长征胜利的“终点”与“起点”研究

长征的“起点”不是单纯地理意义上的概念,而是中央红军由不成熟走向成熟的起点。长征的“终点”不是地域上的尽头,而是党和中央红军建立新的革命根据地的起点。“起点”与“终点”的转换是在以解决以王明为代表的“左”倾教条主义的错误,确立以毛泽东为代表的正确领导地位,摆脱共产国际的干预和控制,确定北上抗日的根本主张,促成抗日民族统一战线的建立。长征是共产党人第一次把马列主义同中国革命的实际情况相结合,独立自主的制定出路线、方针、政策,找到的一条适合中国国情的革命道路。

课堂提问的三个有效“落点”

数学课堂教学中,要使教学达到事半功倍的效果,教师可通过提问给学生创设思维空间,激发学生的探究欲望,引导学生自主学习。因此,教师应积极探究提问的有效“落点”,让数学课堂教学更高效。

In-line spectroscopy combined with multivariate analysis methods for endpoint determination in column chromatographic adsorption processes for herbal medicine

Objective: In a chromatographic cycle, the adsorption process is a critical unit operation that has a significant impact on downstream processes and, ultimately, the quality of the final products. The development of a rapid method to determine the endpoints of adsorption processes in a large-scale manufacturing is of substantial importance for herbal medicine(HM) manufacturers.Methods: In this study, the adsorption of saponins on a macroporous resin column chromatograph, a critical unit operation in Panax notoginseng(Burkill) F.H.Chen injection manufacturing, was considered as an example. The evaluation results of in-line ultraviolet and visible spectra combined with various multivariate analysis methods, including the moving block standard deviation(MBSD), difference between the moving block average and the target spectrum(DMBA-TS), soft-independent modeling of class analogy(SIMCA), and partial least-squares discriminant analysis(PLS-DA), were compared.Results: MBSD was unsuitable for adsorption processes. The relative standard errors of prediction between the predicted and experimental endpoints were 13.2%, 4.67%, and 5.71% using DMBA-TS, SIMCA, and PLS-DA, respectively.Conclusions: Among the considered analysis methods, SIMCA and PLS-DA were more effective for endpoint determination. The results of this study provide a more comprehensive overview of the effectiveness of various multivariate analysis methods to facilitate the selection of the most suitable method. This study was also conducive to address the issues of the in-line detection of adsorption endpoints to guide practical HM manufacturing.

Unprecedented Retreat in a 50-Year Observational Record for Petermann Glacier, North Greenland

Petermann Glacier is a marine-terminating outlet glacier that had a 70 km-long floating ice tongue prior to a ～ 270 km2 calving event that was observed from satellite sensors in August 2010,shortening the ice tongue by ～ 27 km.Further,in July 2012,another 10 km was lost through calving.In order to understand these events in perspective,here the authors perform a long-term data analysis of Petermann Glacier calving-front variability and ice velocity for each year in the 1990s-2000s,supplemented by available observations from the previous three decades.Five major （on the order of 100 krm2） calving events are identified,with ～ 153 km2 calved from 1959 to 1961,～ 168 km2 in 1991,～ 71 km2 in 2001,～ 270 km2 in 2010,and ～ 130 km2 in 2012-as well as ～ 31 k m2 calved in 2008.The increased frequency of major calving events in recent years has left the front terminus position retreated nearly 25 km beyond the range of observed in previous decades.In contrast,stable ice-dynamics are suggested from ice-velocity measurements made each year between 1993-2012,which are on average 1063 m yr-1,with limited interannual variability and no significant trend; moreover,there is no apparent relationship between ice-velocity variability and calving events.The degree to which the massive calving events in 2010 and 2012 represent natural episodic variability or a response to atmospheric and/or oceanic changes remains speculative; however,melt-induced weakening of the floating ice tongue in recent years is strongly suggested.

高考奇迹背后:唤醒学生沉睡的“我”——对北京市立新学校曾军良校长教育教学经验的学习与思考

北京市立新学校曾军良校长从教26年,进行过上百个教育教学实验。其对学生进行激励教育,用爱与智慧"推动学生发展";用创新思维推动学校工作系统变革,在如课堂管理、命题管理、班会管理等多方面切实落实学生的主体地位,提升教师专业水平,在"终点思考"中不断超越自我。

Factors Determining the Development of Non-cash Payments in Rural Areas in Poland

This article aims at characterization and assessment of the financial behaviors of rural dwellers on non-cash payment markets and identification of factors determining the intensity of using individual methods of payment by the inhabitants of rural areas. The main source of data used for analysis and inference was information originating from the authors＇ own investigations conducted in 2013 on a group of 500 rural households and on a group of 150 trade and service points operating in non-urbanized areas. This work made use of statistical summary measures and Z2 independence test. According to the results of the conducted studies, forms of payment used by rural dwellers depend on many variables, of demographic, economic, and psychological character. Cash payments are more frequently used by persons possessing vocational or secondary education, elderly people, old-age pensioners, annuitants, or households with lower incomes. Also, persons who do not trust financial institutions or do not perceive benefits resulting from the use of non-cash instruments prefer cash. It is a group of households which require urgent educational activities in the area of non-cash payment instruments. A significant barrier to using non-cash payment instruments by rural dwellers was a limited access to non-cash channels. It is connected in the first place with a poorer development of financial infrastructure in rural areas （banks or cash points）, insufficient Internet access conditioning a possibility to use electronic banking points, and also a worse development of credit card acceptance network. As has been demonstrated by the results of conducted studies, the main reason for a lack of point of sale （POS） terminals in retail and service-providing points operating in rural areas, in the opinion of their owners, is the very high interchange fee （50% indications）, which under Polish conditions is one of the highest in the European Union （EU）.

Effect of Serial PMSs on Operational Benefits of Arrival Flights

In order to alleviate the flight congestion in terminal areas(TMAs),it is of great significance to develop an effective method.An arrival sequencing model based on the serial point merge systems(PMSs)is constructed to improve the operational benefits of arrival flights.The approach of first come first service(FCFS)combined with the method of constraint position shift(CPS)is used as the sequencing strategy.Through the simulated annealing algorithm,the results show that the arrival flights sequencing through serial PMSs has significant advantages in reducing delays and increasing runway throughput especially in the case of high traffic loads.The proposed approach is conducive in promoting the implementation and application of serial PMS.

Lossy nodes inference based on end-to-end passive monitoring in wireless sensor networks

This paper presents a passive monitoring mechanism, loss）, nodes inference （LoNI）, to identify loss）, nodes in wireless sensor network using end-to-end application traffic. Given topology dynamics and bandwidth constraints, a space-efficient packet marking scheme is first introduced. The scheme uses a Bloom filter as a compression tool so that path information can bc piggybacked by data packets. Based on the path information, LoNI then adopts a fast algorithm to detect lossy nodes. The algorithm formulates the inference problem as a weighted set-cover problem and solves it using a greedy approach with low complexity. Simulations show that LoNI can locate about 80% of lossy nodes when lossy nodes are rare in the network. Furthermore, LoNI performs better for the lossy nodes near the sink or with higher loss rates.

Efficacy and safety of chiglitazar,a novel peroxisome proliferatoractivated receptor pan-agonist,in patients with type 2 diabetes:a randomized,double-blind,placebo-controlled,phase 3 trial(CMAP)

Chiglitazar(Carfloglitazar)is a novel non-thiazolidinedione(TZD)structured peroxisome proliferatoractivated receptor(PPAR)pan-agonist that has shown promising effects on glycemic control and lipid regulation in patients with type 2 diabetes in previous clinical studies.This randomized phase 3 trial aimed to compare the efficacy and safety of chiglitazar with placebo in patients with type 2 diabetes with insufficient glycemic control by strict diet and exercise alone.Eligible patients were randomly assigned to receive chiglitazar 32 mg(n=167),chiglitazar 48 mg(n=166),or placebo(n=202)once daily.The primary endpoint was the change in glycosylated hemoglobin A_(1c)(HbA_(1c))at week 24 with superiority of chiglitazar over placebo.The results showed that both chiglitazar 32 and 48 mg resulted in significant and clinically meaningful reductions in HbA_(1c),and placebo-adjusted estimated treatment differences at week 24 for chiglitazar 32 and 48 mg were-0.87%(95%confidential interval(CI):-1.10 to-0.65;P<0.0001)and-1.05%(95%CI:-1.29 to-0.81;P<0.0001),respectively.Secondary efficacy parameters including glycemic control,insulin sensitivity and triglyceride reduction were also significantly improved in the chiglitazar groups.The overall frequency of adverse events and study discontinuation attributable to adverse events were similar among the groups.Low incidences of mild edema and body weight gain were reported in the chiglitazar dose groups.The results from this phase 3 trial demonstrated that the PPAR pan-agonist chiglitazar possesses an overall good efficacy and safety profile in patients with type 2 diabetes inadequately controlled with lifestyle interventions,thereby providing adequate supporting evidence for using this PPAR pan-agonist as a treatment option for type 2 diabetes.

A near-infrared spectroscopy-based end-point determination method for the blending process of Dahuang soda tablets

Objectives:This study is aimed to explore the blending process of Dahuang soda tablets.These are composed of two active pharmaceutical ingredients(APIs,emodin and emodin methyl ether)and four kinds of excipients(sodium bicarbonate,starch,sucrose,and magnesium stearate).Also,the objective is to develop a more robust model to determine the blending end-point.Methods:Qualitative and quantitative methods based on near-infrared(NIR)spectroscopy were established to monitor the homogeneity of the powder during the blending process.A calibration set consisting of samples from 15 batches was used to develop two types of calibration models with the partial least squares regression(PLSR)method to explore the influence of density on the model robustness.The principal component analysis-moving block standard deviation(PCA-MBSD)method was used for the end-point determination of the blending with the process spectra.Results:The model with different densities showed better prediction performance and robustness than the model with fixed powder density.In addition,the blending end-points of APIs and excipients were inconsistent because of the differences in the physical properties and chemical contents among the materials of the design batches.For the complex systems of multi-components,using the PCA-MBSD method to determine the blending end-point of each component is difficult.In these conditions,a quantitative method is a more suitable alternative.Conclusions:Our results demonstrated that the effect of density plays an important role in improving the performance of the model,and a robust modeling method has been developed.