A theoretical calculation method of the axial compressive strength of a high strength concrete with fibre reinforced plastics (FRP) constraint is proposed. It is shown by test verification that the FRP strength devoti...A theoretical calculation method of the axial compressive strength of a high strength concrete with fibre reinforced plastics (FRP) constraint is proposed. It is shown by test verification that the FRP strength devotion factor used for this method is in accordance with actual conditions. FRP is not up to the ultimate strength when the concrete reaches the ultimate strength, whose strength devotion factor is in the range of 0.28 to 0.59, which is related to an elastic modulus. The method can be used to estimate axial compressive strength of the concrete strengthened with FRP. The theoretical strength is 10% to 30% higher than the measured one. The deviation comes mainly from a non-ideal bonding condition of FRP-concrete interfaces and discrete property of the testing data of compressive strength.展开更多
The last decade has witnessed a growing appreciation of the fundamental role played by an early assembly of a diverse and balanced gut microbiota and its subsequent maintenance for future health of the host. Gut micro...The last decade has witnessed a growing appreciation of the fundamental role played by an early assembly of a diverse and balanced gut microbiota and its subsequent maintenance for future health of the host. Gut microbiota is currently viewed as a key regulator of a fluent bidirectional dialogue between the gut and the brain(gut-brain axis). A number of preclinical studies have suggested that the microbiota and its genome(microbiome) may play a key role in neurodevelopmental and neurodegenerative disorders. Furthermore, alterations in the gut microbiota composition in humans have also been linked to a variety of neuropsychiatric conditions, including depression, autism and Parkinson's disease. However, it is not yet clear whether these changes in the microbiome are causally related to such diseases or are secondary effects thereof. In this respect, recent studies in animals have indicated that gut microbiota transplantation can transfer a behavioral phenotype, suggesting that the gut microbiota may be a modifiable factor modulating the development or pathogenesis of neuropsychiatric conditions. Further studies are warranted to establish whether or not the findings of preclinical animal experiments can be generalized to humans. Moreover, although different communication routes between the microbiota and brain have been identified, further studies must elucidate all the underlying mechanisms involved. Such research is expected to contribute to the design of strategies to modulate the gut microbiota and its functions with a view to improving mental health, and thus provide opportunities to improve the management of psychiatric diseases. Here, we review the evidence supporting a role of the gut microbiota in neuropsychiatric disorders and the state of the art regarding the mechanisms underlying its contribution to mental illness and health. We also consider the stages of life where the gut microbiota is more susceptible to the effects of environmental stressors, and the possible microbiota-targeted intervention strategies that could improve health status and prevent psychiatric disorders in the near future.展开更多
A dynamics model of the self-aligning ball bearing is proposed based on the Jones-Harris method （JHM）, and a computer program is developed to solve the equations by using the Newton-Raphson method. A parametric anal...A dynamics model of the self-aligning ball bearing is proposed based on the Jones-Harris method （JHM）, and a computer program is developed to solve the equations by using the Newton-Raphson method. A parametric analysis of the centrifugal force and the gyroscopic moment, the contact loads, the contact angles, the radial deformation and the radial stiffness is carried out. The analytical results show that the applied loads and the rotational speed are two main factors that can influence the distributions of the contact loads and values of the contact angles. The centrifugal force and the gyroscopic moment increase with the increase in the rotational speed, resulting in the decrease of the inner raceway contact load and the increase of the outer raceway contact load. The outer raceway contact angle increases under the centrifugal force; on the contrary, the inner raceway contact angle decreases. Furthermore, the differences between the inner and the outer contact angles increase with the increase in the rotational speed. The higher rotational speed results in the decrease in radial stiffness for the self-aligning ball bearing, and the raceway curvature coefficient, to some extent, also influences the radial stiffness.展开更多
文摘A theoretical calculation method of the axial compressive strength of a high strength concrete with fibre reinforced plastics (FRP) constraint is proposed. It is shown by test verification that the FRP strength devotion factor used for this method is in accordance with actual conditions. FRP is not up to the ultimate strength when the concrete reaches the ultimate strength, whose strength devotion factor is in the range of 0.28 to 0.59, which is related to an elastic modulus. The method can be used to estimate axial compressive strength of the concrete strengthened with FRP. The theoretical strength is 10% to 30% higher than the measured one. The deviation comes mainly from a non-ideal bonding condition of FRP-concrete interfaces and discrete property of the testing data of compressive strength.
基金Supported by Spanish Ministry of Economy and Competitiveness(MINECO),No.AGL2014-52101-PA Sara Borrell postdoctoral fellowship from the Instituto de Salud Carlos Ⅲ at the Spanish Ministry of Health(Spain),No.CD14/00237(Cenit MC)
文摘The last decade has witnessed a growing appreciation of the fundamental role played by an early assembly of a diverse and balanced gut microbiota and its subsequent maintenance for future health of the host. Gut microbiota is currently viewed as a key regulator of a fluent bidirectional dialogue between the gut and the brain(gut-brain axis). A number of preclinical studies have suggested that the microbiota and its genome(microbiome) may play a key role in neurodevelopmental and neurodegenerative disorders. Furthermore, alterations in the gut microbiota composition in humans have also been linked to a variety of neuropsychiatric conditions, including depression, autism and Parkinson's disease. However, it is not yet clear whether these changes in the microbiome are causally related to such diseases or are secondary effects thereof. In this respect, recent studies in animals have indicated that gut microbiota transplantation can transfer a behavioral phenotype, suggesting that the gut microbiota may be a modifiable factor modulating the development or pathogenesis of neuropsychiatric conditions. Further studies are warranted to establish whether or not the findings of preclinical animal experiments can be generalized to humans. Moreover, although different communication routes between the microbiota and brain have been identified, further studies must elucidate all the underlying mechanisms involved. Such research is expected to contribute to the design of strategies to modulate the gut microbiota and its functions with a view to improving mental health, and thus provide opportunities to improve the management of psychiatric diseases. Here, we review the evidence supporting a role of the gut microbiota in neuropsychiatric disorders and the state of the art regarding the mechanisms underlying its contribution to mental illness and health. We also consider the stages of life where the gut microbiota is more susceptible to the effects of environmental stressors, and the possible microbiota-targeted intervention strategies that could improve health status and prevent psychiatric disorders in the near future.
基金The National Natural Science Foundation of China (No.5047507, 50775036)the High Technology Research Program of Jiangsu Province (No.BG2006035)the Natural Science Foundation of JiangsuProvince (No.BK2009612)
文摘A dynamics model of the self-aligning ball bearing is proposed based on the Jones-Harris method （JHM）, and a computer program is developed to solve the equations by using the Newton-Raphson method. A parametric analysis of the centrifugal force and the gyroscopic moment, the contact loads, the contact angles, the radial deformation and the radial stiffness is carried out. The analytical results show that the applied loads and the rotational speed are two main factors that can influence the distributions of the contact loads and values of the contact angles. The centrifugal force and the gyroscopic moment increase with the increase in the rotational speed, resulting in the decrease of the inner raceway contact load and the increase of the outer raceway contact load. The outer raceway contact angle increases under the centrifugal force; on the contrary, the inner raceway contact angle decreases. Furthermore, the differences between the inner and the outer contact angles increase with the increase in the rotational speed. The higher rotational speed results in the decrease in radial stiffness for the self-aligning ball bearing, and the raceway curvature coefficient, to some extent, also influences the radial stiffness.
