基于“质-量”双标的吴茱萸质量分析方法研究

目的建立以对照药材为对照物质的定性和不依赖多种对照品定量的吴茱萸药材“质-量”双标控制方法。方法采用高效液相色谱(HPLC)技术,以对照药材为对照物质,建立吴茱萸特征图谱,并通过质谱技术鉴定共有峰化学成分,通过评价对照药材与供试药材特征图谱相似度,判别药材真伪,即“质”;以吴茱萸碱作为基准物质进行准确定量,以吴茱萸碱为基准,计算其余特征峰相对含量,并采用特性峰的相对含量下限来判定吴茱萸药材优劣,即“量”。结果建立的吴茱萸特征图谱以及吴茱萸含量测定的方法符合方法学考察要求;鉴定3个共有色谱峰,分别为柠檬苦素、吴茱萸碱、吴茱萸次碱;不同产地供试药材与吴茱萸对照药材相比相似度均大于0.970;规定了吴茱萸特征峰化学成分相对含量下限。结论该方法不依赖多种对照品,可以快速简便的判别药材真伪,同时达到全面控制吴茱萸药材质量的目的。

THE OPTIMUM MODEL AND ITS DECISION SUPPORT SYSTEM OF COAL QUALITY BALANCE

The meaning and significance of coal quality balance are summaized in this paper.Practical steps concerning constructing the synthetic tech-economic model and its decision support system of coal quality balance using the optimization techology of inverse recurrence of established initializing parameters are also introduced. The principles and methods as being applied in the model system development and procedure construction are discussed accordingly.