Objective . To improve the treatment of tumors, we studied the combined effects of docetaxel and batimastat (BB 94) on mouse forestomach carcinoma (MFC), and compared them with doxorubicin. Methods and results. In vit...Objective . To improve the treatment of tumors, we studied the combined effects of docetaxel and batimastat (BB 94) on mouse forestomach carcinoma (MFC), and compared them with doxorubicin. Methods and results. In vitro, growth curve analysis, MTT assay and clonogenic assay used to determine the cytotoxic effect of docetaxel or/and BB 94 on MFC cell showed that docetaxel but not BB 94 had a significant cytotoxicity, and the effect of docetaxel wasn’t enhanced by BB 94. In early stage MFC tumor model, obvious antitumor effect of docetaxel or doxorubicin given i.v. at maximum tolerated dose (MTD, docetaxel: 20mg/kg; doxorubicin: 6mg/kg) every 4 days for 3 injections (q4d×3), even that of BB 94 (30mg/kg i.p. qd×20) was observed. Tumor growth inhibition was greater for docetaxel batimastat (96.0%) than for doxorubicin-batimastat (88.0%), docetaxel (89.0%), doxorubicin (68.0%) and BB 94 (33.0%), and the effect of docetaxel could be potentiated by BB 94. Docetaxel also showed activity against advanced stage MFC tumor in dose-dependent manner, and was more effective at MTD than doxorubicin with 4/5 regressions, 46.5 days tumor growth delay and 2.8log10 tumor cell kill. Conclusion. Our results suggest that in the MFC model with dose and schedule used, docetaxel is an effective cytotoxic new drug against MFC tumor and BB 94 enchances the antitumor activity of docetaxel.展开更多
To reduce the cost, size and complexity, a consumer digital camera usually uses a single sensor overlaid with a color filter array(CFA) to sample one of the red-green-blue primary color values, and uses demosaicking a...To reduce the cost, size and complexity, a consumer digital camera usually uses a single sensor overlaid with a color filter array(CFA) to sample one of the red-green-blue primary color values, and uses demosaicking algorithm to estimate the missing color values at each pixel. A novel image correlation and support vector machine(SVM) based edge-adaptive algorithm was proposed, which can reduce edge artifacts and false color artifacts, effectively. Firstly, image pixels were separated into edge region and smooth region with an edge detection algorithm. Then, a hybrid approach switching between a simple demosaicking algorithm on the smooth region and SVM based demosaicking algorithm on the edge region was performed. Image spatial and spectral correlations were employed to create middle planes for the interpolation. Experimental result shows that the proposed approach produced visually pleasing full-color result images and obtained higher CPSNR and smaller S-CIELAB*ab?E than other conventional demosaicking algorithms.展开更多
This paper presents a fast image mosaic algorithm based on the characteristic of the edge grads. Unlike some previous algorithms, which require pure horizontal camera panning, this algorithm doesn＇t require constrain...This paper presents a fast image mosaic algorithm based on the characteristic of the edge grads. Unlike some previous algorithms, which require pure horizontal camera panning, this algorithm doesn＇t require constraints on how the image is taken. The algorithm can determine the matching regions of the two adjacent images by finding out the feature points and can piece up images bath horizontally and vertically. Experimental results show that this algorithm is effective.展开更多
This article involves the study of the psychic remnants commonly known as Archetypes in Sean O＇Casey＇s play Juno and the Paycock. Archetypes are the images or patterns recurring again and again in literature through...This article involves the study of the psychic remnants commonly known as Archetypes in Sean O＇Casey＇s play Juno and the Paycock. Archetypes are the images or patterns recurring again and again in literature through the ages. It also focuses on the minute difference between archetype and archetypal image as discussed by Jung with special reference to the characters and other images in the play beating relevance with the universal archetypes. This article also highlights the play as a connective link in the series of the different pieces of literature via the unique use of the psychic remnants. It emphasises on the different use of those remnants interwoven in the mosaic of the characters and plot of the play.展开更多
文摘Objective . To improve the treatment of tumors, we studied the combined effects of docetaxel and batimastat (BB 94) on mouse forestomach carcinoma (MFC), and compared them with doxorubicin. Methods and results. In vitro, growth curve analysis, MTT assay and clonogenic assay used to determine the cytotoxic effect of docetaxel or/and BB 94 on MFC cell showed that docetaxel but not BB 94 had a significant cytotoxicity, and the effect of docetaxel wasn’t enhanced by BB 94. In early stage MFC tumor model, obvious antitumor effect of docetaxel or doxorubicin given i.v. at maximum tolerated dose (MTD, docetaxel: 20mg/kg; doxorubicin: 6mg/kg) every 4 days for 3 injections (q4d×3), even that of BB 94 (30mg/kg i.p. qd×20) was observed. Tumor growth inhibition was greater for docetaxel batimastat (96.0%) than for doxorubicin-batimastat (88.0%), docetaxel (89.0%), doxorubicin (68.0%) and BB 94 (33.0%), and the effect of docetaxel could be potentiated by BB 94. Docetaxel also showed activity against advanced stage MFC tumor in dose-dependent manner, and was more effective at MTD than doxorubicin with 4/5 regressions, 46.5 days tumor growth delay and 2.8log10 tumor cell kill. Conclusion. Our results suggest that in the MFC model with dose and schedule used, docetaxel is an effective cytotoxic new drug against MFC tumor and BB 94 enchances the antitumor activity of docetaxel.
基金Projects(51174258,11105002)supported by the National Natural Science Foundation of ChinaProject(KJ2013B087)supported by Anhui Provincial Natural Science Research Projects in Central Universities,China+1 种基金Projects(2011B31,2013A4017)support by the Guidance Science and Technology Plan Projects of Huainan,ChinaProject(2012QNZ06)supported by the Youth Foundation of Anhui University of Science&technology of China
文摘To reduce the cost, size and complexity, a consumer digital camera usually uses a single sensor overlaid with a color filter array(CFA) to sample one of the red-green-blue primary color values, and uses demosaicking algorithm to estimate the missing color values at each pixel. A novel image correlation and support vector machine(SVM) based edge-adaptive algorithm was proposed, which can reduce edge artifacts and false color artifacts, effectively. Firstly, image pixels were separated into edge region and smooth region with an edge detection algorithm. Then, a hybrid approach switching between a simple demosaicking algorithm on the smooth region and SVM based demosaicking algorithm on the edge region was performed. Image spatial and spectral correlations were employed to create middle planes for the interpolation. Experimental result shows that the proposed approach produced visually pleasing full-color result images and obtained higher CPSNR and smaller S-CIELAB*ab?E than other conventional demosaicking algorithms.
基金The Scientific Research Fund of Hunan Province Education Committee, China ( No.09A046)Natural Science Foundation of Hunan Province of China (No.07JJ6116)the Construct Program of the Key Discipline in Hunan Province of China
文摘This paper presents a fast image mosaic algorithm based on the characteristic of the edge grads. Unlike some previous algorithms, which require pure horizontal camera panning, this algorithm doesn＇t require constraints on how the image is taken. The algorithm can determine the matching regions of the two adjacent images by finding out the feature points and can piece up images bath horizontally and vertically. Experimental results show that this algorithm is effective.
文摘This article involves the study of the psychic remnants commonly known as Archetypes in Sean O＇Casey＇s play Juno and the Paycock. Archetypes are the images or patterns recurring again and again in literature through the ages. It also focuses on the minute difference between archetype and archetypal image as discussed by Jung with special reference to the characters and other images in the play beating relevance with the universal archetypes. This article also highlights the play as a connective link in the series of the different pieces of literature via the unique use of the psychic remnants. It emphasises on the different use of those remnants interwoven in the mosaic of the characters and plot of the play.
