《金匮要略》“调和”思想及在肝病证治上的运用

中医"调和"思想之学理源自《内经》,光大于仲景《金匮要略》,其精髓在于动态调整、趋于和谐,大略为未病之时重调摄、既病防变需调理、病瘥防复宜调养,在肝病证治中体现为调中焦和少阳。试图阐明这一思想的渊源、内涵和实际运用之道。

“差异”、“调和”与“崇今”:李大钊马克思主义文学批评论

从马克思主义理论出发,李大钊将文学视为社会整体系统的有机组成部分,以东西方文明“差异”论、“美在调和”论为思想基础,提出文学“先声”论、“崇今”论和“心理表现”论,三者构成其相对完整的文学批评形态。其中处于核心地位的是“崇今”论,它与李大钊“平民主义”思想密切相关,表明他对文学社会功能的高度重视。文学在揭露现实黑暗、同情底层民众、感化与涵育民族特性之中,预示社会进化的规律,显示社会革命的趋势。也因此,写实和理想构成李大钊马克思主义文学批评实践的两翼。

“调和式”司法裁判的法理思考

调和式,意为无原则的调和折中。司法裁判本应是在查清法律事实的基础上,准确适用法律、划分权责,在公众心理期待限度内进行定纷止争,本应与"调和式"一词相去甚远。公众时常将"调和式"与司法裁判联系在一起,是因为有的案件或是事实不清,或是适用法律错误,或是违背社会公序良俗和背离公众道德认知,为了消解不稳定因素,判令无责之人担责。文章试图从法理学中的司法功能入手,对"调和式"司法裁判的特点以及产生的原因进行分析,进而提出改进路径。

调和止动方联合磁珠耳穴贴治疗儿童抽动障碍脾虚肝旺型29例临床观察

目的观察调和止动方联合磁珠耳穴贴治疗儿童抽动障碍脾虚肝旺型的临床疗效。方法选取2021年6月1日至2022年12月31日于浙江中医药大学附属第一医院(浙江省中医院)儿科门诊治疗的抽动障碍脾虚肝旺型患儿60例,按照随机数字表法分为治疗组和对照组,各30例,因对照组脱落2例,治疗组失访1例,最终治疗组29例,对照组28例。对照组予盐酸硫必利片口服,治疗组予调和止动方口服联合磁珠耳穴贴治疗。2组均以4周为1个疗程,1个疗程后统计疗效。结果治疗前2组的耶鲁综合抽动严重程度量表(YGTSS)评分及社会缺损评分比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组的上述评分均显著降低,与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组的YGTSS评分降低更显著(P<0.05)。治疗前2组的中医证候主症、次症及总积分比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组的上述积分均显著降低,与同组治疗前比较,差异均有统计学意义(P<0.05),且治疗组的次症积分及总积分降低更显著(P<0.05)。治疗组的总有效率为86.21%(25/29),显著高于对照组的64.28%(18/28),2组比较,差异有统计学意义(P<0.05)。结论调和止动方联合磁珠耳穴贴治疗儿童抽动障碍脾虚肝旺型疗效确切,可显著改善临床症状,降低YGTSS评分,值得临床推广应用。

本真性和公共领域:查尔斯·泰勒的自由社会观

本文围绕查尔斯·泰勒的两篇文章"消极自由有什么错""自由主义政治与公共领域",以及泰勒与哈贝马斯在2009年的对话,来阐释他对自由主义的修正。这两篇文章相互呼应,前一篇阐释作为道德心理学的个人本真性,后一篇阐释使(个人或群体的)本真性得以充分发挥的多元公共领域。公共领域是市民社会的核心环节,而市民社会是与自由主义联系在一起的自由社会的主要形式。在对自由社会的阐释中,泰勒总结了修正自由主义的中庸观:在个人自由、自治和基于平等权利的规则之间寻求平衡和相互支持。在2009年与哈贝马斯的对话中他进而指出,宗教是多元公共领域中的议题之一。这种历史观基于他对韦伯观点的修正而形成,而此历史观对当前中国的处境有启发价值。

Visualization of uncertainty associated with spatial prediction of continuous variables using HSI color model:a case study of prediction of pH for topsoil in peri-urban Beijing,China

Hue-Saturation-Intensity （HSI） color model, a psychologically appealing color model, was employed to visualize uncertainty represented by relative prediction error based on the case of spatial prediction of pH of topsoil in the peri-urban Beijing. A two-dimensional legend was designed to accompany the visualization-vertical axis （hues） for visualizing the predicted values and horizontal axis （whiteness） for visualizing the prediction error. Moreover, different ways of visualizing uncertainty were briefly reviewed in this paper. This case study indicated that visualization of both predictions and prediction uncertainty offered a possibility to enhance visual exploration of the data uncertainty and to compare different prediction methods or predictions of totally different variables. The whitish region of the visualization map can be simply interpreted as unsatisfactory prediction results, where may need additional samples or more suitable prediction models for a better prediction results.

On the Ecological Landscape Design of Urban Bridges in Chongqing City

This paper elaborated the special geological conditions of Chongqing City and the characteristics of urban bridges formed by natural environment, and put forth the ecological landscape design ideas of urban bridges. 3 principles of ecological landscape design were presented including paying attention to the creation of great environment, focusing on the comparison and harmony between natural and artificial factors and seeking for simple lines and unified colors, and the application of ecological landscape design principles in constructing ecological landscape of bridges in Chongqing City was analyzed. By discussing the existing problems of ecological landscape design of bridges in Chongqing City, some suggestions were summarized, which were expected to produce positive effects for the researches of ecological landscape design of bridges.

Characteristic analysis of Tianjin offshore tide

Tidal data of Tanggu marine environment monitoring stations for 59 years （1950-2008） was processed by using harmonic analysis, harmonic constants curves were discussed. And by using FFT spectral analysis periodicity and causation of its harmonic constants were analyzed. Alter astronomic tide signal was eliminated, residual water level was decomposed by using FFT spectral analysis, and then we got the periodic variation of mean residual water level over the past 50 years and discussed mean sea level changing trends of Tianjin offshore. The results show that variety of amplitude of M2 tidal constituent reveals 20 years, 4-6 years, 2-3-year periods, and it was obviously influenced by engineering construction since reform and opening age. Residual water level fluctuations reveal 20 years, 5-6 years, 2-3 years and 1 year periods. Sea level of Tianjin offshore displays a progressive ascending trend with rate about 3.4mm/a, which was influenced mainly by sea level rise and land subsidence.

A Remark of M.Riesz Theorem

Let u(z) be a real_valued harmonic function in the unit disk, we say u(z)∈h p(1【p【+∞), if the p _mean M p(r,u)=12π∫ 2π 0|u(re i θ )| p d θ 1/p is bounded. M.Riesz showed that if u(z)∈h p(1【p【+∞), then there exists a constant A p, depending only on p such that M p(r,v)≤A pM p(r,u), where v(z) is the conjugate harmonic function of u(z).When v(0)=0 and 1【p≤2, W.K.Hayman showed that A p can be given by pp-1 1/p . First, this paper shows that the constant pp-1 1/p can be changed by a smaller constant pp-1 2/p -1 1/2 . Next, if 1【p≤2, then there exists a constant θ 0∈2-p2pπ,π2p such that M p p(r,v)≤ Im p sin pπ2+ tg pπ2pM p p(r,u) for any analytic function f(z)=u(z)+ i v(z) in the unit disk, whenever -θ 0【 arg f(z)【π2.

Biharmonic product maps between doubly warped product manifolds

The biharmonicity of the product map Φ2=φ×ψ and the two generalized projections φ-and ψ-are analyzed. Some results are obtained, that is, Φ2 is a proper biharmonic map if and only if b is a non-constant solution of -1/f2 Jφ（dφ（grad（lnb）））＋n/2 grad｜dφ（grad（lnb））｜2=0 and f is a non-constant solution of -1/b2Jψ（dψ（grad（lnf）））＋m/2grad｜dψ（grad（lnf））｜2=0, and Φ2=φ×ψ is a proper biharmonic map if and only if φ-and ψ-are proper biharmonic maps.

ANALYSIS OF REGULATION AND HARMONIZATION IMPLIED IN A-B CLASSIC ON ACUPUNCTURE AND MOXIBUSTION

It aims to draw the conclusion that the ideas of treatment in Zhen Jiu Jia Yi Jing （《针灸甲乙经》, A-B Classic on Acupuncture and Moxibustion ） can be summarized as ＂regulation＂ and ＂harmonization＂ through the research of words in the Classic, such as ＂being normal＂, ＂regulation＂ and ＂harmonization＂. The lost of regulation of a normal person shows disharmony. Regulation can make the person-being-sick become harmony and back to ＂being normal＂. ＂Regulation＂ and ＂harmonization＂ right imply the quintessence of traditional Chinese medicine.

Tuning of the textural features and acidic properties of sulfated mesoporous lanthana-zirconia solid acid catalysts for alkenylation of diverse aromatics to their corresponding α-arylstyrenes

The textural features and acidic properties of sulfated mesoporous lanthana‐zirconia solid acids （SO42？/meso‐La0.1Zr0.9Oδ） were efficiently tuned by modifying the conditions used to prepare the meso‐La0.1Zr0.9Oδcomposites, such as the molar ratio of the template to La and Zr metal ions （Nt/m）, molar ratio of ammonia to La and Zr metal ions （Na/m）, hydrothermal temperature （Thydro）, and hy‐drothermal time （thydro）. The effect of the textural features and acidic properties on the catalytic performance of solid acid catalysts for alkenylation of p‐xylene with phenylacetylene was investi‐gated. Various characterization techniques such as N2 physisorption, X‐ray diffraction, NH3 temper‐ature‐programmed desorption, and thermogravimetric analysis were employed to reveal the rela‐tionship between the nature of catalyst and its catalytic performance. It was found that the catalytic performance significantly depended on the textural features and acidic properties, which were strongly affected by preparation conditions of the meso‐La0.1Zr0.9Oδcomposite. Appropriate acidic sites and high accessibility were required to obtain satisfactory catalytic reactions for this reaction. It was also found that the average crystallite size of t‐ZrO2 affected by the preparation conditions had significant influence on the ultrastrong acidic sites of the catalysts. The optimized SO42？/meso‐La0.1Zr0.9Oδcatalyst exhibited much superior catalytic activity and coke‐resistant stabil‐ity. Moreover, the developed SO42？/meso‐La0.1Zr0.9Oδcatalyst demonstrated excellent catalytic per‐formance for alkenylation of diverse aromatics with phenylacetylene to their correspondingα‐arylstyrenes. Combining the previously established complete regeneration of used catalysts by a facile calcination process with the improved catalytic properties, the developed SO42？/meso‐La0.1Zr0.9Oδ solid acid could be a potential catalyst for industrial production ofα‐arylstyrenes through clean and atom efficient solid‐acid‐mediated Friedel‐Crafts alkenylation of diverse aromatics with phenylacetylene.

External Application of Herbal Medicine to Acupoints

Application of herbal medicine to acupoints is to regulate the meridians, yin-yang, and qi and blood for preventing and treating diseases through the pharmacological action of herbal medicines and with their stimulation to the acupoints. This article explains how to apply herbal medicines and gave the examples for the treatment of hypertension, asthma, chronic bronchitis and allergic rhinitis. Application of herbal medicines to acupoints is one of the important components of TCM, which shows satisfactory effects in treatment of some chronic diseases.

Bystin-like protein is upregulated in hepatocellular carcinoma and required for nucleologenesis in cancer cell proliferation

The bystin-like （BYSL） gene was previously characterized to encode an accessory protein for cell adhesion that participates in early embryo implantation. It is also involved in 40S ribosomal subunit biogenesis and is found to be expressed in rapidly growing embryo and cancer cell lines. In order to explore the role of BYSL in cancer cell proliferation and growth, we used hepatocellular carcinoma （HCC） as a model. Here, we report that BYSL is crucial for HCC cell growth both in vitro and in vivo. Expression levels of BYSL mRNA and protein in human HCC specimens were markedly increased compared with those seen in adjacent non-cancerous tissue. In vitro, inhibition of BYSL by short hairpin RNA decreased HCC cell proliferation, induced apoptosis and partially arrested the cell cycle in the G2/M phase. In vivo, HCC cells treated with BYSL siRNA failed to form tumors in nude mice after subcutaneous implantation. To determine the cellular basis for BYSL RNAi-induced cell growth arrest, BYSL subcellular localization in mitotic and interphase HepG2 cells was examined. BYSL was present at multiple stages during nucleologenesis, including in nucleolus-derived foci （NDF）, perichromosomal regions and the prenucleolar body （PNB） during mitosis. BYSL depletion remarkably suppressed NDF and PNB formation, and disrupted nucleoli assembly after mitosis, resulting in increased apoptosis and reduced tolerance of HCC cells to serum starvation. Taken together, our studies indicate that upregulated BYSL expression plays a role in hepatocarcinogenesis.

Leader-following coordination of multiple UUVs formation under two independent topologies and time-varying delays

The new method which uses the consensus algorithm to solve the coordinate control problems of multiple unmanned underwater vehicles （multi-UUVs） formation in the case of leader-following is adapted. As the communication between the UUVs is difficult and it is easy to be interfered under the water, time delay is assumed to be time-varying during the members communicate with each other. Meanwhile, the state feedback linearization method is used to transfer the nonlinear and coupling model of UUV into double-integrator dynamic. With this simplified double-integrator math model, the UUV formation coordinate control is regarded as consensus problem with time-varying communication delays. In addition, the position and velocity topologies are adapted to reduce the data volume in each data packet which is sent between members in formation. With two independent topologies designed, two cases of communication delay which are same and different are considered and the sufficient conditions are proposed and analyzed. The stability of the multi-UUVs formation is proven by using Lyapunov-Razumilkhin theorem. Finally, the simulation results are presented to confirm and illustrate the theoretical results.

Coordination and nursing care of pediatric patients undergoing double balloon enteroscopy

AIM:To review safety,efficacy,and proper nursing care of double-balloon enteroscopy (DBE) in pediatric patients with small intestinal disease.METHODS:Our study included 37 patients with abdominal pain,diarrhea,passage of blood in the stools,and other symptoms,who underwent DBE from December 2006 to July 2010.DBE was retrograde in 36 procedures,antegrade in six,and from both ends in five.The diagnostic significance and salient points in nursing care are discussed in this article.RESULTS:At least one lesion was discovered in 28 out of 37 patients,which yielded a positive diagnosis in 75.7% of cases.Good bowel preparation and skilled nursing care not only shortened the procedure time,but could also alleviate patient discomfort and enhance the quality of examination.No serious procedure-related complications were observed in any cases.CONCLUSION:DBE is a new modality of endoscopic procedure that improves the standard of diagnosis and treatment of small bowel diseases in children.Good nursing care is essential to the successful execution of the procedure.

Spherical parametrization of genus-zero meshes by minimizing discrete harmonic energy

The problem of spherical parametrization is that of mapping a genus-zero mesh onto a spherical surface. For a given mesh, different parametrizations can be obtained by different methods. And for a certain application, some parametrization results might behave better than others. In this paper, we will propose a method to parametrize a genus-zero mesh so that a surface fitting algorithm with PHT-splines can generate good result. Here the parametrization results are obtained by minimizing discrete har- monic energy subject to spherical constraints. Then some applications are given to illustrate the advantages of our results. Based on PHT-splines, parametric surfaces can be constructed efficiently and adaptively to fit genus-zero meshes after their spherical parametrization has been obtained.

A role based coordination model in agent systems

Coordination technology addresses the construction of open, flexible systems from active and independent software agents in concurrent and distributed systems. In most open distributed applications, multiple agents need interaction and communication to achieve their overall goal. Coordination technologies for the Internet typically are concerned with enabling interaction among agents and helping them cooperate with each other. At the same time, access control should also be considered to constrain interaction to make it harmless. Access control should be regarded as the security counterpart of coordination. At present, the combination of coordination and access control remains an open problem. Thus, we propose a role Dased coordination model with policy enforcement in agent application systems. In this model, coordination is combined with access control so as to fully characterize the interactions in agent systems. A set of agents interacting with each other for a common global system task constitutes a coordination group. Role based access control is applied in this model to prevent unauthorized accesses. Coordination policy is enforced in a distributed manner so that the model can be applied to the open distributed systems such as Internet. An Internet online auction system is presented as a case study to illustrate the proposed coordination model and finally the performance analysis of the model is introduced.

How to improve patient satisfaction during midazolam sedation for gastrointestinal endoscopy?

To determine the procedure-related factors that affect sedation satisfaction and to make a suggestion to improve it.METHODSWe prospectively enrolled a total of 456 patients who underwent outpatient endoscopy procedures with midazolam sedation between March 2014 and August 2014. All patients completed both pre- and post-endoscopy questionnaires about sedation expectations and satisfaction.RESULTSThe study cohort included 167 (36.6%) patients who underwent esophagogastroduodenoscopy (EGD), 167 (36.6%) who underwent colonoscopy, and 122 (26.8%) who underwent a combined procedure (EGD and colonoscopy). Over 80% of all patients were satisfied with sedation using midazolam. In univariate and multivariate analyses, total procedure time in the EGD group, younger age (≤ 50 years), and longer colonoscopy withdrawal time in the colonoscopy group were related to decreased satisfaction with sedation. However, in active monitoring and intervention group, there was no decrease in grade of satisfaction despite longer procedure time due to more procedures during colonoscopy. Younger age (≤ 50 years), longer inter-procedure time gap, and colonoscopy withdrawal time were related to decreased satisfaction in the combined EGD and colonoscopy group.CONCLUSIONMidazolam is still a safe and effective sedative for gastrointestinal endoscopy. Satisfaction with sedation depends on several factors including age (≤ 50 years) and procedure time duration. To improve patient satisfaction with sedation, active monitoring of sedation status by the endoscopist should be considered for patients who require long procedure time.

Spectral Method for Three-Dimensional Nonlinear Klein-Gordon Equation by Using Generalized Laguerre and Spherical Harmonic Functions

In this paper,a generalized Laguerre-spherical harmonic spectral method is proposed for the Cauchy problem of three-dimensional nonlinear Klein-Gordon equation. The goal is to make the numerical solutions to preserve the same conservation as that for the exact solution.The stability and convergence of the proposed scheme are proved.Numerical results demonstrate the efficiency of this approach.We also establish some basic results on the generalized Laguerre-spherical harmonic orthogonal approximation,which play an important role in spectral methods for various problems defined on the whole space and unbounded domains with spherical geometry.