We have developed an iron（III） phthalocyanine chloride‐catalyzed oxidation–aromatization ofα,β‐unsaturated ketones with hydrazine hydrate. Various 3,5‐disubstituted 1H‐pyrazoles were obtained in good to excel...We have developed an iron（III） phthalocyanine chloride‐catalyzed oxidation–aromatization ofα,β‐unsaturated ketones with hydrazine hydrate. Various 3,5‐disubstituted 1H‐pyrazoles were obtained in good to excellent yields. This method offers several advantages, including room‐tem‐perature conditions, short reaction time, high yields, simple work‐up procedure, and use of air as an oxidant. The catalyst can be recovered and reused five times without loss of activity.展开更多
A wide-range and phase-locked Michelson interferometer technique is described. This technique combined with femtosecond laser is used to measure the spectrum of the rare-earth ion Nd：YVO4, which presents very high si...A wide-range and phase-locked Michelson interferometer technique is described. This technique combined with femtosecond laser is used to measure the spectrum of the rare-earth ion Nd：YVO4, which presents very high signal to noise ratio of interferometric intensity output and higher spectral resolution than traditional grating spectrophotometer.展开更多
Effect of salinity on survival,feeding behavior and growth of juvenile swimming crab P ortunus trituberculatus was investigated under 5 salinity levels of 5,10,20,30 and 40. The results show that the crab juveniles fe...Effect of salinity on survival,feeding behavior and growth of juvenile swimming crab P ortunus trituberculatus was investigated under 5 salinity levels of 5,10,20,30 and 40. The results show that the crab juveniles fed 2 or 3 times at the salinity 20 and 30,each lasted for about 25 minutes,for a total feeding time of 73.2±22.65 minutes per day. At these salinities,there were significantly higher in the frequency of feeding and in total feeding time than those at lower salinities of 5 and 10. All crab juveniles moulted when reared at a salinity of 20 during the 5 days duration of the experiment,which is significantly higher than those at other salinities. All juveniles survived at salinity 20,and the survivorship was not significantly different from that at 30,but was signif icantly higher than those at other salinities. The crab juveniles reared at a salinity of 20 had the highest value of food ration of 0.190 8±0.011 3 g/g BW,average body weight gain of 0.796±0.128 g,gain rate of 87%–96%,and food conversion ratio of 1.20±0.09. There was no significant difference in the values found between 20 and 30 but these values were significantly lower than that at the other salinities( P> 0.05). Highest activities of digestive enzymes(Amylase,Protease,Lipase) and lowest activities of protective enzymes(SOD,PO,CAT) were also obtained on crab juveniles reared at salinity of 20.展开更多
Distributed polarization coupling in polarization-maintaining fibers can be detected by using a white light Michelson interferometer.This technique usually requires that only one polarization mode is excited.However,i...Distributed polarization coupling in polarization-maintaining fibers can be detected by using a white light Michelson interferometer.This technique usually requires that only one polarization mode is excited.However,in practical measurement,the injection polarization direction could not be exactly aligned to one of the principal axes of the PMF,so the influence of the polarization extinction ratio should be considered.Based on the polarization coupling theory,the influence of the incident polarization extinction on the measurement result is evaluated and analyzed,and a method for distributed polariza-tion coupling detection is developed when both two orthogonal eigenmodes are excited.展开更多
A Michael addition is usually taken as a base-catalysed reaction. However, our synthesized 2-（quinolin-2-ylmethylene） malonic acid （QMA） as a Michael-type thiol fluorescent probe is acid-active in its sensing reac...A Michael addition is usually taken as a base-catalysed reaction. However, our synthesized 2-（quinolin-2-ylmethylene） malonic acid （QMA） as a Michael-type thiol fluorescent probe is acid-active in its sensing reaction. In this work, based on theoretic calculation and experimental study on 7-hydroxy-2-（quinolin-2-ylmethylene） malonic acid, we demonstrated that QMA as a Michael acceptor is acid-activatable, i.e., it works only in solutions at pH〈7, and the lower the pH of solutions is, the higher reactivity QMA has. In alkaline solution, the malonate QMA[-2H＋]2- cannot react with both RSand RSH. In contrast, 2-（quinolin-2- ylmethylene） malonic ester （QME）, the ester of QMA, reveal a contrary pH effect on its sensing reaction, that is, it can sense thiols in alkaline solutions but not in acidic solutions, like a normal base-catalysed Michael addition. The values of activation enthalpies from theoretic calculation support the above sensing behavior of two probes under different pH conditions. In acidic solutions, the protonated QMA is more highly reactive towards electrophilic attack over its other ionized states in neutral and alkaline solutions, and so can react with lowly reactive RSH. In contrast, there is a big energy barrier in the interaction of QME with RSH （acidic solutions）, and the reaction of QME with the highly reactive nucleophile RS- is a low activation energy process （in alkaline solutions）. Theoretic calculation reveals that the sensing reaction of QMA undergoes a 1,4-addition process with neutral thiols （RSH）, and a 1,2-addition pathway for the sensing reaction of QME with RS-. Therefore, the sensing reaction of QMA is an acid-catalysed Michael addition via a 1,4-addition, and a normal base-catalysed Michael addition via a 1,2-addition.展开更多
The method to measure the refractive index of the liquid-state metal is introduced. By inserting a wedge sample cell to the optical path of the Michelson interferometer, the refractive index of the liquid-state alloy ...The method to measure the refractive index of the liquid-state metal is introduced. By inserting a wedge sample cell to the optical path of the Michelson interferometer, the refractive index of the liquid-state alloy SCN-Eth is measured at different temperatures and densities. The results show that this method can be applied to measure the refractive index of various liquids, especially at different temperatures.展开更多
Personalized cancer medicine has seen significant improvements over the past decade. Recent Elsevier conference： Miami winter symposium 2015 （MWS2015） ＂Towards Personalized Cancer Medicine＂ meeting was dedicated ...Personalized cancer medicine has seen significant improvements over the past decade. Recent Elsevier conference： Miami winter symposium 2015 （MWS2015） ＂Towards Personalized Cancer Medicine＂ meeting was dedicated to this exciting field, and focused on new progress in personalized drug development and antibody drug against checkpoint pathway. Tais meeting report summarizes the key developments presented and discussed at the meeting, with a focus on immunotherapy, especially on the CTLA-4 and PD-1/PD-L1 pathways. The monoclonal antibody drugs intervening these checkpoint pathways have the potential to play a larger role in personalize medicine within the near future. Here we intended to provide a comprehensive summary about ongoing trends and future perspectives on personalized medicine in cancer therapy.展开更多
It was discovered a new approach modification Bart, Beschamp, Mayer, Rosenmund, Scheller, Sherlyn-Braz reactions with of arsine, stibine and bismuthine in organometallic chemistry. The authors have proposed a new mech...It was discovered a new approach modification Bart, Beschamp, Mayer, Rosenmund, Scheller, Sherlyn-Braz reactions with of arsine, stibine and bismuthine in organometallic chemistry. The authors have proposed a new mechanism for possible reactions.展开更多
Many definitions of pornography implicitly involve begging the question concerning its moral value. One exception to this is Michael Rea＇s 2001 definition. The present paper identifies some counter-intuitive conseque...Many definitions of pornography implicitly involve begging the question concerning its moral value. One exception to this is Michael Rea＇s 2001 definition. The present paper identifies some counter-intuitive consequences of this definition of pornography and seeks to amend it. The aim of the paper is to separate a definitional understanding of pornography from a normative understanding of pornography in order to lay the foundations for future, coherent moral thinking on the subject.展开更多
In many of his most memorable ballads, Cowboy Junkies lyricist and lead guitarist Michael Timmins combines imagery of seasonal change, of the year, notably of Winter, with religious and mythological references to crea...In many of his most memorable ballads, Cowboy Junkies lyricist and lead guitarist Michael Timmins combines imagery of seasonal change, of the year, notably of Winter, with religious and mythological references to create richly textured metaphors and analogies of love, loss and anguish. Some of the band’s songs which display these symbolic networks and thematic linkages which we Will consider here are “Winter’s Song,” “’Cause Cheap is How I Feel,” “Crescent Moon,” “First Recollection,” “Sad to See the Season Go,” “Good Friday” and “Ring on the Sill.” We will show that Timmins succeeds not only in rendering vivid tableaux of life in a world where Winter dominates the seasonal round, but also in making those exterior visions, in effect, objective correlatives of the inner lives of the characters of his ballads.展开更多
The films Catch-22 （1970） and The English Patient （1996） are based on literary novels, and set in the specific time and place of World War II Italy. Each work uses the topic of the war to raise the issues of ident...The films Catch-22 （1970） and The English Patient （1996） are based on literary novels, and set in the specific time and place of World War II Italy. Each work uses the topic of the war to raise the issues of identity and loyalty that loom large during wartime, when nations place huge demands on their people. Both works explore these issues as relevant to their own time. In the 1960s, Catch-22 elevates loyalty to self as a value and challenges the dehumanizing conformity demanded by the bureaucratic states of the postwar world. Twenty-six years later, The English Patient honors loyalty to people rather than to nations. Both movies end in hope, with Yossarian＇s escape in Catch-22, and the end to the European war in The English Patient. This paper argues that Michael Ondaatje＇s novel, The English Patient, goes beyond the issues of identity and loyalty and the hopeful Hollywood ending as seen in the movies. By giving Kip＇s and Hana＇s points of view, which were not shown in the film--the view of a brown man in a world controlled by whites and of a woman who understands the horrors of the atomic bomb--Ondaatje offers the possibilities of a new sense of identity and loyalty, one more in tune with issues of a post-colonial 21 st century world展开更多
基金supported by the Industrial Research Project of Shaanxi Science and Technology Department(2014K08-29)Science and Technology Plan Project of Xi’an(CXY1511(7))Scientific Research Foundation of Northwest University~~
文摘We have developed an iron（III） phthalocyanine chloride‐catalyzed oxidation–aromatization ofα,β‐unsaturated ketones with hydrazine hydrate. Various 3,5‐disubstituted 1H‐pyrazoles were obtained in good to excellent yields. This method offers several advantages, including room‐tem‐perature conditions, short reaction time, high yields, simple work‐up procedure, and use of air as an oxidant. The catalyst can be recovered and reused five times without loss of activity.
基金ACKNOWLEDGMENTS This work was supported by the National Natural Science Foundation of China （No.60677051 and No.10774193） and the National Key Basic Research Special Foundation （No.G2010CB923204）.
文摘A wide-range and phase-locked Michelson interferometer technique is described. This technique combined with femtosecond laser is used to measure the spectrum of the rare-earth ion Nd：YVO4, which presents very high signal to noise ratio of interferometric intensity output and higher spectral resolution than traditional grating spectrophotometer.
基金Supported by the Science and Technology Innovation Team of Marine Crab Industry in Ningbo City(No.2011B81003)the National Natural Science Foundation of China(No.41276123)+2 种基金the National Spark Plan Program of China(No.2012GA701048)the Key Project of Ministry of Education,Science and Technology(No.212070)the K C Wong Magana Fund in Ningbo University
文摘Effect of salinity on survival,feeding behavior and growth of juvenile swimming crab P ortunus trituberculatus was investigated under 5 salinity levels of 5,10,20,30 and 40. The results show that the crab juveniles fed 2 or 3 times at the salinity 20 and 30,each lasted for about 25 minutes,for a total feeding time of 73.2±22.65 minutes per day. At these salinities,there were significantly higher in the frequency of feeding and in total feeding time than those at lower salinities of 5 and 10. All crab juveniles moulted when reared at a salinity of 20 during the 5 days duration of the experiment,which is significantly higher than those at other salinities. All juveniles survived at salinity 20,and the survivorship was not significantly different from that at 30,but was signif icantly higher than those at other salinities. The crab juveniles reared at a salinity of 20 had the highest value of food ration of 0.190 8±0.011 3 g/g BW,average body weight gain of 0.796±0.128 g,gain rate of 87%–96%,and food conversion ratio of 1.20±0.09. There was no significant difference in the values found between 20 and 30 but these values were significantly lower than that at the other salinities( P> 0.05). Highest activities of digestive enzymes(Amylase,Protease,Lipase) and lowest activities of protective enzymes(SOD,PO,CAT) were also obtained on crab juveniles reared at salinity of 20.
基金National Natural Science Foundation of China (60577013)the Teaching and Research Award Program for Outstanding Young Teachers of MOE, China
文摘Distributed polarization coupling in polarization-maintaining fibers can be detected by using a white light Michelson interferometer.This technique usually requires that only one polarization mode is excited.However,in practical measurement,the injection polarization direction could not be exactly aligned to one of the principal axes of the PMF,so the influence of the polarization extinction ratio should be considered.Based on the polarization coupling theory,the influence of the incident polarization extinction on the measurement result is evaluated and analyzed,and a method for distributed polariza-tion coupling detection is developed when both two orthogonal eigenmodes are excited.
基金This work is supported by the National Natural Science Foundation of China （No.21272224）, the Open Research Fund of State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University （No.201410）, and the Open Research Fund of Key Laboratory of Advanced Scientific Computation, Xihua University （No.szjj2013-024）.
文摘A Michael addition is usually taken as a base-catalysed reaction. However, our synthesized 2-（quinolin-2-ylmethylene） malonic acid （QMA） as a Michael-type thiol fluorescent probe is acid-active in its sensing reaction. In this work, based on theoretic calculation and experimental study on 7-hydroxy-2-（quinolin-2-ylmethylene） malonic acid, we demonstrated that QMA as a Michael acceptor is acid-activatable, i.e., it works only in solutions at pH〈7, and the lower the pH of solutions is, the higher reactivity QMA has. In alkaline solution, the malonate QMA[-2H＋]2- cannot react with both RSand RSH. In contrast, 2-（quinolin-2- ylmethylene） malonic ester （QME）, the ester of QMA, reveal a contrary pH effect on its sensing reaction, that is, it can sense thiols in alkaline solutions but not in acidic solutions, like a normal base-catalysed Michael addition. The values of activation enthalpies from theoretic calculation support the above sensing behavior of two probes under different pH conditions. In acidic solutions, the protonated QMA is more highly reactive towards electrophilic attack over its other ionized states in neutral and alkaline solutions, and so can react with lowly reactive RSH. In contrast, there is a big energy barrier in the interaction of QME with RSH （acidic solutions）, and the reaction of QME with the highly reactive nucleophile RS- is a low activation energy process （in alkaline solutions）. Theoretic calculation reveals that the sensing reaction of QMA undergoes a 1,4-addition process with neutral thiols （RSH）, and a 1,2-addition pathway for the sensing reaction of QME with RS-. Therefore, the sensing reaction of QMA is an acid-catalysed Michael addition via a 1,4-addition, and a normal base-catalysed Michael addition via a 1,2-addition.
文摘The method to measure the refractive index of the liquid-state metal is introduced. By inserting a wedge sample cell to the optical path of the Michelson interferometer, the refractive index of the liquid-state alloy SCN-Eth is measured at different temperatures and densities. The results show that this method can be applied to measure the refractive index of various liquids, especially at different temperatures.
文摘Personalized cancer medicine has seen significant improvements over the past decade. Recent Elsevier conference： Miami winter symposium 2015 （MWS2015） ＂Towards Personalized Cancer Medicine＂ meeting was dedicated to this exciting field, and focused on new progress in personalized drug development and antibody drug against checkpoint pathway. Tais meeting report summarizes the key developments presented and discussed at the meeting, with a focus on immunotherapy, especially on the CTLA-4 and PD-1/PD-L1 pathways. The monoclonal antibody drugs intervening these checkpoint pathways have the potential to play a larger role in personalize medicine within the near future. Here we intended to provide a comprehensive summary about ongoing trends and future perspectives on personalized medicine in cancer therapy.
文摘It was discovered a new approach modification Bart, Beschamp, Mayer, Rosenmund, Scheller, Sherlyn-Braz reactions with of arsine, stibine and bismuthine in organometallic chemistry. The authors have proposed a new mechanism for possible reactions.
文摘Many definitions of pornography implicitly involve begging the question concerning its moral value. One exception to this is Michael Rea＇s 2001 definition. The present paper identifies some counter-intuitive consequences of this definition of pornography and seeks to amend it. The aim of the paper is to separate a definitional understanding of pornography from a normative understanding of pornography in order to lay the foundations for future, coherent moral thinking on the subject.
文摘In many of his most memorable ballads, Cowboy Junkies lyricist and lead guitarist Michael Timmins combines imagery of seasonal change, of the year, notably of Winter, with religious and mythological references to create richly textured metaphors and analogies of love, loss and anguish. Some of the band’s songs which display these symbolic networks and thematic linkages which we Will consider here are “Winter’s Song,” “’Cause Cheap is How I Feel,” “Crescent Moon,” “First Recollection,” “Sad to See the Season Go,” “Good Friday” and “Ring on the Sill.” We will show that Timmins succeeds not only in rendering vivid tableaux of life in a world where Winter dominates the seasonal round, but also in making those exterior visions, in effect, objective correlatives of the inner lives of the characters of his ballads.
文摘The films Catch-22 （1970） and The English Patient （1996） are based on literary novels, and set in the specific time and place of World War II Italy. Each work uses the topic of the war to raise the issues of identity and loyalty that loom large during wartime, when nations place huge demands on their people. Both works explore these issues as relevant to their own time. In the 1960s, Catch-22 elevates loyalty to self as a value and challenges the dehumanizing conformity demanded by the bureaucratic states of the postwar world. Twenty-six years later, The English Patient honors loyalty to people rather than to nations. Both movies end in hope, with Yossarian＇s escape in Catch-22, and the end to the European war in The English Patient. This paper argues that Michael Ondaatje＇s novel, The English Patient, goes beyond the issues of identity and loyalty and the hopeful Hollywood ending as seen in the movies. By giving Kip＇s and Hana＇s points of view, which were not shown in the film--the view of a brown man in a world controlled by whites and of a woman who understands the horrors of the atomic bomb--Ondaatje offers the possibilities of a new sense of identity and loyalty, one more in tune with issues of a post-colonial 21 st century world
