Objectives:This study aimed to explore the effectiveness of the theory-based tailored mHealth physical activity(PA)intervention among patients with breast cancer undergoing chemotherapy.Methods:A quasi-experimental st...Objectives:This study aimed to explore the effectiveness of the theory-based tailored mHealth physical activity(PA)intervention among patients with breast cancer undergoing chemotherapy.Methods:A quasi-experimental study design was adopted.A total of 60 breast cancer patients were selected from two tertiary hospitals in Shanghai and Hangzhou City from September 2019 to August 2021.According to the admission order,30 patients werefirst included in the control group,followed by 30 patients in the intervention group.A smartphone application(app)named“Breast Care”was developed based on social cognitive theory,self-efficacy theory,and the theory of planned behavior.The app integrated various functions,including information browsing,PA monitoring and feedback,symptom reporting,and social interaction.Patients in the intervention group received three months of personalized online PA guidance in addition to routine care.The control group received routine care.Baseline and post-intervention investigations after three months were conducted in two groups using the Short Form of International Physical Activity Questionnaire,the Hospital Anxiety and Depression Scale,and the Functional Assessment of Cancer TherapydBreast cancer.Results:After three months of intervention,compared to the control group,breast cancer patients in the intervention group showed significant improvements in walking,moderate PA,and overall PA(P<0.05).Compared to the baseline data,breast cancer patients in the intervention group had significant improvements in walking and overall PA after three months(P<0.05),whereas the control group experienced significant declines in walking,moderate PA,and overall PA after three months(P<0.05).There were statistically differences between the two groups in scores for anxiety,overall quality of life,and its dimensions,such as physical well-being,emotional well-being,and additional breast cancer well-being(P<0.05).Conclusions:The theory-based tailored mHealth PA intervention has demonstrated a positive impact on promoting PA behavior change and emotional management among breast cancer patients.The‘Breast Care’app integrated various practical behavior change strategies,offering valuable guidance for personalized remote rehabilitation support for cancer patients.展开更多
A 56-day feeding trial was performed to evaluate the effects of dietary probiotic Clostridium butyricum(CB) on intestine digestive and metabolic capacities, intestine short-chain fatty acids(SCFA) content and body com...A 56-day feeding trial was performed to evaluate the effects of dietary probiotic Clostridium butyricum(CB) on intestine digestive and metabolic capacities, intestine short-chain fatty acids(SCFA) content and body composition of kuruma shrimp Marsupenaeus japonicus. Shrimp s were randomly allocated into 9 tanks, 30 each, and f ed with diets containing different levels of C. butyricum(1×10~9 cfug^(-1)): 0 mgg^(-1) feed(Control), 100 mgg^(-1) feed(CB-100), 200 mgg^(-1) feed(CB-200), while each level was triplicated. The results indicated that compared with the control group, the intestine pepsin(Pep) activity and 5-hydroxytryptamine(5-HT) concentration of two C. butyricum group s were both increased. Amylase(AM Y) and lipase(LPS) activities wer e only induced in CB-200 group. Alanine aminotransferase(ALT) and aspartate aminotransferase(A ST) activities of two C. butyricum group s showed no significant change. The α-amylase(AM Y) gene expression was induced in CB-200 group, and tryp sin gene expression of two C. butyricum treated group s were both induced. Intestine SCFA content and body composition analysis showed that the contents of propionic acid, butyric acid and the crude protein of two C. butyricum group s were all higher than those of control. These results revealed that C. butyricum can modulate intestine digestive and metabolic capacities, improve intestine SCFA content and body crude protein content in M. japonicus.展开更多
AIM: To investigate the visceral response to acute retrograde gastric electrical stimulation (RGES) in healthy humans and to derive optimal parameters for treatment of patients with obesity.METHODS: RGES with a series...AIM: To investigate the visceral response to acute retrograde gastric electrical stimulation (RGES) in healthy humans and to derive optimal parameters for treatment of patients with obesity.METHODS: RGES with a series of effective parameters were performed via a bipolar mucosal electrode implanted along the great curvature 5 cm above pylorus of stomach in 12 healthy human subjects. Symptoms associated with dyspepsia and other discomfort were observed and graded during RGES at different settings, including long pulse and pulse train. Gastric myoelectrical activity at baseline and during different settings of stimulation was recorded by a multi-channel electrogastrography.RESULTS: The gastric slow wave was entrained in all the subjects at the pacing parameter of 9 cpm in frequency, 500 ms in pulse width, and 5 mA in amplitude.The frequently appeared symptoms during stimulation were satiety, bloating, discomfort, pain, sting, and nausea. The total symptom score for each subject significantly increased as the amplitude or pulse width was adjusted to a higher scale in both long pulse and pulse train. There was a wide diversity of visceral responses to RGES among individuals.CONCLUSION: Acute RGES can result in a series of symptoms associated with dyspepsia, which is beneficial to the treatment of obesity. Optimal parameter should be determined according to the individual sensitivity to electrical stimulation.展开更多
Background: Floorball training offers a motivating and socially stimulating team activity for older adults, and 12 weeks of floorball training twice a week among men aged 65—76 years have been shown to have positive ...Background: Floorball training offers a motivating and socially stimulating team activity for older adults, and 12 weeks of floorball training twice a week among men aged 65—76 years have been shown to have positive effects on a number of physiological parameters important for health. However, the effect of long-term participation in floorball training among male elderly has not been investigated. The aim of the present study was to examine the effect of 26-month self-organized regular participation in floorball training on cardiovascular fitness, body composition, blood lipids, glucose control, and physical function among recreationally active men aged 66—78 years.Methods: After completing a 12-week randomized and controlled intervention with floorball and petanque training in the autumn 2014 or spring2015, 15 subjects chose to participate in floorball training(floorball group, FG), whereas 16 subjects resumed their usual lifestyle(control group,CG). FG took part in self-organized floorball training 1.7 sessions of 40 min/week, and CG continued their normal recreationally active lifestyle during a 26-month follow-up period. At baseline and after the follow-up period subjects were tested for cardiovascular fitness, glucose control(resting blood samples), body composition dual-energy X-ray absorptiometry(DXA-scanning), and functional capacity.Results: In FG, the decline in maximal oxygen uptake(VO_(2max)) during the follow-up period was lower(242 ± 379 mL/min, p = 0.01), blood glycosylated hemoglobin(HbA1c) increased less(—1.6 ± 2.9 mmol/L, p = 0.02), and leg bone mineral density increased more(0.03 ± 0.05 g/cm^2,p = 0.02) than those in CG. The effects on body mass, total lean body mass, fat mass, blood lipids, and physical function were similar in FG and CG.Conclusion: Approximately twice weekly floorball sessions with 40 min/session over 26-month appear to reduce age-related decline in cardiovascular fitness and glucose control and improve leg bone mineral density, suggesting that long-term participation in floorball training can be considered as a health-enhancing activity in recreationally active male elderly.展开更多
Two modes of regulating the water quality of experimental ponds in indoor raceway culture of Litopenaeus vannamei were evaluated using simple water treatment facilities. A self-made water purifying net, aeration stone...Two modes of regulating the water quality of experimental ponds in indoor raceway culture of Litopenaeus vannamei were evaluated using simple water treatment facilities. A self-made water purifying net, aeration stone, composite microbe preparation, and Ceratophyllum demersum were placed in the experimental ponds and the culture water was circulated along the raceway inside the pond using a paddle wheel aerator. In addition, the water quality in the experimental pond was improved by draining effluent from the pipeline at the bottom of ponds 7 and 8 (mode I) and exchanging the circulating water in pond 10 (mode Ⅱ) with the reservoir water in pond 9 using a pump and pipeline. The water quality in the experimental ponds was similar in response to regulation using mode Ⅰ or mode Ⅱ. Water quality parameters in the experimental ponds were controlled within a suitable range by simple facilities during culture period without using any chemical treatments. The rich content of dissolved oxygen was maintained by the circular flow and continuous aeration of the pond water. The respective average values of the main water parameters in experimental ponds 7 and 10 in response to regulation of the water quality using modes Ⅰ and Ⅱwere as follows: pH 8.17 and 7.99; DO 5.16 mg/L and 5.97 mg/L; CODMn18.45 and 12.61 mg/L; TAN (NH3-N) 0.854 mg/L (0.087 mg/L) and 0.427 mg/L (0.012 mg/L); NO2-N 0.489 mg/L and 0.337 mg/L. Moreover, the average body length and body weight of harvested shrimp of pond 7 and pond l0 were 7.56 cm and 8.99 cm, 5.10 g and 8.33 g, respectively. Furthermore, the survival rate, average biomass yield and average condition factor of the shrimp harvested were 70% and 60%, 2.54 kg/m2 and 2.14 kg/m2, and 0.675 g/cm and 0.927 g/cm, respectively. Linear equations describing the relationship between body length and culture time and cubic or power functions describing the relationship between body weight and body length were obtained based on evaluation of the growth data of shrimps throughout the culture period.展开更多
Three color variants of the sea cucumber,Apostichopus japonicus are recognized,the red one is highly valued in the market. When the red variant is cultured in ponds in China,its body color changes from red to celadon ...Three color variants of the sea cucumber,Apostichopus japonicus are recognized,the red one is highly valued in the market. When the red variant is cultured in ponds in China,its body color changes from red to celadon in 3–6 months. The effects of water depth and substrate color on the growth and body color of this animal were investigated. Juveniles of red A. japonicus were cultured in cages suspended at a range of water depths(20,50,100,150 and 200 cm). The specific growth rate of red sea cucumbers was significantly higher in animals cultured at deeper water layers compared with those grown at shallowers. Body weights were greatest for sea cucumbers cultured at a depth of 150 cm and their survival rates were highest at a depth of 200 cm. A scale to evaluate the color of red sea cucumbers(R value) was developed using a Pantone standard color card. All stocked animals in the 9-month trial retained a red color,however the red body color was much more intense in sea cucumbers cultured at shallower depths,while animals suspended in deeper layers became pale. In a separate trial,A. japonicus were cultured in suspended cages with seven different colored substrates. Substrate color had a significant effect on the growth and body-color of red A. japonicus. The yield were greatest for A. japonicus cultured on a yellow substrate,followed by green > white > orange > red > black and blue. All sea cucumbers in the 7-month trial retained a red color,although the red was most intense(highest R value) in animals cultured on a blue substrate and pale(lowest R value) for animals cultured on a green substrate.展开更多
Aging is associated with physiological declines, notably a decrease in bone mineral density (BMD) and lean body mass, with a concurrent increase in body fat and central adiposity. Interest in women and aging is of p...Aging is associated with physiological declines, notably a decrease in bone mineral density (BMD) and lean body mass, with a concurrent increase in body fat and central adiposity. Interest in women and aging is of particular interest partly as a result of gender specific responses to aging, particularly as a result of menopause. It is possible that the onset of menopause may augment the physiological decline associated with aging and inactivity. More so, a higher incidence of metabolic syndrome (an accumulation of cardiovascular disease risk factors including obesity, low-density lipoprotein cholesterol, high blood pressure, and high fasting glucose) has been shown in middle-aged women during the postmenopausal period. This is due in part to the drastic changes in body composition, as previously discussed, but also a change in physical activity (PA) levels. Sarcopenia is an age related decrease in the cross-sectional area of skeletal muscle fibers that consequently leads to a decline in physical function, gait speed, balance, coordination, decreased BMD, and quality of life. PA plays an essential role in combating physiological decline associated with aging. Maintenance of adequate levels of PA can result in increased longevity and a reduced risk for metabolic disease along with other chronic diseases. The aim of this paper is to review relevant literature, examine current PA guidelines, and provide recom- mendations specific to women based on current research.展开更多
Primary biliary cirrhosis(PBC) is an autoimmune disease of the liver characterized by progressive bile duct destruction eventually leading to cirrhosis and liver failure.The serological hallmark of the disease is the ...Primary biliary cirrhosis(PBC) is an autoimmune disease of the liver characterized by progressive bile duct destruction eventually leading to cirrhosis and liver failure.The serological hallmark of the disease is the presence of circulating antimitochondrial antibodies(AMA).These reflect the presence of autoreactive T and B cells to the culprit antigens,the E2 subunits of mitochondrial 2-oxo-acid dehydrogenase enzymes,chiefly pyruvate dehydrogenase(PDC-E2).The disease results from a combination of genetic and environmental risk factors.Genetic predisposition is indicated by the higher familial incidence of the disease particularly among siblings and the high concordance rate among monozygotic twins.Environmental triggering events appear crucial to disrupt a pre-existing unstable immune tolerance of genetic origin allowing,after a long latency,the emergence of clinical disease.Initiating mimetopes of the vulnerable epitope of the PDC-E2 autoantigen can be derived from microbes that utilize the PDC enzyme or,alternatively,environmental xenobiotics/chemical compounds that modify the structure of native proteins to make them immunogenic.A further alternative as a source of antigen is PDC-E2 derived from apoptotic cells.In the effector phase the biliary ductular cell,by reason of itsproclivity to express the antigen PDC-E2 in the course of apoptosis,undergoes a multilineage immune attack comprised of CD4+ and CD8+ T cells and antibody.In this article,we critically review the available evidence on etiopathogenesis of PBC and present interpretations of complex data,new developments and theories,and nominate directions for future research.展开更多
Primary sclerosing cholangitis(PSC) is a chronic cholestatic liver disease of unknown etiology but lymphocytic portal tract infiltration is suggestive of an immune-mediated basis for this disease.Associations with inf...Primary sclerosing cholangitis(PSC) is a chronic cholestatic liver disease of unknown etiology but lymphocytic portal tract infiltration is suggestive of an immune-mediated basis for this disease.Associations with inflammatory bowel disease(IBD) especially ulcerative colitis(UC),and with particular autoimmune diseases,as well as the genetic associations further suggest PSC may be an immune-mediated disease.The immunogenetics of PSC have been the subject of active research and several HLA and non-HLA associated genes have been implicated in the development of the disease.Lymphocytes derived from the inflamed gut may enter the liver via the enterohepatic circulation to cause hepatic disease.PSC may be triggered in genetically susceptible individuals by infections or toxins entering the portal circulation through a permeable colon and hence evoking an abnormal immune response.展开更多
Objective: To purify the natural antikeratin autoantibody (AK auto-Ab) and observe its effects on the prolif eration of the cultured keratinocytes. Methods: Natural AK auto-Ab was purified by using keratin affinity co...Objective: To purify the natural antikeratin autoantibody (AK auto-Ab) and observe its effects on the prolif eration of the cultured keratinocytes. Methods: Natural AK auto-Ab was purified by using keratin affinity column, and then the titre and specificity of the Abs were studied by ELISA, immunoperoxidase staining and immuno-electronicmicroscope. The effect of the purified Abs on the cultured keratino-cytes was assayed by 3H-TdR incorporation. Results: Natural AK auto-Ab was obtained. The binding activity of IgG AK auto-Ab in purified Ah remained similar to that in pooled human sera. and the specificity of the obtained antibody is strong. The purified antibody could decrease the Il-TdR incorporation of the cultured keratinocytes in a dose-dependent manner. Conclusion: The method of punning AK auto-Ab is simple, practicable and reliable. Natural AK auto-Ab, existing in normal human individuals, has inhibitory etiect on the proliferation of the cultured keratinocytes.展开更多
"Emotion is a specific manner of apprehending the world" and transforming the world rather than an "accidental modification of a subject who is surrounded by an unchanged world," according to Jean-Paul Sartre. Bot..."Emotion is a specific manner of apprehending the world" and transforming the world rather than an "accidental modification of a subject who is surrounded by an unchanged world," according to Jean-Paul Sartre. Both Sketch for a Theory of the Emotions and Being and Nothingness set out to investigate these relationships in broadly two ways. One, consciousness of the world of others is experienced through our emotions (anger, fear, shame, and pride for instance) as a body that escapes our grasp in being-seen-by-another. Two, we apprehend the world through our emotions in the process of magical transformation (for example, fear, melancholy, and sadness). This paper examines emotions on two levels: how we experience our ontological state as being-for-itself-in-itself and being-in-the-world-for-others; and how we conceive emotions as "magic" changing its relationship with the world "so that the world should change its qualities." What is of critical interest here is the relationship between consciousness and emotions. Situating this discussion in the context of Satre's critique on psychology, it proceeds to advance his existential psychoanalysis, starting with establishing a place for emotions and concluding with its transformative power to escape their situations.展开更多
This paper compares 18th and 19th century travelogues written by women and men travelling the cultural contact zones of the empire, as well as fictional recreations of such first encounters. A juxtaposition of the wri...This paper compares 18th and 19th century travelogues written by women and men travelling the cultural contact zones of the empire, as well as fictional recreations of such first encounters. A juxtaposition of the writers' reaction to the dynamics of gazing and the ethics of touch yields surprising results. Many women travellers have no problem to acknowledge the reciprocity of the gaze, accepting, as a matter of course, that the objects of their ethnological interest will gaze at them in return. In comparison, male travellers often exhibit unease at becoming an object of appraisal and observation. Even more interestingly, male travellers often shy away from haptic contact with members of the indigenous population, whereas many (though not all) women are more tolerant of touch and proximity. Regarded as "unwomanly" by their contemporaries, they carved out for themselves roles which allowed for a more intimate interaction with foreign ethnicities; also, they wrote in different genres--private memoirs instead of official reports. But even in their (semi) fictional writings male authors seem to imagine inter-cultural encounters in different terms from women and tend not let their protagonists enter into close bodily contact with the indigenous population.展开更多
The aetiology of primary sclerosing cholangitis (PSC) is not known and controversy exists as to whether PSC should be denominated an autoimmune disease. A large number of autoantibodies have been detected in PSC patie...The aetiology of primary sclerosing cholangitis (PSC) is not known and controversy exists as to whether PSC should be denominated an autoimmune disease. A large number of autoantibodies have been detected in PSC patients,but the specifi city of these antibodies is generally low,and the frequencies vary largely between different studies. The presence of autoantibodies in PSC may be the result of a nonspecifi c dysregulation of the immune system,but the literature in PSC points to the possible presence of specifi c antibody targets in the biliary epithelium and in neutrophil granulocytes. The present review aims to give an overview of the studies of autoantibodies in PSC,with a particular emphasis on the prevalence,clinical relevance and possible pathogenetic importance of each individual marker.展开更多
Two types of mafic intrusions have been recognized in the north of the Bafq district, Central Iran. A number of olivine-gabbroic to gabbroic sills intruded the Rizu Formation, comprised of alternating carbonate and vo...Two types of mafic intrusions have been recognized in the north of the Bafq district, Central Iran. A number of olivine-gabbroic to gabbroic sills intruded the Rizu Formation, comprised of alternating carbonate and volcanic rocks. Mineralogical data show that olivine + pyroxene +brown amphibole(kaersutite) + calcic plagioclase +opaque comprise the olivine-gabbroic rocks, and intermediate(or sodic) plagioclase + altered pyroxene and altered amphibole to biotite + opaque minerals the gabbroic rocks.Both rock types have shown within-plate and alkaline characters and have been presumed to be related to rift formation. The mafic-alkaline magma source of the sills is proposed to have been derived from enriched mantle.Regionally, two Gabbro–Diorite intrusions have been identified in the metamorphic complexes. Mineralogical data suggest that the pyroxene + amphibole(hornblende) +plagioclase + biotite + opaque minerals formed the gabbro to diorite intrusions. These rocks have shown characteristics of calc-alkaline and volcanic arc magmatism.展开更多
Over the past few years, vampire genre has populated young adult (YA) literature. YA literature can be defined as narratives about the individual growth and maturation of adolescent protagonist. Adolescence is the b...Over the past few years, vampire genre has populated young adult (YA) literature. YA literature can be defined as narratives about the individual growth and maturation of adolescent protagonist. Adolescence is the bridging process of growing from childhood to adulthood. Furthermore, it is a turbulent time of rapid physical growth and sexual development. It also creates a critical phase in the formation of identity. In this paper, the author shall identify the ways in which representation of adolescence in an American contemporary young adult novel, Anderson's Thirsty (2008), reflects and shapes the maturation of its young protagonist. The author argues that the transformation of vampire in the novel works as a metaphor for the various changes and maturation process experienced by the protagonist in the novel. Furthermore, the author's discussion will be preceded by a short history of vampire narrative. The author's analysis is supported by psychological theories of adolescence and socio-cultural approach which focuses on the ambiguities of adolescents' identity. Moreover, this paper alludes a psychoanalytic reading of the symbolism of the vampire which refers to Freud's notions of libido and death drive The conclusion of this paper is that Anderson's Thirsty is a paranormal novel which positions the implied readers to understand the trials of an adolescent protagonist during his difficult time of transition from childhood to adulthood.展开更多
This paper is based on the interviews that the author carried out between 2005 and 2006 on the Nholowemwizana custom in Plumtree, Zimbabwe. Here the author deploys the concept of cultural violence following the peace ...This paper is based on the interviews that the author carried out between 2005 and 2006 on the Nholowemwizana custom in Plumtree, Zimbabwe. Here the author deploys the concept of cultural violence following the peace researcher Johan Galtung, who suggested speaking of cultural violence as aspects of culture that can be used to justify or legitimize direct or structural violence, and may be exemplified by religion and ideology, language and art, empirical science and formal science (Galtung, 1969, pp. 167-191). Using the example of the Nholowemwizana custom among the Kalanga people, the paper will highlight the extent to which women in this society have been exposed to cultural, gender based violence and direct sexual violence. However literature on Nholowemwizana is scarce in Zimbabwe. As such the paper will borrow from literature on cultural violence in general. The paper also acknowledges the fact that not all culture is violent, and that in some certain aspects of culture that permit gender based violence especially in African societies. The starting point for this paper is the question of what role cultural arguments have played in the abuse of women through the Nholowemwizana custom.展开更多
Iron overload is closely related to many diseases. Iron overload is a risk factor that triggers a series of health problems. The toxicity of iron is that iron can catalyze the formation of oxygen free radicals and can...Iron overload is closely related to many diseases. Iron overload is a risk factor that triggers a series of health problems. The toxicity of iron is that iron can catalyze the formation of oxygen free radicals and can be used as a nutrient necessary for the growth of microorganisms and tumor cells. The sensitivity of human cells to iron toxicity varies widely. Causes of iron overload include genetic factors, behavioral factors and environmental factors. With the rapid development of modem industry, iron and its compound dust distribution industry and the increasingly widespread, in the iron pigment production, mechanical casting, iron ore mining and iron smelting operations will produce a lot of iron and its compound dust, Its impact on the human body has been of concern. Long-term exposure to iron and its compounds can cause different degrees of damage to the respiratory system, resulting in iron in vivo disorder. The relationship between iron metabolism and lung injury has also begun to be concerned, and maintaining iron homeostasis is important for lung injury and its protection.展开更多
This article investigates the role of the body in Jean-Luc Nancy's powerful essay Corpus, and critiques it from the standpoint of Agamben's biopolitics. For Nancy, the body becomes the privileged site of both existe...This article investigates the role of the body in Jean-Luc Nancy's powerful essay Corpus, and critiques it from the standpoint of Agamben's biopolitics. For Nancy, the body becomes the privileged site of both existence and sense in a way that threatens to obscure the logic of exceptional decision that Agamben takes from Carl Schmitt. As an alternative to Nancy's understanding of the body, we can see in Deleuze a series of bodies that works in parallel to a series of sense or language, where sense and body do not get collapsed into each other. At the same time, contemporary continental philosophy resists the idealistic separation of thinking and embodiment. Deleuze calls this relation between sense and body a cut, but we could also consider a parallax, following Slavoj Zizek. Finally, African-American historian of religion Charles H. Long's work complements some of Deleuze's insights in a more explicitly postcolonial context.展开更多
基金the National Natural Science Foundation of China(72104145)the Humanities and Social Science Research Project of the Ministry of Education(21YJCZH032)+1 种基金the Shanghai Science and Technology Innovation Action Plan Sail-ing Project(21YF1447700)The funders had no role in the study design,collection,analysis and interpretation of data,writing of the report,or the decision to submit the article for publication.
文摘Objectives:This study aimed to explore the effectiveness of the theory-based tailored mHealth physical activity(PA)intervention among patients with breast cancer undergoing chemotherapy.Methods:A quasi-experimental study design was adopted.A total of 60 breast cancer patients were selected from two tertiary hospitals in Shanghai and Hangzhou City from September 2019 to August 2021.According to the admission order,30 patients werefirst included in the control group,followed by 30 patients in the intervention group.A smartphone application(app)named“Breast Care”was developed based on social cognitive theory,self-efficacy theory,and the theory of planned behavior.The app integrated various functions,including information browsing,PA monitoring and feedback,symptom reporting,and social interaction.Patients in the intervention group received three months of personalized online PA guidance in addition to routine care.The control group received routine care.Baseline and post-intervention investigations after three months were conducted in two groups using the Short Form of International Physical Activity Questionnaire,the Hospital Anxiety and Depression Scale,and the Functional Assessment of Cancer TherapydBreast cancer.Results:After three months of intervention,compared to the control group,breast cancer patients in the intervention group showed significant improvements in walking,moderate PA,and overall PA(P<0.05).Compared to the baseline data,breast cancer patients in the intervention group had significant improvements in walking and overall PA after three months(P<0.05),whereas the control group experienced significant declines in walking,moderate PA,and overall PA after three months(P<0.05).There were statistically differences between the two groups in scores for anxiety,overall quality of life,and its dimensions,such as physical well-being,emotional well-being,and additional breast cancer well-being(P<0.05).Conclusions:The theory-based tailored mHealth PA intervention has demonstrated a positive impact on promoting PA behavior change and emotional management among breast cancer patients.The‘Breast Care’app integrated various practical behavior change strategies,offering valuable guidance for personalized remote rehabilitation support for cancer patients.
基金supported by Guangdong Provincial Special Fund for Marine Fisheries Technology (No. A 201701B09)Fund of Key Laboratory of South China Sea Fishery Resources Exploitation & Utilization, Ministry of Agriculture, P. R. China (No. FREU2017-01)+4 种基金Guangdong Natural Science Foundation (No. 2017A 030 313147)Special Scientific Research Funds for Central Public-interest Scientific Institution Basal Research Fund, South China Sea Fisheries Research Institute, CAFS (Nos. 2016TS07, 2017YB12)Guangdong Provincial Key Laboratory of Fishery Ecology and Environment (No. LFE2016-12)the National Natural Science Foundation of China (Nos. 31502183, 31702352)Shenzhen Science and Technology Planning Project (No. JCYJ201704 12110605075)
文摘A 56-day feeding trial was performed to evaluate the effects of dietary probiotic Clostridium butyricum(CB) on intestine digestive and metabolic capacities, intestine short-chain fatty acids(SCFA) content and body composition of kuruma shrimp Marsupenaeus japonicus. Shrimp s were randomly allocated into 9 tanks, 30 each, and f ed with diets containing different levels of C. butyricum(1×10~9 cfug^(-1)): 0 mgg^(-1) feed(Control), 100 mgg^(-1) feed(CB-100), 200 mgg^(-1) feed(CB-200), while each level was triplicated. The results indicated that compared with the control group, the intestine pepsin(Pep) activity and 5-hydroxytryptamine(5-HT) concentration of two C. butyricum group s were both increased. Amylase(AM Y) and lipase(LPS) activities wer e only induced in CB-200 group. Alanine aminotransferase(ALT) and aspartate aminotransferase(A ST) activities of two C. butyricum group s showed no significant change. The α-amylase(AM Y) gene expression was induced in CB-200 group, and tryp sin gene expression of two C. butyricum treated group s were both induced. Intestine SCFA content and body composition analysis showed that the contents of propionic acid, butyric acid and the crude protein of two C. butyricum group s were all higher than those of control. These results revealed that C. butyricum can modulate intestine digestive and metabolic capacities, improve intestine SCFA content and body crude protein content in M. japonicus.
文摘AIM: To investigate the visceral response to acute retrograde gastric electrical stimulation (RGES) in healthy humans and to derive optimal parameters for treatment of patients with obesity.METHODS: RGES with a series of effective parameters were performed via a bipolar mucosal electrode implanted along the great curvature 5 cm above pylorus of stomach in 12 healthy human subjects. Symptoms associated with dyspepsia and other discomfort were observed and graded during RGES at different settings, including long pulse and pulse train. Gastric myoelectrical activity at baseline and during different settings of stimulation was recorded by a multi-channel electrogastrography.RESULTS: The gastric slow wave was entrained in all the subjects at the pacing parameter of 9 cpm in frequency, 500 ms in pulse width, and 5 mA in amplitude.The frequently appeared symptoms during stimulation were satiety, bloating, discomfort, pain, sting, and nausea. The total symptom score for each subject significantly increased as the amplitude or pulse width was adjusted to a higher scale in both long pulse and pulse train. There was a wide diversity of visceral responses to RGES among individuals.CONCLUSION: Acute RGES can result in a series of symptoms associated with dyspepsia, which is beneficial to the treatment of obesity. Optimal parameter should be determined according to the individual sensitivity to electrical stimulation.
文摘Background: Floorball training offers a motivating and socially stimulating team activity for older adults, and 12 weeks of floorball training twice a week among men aged 65—76 years have been shown to have positive effects on a number of physiological parameters important for health. However, the effect of long-term participation in floorball training among male elderly has not been investigated. The aim of the present study was to examine the effect of 26-month self-organized regular participation in floorball training on cardiovascular fitness, body composition, blood lipids, glucose control, and physical function among recreationally active men aged 66—78 years.Methods: After completing a 12-week randomized and controlled intervention with floorball and petanque training in the autumn 2014 or spring2015, 15 subjects chose to participate in floorball training(floorball group, FG), whereas 16 subjects resumed their usual lifestyle(control group,CG). FG took part in self-organized floorball training 1.7 sessions of 40 min/week, and CG continued their normal recreationally active lifestyle during a 26-month follow-up period. At baseline and after the follow-up period subjects were tested for cardiovascular fitness, glucose control(resting blood samples), body composition dual-energy X-ray absorptiometry(DXA-scanning), and functional capacity.Results: In FG, the decline in maximal oxygen uptake(VO_(2max)) during the follow-up period was lower(242 ± 379 mL/min, p = 0.01), blood glycosylated hemoglobin(HbA1c) increased less(—1.6 ± 2.9 mmol/L, p = 0.02), and leg bone mineral density increased more(0.03 ± 0.05 g/cm^2,p = 0.02) than those in CG. The effects on body mass, total lean body mass, fat mass, blood lipids, and physical function were similar in FG and CG.Conclusion: Approximately twice weekly floorball sessions with 40 min/session over 26-month appear to reduce age-related decline in cardiovascular fitness and glucose control and improve leg bone mineral density, suggesting that long-term participation in floorball training can be considered as a health-enhancing activity in recreationally active male elderly.
基金Supported by the Shanghai Commission of Science and Technology (No.063919112073919102)the Shanghai Agricultural Committee (No.2006,9-4)
文摘Two modes of regulating the water quality of experimental ponds in indoor raceway culture of Litopenaeus vannamei were evaluated using simple water treatment facilities. A self-made water purifying net, aeration stone, composite microbe preparation, and Ceratophyllum demersum were placed in the experimental ponds and the culture water was circulated along the raceway inside the pond using a paddle wheel aerator. In addition, the water quality in the experimental pond was improved by draining effluent from the pipeline at the bottom of ponds 7 and 8 (mode I) and exchanging the circulating water in pond 10 (mode Ⅱ) with the reservoir water in pond 9 using a pump and pipeline. The water quality in the experimental ponds was similar in response to regulation using mode Ⅰ or mode Ⅱ. Water quality parameters in the experimental ponds were controlled within a suitable range by simple facilities during culture period without using any chemical treatments. The rich content of dissolved oxygen was maintained by the circular flow and continuous aeration of the pond water. The respective average values of the main water parameters in experimental ponds 7 and 10 in response to regulation of the water quality using modes Ⅰ and Ⅱwere as follows: pH 8.17 and 7.99; DO 5.16 mg/L and 5.97 mg/L; CODMn18.45 and 12.61 mg/L; TAN (NH3-N) 0.854 mg/L (0.087 mg/L) and 0.427 mg/L (0.012 mg/L); NO2-N 0.489 mg/L and 0.337 mg/L. Moreover, the average body length and body weight of harvested shrimp of pond 7 and pond l0 were 7.56 cm and 8.99 cm, 5.10 g and 8.33 g, respectively. Furthermore, the survival rate, average biomass yield and average condition factor of the shrimp harvested were 70% and 60%, 2.54 kg/m2 and 2.14 kg/m2, and 0.675 g/cm and 0.927 g/cm, respectively. Linear equations describing the relationship between body length and culture time and cubic or power functions describing the relationship between body weight and body length were obtained based on evaluation of the growth data of shrimps throughout the culture period.
基金Supported by the National Natural Science Foundation of China(No.31440089)the National Spark Program of China(No.2014GA690259)+2 种基金the National Marine Public Welfare Project of China(No.200905020)the Natural Science Research General Program of Jiangsu Provincial Higher Education Institutions(No.14KJD240002)the Special Guide Fund Project of Agricultural Science and Technology Innovation of Yancheng(No.13KJB610056)
文摘Three color variants of the sea cucumber,Apostichopus japonicus are recognized,the red one is highly valued in the market. When the red variant is cultured in ponds in China,its body color changes from red to celadon in 3–6 months. The effects of water depth and substrate color on the growth and body color of this animal were investigated. Juveniles of red A. japonicus were cultured in cages suspended at a range of water depths(20,50,100,150 and 200 cm). The specific growth rate of red sea cucumbers was significantly higher in animals cultured at deeper water layers compared with those grown at shallowers. Body weights were greatest for sea cucumbers cultured at a depth of 150 cm and their survival rates were highest at a depth of 200 cm. A scale to evaluate the color of red sea cucumbers(R value) was developed using a Pantone standard color card. All stocked animals in the 9-month trial retained a red color,however the red body color was much more intense in sea cucumbers cultured at shallower depths,while animals suspended in deeper layers became pale. In a separate trial,A. japonicus were cultured in suspended cages with seven different colored substrates. Substrate color had a significant effect on the growth and body-color of red A. japonicus. The yield were greatest for A. japonicus cultured on a yellow substrate,followed by green > white > orange > red > black and blue. All sea cucumbers in the 7-month trial retained a red color,although the red was most intense(highest R value) in animals cultured on a blue substrate and pale(lowest R value) for animals cultured on a green substrate.
文摘Aging is associated with physiological declines, notably a decrease in bone mineral density (BMD) and lean body mass, with a concurrent increase in body fat and central adiposity. Interest in women and aging is of particular interest partly as a result of gender specific responses to aging, particularly as a result of menopause. It is possible that the onset of menopause may augment the physiological decline associated with aging and inactivity. More so, a higher incidence of metabolic syndrome (an accumulation of cardiovascular disease risk factors including obesity, low-density lipoprotein cholesterol, high blood pressure, and high fasting glucose) has been shown in middle-aged women during the postmenopausal period. This is due in part to the drastic changes in body composition, as previously discussed, but also a change in physical activity (PA) levels. Sarcopenia is an age related decrease in the cross-sectional area of skeletal muscle fibers that consequently leads to a decline in physical function, gait speed, balance, coordination, decreased BMD, and quality of life. PA plays an essential role in combating physiological decline associated with aging. Maintenance of adequate levels of PA can result in increased longevity and a reduced risk for metabolic disease along with other chronic diseases. The aim of this paper is to review relevant literature, examine current PA guidelines, and provide recom- mendations specific to women based on current research.
文摘Primary biliary cirrhosis(PBC) is an autoimmune disease of the liver characterized by progressive bile duct destruction eventually leading to cirrhosis and liver failure.The serological hallmark of the disease is the presence of circulating antimitochondrial antibodies(AMA).These reflect the presence of autoreactive T and B cells to the culprit antigens,the E2 subunits of mitochondrial 2-oxo-acid dehydrogenase enzymes,chiefly pyruvate dehydrogenase(PDC-E2).The disease results from a combination of genetic and environmental risk factors.Genetic predisposition is indicated by the higher familial incidence of the disease particularly among siblings and the high concordance rate among monozygotic twins.Environmental triggering events appear crucial to disrupt a pre-existing unstable immune tolerance of genetic origin allowing,after a long latency,the emergence of clinical disease.Initiating mimetopes of the vulnerable epitope of the PDC-E2 autoantigen can be derived from microbes that utilize the PDC enzyme or,alternatively,environmental xenobiotics/chemical compounds that modify the structure of native proteins to make them immunogenic.A further alternative as a source of antigen is PDC-E2 derived from apoptotic cells.In the effector phase the biliary ductular cell,by reason of itsproclivity to express the antigen PDC-E2 in the course of apoptosis,undergoes a multilineage immune attack comprised of CD4+ and CD8+ T cells and antibody.In this article,we critically review the available evidence on etiopathogenesis of PBC and present interpretations of complex data,new developments and theories,and nominate directions for future research.
文摘Primary sclerosing cholangitis(PSC) is a chronic cholestatic liver disease of unknown etiology but lymphocytic portal tract infiltration is suggestive of an immune-mediated basis for this disease.Associations with inflammatory bowel disease(IBD) especially ulcerative colitis(UC),and with particular autoimmune diseases,as well as the genetic associations further suggest PSC may be an immune-mediated disease.The immunogenetics of PSC have been the subject of active research and several HLA and non-HLA associated genes have been implicated in the development of the disease.Lymphocytes derived from the inflamed gut may enter the liver via the enterohepatic circulation to cause hepatic disease.PSC may be triggered in genetically susceptible individuals by infections or toxins entering the portal circulation through a permeable colon and hence evoking an abnormal immune response.
文摘Objective: To purify the natural antikeratin autoantibody (AK auto-Ab) and observe its effects on the prolif eration of the cultured keratinocytes. Methods: Natural AK auto-Ab was purified by using keratin affinity column, and then the titre and specificity of the Abs were studied by ELISA, immunoperoxidase staining and immuno-electronicmicroscope. The effect of the purified Abs on the cultured keratino-cytes was assayed by 3H-TdR incorporation. Results: Natural AK auto-Ab was obtained. The binding activity of IgG AK auto-Ab in purified Ah remained similar to that in pooled human sera. and the specificity of the obtained antibody is strong. The purified antibody could decrease the Il-TdR incorporation of the cultured keratinocytes in a dose-dependent manner. Conclusion: The method of punning AK auto-Ab is simple, practicable and reliable. Natural AK auto-Ab, existing in normal human individuals, has inhibitory etiect on the proliferation of the cultured keratinocytes.
文摘"Emotion is a specific manner of apprehending the world" and transforming the world rather than an "accidental modification of a subject who is surrounded by an unchanged world," according to Jean-Paul Sartre. Both Sketch for a Theory of the Emotions and Being and Nothingness set out to investigate these relationships in broadly two ways. One, consciousness of the world of others is experienced through our emotions (anger, fear, shame, and pride for instance) as a body that escapes our grasp in being-seen-by-another. Two, we apprehend the world through our emotions in the process of magical transformation (for example, fear, melancholy, and sadness). This paper examines emotions on two levels: how we experience our ontological state as being-for-itself-in-itself and being-in-the-world-for-others; and how we conceive emotions as "magic" changing its relationship with the world "so that the world should change its qualities." What is of critical interest here is the relationship between consciousness and emotions. Situating this discussion in the context of Satre's critique on psychology, it proceeds to advance his existential psychoanalysis, starting with establishing a place for emotions and concluding with its transformative power to escape their situations.
文摘This paper compares 18th and 19th century travelogues written by women and men travelling the cultural contact zones of the empire, as well as fictional recreations of such first encounters. A juxtaposition of the writers' reaction to the dynamics of gazing and the ethics of touch yields surprising results. Many women travellers have no problem to acknowledge the reciprocity of the gaze, accepting, as a matter of course, that the objects of their ethnological interest will gaze at them in return. In comparison, male travellers often exhibit unease at becoming an object of appraisal and observation. Even more interestingly, male travellers often shy away from haptic contact with members of the indigenous population, whereas many (though not all) women are more tolerant of touch and proximity. Regarded as "unwomanly" by their contemporaries, they carved out for themselves roles which allowed for a more intimate interaction with foreign ethnicities; also, they wrote in different genres--private memoirs instead of official reports. But even in their (semi) fictional writings male authors seem to imagine inter-cultural encounters in different terms from women and tend not let their protagonists enter into close bodily contact with the indigenous population.
文摘The aetiology of primary sclerosing cholangitis (PSC) is not known and controversy exists as to whether PSC should be denominated an autoimmune disease. A large number of autoantibodies have been detected in PSC patients,but the specifi city of these antibodies is generally low,and the frequencies vary largely between different studies. The presence of autoantibodies in PSC may be the result of a nonspecifi c dysregulation of the immune system,but the literature in PSC points to the possible presence of specifi c antibody targets in the biliary epithelium and in neutrophil granulocytes. The present review aims to give an overview of the studies of autoantibodies in PSC,with a particular emphasis on the prevalence,clinical relevance and possible pathogenetic importance of each individual marker.
文摘Two types of mafic intrusions have been recognized in the north of the Bafq district, Central Iran. A number of olivine-gabbroic to gabbroic sills intruded the Rizu Formation, comprised of alternating carbonate and volcanic rocks. Mineralogical data show that olivine + pyroxene +brown amphibole(kaersutite) + calcic plagioclase +opaque comprise the olivine-gabbroic rocks, and intermediate(or sodic) plagioclase + altered pyroxene and altered amphibole to biotite + opaque minerals the gabbroic rocks.Both rock types have shown within-plate and alkaline characters and have been presumed to be related to rift formation. The mafic-alkaline magma source of the sills is proposed to have been derived from enriched mantle.Regionally, two Gabbro–Diorite intrusions have been identified in the metamorphic complexes. Mineralogical data suggest that the pyroxene + amphibole(hornblende) +plagioclase + biotite + opaque minerals formed the gabbro to diorite intrusions. These rocks have shown characteristics of calc-alkaline and volcanic arc magmatism.
文摘Over the past few years, vampire genre has populated young adult (YA) literature. YA literature can be defined as narratives about the individual growth and maturation of adolescent protagonist. Adolescence is the bridging process of growing from childhood to adulthood. Furthermore, it is a turbulent time of rapid physical growth and sexual development. It also creates a critical phase in the formation of identity. In this paper, the author shall identify the ways in which representation of adolescence in an American contemporary young adult novel, Anderson's Thirsty (2008), reflects and shapes the maturation of its young protagonist. The author argues that the transformation of vampire in the novel works as a metaphor for the various changes and maturation process experienced by the protagonist in the novel. Furthermore, the author's discussion will be preceded by a short history of vampire narrative. The author's analysis is supported by psychological theories of adolescence and socio-cultural approach which focuses on the ambiguities of adolescents' identity. Moreover, this paper alludes a psychoanalytic reading of the symbolism of the vampire which refers to Freud's notions of libido and death drive The conclusion of this paper is that Anderson's Thirsty is a paranormal novel which positions the implied readers to understand the trials of an adolescent protagonist during his difficult time of transition from childhood to adulthood.
文摘This paper is based on the interviews that the author carried out between 2005 and 2006 on the Nholowemwizana custom in Plumtree, Zimbabwe. Here the author deploys the concept of cultural violence following the peace researcher Johan Galtung, who suggested speaking of cultural violence as aspects of culture that can be used to justify or legitimize direct or structural violence, and may be exemplified by religion and ideology, language and art, empirical science and formal science (Galtung, 1969, pp. 167-191). Using the example of the Nholowemwizana custom among the Kalanga people, the paper will highlight the extent to which women in this society have been exposed to cultural, gender based violence and direct sexual violence. However literature on Nholowemwizana is scarce in Zimbabwe. As such the paper will borrow from literature on cultural violence in general. The paper also acknowledges the fact that not all culture is violent, and that in some certain aspects of culture that permit gender based violence especially in African societies. The starting point for this paper is the question of what role cultural arguments have played in the abuse of women through the Nholowemwizana custom.
文摘Iron overload is closely related to many diseases. Iron overload is a risk factor that triggers a series of health problems. The toxicity of iron is that iron can catalyze the formation of oxygen free radicals and can be used as a nutrient necessary for the growth of microorganisms and tumor cells. The sensitivity of human cells to iron toxicity varies widely. Causes of iron overload include genetic factors, behavioral factors and environmental factors. With the rapid development of modem industry, iron and its compound dust distribution industry and the increasingly widespread, in the iron pigment production, mechanical casting, iron ore mining and iron smelting operations will produce a lot of iron and its compound dust, Its impact on the human body has been of concern. Long-term exposure to iron and its compounds can cause different degrees of damage to the respiratory system, resulting in iron in vivo disorder. The relationship between iron metabolism and lung injury has also begun to be concerned, and maintaining iron homeostasis is important for lung injury and its protection.
文摘This article investigates the role of the body in Jean-Luc Nancy's powerful essay Corpus, and critiques it from the standpoint of Agamben's biopolitics. For Nancy, the body becomes the privileged site of both existence and sense in a way that threatens to obscure the logic of exceptional decision that Agamben takes from Carl Schmitt. As an alternative to Nancy's understanding of the body, we can see in Deleuze a series of bodies that works in parallel to a series of sense or language, where sense and body do not get collapsed into each other. At the same time, contemporary continental philosophy resists the idealistic separation of thinking and embodiment. Deleuze calls this relation between sense and body a cut, but we could also consider a parallax, following Slavoj Zizek. Finally, African-American historian of religion Charles H. Long's work complements some of Deleuze's insights in a more explicitly postcolonial context.