AIM： To investigate the cellular mechanisms of action of Yiguanjian （YGJ） decoction in treatment of chronic hepatic injury. METHODS： One group of mice was irradiated, and received enhanced green fluorescent prote...AIM： To investigate the cellular mechanisms of action of Yiguanjian （YGJ） decoction in treatment of chronic hepatic injury. METHODS： One group of mice was irradiated, and received enhanced green fluorescent protein （EGFP）- positive bone marrow transplants followed by 13 wk of CCh injection and 6 wk of oral YGJ administration. A second group of Institute for Cancer Research mice was treated with 13 wk of CCI4 injection and 6 wk of oral YGJadministration. Liver function, histological changes in the liver, and Hyp content were analyzed. The expres- sion of m-smooth muscle actin （α-SMA）, F4/80, albumin （AIb）, EGFP, mitogen-activated protein kinase-2 （PKM2）, Ki-67, fetoprotein （AFP）, monocyte chemotaxis pro- tein-1 and CC chemokine receptor 2 were assayed. RESULTS： As hepatic damage progressed, EGFP-po- sitive marrow cells migrated into the liver and were mainly distributed along the fibrous septa. They showed a conspicuous coexpression of EGFP with ^-SMA and F4/80 but no coexpression with AIb. Moreover, the expression of PKM2, AFP and Ki-67 was enhanced dy- namically and steadily over the course of liver injury. YGJ abrogated the increases in the number of bone marrow-derived fibrogenic cells in the liver, inhibited expression of both progenitor and mature hepatocyte markers, and reduced fibrogenesis. CONCLUSION： YGJ decoction improves liver fibrosis by inhibiting the migration of bone marrow cells into the liver as well as inhibiting their differentiation and suppressing the proliferation of both progenitors and hepatocytes in the injured liver.展开更多
Ovarian tumor may occur in women ofany age, but mostly seen in women duringtheir child-bearing period. The disease shouldbe treated mainly by surgical operation,supplemented by radiotherapy and chemo-therapy. However,...Ovarian tumor may occur in women ofany age, but mostly seen in women duringtheir child-bearing period. The disease shouldbe treated mainly by surgical operation,supplemented by radiotherapy and chemo-therapy. However, the above therapies maycause a series of toxic side-effects, such asalopecia, diarrhea, edema, anorexia, nausea,dry mouth, spontaneous perspiration, headache,展开更多
Effects of coupling distance on synchronization and coherence of chaotic neurons in complex networks arenumerically investigated.We find that it is not beneficial to neurons synchronization if confining the coupling d...Effects of coupling distance on synchronization and coherence of chaotic neurons in complex networks arenumerically investigated.We find that it is not beneficial to neurons synchronization if confining the coupling distanceof random edges to a limit d_(max),but help to improve their coherence.Moreover,there is an optimal value of d_(max) atwhich the coherence is maximum.展开更多
Traumatological and orthopedical diseases with obstruction and blockage are in most cases treated by the reducing method like promoting qi flow and activating blood circulation, dispersing and removing obstruction. Ho...Traumatological and orthopedical diseases with obstruction and blockage are in most cases treated by the reducing method like promoting qi flow and activating blood circulation, dispersing and removing obstruction. However, the therapeutic展开更多
The topological expression of the reduced quantum trajectory is given by using C-mapping topological current theory. The topological expression is used in study of the coherence and the decoherence. We find the expres...The topological expression of the reduced quantum trajectory is given by using C-mapping topological current theory. The topological expression is used in study of the coherence and the decoherence. We find the expression of vorticity for decoherence has a similar form as that for coherence. A topological reason leading to the decoherence is given and a new parameter is defined to indicate the coherence degree. The parameter is different from the damping factor because it relates to the topological structure of the reduced quantum trajectory.展开更多
基金Supported by National Natural Science Foundation of China,No. 30772758National Science and Technology Major Project of China,No. 2009ZX09311-003
文摘AIM： To investigate the cellular mechanisms of action of Yiguanjian （YGJ） decoction in treatment of chronic hepatic injury. METHODS： One group of mice was irradiated, and received enhanced green fluorescent protein （EGFP）- positive bone marrow transplants followed by 13 wk of CCh injection and 6 wk of oral YGJ administration. A second group of Institute for Cancer Research mice was treated with 13 wk of CCI4 injection and 6 wk of oral YGJadministration. Liver function, histological changes in the liver, and Hyp content were analyzed. The expres- sion of m-smooth muscle actin （α-SMA）, F4/80, albumin （AIb）, EGFP, mitogen-activated protein kinase-2 （PKM2）, Ki-67, fetoprotein （AFP）, monocyte chemotaxis pro- tein-1 and CC chemokine receptor 2 were assayed. RESULTS： As hepatic damage progressed, EGFP-po- sitive marrow cells migrated into the liver and were mainly distributed along the fibrous septa. They showed a conspicuous coexpression of EGFP with ^-SMA and F4/80 but no coexpression with AIb. Moreover, the expression of PKM2, AFP and Ki-67 was enhanced dy- namically and steadily over the course of liver injury. YGJ abrogated the increases in the number of bone marrow-derived fibrogenic cells in the liver, inhibited expression of both progenitor and mature hepatocyte markers, and reduced fibrogenesis. CONCLUSION： YGJ decoction improves liver fibrosis by inhibiting the migration of bone marrow cells into the liver as well as inhibiting their differentiation and suppressing the proliferation of both progenitors and hepatocytes in the injured liver.
文摘Ovarian tumor may occur in women ofany age, but mostly seen in women duringtheir child-bearing period. The disease shouldbe treated mainly by surgical operation,supplemented by radiotherapy and chemo-therapy. However, the above therapies maycause a series of toxic side-effects, such asalopecia, diarrhea, edema, anorexia, nausea,dry mouth, spontaneous perspiration, headache,
基金Supported by the Sustentation Fund for Young Teachers in Colleges and Universities of Anhui Province under Grant No.2008jq1055Anhui Normal University Fund for Doctor
文摘Effects of coupling distance on synchronization and coherence of chaotic neurons in complex networks arenumerically investigated.We find that it is not beneficial to neurons synchronization if confining the coupling distanceof random edges to a limit d_(max),but help to improve their coherence.Moreover,there is an optimal value of d_(max) atwhich the coherence is maximum.
文摘Traumatological and orthopedical diseases with obstruction and blockage are in most cases treated by the reducing method like promoting qi flow and activating blood circulation, dispersing and removing obstruction. However, the therapeutic
基金Supported by the Fundamental Research Fonds for the Central Universities
文摘The topological expression of the reduced quantum trajectory is given by using C-mapping topological current theory. The topological expression is used in study of the coherence and the decoherence. We find the expression of vorticity for decoherence has a similar form as that for coherence. A topological reason leading to the decoherence is given and a new parameter is defined to indicate the coherence degree. The parameter is different from the damping factor because it relates to the topological structure of the reduced quantum trajectory.
