Web-based cognitive interventions on subjective cognitive impairment in cancer survivors:A systemic review

Objective:Cancer survivors have experienced subjective cognitive impairment(SCI)when they received cancer diagnoses or treatments.Their psychosocial and emotional statuses were also impacted.With the advancement of web technologies,web-based cognitive interventions have been implemented in the management and the alleviation of the SCI,the psychosocial distress,and the emotional distress in cancer survivors.This review aimed to summarize the intervention contents of web-based cognitive interventions for SCI,and to explore the effects of the interventions on SCI,psychosocial status,and emotional health.Methods:Six databases(CINAHL Plus,Cochrane Library,Embase,APA PsycInfo,PubMed and CNKI)were searched from the establishment of databases up to December 2023.Literature references were also manually searched for related articles.Results:This review contained 21 studies that covered the contents of web-based cognitive interventions,such as computer-assisted cognitive training,online cognitive rehabilitation,cognitive behavior therapy with the Internet,telehealth physical exercise,and web-based mindfulness interventions.The effects of web-based cognitive interventions positively impacted SCI for cancer survivors.Also,these interventions showed varying degrees of effectiveness in alleviating psychosocial and emotional distresses.Conclusion:By summarizingfive types of cognitive intervention contents delivered via web technology,this review demonstrated that web-based cognitive interventions optimized SCI and overall psychosocial and emotional statuses for the cancer survivors.It is recommended that future research focus on the development of customized web-based cognitive interventions for individuals with SCI,along with their psychosocial and emotional statuses.

Hippocampal HMGB1/TLR4 Pathway Mediates Cognitive Dysfunction in Chronic Stress Mice

Objective Chronic stress can induce cognitive dysfunction,but the underlying mechanisms remain unknown.Studies have confirmed that the high mobility group box 1/Toll-like receptor 4(HMGB1/TLR4)pathway is closely associated with cognitive impairment.Therefore,this research aimed to explore whether the HMGB1/TLR4 pathway involves in chronic stress-induced cognitive dysfunction.Methods The chronic unpredictable mild stress(CUMS)mouse model was established by randomly giving different types of stress every day for four consecutive weeks.Cognitive function was detected by novel object recognition test,Y-maze test,and Morris water maze test.The protein expressions of HMGB1,TLR4,B-cell lymphoma 2(BCL2),and BCL2 associated X(BAX)were determined by Western blot.The damage of neurons in the hippocampal CA1 region was observed by hematoxylin-eosin(HE)staining.Results The protein expressions of HMGB1 and TLR4 were significantly increased in the hippocampus of chronic stress mice.Furthermore,inhibition of the HMGB1/TLR4 pathway induced by ethyl pyruvate(EP,a specific inhibitor of HMGB1)and TAK242(a selective inhibitor of TLR4)treatment attenuated cognitive impairment in chronic stress mice,according to the novel object recognition test,Y-maze test,and Morris water maze test.In addition,administration of EP and TAK242 also mitigated the increase of apoptosis in the hippocampus of chronic stress mice.Conclusion These results indicate that the hippocampal HMGB1/TLR4 pathway contributes to chronic stress-induced apoptosis and cognitive dysfunction.

Research progresses of resting-state functional MRI in mild cognitive impairment and Alzheimer's disease

Alzheimer's disease(AD)is a prevalent neurodegenerative disease characterized by cognitive decline in the early stage.Mild cognitive impairment(MCI)is considered as an intermediate stage between normal aging and AD.In recent years,studies related to resting-state functional MRI(rs-fMRI)indicated that the occurrence and development process of MCI and AD might be closely linked to spontaneous brain activity and alterations in functional connectivity among brain regions,and rs-fMRI could provide important reference for specific diagnosis and early treatment of MCI and AD.The research progresses of rs-fMRI for MCI and AD were reviewed in this article.

新型阳离子胶粘物控制剂

使用阳离子胶粘物控制剂消除纸张抄造过程中废纸浆中残余胶粘物产生的“障碍”

Cultivation Techniques of Panax notoginseng F.H. Chen under Different Forests

To overcome the issues of high cost and continuous cropping obstacles in facility cultivation of Panax notoginseng_ F. H. Chen, satisfy the market demand, save the production cost, improve the utilization rate of forest land, increase the in-come of forest farmers and protect the ecological environment, the cultivation tech-niques of high-quality P. notoginseng seedlings from Wenshan, Yunnan under four kinds of forests （walnut forest, China fir forest, grape forest and kiwi forest） were in-vestigated in this study. The results showed that the height growth, crown diameter, survival rate and 3-year-old tuber weight of P. notoginseng_under walnut forest were higher than those under the other three kinds of forests; the height growth, crown diameter, survival rate and 3-year-old tuber weight of P. notoginseng under China fir forest were higher than those under grape forest and kiwi forest; and the crown di-ameter and survival rate under grape forest were higher, and the height growth and tuber weight under grape forest were lower than those under kiwi forest. Walnut is a broad-leaved deciduous tree species, so large-scale cultivation of P. notoginseng_should be conducted under broadleaf deciduous forest with canopy density around 0.8, taking advantage of the cool environment and rich humus layer under forest. This cultivation technology could save labor, shade, fertilizer and other costs, and accord with the ecological habit and the growth rules of P. notoginseng, thus im-proving yield and achieving high economic benefit.

Analysis of the Causes of Continuous Cropping Obstacles for Atractylodes macrocephala Koidz in Pingjiang County and Its Control Methods

First at all, it introduced the concept and the damages of continuous cropping obstacle. Then, it analyzed the causes of continuous cropping obstacles for Atractylodes macrocephala Koidz. In the end, in order to provide guidance for pro- moting sustainable development of Atractylodes macrocephala Koidz industry in Pingjiang County, it put forward some control methods for eliminating continuous cropping obstacles of Atractylodes macrocephala Koidz, including breeding varieties with high resistance; applying rotation cropping and intercropping reasonable; rational fertilization and soil disinfection; introducing antagonistic bacterial and eliminating au- tointoxication.

Objective and subjective measures for sleep disorders

Subjective and objective measures of sleep structure or quality could help to characterize the chronic sleep disturbances, with relation to patients＇ risk factor profiles and co-morbidities. Studies have shown that discrepancies can occur between subjective data regarding sleep disturbances and the impact of insomnia and objective assays, and surrogate markers of sleep and sleep disturbances. Both objective and subjective measures should be incorporated into clinic studies. It seems likely that sleep quality is represented by a combination of more than one subjective sleep parameter. Objective and subjective assessments of sleep quality may relate to different parameters. Future studies incorporated both subjective and objective measures could help to address the sleep disorders.

CLINICAL RESEARCH ON TREATMENT OF DYSPHAGIA WITH NECK ACUPUNCTURE

Objective To observe the clinical therapeutic effects on dysphagia induced by pseudobulbar palsy chiefly treated with neck acupuncture and probe into the mechanism on the effects. Methods The 86 cases that had been diagnosed definitely were randomized into two groups, the treatment group and control group. The treatment group （acupuncture＋western medication） （44 cases） was treated with acupuncture on Fēngfǔ（风府 GV16）, Fēngchí （风池GB20）, Gòngxě（供血 Extra）, Yīmíng （翳明 EX-HN14）, Zhìqiāng （治呛 Extra）, Tūnyàn （吞咽 Extra）, Fāyīn （发音 Extra）, Liánquán （廉泉CV23）, etc., and the intravenous injection with Shuxuetong （疏血通） 6- 10 mL and 0.9%, NaCl 250 mL. The control group （western medication） （42 cases） was treated with the intravenous injection with Shuxuetong （疏血通） 6- 10 mL and 0.9%, NaCl 250 mL. Results The total effective rate was 97.73 % and 80.95 % in the treatment group and control group respectively, indicating very significant difference （P 〈 0.01 ）. Conclusion The therapeutic effects mainly with neck acupuncture are better on dysphagia induced by psudalbulbar palsy, which is superior to that with simple western medication and worth to be promoted. Concerning to the mechanism on the therapeutic results, it is viewed that acupuncture on neck points improves the excitability of cerebral neurocytes, resuscitates the reversible neurocytes or awakens the inhibited neurocytes.

科学课堂互动共享教学三策略

互动共享的教学模式要求共享能在互动中有自然的反应,有了互动,共享就能更加自如的实施。在小学科学课的课堂教学中,教师通过改善课堂交流模式、人为设置“障碍”、组织小组活动等多种途径,为互动学习在科学课课堂教学中创设共享的氛围、激发互动的心理需求、提供互动的机会、认识互动的技巧、强化互动的意识,促进了教师与学生、学生与学生、小组与小组之间的交流互动活动,从而使学生在互动活动过程中实现互动意识、共享能力、学业成绩及各方面能力的提高。

Towards the Integrating Wind Power into Power Grid in China

With abundant wind resources and high pressure imposed on en-vironmental protection, wind power development has a promising future. Butdue to intermittent nature, wind power can bring into full play only if being con-nected into power grid to ensure its supply reliability and continuity, aswell as operational economy. However, technical and market barriers haveprevented wind power from integrating into power grid. To foster wind powerdevelopment, these barriers should be removed by both government incentivepolicies and sophisticated technologies.

塑件成型时的“运动干涉”与注射模结构分析

"运动干涉"是注射模结构设计时不可回避的因素,也是注射模结构设计的要点。在模具设计时,就要消除各种运动机构所能产生"运动干涉"的隐患。其具体方法就是应用塑件的"运动干涉"要素,去分析注射模的各种运动机构能否会产生"运动干涉",并且要采取有效的措施去避免"运动干涉"现象的发生。

混合要素类型的综合分析法在注射模结构设计方案中的应用

以"带灯箱锁主体部件"注射模结构设计分析为例,以(注射模)结构设计分析的四大要素和成型(注射模)结构设计的3种分析法为基础。对于模具结构设计进行了严谨而周密的分析。

Methods and Countermeasures for Urban Agricultural Supply-Side Structural Reform in the New Era

Based on the theoretical basis of structural reform of agricultural supply side, the status quo and existing problems of urban agricultural supply side in Tian- jin under the new normal were analyzed. On this basis, the paper analyzed the paths of urban agricultural supply-side structural reform separately from the perspec- tives of factors, investment structure and system innovation, and proposed specific policies and opinions on the structural reform of urban agricultural supply side, pro- viding the theoretical basis and realistic basis for the sustainable development of ur- ban agriculture.

初中语文课堂问题设计探讨

问题是发展学生思维能力的一种重要手段。在初中语文教学中,如何设计课堂问题呢?问题要面向所有的学生而设计;巧设"障碍",制造"冲突",激活思维;提问变直为曲,引人入胜;问题设计要给学生思维预留想象空间;分层设问,化难为易,化大为小。

Multi-sensor systems and information processing of mobile robot in uncertain environments

The PBJ- 01 robot is a kind of mobile robot featuring six wheels and two swing arms which can help it to fit many terrains. The robot has a sophisticated sensor system, which includes ultrasonic sensors, tentacle sensors and a vision sensor. The PBJ- 01 adopts behavior-based reactive control architecture in which the key part is an object recognition system based on a fuzzy neural network. Simulation validates that this system can conclude the obstacle type from the sensor data, and help the robot decide whether to negotiate or to avoid obstacles.

Histopathological Study on Chickens Artificially Infected with Infectious Laryngotracheitis

[Objective] This study aimed to investigate the histopathological changes in chickens artificially infected with infectious laryngotracheitis（ILT）. [Method] Through ar- tificial injection of allantoic liquid containing ILTV into chickens to induce infectious laryngotracheitis, the clinical symptoms in infected chickens were observed; tissues of trachea, lungs, heart, liver, kidney and spleen were collected from dead chickens, and prepared into paraffin sections, followed by histopathological observation under a microscope. [Results] This disease occured in the inoculated chickens 3d later, with a morbidity rate of 95%. The main symptoms were dyspnea, asthma and coughing up of bloody exudate; yellowish-white pseudomembrane was observed on dissected larynx trachea; swelling, haemorrhage, and further erosion were observed on the in- fected tracheal mucosa, resulting in death of chickens, with the mortality rate of 25%; histopathological observation showed that parenchymal organs exhibited exuda- tive inflammation; swelling, degeneration, necrosis and shedding of epithelial cells were observed; disturbance of blood circulation occured.[Conclusion] This study pro- vides reference bases for the treatment of ILT.

多重要素类型的综合分析法在成型模结构设计方案中的应用

头盔外壳产品是一典型多重同种要素的成型案例。根据模具结构方案3种分析方法的原理,可采用一种刚性袋压成型的工艺方法,而模具则需要采用多个分型面对存在"障碍体"的型芯、型腔型面进行多次分模的结构。只有如此才能够确保头盔外壳顺利地成型与脱模以及型芯、型腔能进行正常地分模,并可确保头盔外壳的质量达到技术要求。

连接环注射模结构可行性分析与设计

通过对连接环形体分析，找到了其外形上有弓形高和3处凸台与内形中有2处凸台“障碍体”。由于连接环产量较少，只能采用低效的模具结构方案。经过充分论证分析，连接环以放在模具中倒置位置方案为最佳优化方案。成型连接环外形，采用了弯销和滑块抽芯机构。成型连接环内形的型芯，是以R2-0/0.2mm凸台A面为分型面，将A面内凸台分成五个独立部分。抽取中间部分可腾出足够空间，再分别抽取其它四部分，避开内形2处凸台对连接环脱模的阻挡，以到达脱模的目的。该模具结构方案，能使连接环顺利地成型和脱模。但手工抽取5块模块毕竟效率低下，故只能适应小批量产品的加工。若要实现大批量加工，得将手工抽取5块模块改成自动化抽芯才行。

An Analysis of the Key Elements and Barriers of English Listening

While illustrating the process and the essence of listening and analyzing various subjective and objective barriers in listening, the author tries to show that English learners can improve their quality of listening comprehension by transferring the negative elements to the positive ones.

审视语文课堂提问

语文教师。应精心设计好各种类型的课堂提问。巧妙地、科学地利用课堂提问。营造出良好的、积极的、活跃的、有创意的课堂气氛，促进学生思维的发展。在有限的时间内取得最佳教学效果。提高教学质量。