太行抗日根据地的反“维持”斗争

从1941年初开始,日伪在对抗日根据地进行的“扫荡”中更加注重政治进攻。在日伪的威逼利诱之下,太行抗日根据地内发生了一些“维持”现象。这对党与群众的联系造成了疏远和弱化,削弱了部分干部群众的对敌斗争意志,对根据地和党的生存空间造成严重危害。通过分析发生“维持”的原因,太行抗日根据地有针对性地采取了多项举措,明确斗争策略的适用范围和限度,切实执行土地政策,发动群众开展锄奸反特工作,扩充群众武装开展游击战,积极进行反“维持”斗争。这些正确的举措改善了群众生活,激发了群众斗争热情,清除了日伪发动“维持”的爪牙,壮大了群众武装力量,推动了抗日游击战争的深入开展,从而取得了反“维持”斗争的胜利。太行抗日根据地反“维持”斗争的胜利表明,密切联系群众,才能取得群众的支持,而这也是党的最大政治优势。

蒙古族药那如-3抑制星形胶质细胞活化对神经病理性疼痛“维持期”神经炎症的干预作用

神经病理性疼痛(NP)临床治疗棘手,其表型相似但不同病理阶段病机各异,靶向干预NP不同病理阶段核心调控元件成为近年来药物研发新方向并为NP的救治提供了可能。蒙古族药那如-3(NR-3)临床治疗坐骨神经痛、三叉神经痛等全程皆效,但机制不明。该研究在前期“启动期”研究的基础上,建立小鼠脊神经结扎(SNL)模型并采用行为学检测痛敏阈值变化,结合网络分析、Western blot、免疫荧光、ELISA检测、激动剂/拮抗剂等探讨NR-3治疗NP“维持期”的药效机制。结果显示,NR-3可以提高“维持期”SNL小鼠机械痛敏与热痛敏阈值而对正常小鼠基础痛阈无明显影响。实验进一步以背根神经节(DRG)、病变脊髓节段为研究对象发现NR-3对NP“维持期”发挥镇痛作用机制可能与其破坏DRG、脊髓星形胶质细胞的基质金属蛋白酶2(MMP2)/白细胞介素-1β(IL-1β)炎症通路相关。相关研究丰富了NR-3治疗NP“维持期”的生物学内涵,并为其临床合理用药提供了参考。

基于网络资源的计算机文化双语教学的实践和思考

基于网络资源的优势,对计算机文化双语教学具有很重要的意义。在计算机文化双语教学实践中,分了三种课型及对应的教学模式和教学策略,还有评价方法。通过实践,对其进行了三方面的反思。

DIMENSIONALITY REDUCTION BASED ON SVM AND LDA,AND ITS APPLICATION TO CLASSIFICATION TECHNIQUE

Some dimensionality reduction （DR） approaches based on support vector machine （SVM） are proposed. But the acquirement of the projection matrix in these approaches only considers the between-class margin based on SVM while ignoring the within-class information in data. This paper presents a new DR approach, call- ed the dimensionality reduction based on SVM and LDA （DRSL）. DRSL considers the between-class margins from SVM and LDA, and the within-class compactness from LDA to obtain the projection matrix. As a result, DRSL can realize the combination of the between-class and within-class information and fit the between-class and within-class structures in data. Hence, the obtained projection matrix increases the generalization ability of subsequent classification techniques. Experiments applied to classification techniques show the effectiveness of the proposed method.

SELF-DEPENDENT LOCALITY PRESERVING PROJECTION WITH TRANSFORMED SPACE-ORIENTED NEIGHBORHOOD GRAPH

Locality preserving projection （LPP） is a typical and popular dimensionality reduction （DR） method,and it can potentially find discriminative projection directions by preserving the local geometric structure in data. However,LPP is based on the neighborhood graph artificially constructed from the original data,and the performance of LPP relies on how well the nearest neighbor criterion work in the original space. To address this issue,a novel DR algorithm,called the self-dependent LPP （sdLPP） is proposed. And it is based on the fact that the nearest neighbor criterion usually achieves better performance in LPP transformed space than that in the original space. Firstly,LPP is performed based on the typical neighborhood graph; then,a new neighborhood graph is constructed in LPP transformed space and repeats LPP. Furthermore,a new criterion,called the improved Laplacian score,is developed as an empirical reference for the discriminative power and the iterative termination. Finally,the feasibility and the effectiveness of the method are verified by several publicly available UCI and face data sets with promising results.

Wnt signaling in disease and in development

The highly conserved Wnt secreted proteins are critical mediators of cell-to-cell signaling during development of animals. Recent biochemical and genetic analyses have led to significant insight into understanding how Wnt signals work. The catalogue of Wnt signaling components has exploded. We now realize that multiple extracellular, cytoplasmic, and nuclear components modulate Wnt signaling. Moreover, receptor-ligand specificity and multiple feedback loops determine Wnt signaling outputs. It is also clear that Wnt signals are required for adult tissue maintenance. Perturbations in Wnt signaling cause human degenerative diseases as well as cancer.

论蒲安臣的“合作政策”得以推行的因素

“合作政策”是由美国倡导,美、英、法、俄公使共同推行的列强联合对华政策。19世纪60年代,中国对外关系开始出现了新的变化;西方也出现了相对稳定的局面;在中国,列强要求保持在华的均势。这些因素使合作政策得以正常运行。由于合作政策的推行,使列强取得了在华的特殊利益,它对近代中外关系也产生了一定的影响。

DUAL-SPARSITY PRESERVING PROJECTION

Sparsity preserving projection（SPP） is a popular graph-based dimensionality reduction（DR） method, which has been successfully applied to solve face recognition recently. SPP contains natural discriminating information by preserving sparse reconstruction relationship of data sets. However, SPP suffers from the fact that every new feature learned from data sets is linear combinations of all the original features, which often makes it difficult to interpret the results. To address this issue, a novel DR method called dual-sparsity preserving projection （DSPP） is proposed to further impose sparsity constraints on the projection directions of SPP. Specifically, the proposed method casts the projection function learning of SPP into a regression-type optimization problem, and then the sparse projections can be efficiently computed by the related lasso algorithm. Experimental results from face databases demonstrate the effectiveness of the proposed algorithm.

Current status and influencing factors of post-traumatic growth in maintenance hemodialysis

Objective:To study the post-traumatic growth level and influencing factors in patients with maintenance hemodialysis.Methods:A total of 179 patients receiving maintenance hemodialysis from a third-level grade A hospital in Tianjin,China were investigated using Post-traumatic Growth Inventory(PTGI),Perceived Social Support Scale,and Medical Coping Modes Questionnaire.Results:The total score for the PTGI was 53.73±16.45.Multiple linear regression analysis showed that social support,coping style,marital status,and family income significantly influenced the post-traumatic growth level in patients undergoing maintenance hemodialysis.These factors explained 41.4%of the variance.Conclusion:Medical staff should help patients under maintenance hemodialysis to fulfill their potentials by boosting the level of social support and to effectively cope with internal conflicts.In addition,nursing staff should provide relevant psychological health education to patients to improve their post-traumatic growth.

Design and fabrication of Panda-type erbium-doped polarization-maintaining fibres

To obtain the stable operation of erbium-doped fibre laser, the simple and ideal technology is adopted by use of the erbium doped polarization maintaining fibre （EDPMF）. The design criteria of the Panda-type EDPMF are presented, which take into account the cutoff wavelength, mode field diameter, modal birefringence and background loss. Four groups of optimum structural paramcter combinations are determined in terms of the design criteria. Two kinds of the Panda-type EDPMFs are selected to be fabricated. The fabrication process and the parameter control of the Panda-type EDPMFs are presented in detail. Their refractive index profiles, birefringence and absorption spectra are experimentally investigated. The absorption coefficient of the EDPMF, whose core is co-doped with Bi, Ga, A1 and Ge, is about 57.9dB/m at 1.53μm. Co-doping Bi, Ga and A1 can greatly increase the erbium concentration in the silica-based fibre. The high birefringence is obtained for the Panda-type EDPMF. The group birefringence of the EDPMF, whose outer cladding diameter is 125 μm, is about 4.8 × 10%^-4.

A Possible Minimum Toy Model with Negative Differential Capacitance for Self-sustained Current Oscillation

We generalize a simple model for superlattices to include the effect of differential capacitance. It is shown that the model always has a stable steady-state solution （SSS） if all differential capacitances are positive. On the other hand, when negative differential capacitance is included, the model can have no stable SSS and be in a self-sustained current oscillation behavior. Therefore, we find a possible minimum toy model with both negative differential resistance and negative differential capacitance which can include the phenomena of both self-sustained current oscillation and I-V oscillation of stable SSSs.

Land use optimization for sustainable development of mountain regions of western Serbia

This study analyses the possibilities for optimal land use structure in mountainous areas of rural Serbia, which is faced with problems such as unfavorable terrain characteristics and inadequate land use patterns causing economic underdevelopment and increasing population migration. In the case of a small privately owned farm in Western Serbia, optimal land use pattern is determined using the linear programming model. The objective function-cost-effectiveness or soil erosion reduction, as well as constraints, are formulated using the benefit-cost ratio(BCR) for a 15-year production period and soil losses data calculated using the Universal Soil Loss Equation(USLE). The best results are achieved using the scenario with the aim to minimize soil erosion, considering the BCR in the constraints. This scenario is proposed since it was registered that the benefit for landowners would increase by five times, while the losses of land would decline about 80%. The sensitivity analysis of investments is performed to check whether the price variation affects the cost-effectiveness of proposed land use. Results show that market changes(nine cases are considered) do not lead to significant changes in land use allocation. Proposed land use pattern improves the environmental condition, strengthens the rural economy and thus offers the greatest potential for sustainable development of mountainous rural areas.

Pressure Buildup Analysis Using Type Curves for a Well in a Pressure-Maintained System

The development and application of a new solution is demonstrated for the type-curve analysis and in-terpretation of well test data from a multiwell reservoir system of both production and injection wells with two-phase flow. The buildup type curves or buildup behavior could be obtained through the solution by using su-perposition. But a new outer boundary condition for variable pressure boundary must be introduced to obtain the correct pressure buildup solutions by superposition. A technique is shown to determine the deviation time from the infinite-acting semilog radial flow stabilization in the derivatives of pressure, which is calculated with respect to and plotted vs. shut-in time. Field examples are given to illustrate the use of the proposed method for analyzing transient pressure data from a well located in a multi-well water-injection reservoir. An adaptive genetic algorithm-based method is used to match the pressure and pressure derivative data to estimate reservoir parameters. The validity and applicability of the proposed method are also demonstrated through the examples.

Reversal process of the South China Sea western boundary current in autumn 2011

Using merged sea level anomaly and absolute geostrophic velocity products from satellite altimetry and Argos drifter data, we analyzed the reversal process of the South China Sea （SCS） westem boundary current （SCSwbc） from a summer to winter pattern in 2011 and important oceanic phenomena during this process. Results show that the outbreak time of the northeast monsoon over the southern SCS lagged that over the northern SCS by about 1 month. During the SCS monsoon reversal period, the SCSwbc reversed rapidly into the winter pattern at the Guangdong continental slope in late September. Subsequently, the southward Vietnam coastal boundary current strengthened. However, the northward Natuna Current maintained a summer state until mid-October. Thus, the balance between the southward and northward currents was lost when they met, their junction moved gradually southward. However, a loop current formed southeast of Vietnam because the main stream of the Vietnam Offshore Current （VOC） remained near its original latitude, Meanwhile, the VOC and associated dipole circulation system strengthened. After mid- October, the northward Natuna Current began to weaken, the loop current finally shed, becoming a cool ring. The VOC and its associated dipole sub-basin circulation system also weakened gradually until it disappeared.

Supervisory control of the hybrid off-highway vehicle for fuel economy improvement using predictive double Q-learning with backup models

This paper studied a supervisory control system for a hybrid off-highway electric vehicle under the chargesustaining(CS)condition.A new predictive double Q-learning with backup models(PDQL)scheme is proposed to optimize the engine fuel in real-world driving and improve energy efficiency with a faster and more robust learning process.Unlike the existing“model-free”methods,which solely follow on-policy and off-policy to update knowledge bases(Q-tables),the PDQL is developed with the capability to merge both on-policy and off-policy learning by introducing a backup model(Q-table).Experimental evaluations are conducted based on software-in-the-loop(SiL)and hardware-in-the-loop(HiL)test platforms based on real-time modelling of the studied vehicle.Compared to the standard double Q-learning(SDQL),the PDQL only needs half of the learning iterations to achieve better energy efficiency than the SDQL at the end learning process.In the SiL under 35 rounds of learning,the results show that the PDQL can improve the vehicle energy efficiency by 1.75%higher than SDQL.By implementing the PDQL in HiL under four predefined real-world conditions,the PDQL can robustly save more than 5.03%energy than the SDQL scheme.

Does maintenance of Bevacizumab after treatment failure have a role in metastatic colon cancer?

Objective： To study the timing of Bevacizumab （BVC） in the overall treatment strategy of advanced metastatic colorectal cancer - early use （first-line） or later use. Methods： 41 patients with progressive metastatic colorectal carcinoma were included. Patients were randomized to receive chemotherapy with or without BVC. Primary end point was objective response. Secondary end points were median survival, time to tumor progression, and toxicity. Results： Partial response with second-line BVC group constituted 25% and 18.8% in patients with first-line chemotherapy and BVC-based regimen respectively, compared to 11.8% and 5.9% with second-line chemotherapy. Median time to progression was 3.1 vs. 2.3 months for cases with first-line chemotherapy and BVC-based regimens respectively. Median survival was 8.2 vs. 4 months in both groups respectively （P = 0.019）. Conclusion： Second-line chemotherapy combined BVC had higher disease control rate （partial response and stable disease）, median time to progression and median survival in BVC-naive patients compared to patients with first-line BVC-based therapy. BVC should be maintained in the second- and third-line settings, as cases with BVC discontinuation had significantly lower median time to disease progression and median survival. Selection of patients for use of BVC was recommended with taking into consideration the cost-benefit value and that the discontinuation of BVC would increase tumor progression.

基于流域经济与环境保护协调发展的路径探讨

本文首先简要分析了流域协调的最终目标,探讨了流域协调的二元特性及制约因素,最后提出了构建流域协调机制的有效途径,望能以此为相关研究提供些许参考。

Pneumocystis jiroveci pneumonia and pneumomediastinum in an anti-TNFαnaive patient with ulcerative colitis

We report the case of a 21-year-old man who was noted to have pneumomediastinum during an admission for an acute flare of ulcerative colitis. At that time, he was on maintenance treatment with azathioprine at a dose of 2.25 mg/kg per day, and had not received supplementary steroids for 9 mo. He had never received anti-tumor necrosis factor （TNF）α therapy. Shortly after apparently effective treatment with intravenous steroids and an increased dose of azathioprine, he developed worsening colitic and new respiratory symptoms, and was diagnosed with Pneumocystis jiroveci （carinii） pneumonia （PCP）. Pneumomediastinum is rare in immunocompetent hosts, but is a recognized complication of PCP in human immunodeficiency virus （HIV） patients, although our patient＇s HIV test was negative. Treatment of PCP with co-trimoxazole resulted in resolution of both respiratory and gastrointestinal symptoms, without the need to increase the steroid dose. There is increasing vigilance for opportunistic infections in patients with inflammatory bowel disease following the advent of anti-TNFα therapy. This case emphasizes the importance of considering the possibility of such infections in all patients with inflammatory bowel disease, irrespective of the immunosuppressants they receive, and highlights the potential of steroid-responsive opportunistic infections to mimic worsening colitic symptoms in patients with ulcerative colitis.

Effect of Market Power in Electricity Markets

The main objective of this paper is to show an overview analysis of market power issues.Market power reflects the scarcity of power supply.It is the ability of a particular seller or group of sellers to maintain prices profitably above competitive levels for a significant period of time.Because the electric power system has its own characteristics that are different to other economic systems,both physical factors and economic factors of power system are key elements on this definition.We study some cases here,including different line limit levels,load levels and bid strategy through a market model based on OPF (optimal power flow) with a decommitment algorithm.

Study on the forecasting and maintenance system of special railway subsidence in mine area

The fully mechanized caving coal mining under the railway in mine area will result in difficulty maintenance of railway because of great distortion and subsidence speed of terrene and railway. If the subsidence forecasting is incorrect and maintenance measure is not suitable in the preceding and the process of mining, the normal operation of the railway in mine area will not be ensured and perhaps the safety accident will be resulted. The railway subsidence forecasting and maintenance system for fully mechanized caving coal face are studied and developed in this connection. Based on the accurate subsidence forecasting of the terrene and railway, the maintenance measure for track and switch turnout in railway is put forward in this system.