to predict its possible impact in humans.展开更多
Here we report a femtosecond laser direct writing(a precise 3D printing also known as two-photon polymerization lithography) of hybrid organic-inorganic SZ2080^(TM)pre-polymer without using any photo-initiator and app...Here we report a femtosecond laser direct writing(a precise 3D printing also known as two-photon polymerization lithography) of hybrid organic-inorganic SZ2080^(TM)pre-polymer without using any photo-initiator and applying ~100 fs oscillator operating at 517 nm wavelength and 76 MHz repetition rate. The proof of concept was experimentally demonstrated and benchmarking 3D woodpile nanostructures, micro-scaffolds, free-form micro-object “Benchy” and bulk micro-cubes are successfully produced. The essential novelty underlies the fact that non-amplified laser systems delivering just 40-500 p J individual pulses are sufficient for inducing localized cross-linking reactions within hundreds of nanometers in cross sections. And it is opposed to the prejudice that higher pulse energies and lower repetition rates of amplified lasers are necessary for structuring non-photosensitized polymers. The experimental work is of high importance for fundamental understanding of laser enabled nanoscale 3D additive manufacturing and widens technology’ s field of applications where the avoidance of photo-initiator is preferable or is even a necessity, such as micro-optics, nano-photonics, and biomedicine.展开更多
Nanometer materials include roughly nanoparticle,nanotube, nanowire, nanofiber, nanofilm and nanoblock, among which nanofiber is defined as material with nanometer-sized diameter and longer than 1 micron in length. Th...Nanometer materials include roughly nanoparticle,nanotube, nanowire, nanofiber, nanofilm and nanoblock, among which nanofiber is defined as material with nanometer-sized diameter and longer than 1 micron in length. The research development of polymer nanofibers, including manufacture methods and properties of some polymer nanofibers as well as their potential applications is reviewed.展开更多
Large-scale amorphous silicon nanowires (SiNWs) with a diameter about 100 nm and a length of dozens of micrometers on silicon wafers were synthesized by thermal evaporation of silicon monoxide (SiO). Scanning electron...Large-scale amorphous silicon nanowires (SiNWs) with a diameter about 100 nm and a length of dozens of micrometers on silicon wafers were synthesized by thermal evaporation of silicon monoxide (SiO). Scanning electron microscope (SEM) and transmission electron microscope (TEM) observations show that the silicon nanowires are smooth. Selected area electron diffraction (SAED) shows that the silicon nanowires are amorphous and en-ergy-dispersive X-ray spectroscopy (EDS) indicates that the nanowires have the composition of Si and O elements in an atomic ratio of 1:2,their composition approximates that of SiO2. SiO is considered to be used as a Si sources to produce SiNWs. We conclude that the growth mechanism is closely related to the defect structure and silicon monoxide followed by growth through an oxide-assisted vapor-solid reaction.展开更多
Three different nitrogen ion doses were implanted into a Ti6A14V alloy to improve its mechanical surface properties for the application of artificial joints. The titanium nitride phase and nitrogen element distributio...Three different nitrogen ion doses were implanted into a Ti6A14V alloy to improve its mechanical surface properties for the application of artificial joints. The titanium nitride phase and nitrogen element distribution profile were characterized with X-ray photoelectron spectroscopy (XPS). Nano-indentation tests were carried out on the surface of the Ti6A14V alloy and implanted samples on a large scale of applied loads. The XPS analysis results indicate that nitrogen diffuses into the titanium alloy and forms a hard TiN layer on the Ti6A14V alloy. The nanohardness results reveal that nitrogen ion implantation effectively enhances the surface hardness of Ti6A14V. In addition, the nanohardness clearly reveals load dependence over a large segment of the applied loads. Thus a concept of nanohardness fractal dimension is first proposed and the dual fractal model can effectively describe nonlinear deformation in indentation areas on the Ti6A14V surface. The fractal dimension shows a decreased trend in two regions of applied loads, indicating a decrease of the self-similarity complexity in surface indentation owing to an increase in nanohardness after nitrogen ion implantation.展开更多
Cancer is a major threat to public health in the 21st century because it is one of the leading causes of death worldwide.The mechanisms of carcinogenesis,cancer invasion,and metastasis remain unclear.Thus,the developm...Cancer is a major threat to public health in the 21st century because it is one of the leading causes of death worldwide.The mechanisms of carcinogenesis,cancer invasion,and metastasis remain unclear.Thus,the development of a novel approach for cancer detection is urgent,and real-time monitoring is crucial in revealing its underlying biological mechanisms.With the optical and chemical advantages of quantum dots(QDs),QD-based nanotechnology is helpful in constructing a biomedical imaging platform for cancer behavior study.This review mainly focuses on the application of QD-based nanotechnology in cancer cell imaging and tumor microenvironment studies both in vivo and in vitro,as well as the remaining issues and future perspectives.展开更多
The absorption process of radiative heat in its transmission medium and the effect of ultra-attenuation on the radiative characteristics are analyzed in detail. A method of ultra-attenuation to enhance the radiative c...The absorption process of radiative heat in its transmission medium and the effect of ultra-attenuation on the radiative characteristics are analyzed in detail. A method of ultra-attenuation to enhance the radiative characteristics of the medium is proposed. It is proved that decreasing the particle size of coatings can increase the transmission depth of radiative heat and get higher emissivity and absorptivity both theoretically and practically. Ultra-attenuation and nanocrystallization will bring a brilliant prospect to the development of radiative coatings.展开更多
A simple chemical method was employed to coat carbon nanotubes with a layer of copper. Due to the hydrophobic nature, large surface curvature, small diameter and large aspect ratio, it is difficult to gain continuous ...A simple chemical method was employed to coat carbon nanotubes with a layer of copper. Due to the hydrophobic nature, large surface curvature, small diameter and large aspect ratio, it is difficult to gain continuous electroless plating layer on the surface of carbon nanotubes. In this paper, a series methods (oxidization, sensitization and activation) are used to add active sites before electroless plating, and the adjustment of the traditional composition of copper electroless plating bath and operating condition can decelerate electroless plating rate. The samples before and after coating were analyzed using transmission electron microscopy and energy-dispersive X-ray spectroscopy. The results showed that the surface of carbon nanotubes was successfully coated with continuous layer of copper, which lays a good foundation for applying carbon nanotubes in composites.展开更多
In nanoscale technology, transistor aging is one of the most critical problems that impact on the reliability of circuits. Aging sensor is a good online way to detect the circuit aging, which performs during the opera...In nanoscale technology, transistor aging is one of the most critical problems that impact on the reliability of circuits. Aging sensor is a good online way to detect the circuit aging, which performs during the operating time with no influence of the normal operation of circuits. In this paper, a Dou- ble-edge-triggered Detection Sensor for circuit Aging (DSDA) is proposed, which employs data signal of logic circuits as its clock to control the sampling process. The simulation is done by Hspice using 45 nm technology. The results show that this technique is not case of the detection precision is more than 80% under aging fault effectively with the 8% power cost and 30% sensitive to the process variations. The worst the different process variations. It can detect performance cost.展开更多
In this paper, nanotechnology for the improvement of dental composite resins has been reviewed in the background of the existing shortcomings, focusing on the improvement for polymerization shrinkage, anti-bacterial p...In this paper, nanotechnology for the improvement of dental composite resins has been reviewed in the background of the existing shortcomings, focusing on the improvement for polymerization shrinkage, anti-bacterial properties and mechanical properties of composite resins. The results show that the use of nanotechnology and nano materials can be an effective method to improve the performance of dental composite resins in a various ways. At last, the paper also discusses the perspective about the dental composite resins.展开更多
Platinum-based anticancer agents are widely used as first-line drugs in cancer chemotherapy for various solid tumors. However, great side effects and occurrence of resistance remain as the major drawbacks for almost a...Platinum-based anticancer agents are widely used as first-line drugs in cancer chemotherapy for various solid tumors. However, great side effects and occurrence of resistance remain as the major drawbacks for almost all the platinum drugs developed. To conquer these problems, new strategies should be adopted for platinum drug based chemotherapy. Modern nanotechnology has been widely employed in the delivery of various therapeutics and diagnostic. It provides the possibility of targeted delivery of a certain anticancer drug to the tumor site, which could minimize toxicity and optimize the drug efficacy. Here, in this review, we focused on the recent progress in polymer based drug delivery systems for platinum-based combination therapy.展开更多
A BiOCl-Bi12O17Cl2 nanocomposite with a high visible-light response and a low photoinduced electron-hole pair recombination rate was successfully synthesized using an ultrasonic-hydrothermal method.The texture,structu...A BiOCl-Bi12O17Cl2 nanocomposite with a high visible-light response and a low photoinduced electron-hole pair recombination rate was successfully synthesized using an ultrasonic-hydrothermal method.The texture,structure,optical,and photocatalytic properties of the composite were characterized.The results showed that the composite had a sheet flower-like structure with a large specific surface area.Ultraviolet-visible diffuse reflection spectra and photoluminescence spectra showed that the composite had an excellent visible-light response and a low recombination rate of photoinduced electron hole pairs.The photocatalytic property of the composite was evaluated by the removal efficiency of rhodamine B and ciprofloxacin under visible-light illumination.The composite’s reaction rate constant of removing rhodamine B(/ciprofloxacin)was approximately 8.14(/4.94),42.63(/11.91)and 64.66(/36.07)times that of Bi12O17Cl2,P25,and BiOCl,respectively.Furthermore,the composite showed a wide applicable pH range and excellent reusability.Mechanism analysis showed that photogenerated holes played a dominant role and·O2–also contributed to photocatalytic degradation.In summary,this study presents a high-efficiency photocatalyst for wastewater treatment.展开更多
文摘This paper studies the preparation method of As_2O_3 nanoparticles and theirantitumor effect on human liver cancer cells. As_2O_3 nanoparticles were prepared by sol-gel method.As_2O_3 nanoparticles were characterized by transmission electron microscope ( TEM), energydispersive spectrometer ( EDS) and computer color magic image analysis system (CMIAS). A methylthiazolyl tetrazolium (MTT) assay and a flow cytometry (FCM) assay were performed to examine theantitumor effect of As_2O_3 nanoparticlesat various concentrations(1, 2, 5, 10 mumol/L). We alsocompared the antitumor effect of As_2O_3 nanoparticles with that of As_2O_3 solution. The averagediameters of two kinds of As_2O_3 nanoparticles prepared were about 80 nm and 40 nm. It wasidentified that the prepared nanoparticles were As_2O_3 and there were no other components by EDS.After 48 h of treatment with As_2O_3 nanoparticles, the survival ratio of cells was significantlylower than that of the As2O3 solution with the same concentration(P < 0. 05). Experimental resultsdemonstrate that by sol-gel method As_2O_3 can be prepared into nanoparticles. As_2O_3 nanoparticlescan produce a better cytotoxic effect on tumor cells than the As_2O_3 solution.
基金the National Natural Science Foundation of China(No.50 0 71 0 4 0 )
文摘In the fabrication of Bi nanowire array thermoelectric materials,electrodeposition technology has been used to deposit bismuth into the nanopores of anodic alumina porous films.The experiments show that the temperature significantly affects the electrodepositing process,and the simple form of Bi 3+ in the solutions is helpful to the deposition of metal Bi.The pulse plating technique is necessary for the electrodeposition because of the diffusive difficulty of Bi 3+ into the nanopores of the films.The XRD analysis indicates that Bi nanowire arrays have been manufactured by this technology.
基金the National Natural Science Foundation of China(No.20704042)the Shanghai Pujiang Talent Plan(No.07PJ14095)+1 种基金the CAS Knowledge Innovation Programthe Committee of Science and Technology of Shanghai(Nos.06XD14020,07JC14058,0752nm016)~~
文摘We describe the fabrication of metal nanogaps of sub-20nm in feature size using the proximity effect in electron beam lithography (EBL). The proximity effect is extended to develop a flexible and practical method for preparing metal (e. g. Au or Ag) nanogaps and arrays in combination with a transfer process (e. g., deposition/lift-off). Different from the direct gap-writing process,the nanogap precursor structures (nanoconnections) were designed by GDSII software and then written by electron beam. Following a deposition and lift-off process, the metal nanogaps were obtained and the nanogap size can be lowered to -10nm by controlling the exposure dose in EBL.
文摘Recently, the study on one-dimensional thermoelectric materials is getting more and more attention. For those one-dimensional thermoelectric materials with nanowire array structure fabricated with alumina film as template, its thickness is often in the range of 10 to several tens micrometers, and the conventional measurement cannot be used. The key difficulties of the thermoelectric performance measurement for nanowire array materials include two aspects: 1) How to heat the two sides of the specimen uniformly and keep the temperature difference constantly at the same time; 2) How to measure the temperature of the two sides of the specimen with the thickness of 10 to several tens micrometers. A new type heating and temperature measuring technology has been used, and it can be simply described as liquid heating and separate temperature measurement. According to this principle, a thermoelectric performance measurement system has been established.
文摘Inflammatory bowel diseases (IBDs) such as Crohn's disease are highly debilitating. There are inconsistencies in response to and side effects in the current conventional medications, failures in adequate drug delivery, and the lack of therapeutics to offer complete remission in the presently available treatments of IBD. This suggests the need to explore beyond the horizons of conventional approaches in IBD therapeutics. This review examines the arena of the evolving IBD nanomedicine, studied so far in animal and in vitro models, before comprehensive clinical testing in humans. The investigations carried out so far in IBD models have provided substantial evidence of the nanotherapeutic approach as having the potential to overcome some of the current drawbacks to conventional IBD therapy. We analyze the pros and cons of nanotechnology in IBD therapies studied in different models, aimed at different targets and mechanisms of IBD pathogenesis, in an attempt to predict its possible impact in humans.
基金Project(S-MIP-20-17) supported by the Research Council of LithuaniaProject(871124) supported by the EU Horizon 2020, Research and Innovation program LASERLAB-EUROPE JRA。
文摘Here we report a femtosecond laser direct writing(a precise 3D printing also known as two-photon polymerization lithography) of hybrid organic-inorganic SZ2080^(TM)pre-polymer without using any photo-initiator and applying ~100 fs oscillator operating at 517 nm wavelength and 76 MHz repetition rate. The proof of concept was experimentally demonstrated and benchmarking 3D woodpile nanostructures, micro-scaffolds, free-form micro-object “Benchy” and bulk micro-cubes are successfully produced. The essential novelty underlies the fact that non-amplified laser systems delivering just 40-500 p J individual pulses are sufficient for inducing localized cross-linking reactions within hundreds of nanometers in cross sections. And it is opposed to the prejudice that higher pulse energies and lower repetition rates of amplified lasers are necessary for structuring non-photosensitized polymers. The experimental work is of high importance for fundamental understanding of laser enabled nanoscale 3D additive manufacturing and widens technology’ s field of applications where the avoidance of photo-initiator is preferable or is even a necessity, such as micro-optics, nano-photonics, and biomedicine.
文摘Nanometer materials include roughly nanoparticle,nanotube, nanowire, nanofiber, nanofilm and nanoblock, among which nanofiber is defined as material with nanometer-sized diameter and longer than 1 micron in length. The research development of polymer nanofibers, including manufacture methods and properties of some polymer nanofibers as well as their potential applications is reviewed.
文摘Large-scale amorphous silicon nanowires (SiNWs) with a diameter about 100 nm and a length of dozens of micrometers on silicon wafers were synthesized by thermal evaporation of silicon monoxide (SiO). Scanning electron microscope (SEM) and transmission electron microscope (TEM) observations show that the silicon nanowires are smooth. Selected area electron diffraction (SAED) shows that the silicon nanowires are amorphous and en-ergy-dispersive X-ray spectroscopy (EDS) indicates that the nanowires have the composition of Si and O elements in an atomic ratio of 1:2,their composition approximates that of SiO2. SiO is considered to be used as a Si sources to produce SiNWs. We conclude that the growth mechanism is closely related to the defect structure and silicon monoxide followed by growth through an oxide-assisted vapor-solid reaction.
基金Projects 2007CB607605 supported by the Major State Basic Research and Development Program of China50535050, 50225519, 50405042 by the National Natural Science Foundation of China2005B032 by the Science Foundation of China University of Mining and Technology
文摘Three different nitrogen ion doses were implanted into a Ti6A14V alloy to improve its mechanical surface properties for the application of artificial joints. The titanium nitride phase and nitrogen element distribution profile were characterized with X-ray photoelectron spectroscopy (XPS). Nano-indentation tests were carried out on the surface of the Ti6A14V alloy and implanted samples on a large scale of applied loads. The XPS analysis results indicate that nitrogen diffuses into the titanium alloy and forms a hard TiN layer on the Ti6A14V alloy. The nanohardness results reveal that nitrogen ion implantation effectively enhances the surface hardness of Ti6A14V. In addition, the nanohardness clearly reveals load dependence over a large segment of the applied loads. Thus a concept of nanohardness fractal dimension is first proposed and the dual fractal model can effectively describe nonlinear deformation in indentation areas on the Ti6A14V surface. The fractal dimension shows a decreased trend in two regions of applied loads, indicating a decrease of the self-similarity complexity in surface indentation owing to an increase in nanohardness after nitrogen ion implantation.
基金supported by the Academic Award for Excellent Ph.D.Candidates Funded by the Ministry of Education of China(No.5052011303014)the National Natural Science Foundation of China(No.81171396)+1 种基金the Science Fund for Creative Research Groups of the National Natural Science Foundation of China(Nos.20621502 and 20921062)the Fundamental Research Funds for the Central Universities of Ministry of Education of China(No.4103005).
文摘Cancer is a major threat to public health in the 21st century because it is one of the leading causes of death worldwide.The mechanisms of carcinogenesis,cancer invasion,and metastasis remain unclear.Thus,the development of a novel approach for cancer detection is urgent,and real-time monitoring is crucial in revealing its underlying biological mechanisms.With the optical and chemical advantages of quantum dots(QDs),QD-based nanotechnology is helpful in constructing a biomedical imaging platform for cancer behavior study.This review mainly focuses on the application of QD-based nanotechnology in cancer cell imaging and tumor microenvironment studies both in vivo and in vitro,as well as the remaining issues and future perspectives.
文摘The absorption process of radiative heat in its transmission medium and the effect of ultra-attenuation on the radiative characteristics are analyzed in detail. A method of ultra-attenuation to enhance the radiative characteristics of the medium is proposed. It is proved that decreasing the particle size of coatings can increase the transmission depth of radiative heat and get higher emissivity and absorptivity both theoretically and practically. Ultra-attenuation and nanocrystallization will bring a brilliant prospect to the development of radiative coatings.
文摘A simple chemical method was employed to coat carbon nanotubes with a layer of copper. Due to the hydrophobic nature, large surface curvature, small diameter and large aspect ratio, it is difficult to gain continuous electroless plating layer on the surface of carbon nanotubes. In this paper, a series methods (oxidization, sensitization and activation) are used to add active sites before electroless plating, and the adjustment of the traditional composition of copper electroless plating bath and operating condition can decelerate electroless plating rate. The samples before and after coating were analyzed using transmission electron microscopy and energy-dispersive X-ray spectroscopy. The results showed that the surface of carbon nanotubes was successfully coated with continuous layer of copper, which lays a good foundation for applying carbon nanotubes in composites.
基金Supported by the National Natural Science Foundation of China (No.61274036 and 61106038)Anhui Provincial Natural Science Foundation of China (No.090412034)
文摘In nanoscale technology, transistor aging is one of the most critical problems that impact on the reliability of circuits. Aging sensor is a good online way to detect the circuit aging, which performs during the operating time with no influence of the normal operation of circuits. In this paper, a Dou- ble-edge-triggered Detection Sensor for circuit Aging (DSDA) is proposed, which employs data signal of logic circuits as its clock to control the sampling process. The simulation is done by Hspice using 45 nm technology. The results show that this technique is not case of the detection precision is more than 80% under aging fault effectively with the 8% power cost and 30% sensitive to the process variations. The worst the different process variations. It can detect performance cost.
文摘In this paper, nanotechnology for the improvement of dental composite resins has been reviewed in the background of the existing shortcomings, focusing on the improvement for polymerization shrinkage, anti-bacterial properties and mechanical properties of composite resins. The results show that the use of nanotechnology and nano materials can be an effective method to improve the performance of dental composite resins in a various ways. At last, the paper also discusses the perspective about the dental composite resins.
基金supported by Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
文摘Platinum-based anticancer agents are widely used as first-line drugs in cancer chemotherapy for various solid tumors. However, great side effects and occurrence of resistance remain as the major drawbacks for almost all the platinum drugs developed. To conquer these problems, new strategies should be adopted for platinum drug based chemotherapy. Modern nanotechnology has been widely employed in the delivery of various therapeutics and diagnostic. It provides the possibility of targeted delivery of a certain anticancer drug to the tumor site, which could minimize toxicity and optimize the drug efficacy. Here, in this review, we focused on the recent progress in polymer based drug delivery systems for platinum-based combination therapy.
基金supported by National Water Pollution Control and Treatment Science and Technology Major Project(2018ZX07110003)Key Research and Development Project of Shandong Province(2018CXGC1007)~~
文摘A BiOCl-Bi12O17Cl2 nanocomposite with a high visible-light response and a low photoinduced electron-hole pair recombination rate was successfully synthesized using an ultrasonic-hydrothermal method.The texture,structure,optical,and photocatalytic properties of the composite were characterized.The results showed that the composite had a sheet flower-like structure with a large specific surface area.Ultraviolet-visible diffuse reflection spectra and photoluminescence spectra showed that the composite had an excellent visible-light response and a low recombination rate of photoinduced electron hole pairs.The photocatalytic property of the composite was evaluated by the removal efficiency of rhodamine B and ciprofloxacin under visible-light illumination.The composite’s reaction rate constant of removing rhodamine B(/ciprofloxacin)was approximately 8.14(/4.94),42.63(/11.91)and 64.66(/36.07)times that of Bi12O17Cl2,P25,and BiOCl,respectively.Furthermore,the composite showed a wide applicable pH range and excellent reusability.Mechanism analysis showed that photogenerated holes played a dominant role and·O2–also contributed to photocatalytic degradation.In summary,this study presents a high-efficiency photocatalyst for wastewater treatment.