Mechanism of Olibanum and Myrrha for the Acute Soft Tissue Injury Based on Network Pharmacology

Objective The objective of this study was to screen the therapeutic target of olibanum and myrrha on acute soft tissue injury(ASTI)by network pharmacology and to clarify their mechanisms.Methods The main chemical constituents and the targets of olibanum and myrrha were obtained by using traditional Chinese medicine systems pharmacology database and analysis platform database.The disease targets of ASTI were searched by GeneCards.The intersection targets of herbs and diseases were selected for protein interaction analysis,protein–protein interaction network was constructed,and potential protein functional modules in the network were explored.A compound–target–disease network was constructed using Cytoscape3.8.2 software.The targets were analyzed by gene ontology analysis and Kyoto Encyclopedia of Genes and Genomes enrichment analysis based on the Metascape database.Results The core active components of olibanum and myrrha were quercetin,β-sitosterol,and stigmasterol.The core targets were PGR,NCOA2,PTGS2,PRKCA,and NR3C2.Pathways in cancer,AGE-RAGE signaling pathway in diabetic complications might play a potential role in olibanum and myrrha in the treatment of ASTI.Conclusion Olibanum and myrrha have the characteristics of multiple components,multiple targets,and overall regulation in the treatment of ASTI.

Boosting Collaborative Project Alignment

Managing a large-scale distributed engineering project needs skilled, motivated and committed personnel. Unified and aligned working methods are needed. Project alignment is the process of ensuring that key stakeholders share a common understanding of the project mission, goals, objectives, tactics, work processes and plans and have the required competences and skills. Based on current advances in the area of collaborative networked organizations, project management and Internet web 2.0 technologies, the authors have identified further needs and opportunities for development in the area of Collaborative Project Management. The Project Alignment Booster is a set of software services used to promote collaborative project management. The tool has been developed to suit industrial requirements in the area of large and complicated engineering project management, The paper reports the results of developing a toolkit to support collaborative project alignment.

Potential Mechanisms of Yanghe Decoction in the Treatment of Soft Tissue Sarcoma and Arteriosclerosis Obliterans Based on Network Pharmacology

Objective The objective of this study was to investigate potential mechanisms of Yanghe Decoction(YHD)in treating soft tissue sarcoma(STS)and arteriosclerosis obliterans(ASO)based on the use of network pharmacology.Methods Candidate compounds and potential targets were identifed through the TCM Systems Pharmacology database and a comprehensive literature search.Related targets of STS and ASO were collected in the GeneCards database,DisGeNET database,and Drugbank database.Furthermore,The STRING 11.0 database was used to determine protein-protein interaction(PPI)networks;common targets were obtained and imported into Cytoscape 3.7.2.Then,a PPI network comprising common targets was drawn,and network topology analysis was performed to screen for key shared targets.Gene ontology functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis of key shared targets were performed by using Metascape software.Subsequently.a compound-target-pathway network was constructed via Cytoscape 3.7.2.Results The following signaling pathways were found to be associated with the mechanisms of YHD in treating STS and ASO:AGE-RAGE signaling pathway,IL-17 signaling pathway;HIF-1 signaling pathway,TNF signaling pathway,interactions between cytokines and cytokine receptors,Th17 cell differentiation,and NOD-like receptor signaling pathway.Among the compounds and targets involved in these pathways,quercetin,luteolin,and kaempferol were found to be core compounds,and TNF,IL-6,and MAPK1 were found to be core targets.Conclusion Taken together,our findings elucidated that potential mechanisms of YHD in treating STS and ASO involved cellular proliferation/differentiation,angiogen-esis,inflammation,immune responses,oxidative stress,and other related signaling pathways.

几种数字监控方案的对比

在安防监控中，逐渐呈现出数字化的趋势，本文就常见的两大类数字监控方案做了对比介绍，分析了它们的优缺点，以及适用范围。

A PAIR OF COUPLING METRICS FOR SOFTWARE NETWORKS

Complex networks are everywhere. A typical example is software network. How to measure and control coupling interactions of software components is a largely explored research problem in software network. In terms of graph theory and linear algebra, this paper investigates a pair of coupling metrics to evaluate coupling interactions between the classes of object-oriented systems. These metrics differ from the majority of existing metrics in three aspects： Taking into account the strength that one class depends on other ones, reflecting indirect coupling, and distinguishing various coupling interaction. An empirical comparison of the novel measures with one of the most widely used coupling metrics is described. Specifically, an experiment about the relationships of this pair metrics is conducted. The result shows that software complexity derived from coupling interaction could not be accurately reflected by one dimension of coupling metric for negative correlation.