Effect of ALA-PDT on the expressions of MMP-9, MMP-13 and TIMP-1 of hypertrophic scar model in rabbit ears

Objective: To investigate the effect of 5-aminolevulinic(ALA)-photodynamic therapy(PDT) on the expressions of MMP-9, MMP-13 and TIMP-1 of hypertrophic scar model in rabbit ears, and analyze the possible therapeutic mechanisms of ALA-PDT treatment to hypertrophic scars of rabbit ears. Methods: The experimental animals were randomly divided into normal control, negative control, high concentration of ALA-PDT, low concentration of ALA-PDT and PDT groups. The latter three groups received ALA-PDT treatment or PDT treatment once a week for 3 weeks. The specimens of the rabbits were collected respectively 1, 2 and 3 months after treatment to be used for RT-PCR and Western-blot test. Results: 1, 2 and 3 months after PDT treatment, the expressions of MMP-9 and MMP-13(including mRNA and protein) in hypertrophic scar tissues of three treatment groups were significantly higher than those of the negative control group(P<0.01), and the expression of TIMP-1 mRNA and protein of three treatment groups were significantly lower than that of the negative control group(P<0.01). There were also significant differences between high-concentration ALA-PDT treatment group and the low one(P<0.05). Conclusion: ALA-PDT is effective in treating hypertrophic scars of rabbit ears, and its possible therapeutic mechanisms are that ALA-PDT treatment generates oxidation activation effect to activate the activity of MMPs and induces the photoaging of fibroblasts of hypertrophic scar tissues of rabbit ears to inhibit the activity of TIMPs, which causes the up-regulation of MMPs and the down-regulation of TIMPs. Because of this, the degradation of collagen and ECM is accelerated and the formation of scars is suppressed.

The Use and the Effects of Militaristic Elements in the Turkish Printed Sports Media

Football is a sports branch comprising a ＂human＂ factor with different aspects, such as intelligence, intuition, will, character, struggle, spectators, and balance. With the created global economic market, football is an indispensable part of our lives. It entices the masses, plays an effective role in the socio-economic destinies of societies, and directs the mass psychology of societies negatively and/or positively. The success that football clubs in Turkey attained recently in Europe and the third standing that our national football team gained in 2002 have accentuated the relationship between the printed football media and football. Today, Turkish sports journalism sometimes tends to exploit the emotions and encourages the discourses inciting violence and biases to get more readers （to increase the circulation rate） and guarantee the continuation of the attention. Many words expressing militarism are used in the headlines of sports news. In these articles, the footballers are depicted as alert soldiers and the teams as troops conditioned to victory. In the frame of both national matches and the European Cups, the militaristic elements are used through nationalistic discourses in the sports news of the printed media. Thus, the aim of this study is to analyze the presentation and quantity of the militaristic elements used in the news on football in newspapers. The news in the Milliyet, as a mainstream newspaper, issued in two periods, namely after the 2002 World Cup （November 1-December 31, 2002） and today （February l-March 30, 2008） will be studied through the discourse analysis method with respect to the headlines and contents. Therefore, the comments and the ideas of columnists will be excluded from the scope of this study.

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