态靶结合辨治青少年抑郁症思路探讨

基于态靶辨证理论,分析青少年抑郁症之“态”与“靶”及其“调态打靶”的可能思路。认为青少年抑郁症之病机主要为气机郁滞,郁积日久而致情志异常,是为“郁”态;久之郁火易上逆上亢,并累及他脏,可产生“逆”态与“虚”态。中枢五羟色胺能系统改变及中缝背核-中脑奖赏系统神经环路可作为青少期抑郁症调控的核心靶点与通路。临证时,“调态”应首先调心理之态,再调病证之态;“打靶”可打中枢五羟色胺能系统及其神经环路之靶。基于态靶辨证构建青少年抑郁症辨治新体系,将有助于阐明青少年抑郁症的宏观与微观防治机制。

Multi-field dynamic modeling and numerical simulation of aluminum alloy resistance spot welding

In order to explore the influence of welding parameters and to investigate the Al alloy (AA) nugget formation process, a comprehensive model involving electrical-thermal-mechanical and metallurgical analysis was established to numerically display the resistance spot welding (RSW) process within multiple fields and understand the AA-RSW physics. A multi-disciplinary finite element method (FEM) framework and a empirical sub-model were built to analyze the affecting factors on weld nugget and the underlying nature of welding physics with dynamic simulation procedure. Specifically, a counter-intuitive phenomenon of the resistance time-variation caused by the transient inverse virtual variation (TIVV) effect was highlighted and analyzed on the basis of welding current and temperature distribution simulation. The empirical model describing the TIVV phenomenon was used for modifying the dynamic resistance simulation during the AA spot welding process. The numerical and experimental results show that the proposed multi-field FEM model agrees with the measured AA welding feature, and the modified dynamic resistance model captures the physics of nugget growth and the electrical-thermal behavior under varying welding current and fluctuating heat input.

Electricity Storage With High Roundtrip Efficiency in a Reversible Solid Oxide Cell Stack

We theoretically investigate the electricity storage/generation in a reversible solid oxide cell stack. The system heat is for the first time tentatively stored in a phase-change metal when the stack is operated to generate electricity in a fuel cell mode and then reused to store electricity in an electrolysis mode. The state of charge （H2 frication in cathode） effectively enhances the open circuit voltages （OCVs） while the system gas pressure in electrodes also increases the OCVs. On the other hand, a higher system pressure facilitates the species diffusion in electrodes that therefore accordingly improve electrode polarizations. With the aid of recycled system heat, the roundtrip efficiency reaches as high as 92% for the repeated electricity storage and generation.

Dynamic analysis, simulation, and control of a 6-DOF IRB-120 robot manipulator using sliding mode control and boundary layer method

Because of its ease of implementation,a linear PID controller is generally used to control robotic manipulators.Linear controllers cannot effectively cope with uncertainties and variations in the parameters;therefore,nonlinear controllers with robust performance which can cope with these are recommended.The sliding mode control(SMC)is a robust state feedback control method for nonlinear systems that,in addition having a simple design,efficiently overcomes uncertainties and disturbances in the system.It also has a very fast transient response that is desirable when controlling robotic manipulators.The most critical drawback to SMC is chattering in the control input signal.To solve this problem,in this study,SMC is used with a boundary layer(SMCBL)to eliminate the chattering and improve the performance of the system.The proposed SMCBL was compared with inverse dynamic control(IDC),a conventional nonlinear control method.The kinematic and dynamic equations of the IRB-120 robot manipulator were initially extracted completely and accurately,and then the control of the robot manipulator using SMC was evaluated.For validation,the proposed control method was implemented on a 6-DOF IRB-120 robot manipulator in the presence of uncertainties.The results were simulated,tested,and compared in the MATLAB/Simulink environment.To further validate our work,the results were tested and confirmed experimentally on an actual IRB-120 robot manipulator.

The status of Chinese medicine in reversing multi-drug resistance of hepatocellular carcinoma

Multi-drug resistance(MDR) is a major obstacle in the chemotherapy of hepatocellular carcinoma.Comparing with western reversal agents,traditional Chinese medicine have advantages of low cost,hypotoxicity,wide safety range,broad-spectrum and multi-targets,etc.Therefore,traditional Chinese medicine may be expected to open up a new path to reverse MDR of liver cancer.Studies about applying traditional Chinese medicine to reverse MDR in hepatocellular carcinoma are outlined below.

ADAPTIVE FLIGHT CONTROL SYSTEM OF ARMED HELICOPTER USING WAVELET NEURAL NETWORK METHOD

A discussion is devoted to the design of an adaptive flight control system of the armed helicopter using wavelet neural network method. Firstly, the control loop of the attitude angle is designed with a dynamic inversion scheme in a quick loop and a slow loop. respectively. Then, in order to compensate the error caused by dynamic inversion, the adaptive flight control system of the armed helicopter using wavelet neural network method is put forward, so the BP wavelet neural network and the Lyapunov stable wavelet neural network are used to design the helicopter flight control system. Finally, the typical maneuver flight is simulated to demonstrate its validity and effectiveness. Result proves that the wavelet neural network has an engineering practical value and the effect of WNN is good.

Calculation and analysis of losses of magnetic-valve controllable reactor

Magnetic-valve controllable reactor(MCR)has characteristics of DC bias and different types of magnetic flux density in the magnetic circuit and winding current distortion.These characteristics not only lead to loss calculation method of MCR different from that of power transformer,but also make it more difficult to calculate the core loss and wingding loss of MCR accurately.Our study combines core partition method with dynamic inverse J-A model to calculate the core loss of MCR.The winding loss coefficient of MCR is proposed,which takes into account the influence of harmonics and magnetic flux leakage on the winding loss of MCR.The result shows that the proposed core loss calculation method and winding loss coefficient are effective and correct for the loss calculation of MCR.

EVOLUTION OF DYNAMIC GAMES AND BACKWARD INDUCTION

As an efficient method of solving subgame-perfect Nash equilibrium,the backward induction is analyzed from an evolutionary point of view in this paper,replacing a player with a population and turning a game into a population game,which shows that equilibrium of a perfect information game is the unique evolutionarily stable outcome for dynamic models in the limit.

Indinavir Resistance Evolution in One Human Immunodeficiency Virus Type 1 Infected Patient Revealed by Single-Genome Amplification

Human Immunodeficiency Virus Type 1 exists in vivo as quasispecies, and one of the genome's characteristics is its diversity. During the antiretroviral therapy, drug resistance is the main obstacle to effective viral prevention. Understanding the molecular evolution process is fundamental to analyze the mechanism of drug resistance and develop a strategy to minimize resistance. Objective: The molecular evolution of drug resistance of one patient who had received reverse transcriptase inhibitors for a long time and had treatment which replaced Nevirapine with Indinavir was analyzed, with the aim of observing the drug resistance evolution pathway. Methods: The patient, XLF, was followed-up for six successive times. The viral populations were amplified and sequenced by single-genome amplification. All the sequences were submitted to the Stanford HIV Drug Resistance Database for the analysis of genotypic drug resistance. Results: 149 entire protease and 171 entire reverse transcriptase sequences were obtained from these samples, and all sequences were identified as subtype B. Before the patient received Indinavir, the viral population only had some polymorphisms in the protease sequences. After the patient began Indinavir treatment, the variants carrying polymorphisms declined while variants carrying the secondary mutation G73S gained the advantage. As therapy was prolonged, G73S was combined with M46I/L90M to form a resistance pattern M46I/G73S/L90M, which then became the dominant population. 97.9% of variants had the M46I/G73S/L90M pattern at XLF6. During the emergence of protease inhibitors resistance, reverse transcriptase inhibitors resistance maintained high levels. Conclusion: Indinavirresistance evolution was observed by single-genome amplification. During the course of changing the regimen to incorporate Indinavir, the G73S mutation occurred and was combined with M46I/L90M.

Nonequilibrium Thermodynamics of Dark Energy on Cosmic Apparent Horizon

In recent several years,some works have been done on cosmic thermodynamics.The apparent horizonwas regarded as the key characteristic supersurface where thermodynamics can be built on perfectly.However,if theirreversible process is considered,the proper position for building thermodynamics will not be the apparent horizonanymore.The new position is related to dark energy state equation and the irreversible process parameters.

Squeezed State Caused by Inverse of Photon Creation Operator

Using the photon creation operator＇s eigenstate theory we derive the normally ordered expansion of inverse of the squeezed creation operator. It turns out that using this operator a kind of excitation on the squeezed vacuum states can be formed.

Dynamic inverse control of feedback linearization in ballistic correction based on nose cone swinging

It is a complicated nonlinear controlling problem to conduct a two-dimensional trajectory correction of rockets.By establishing the aerodynamic correction force mathematical model of rockets on nose cone swinging,the linear control is realized by the dynamic inverse nonlinear controlling theory and the three-time-scale separation method.The control ability and the simulation results are also tested and verified.The results show that the output responses of system track the expected curve well and the error is controlled in a given margin.The maximum correction is about±314 m in the lengthwise direction and±1 212 m in the crosswise direction from the moment of 5 s to the drop-point time when the angle of fire is 55°.Thus,based on the dynamic inverse control of feedback linearization,the trajectory correction capability of nose cone swinging can satisfy the requirements of two-dimensional ballistic correction,and the validity and effectiveness of the method are proved.

Life Extending Control of Helicopter Based on Dynamic Inversion

The purpose of using life extending control for Black Hawk UH-60 helicopter is to make a trade-off between the handling qualities and the service life of critical components. An increase in service life span results in enhanced safety and the reduction in maintenance costs. This paper presents a design methodology of life extending control for structural durability and high performance of mechanical system, which is based on an explicit dynamic inversion control scheme. A real-time nonlinear fatigue crack growth model is built to predict fatigue damage resulting from the impact of cyclic bending stress on rotor shaft, which serves as an indicator of service life. The 4-axis gainscheduled flight controller, whose gains are adjusted as a function of damage and flight velocity, is designed to regulate roll attitude, pitch attitude, vertical velocity and yaw rate. The nonlinear system simulation results show that the responses can meet the requirements on ADS-33 Level 1 handling qualities and that the 4-axis decoupling control is realized. As the damage increases, the tracking performance is slightly degraded, which results in smaller transients in bending moment response.

Reversible Measurement on Quantum States of Trapped-Ion Qubits

We consider reversible quantum measurement process with ultracold trapped ions. Two schemes will be proposed based on currently available experimental techniques. We also study the measurement process with electronic shelving amplification.

A genetic algorithm for dynamic parameters reverse deduction of integrated anchorage system

In the analysis of the system of anchoring bar and wall rock in small strain and longitudinal vibration dynamic response, the influence of the cement grouting as well as the rock layer on the anchor bar can be evaluated as the two kinds of parameters: the dynamic stiffness and the damp, which are the vital reference of the anchorage quality. Based on the analytic solution to the dynamic equation of the integrated anchor bar, the new approach which combines genetic algorithm and the toolbox of Matlab is applied to solve the problem of multi-parameters reverse deduction for integrated anchorage system in dynamic testing. Using the traits of the self-organizing, self-adapting and the fast convergence speed of the genetic algorithm, the optimum of all possible solutions to dynamic parameters is obtained by calculating the project instances. Examples show that the method presented in this paper is effective and reliable.

Fault diagnosis and fault-tolerant control of photovoltaic micro-inverter

An observer-based fault diagnosis method and a fault tolerant control for open-switch fault and current sensor fault are proposed for interleaved flyback converters of a micro-inverter system. First, based on the topology of a grid-connected micro-inverter, a mathematical model of the flyback converters is established. Second, a state observer is applied to estimate the currents online and generate corresponding residuals. The fault is diagnosed by comparing the residuals with the thresholds. Finally, a fault-tolerant control that consists of a fault-tolerant topology for the faulty switch and a simple software redundancy control for the faulty current sensor, is proposed to achieve a fault-tolerant operation. The feasibility and effectiveness of the proposed method has been verified by simulation and experimental results.

Fast and Slow Responses of the North Pacific Mode Water and Subtropical Countercurrent to Global Warming

Six coupled general circulation models from the Coupled Model Intercomparison Project Phase 5 (CMIP5) are em-ployed for examining the full evolution of the North Pacific mode water and Subtropical Countercurrent (STCC) under global warming over 400 years following the Representative Concentration Pathways (RCP) 4.5. The mode water and STCC first show a sharp weakening trend when the radiative forcing increases, but then reverse to a slow strengthening trend of smaller magnitude after the radiative forcing is stablized. As the radiative forcing increases during the 21st century, the ocean warming is surface-intensified and decreases with depth, strengthening the upper ocean's stratification and becoming unfavorable for the mode water formation. Moving southward in the subtropical gyre, the shrinking mode water decelerates the STCC to the south. After the radiative forcing is stabilized in the 2070s, the subsequent warming is greater at the subsurface than at the sea surface, destabilizing the upper ocean and becoming favorable for the mode water formation. As a result, the mode water and STCC recover gradually after the radiative forc-ing is stabilized.

The Analytic Solution of Schrdinger Equation with Potential Function Superposed by Six Terms with Positive-power and Inverse-power Potentials

The analytic solution of the radial Schrodinger equation is studied by using the tight coupling condition of several positive-power and inverse-power potential functions in this article. Furthermore, the precisely analytic solutions and the conditions that decide the existence of analytic solution have been searched when the potential of the radial Schrodinger equation is V（r） =α1r^8 ＋α2r^3 ＋ α3r^2 ＋β3r^-1 ＋β2r^-3 ＋β1r6-4. Generally speaking, there is only an approximate solution, but not analytic solution for SchrSdinger equation with several potentials＇ superposition. However, the conditions that decide the existence of analytic solution have been found and the analytic solution and its energy level structure are obtained for the Schrodinger equation with the potential which is motioned above in this paper. According to the single-value, finite and continuous standard of wave function in a quantum system, the authors firstly solve the asymptotic solution through the radial coordinate r → ∞ and r →0; secondly, they make the asymptotic solutions combining with the series solutions nearby the neighborhood of irregular singularities; and then they compare the power series coefficients, deduce a series of analytic solutions of the stationary state wave function and corresponding energy level structure by tight coupling among the coefficients of potential functions for the radial SchrSdinger equation; and lastly, they discuss the solutions and make conclusions.

The Viable but Non-culturable State in Xanthomonas citri subsp, citri is a Reversible State Induced by Low Nutrient Availability and Copper Stress Conditions

Xcc （Xanthomonas citri subsp, citri） causes citrus bacterial canker, a leaf, stem and fruit spotting disease that affects most commercial citrus species and cultivars. Copper compounds, widely used for management of this pathogen, have been reported as inducers of a VBNC （viable but non-culturable state） in plant pathogenic bacteria. VBNC may be considered as a state preceding bacterial death or as a survival mechanism under adverse conditions. Several experiments were performed to characterize the reversibility and persistence of the VBNC state in Xcc. VBNC was induced in low nutrient medium or with amendment of copper at concentrations used for field disease control. The VBNC condition was demonstrated to persist up to 150 days after copper treatment and was reversed after the addition of culture media without copper or amendment with citrus leaf extract. Xcc viability was evaluated by recovery of colonies on culture media, confirmed by membrane integrity, respiratory activity and by real-time RT-PCR targeting a sequence from the gumD gene. Besides, the colonies recovered were pathogenic on citrus leaves. These results confirm that the VBNC state in Xcc is inducible and reversible and therefore may occur in the phyllosphere when Xcc is under copper stress or starvation.

Decoupling control and zero dynamics stabilization for shunt hybrid active power filter

An inverse system method based optimal control strategy was proposed for the shunt hybrid active power filter （SHAPF） to enhance its harmonic elimination performance. Based on the inverse system method, the d-axis and q-axis current dynamics of the SHAPF system were decoupled and linearized into two pseudolinear subsystems. Then, an optimal feedback controUer was designed for the pseudolinear system, and the stability condition of the resulting zero dynamics was presented. Under the control strategy, the current dynamics can asymptotically converge to their reference states and the zero dynamics can be bounded. Simulation results show that the proposed control strategy is robust against load variations and system parameter mismatches, its steady-state performance is better than that of the traditional linear control strategy.