AIM:To investigate the prognostic factors in patients with hepatocellular carcinoma(HCC) accompanied by microscopic portal vein invasion(PVI).METHODS:Of the 267 patients with HCC undergoing hepatic resection at Aso Ii...AIM:To investigate the prognostic factors in patients with hepatocellular carcinoma(HCC) accompanied by microscopic portal vein invasion(PVI).METHODS:Of the 267 patients with HCC undergoing hepatic resection at Aso Iizuka Hospital,71 had PVI.After excluding 16 patients with HCC that invaded the main trunk and the first and second branches of the portal vein,55 patients with microscopic PVI were enrolled.RESULTS:The patients with HCC accompanied by microscopic invasion were divided into two groups:solitary PVI(PVI-S:n = 44),and multiple PVIs(PVI-M:n = 11).The number of portal vein branches invaded by tumor thrombi was 5.4 ± 3.8(2-16) in patients with PVI-M.In cumulative survival,PVI-M was found to be a significantly poor prognostic factor(P = 0.0019);while PVI-M and non-anatomical resection were significantly poor prognostic factors in disease-free survival(P = 0.0213,and 0.0115,respectively).In patients with PVI-M,multiple intrahepatic recurrence was more common than in the patients with PVI-S(P = 0.0049).In patients with PVI-S,non-anatomical resection was a significantly poor prognostic factor in disease-free survival(P = 0.0370).Operative procedure was not a significant prognostic factor in patients with PVI-M.CONCLUSION:The presence of PVI-M was a poor prognostic factor in patients with HCC,accompanied by microscopic PVI.Anatomical resection is recommended in these patients with HCC.Patients with HCC and PVI-M may also be good candidates for adjuvant chemotherapy.展开更多
Objective:The aims of this study were to evaluate potential side effects of 18F-fluoroerythronitroimidazole (18F-FETNIM) as a new-type hypoxia-imaging agent and to investigate the feasibility of 18F-FETNIM PET imaging...Objective:The aims of this study were to evaluate potential side effects of 18F-fluoroerythronitroimidazole (18F-FETNIM) as a new-type hypoxia-imaging agent and to investigate the feasibility of 18F-FETNIM PET imaging in advanced non-small cell lung cancer (NSCLC) patients and the correlations of hypoxia extent with tumor volume or pathological type. Methods: Twenty-six NSCLC patients were prospectively included in the study. PET/CT scans were performed 2 h after intravenous injection of 18F-FETNIM in all 26 patients. A pixel-by-pixel calculation of tumor to blood (T/B) activity ratio for all image planes was calculated. The number of pixels in the tumor volume with a T/B ratio≥ 1.5,indicating significant hypoxia,was determined and converted to mL units to measure the hypoxia volume (HV). Results: The images were clearly identified after 2 h post-injection of 18F-FETNIM. The tumors in 4 cases were not distinguished from background,while the remaining 22 displayed local 18F-FETNIM uptake in thoracic lesions moderately to markedly higher than background. There was no correlation between 18F-FETNIM uptake with pathological type. There were significant correlations of HV and also the T/B ratio with tumor volume. Conclusion:18F-FETNIM is a promising hypoxia-imaging agent which clinical use is safe and satisfactory. The preliminary study provides valuable methods and experience to its further research.展开更多
A1203/5%SIC nanocomposites were fabricated by pressureless sintering using MgO as a sintering aid and then post hot-isostatic pressed (HIP), which can subsequently break through the disadvantage of hot-pressing proc...A1203/5%SIC nanocomposites were fabricated by pressureless sintering using MgO as a sintering aid and then post hot-isostatic pressed (HIP), which can subsequently break through the disadvantage of hot-pressing process. The MgO additive was able to promote the densification of the composites, but could not induce the grain growth of A1203 matrix due to the grain growth inhibition by nano-sized SiC particles. After HIP treatment, A12OJSiC nanocomposites achieved full densification and homogeneous distribution of nano-sized SiC particles. Moreover, the fracture morphology of HIP treated specimens was identical with that of the hot-pressed A1203/SiC nanocomposites showing complete transgranular fracture. Consequently, high fracture strength of 1 GPa was achieved for the A1203/5%SIC nanocomposites by pressureless sintering and post HIP process.展开更多
The Republic of Serbia is characterized by an unsatisfactory macroeconomic environment. Under the conditions of an evident shortage of liquid assets, the financial capital has moved from real to the financial sector, ...The Republic of Serbia is characterized by an unsatisfactory macroeconomic environment. Under the conditions of an evident shortage of liquid assets, the financial capital has moved from real to the financial sector, which led companies to over-indebtedness and shutdown of their own capacities. Therefore, capital investments largely depend on internal financing sources and the ability of companies to internally generate funds for investments. In this regard, an emphasis is placed on the difference in the assessment of the company's investment capacity based on internal financing sources, which are measured using static and dynamic indicators in order to prove the necessity of applying dynamic coefficients, which are unfortunately not present in our domestic practice. The paper examines and proves the advantages of the use of the dynamic approach for such analyses using the example of energy sector, which is one of the most important branches in Serbian economy.展开更多
English is widely taught as an FL (foreign language) in most middle schools in China. Chinese students have improved their English reading and writing these years, but they are relatively poor in listening and speak...English is widely taught as an FL (foreign language) in most middle schools in China. Chinese students have improved their English reading and writing these years, but they are relatively poor in listening and speaking. The author, based on the empirical study, made an investigation on Senior Three students in Leshan city. The statistics from the questionnaire indicate the problem of "Mute-crux" in English teaching and learning. This paper explores the reasons that cause the problem: teachers' use of the traditional ways, just emphasizing the transmission of English knowledge, but ignoring the meaningful communication with students; exercise-based and exam-oriented teaching, which cause students' rote-learning. The author proposes that Chinese English teachers ought to change the traditional notions and adopt effective ways to encourage students to speak bravely in order to improve their speaking abilities展开更多
The volute of a centrifugal compressor causes a non-uniform pressure distribution which leads to a radial force on the impeller. This force was measured using magnetic bearings. In addition, the radial force was estim...The volute of a centrifugal compressor causes a non-uniform pressure distribution which leads to a radial force on the impeller. This force was measured using magnetic bearings. In addition, the radial force was estimated using the static pressure distribution measured at the impeller outlet. The impeller force was found to be the highest at choke, the lowest at the design flow and moderate at stall. The radial force determined from the pressure measurements was only slightly different from the force obtained from the bearing measurements. The rotational speed was seen to affect the force to some extent.展开更多
In this paper, we develop a macro model for traffic flow with consideration of static bottleneck to explore the impacts of static bottleneck on traffic flow. The analytical and numerical results show that the proposed...In this paper, we develop a macro model for traffic flow with consideration of static bottleneck to explore the impacts of static bottleneck on traffic flow. The analytical and numerical results show that the proposed model can qualitatively describe the equilibrium flux, uniform flow and small perturbation under the action of a static bottleneck.展开更多
During the non-landing measuring of vehicle mounted theodolite, especially under high-speed tracking measurement, the misalignment of theodolite's center of mass and spindle etc. will cause high-frequency vibratio...During the non-landing measuring of vehicle mounted theodolite, especially under high-speed tracking measurement, the misalignment of theodolite's center of mass and spindle etc. will cause high-frequency vibration of theodolite platform, increase the observation error of targets and even unbelievable results. In this paper, a correction method of non-landing measuring of theodolite based on static datum conversion is presented, which can effectively improve the observation accuracy of theodolite. The CCD camera is fixed to the theodolite platform to calculate the gesture shaking quantity of theodolite platform in geodetic coordinate system through the real time imaging of static datum. The observation results of theodolite are corrected by using such shaking quantity. The experiment shows that the correction accuracy exceeds 10 s of arc. The intrinsic parameter calibration technology of camera based on stellar angular distance and absolute conic put forward in this paper can prevent the estimated error of extrinsic parameters influencing the intrinsic parameter calibration and improve the intrinsic parameter calibration accuracy; the static datum conversion technology can reduce the influence of installation error of camera and theodolite platform on gesture measuring of the platform. The simulation experiment shows that when the shaking range of the platform is less than 30 min of arc, the influence of the three-axis installation error of camera within 3deg on the accuracy of correction results is less than 8 s of arc. The method in this paper can be extended to and used in the field of gesture shaking measuring and micro-structure deformation of various unstable platforms, therefore it is of important theoretical research significance and has wide engineering application prospect.展开更多
This paper presents a simple and straight-forward static model of the micro-foundations of the environmental Kuznets curve, in which the relationship between income and pollution depends on the relative magnitudes of ...This paper presents a simple and straight-forward static model of the micro-foundations of the environmental Kuznets curve, in which the relationship between income and pollution depends on the relative magnitudes of the diminishing income-compensated price elasticity of environmental amenity and increasing marginal propensity to earn environmental amenity out of non-environment income. The smaller the income-compensated price elasticity and the larger the marginal propensity to earn out of non-environment income, the earlier the turning point emerges. This key feature of our model generalizes the specific features of many existing models and generates many of their implications.展开更多
文摘AIM:To investigate the prognostic factors in patients with hepatocellular carcinoma(HCC) accompanied by microscopic portal vein invasion(PVI).METHODS:Of the 267 patients with HCC undergoing hepatic resection at Aso Iizuka Hospital,71 had PVI.After excluding 16 patients with HCC that invaded the main trunk and the first and second branches of the portal vein,55 patients with microscopic PVI were enrolled.RESULTS:The patients with HCC accompanied by microscopic invasion were divided into two groups:solitary PVI(PVI-S:n = 44),and multiple PVIs(PVI-M:n = 11).The number of portal vein branches invaded by tumor thrombi was 5.4 ± 3.8(2-16) in patients with PVI-M.In cumulative survival,PVI-M was found to be a significantly poor prognostic factor(P = 0.0019);while PVI-M and non-anatomical resection were significantly poor prognostic factors in disease-free survival(P = 0.0213,and 0.0115,respectively).In patients with PVI-M,multiple intrahepatic recurrence was more common than in the patients with PVI-S(P = 0.0049).In patients with PVI-S,non-anatomical resection was a significantly poor prognostic factor in disease-free survival(P = 0.0370).Operative procedure was not a significant prognostic factor in patients with PVI-M.CONCLUSION:The presence of PVI-M was a poor prognostic factor in patients with HCC,accompanied by microscopic PVI.Anatomical resection is recommended in these patients with HCC.Patients with HCC and PVI-M may also be good candidates for adjuvant chemotherapy.
文摘Objective:The aims of this study were to evaluate potential side effects of 18F-fluoroerythronitroimidazole (18F-FETNIM) as a new-type hypoxia-imaging agent and to investigate the feasibility of 18F-FETNIM PET imaging in advanced non-small cell lung cancer (NSCLC) patients and the correlations of hypoxia extent with tumor volume or pathological type. Methods: Twenty-six NSCLC patients were prospectively included in the study. PET/CT scans were performed 2 h after intravenous injection of 18F-FETNIM in all 26 patients. A pixel-by-pixel calculation of tumor to blood (T/B) activity ratio for all image planes was calculated. The number of pixels in the tumor volume with a T/B ratio≥ 1.5,indicating significant hypoxia,was determined and converted to mL units to measure the hypoxia volume (HV). Results: The images were clearly identified after 2 h post-injection of 18F-FETNIM. The tumors in 4 cases were not distinguished from background,while the remaining 22 displayed local 18F-FETNIM uptake in thoracic lesions moderately to markedly higher than background. There was no correlation between 18F-FETNIM uptake with pathological type. There were significant correlations of HV and also the T/B ratio with tumor volume. Conclusion:18F-FETNIM is a promising hypoxia-imaging agent which clinical use is safe and satisfactory. The preliminary study provides valuable methods and experience to its further research.
基金Project supported by Pusan National University Research GrantProject(2010-0008-276) supported by National Core Research Center Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology
文摘A1203/5%SIC nanocomposites were fabricated by pressureless sintering using MgO as a sintering aid and then post hot-isostatic pressed (HIP), which can subsequently break through the disadvantage of hot-pressing process. The MgO additive was able to promote the densification of the composites, but could not induce the grain growth of A1203 matrix due to the grain growth inhibition by nano-sized SiC particles. After HIP treatment, A12OJSiC nanocomposites achieved full densification and homogeneous distribution of nano-sized SiC particles. Moreover, the fracture morphology of HIP treated specimens was identical with that of the hot-pressed A1203/SiC nanocomposites showing complete transgranular fracture. Consequently, high fracture strength of 1 GPa was achieved for the A1203/5%SIC nanocomposites by pressureless sintering and post HIP process.
文摘The Republic of Serbia is characterized by an unsatisfactory macroeconomic environment. Under the conditions of an evident shortage of liquid assets, the financial capital has moved from real to the financial sector, which led companies to over-indebtedness and shutdown of their own capacities. Therefore, capital investments largely depend on internal financing sources and the ability of companies to internally generate funds for investments. In this regard, an emphasis is placed on the difference in the assessment of the company's investment capacity based on internal financing sources, which are measured using static and dynamic indicators in order to prove the necessity of applying dynamic coefficients, which are unfortunately not present in our domestic practice. The paper examines and proves the advantages of the use of the dynamic approach for such analyses using the example of energy sector, which is one of the most important branches in Serbian economy.
文摘English is widely taught as an FL (foreign language) in most middle schools in China. Chinese students have improved their English reading and writing these years, but they are relatively poor in listening and speaking. The author, based on the empirical study, made an investigation on Senior Three students in Leshan city. The statistics from the questionnaire indicate the problem of "Mute-crux" in English teaching and learning. This paper explores the reasons that cause the problem: teachers' use of the traditional ways, just emphasizing the transmission of English knowledge, but ignoring the meaningful communication with students; exercise-based and exam-oriented teaching, which cause students' rote-learning. The author proposes that Chinese English teachers ought to change the traditional notions and adopt effective ways to encourage students to speak bravely in order to improve their speaking abilities
文摘The volute of a centrifugal compressor causes a non-uniform pressure distribution which leads to a radial force on the impeller. This force was measured using magnetic bearings. In addition, the radial force was estimated using the static pressure distribution measured at the impeller outlet. The impeller force was found to be the highest at choke, the lowest at the design flow and moderate at stall. The radial force determined from the pressure measurements was only slightly different from the force obtained from the bearing measurements. The rotational speed was seen to affect the force to some extent.
基金Supported by the Program for the New Century Excellent Talents in University under Grant No.NCET-08-0038the National Natural Science Foundation of China under Grant No.70971007the WA Centre of Excellence in Industrial Optimization
文摘In this paper, we develop a macro model for traffic flow with consideration of static bottleneck to explore the impacts of static bottleneck on traffic flow. The analytical and numerical results show that the proposed model can qualitatively describe the equilibrium flux, uniform flow and small perturbation under the action of a static bottleneck.
基金supported by the National Natural Science Foundation of China (Grant Nos. 11072263 and 11272347)Program for New Century Talents in University
文摘During the non-landing measuring of vehicle mounted theodolite, especially under high-speed tracking measurement, the misalignment of theodolite's center of mass and spindle etc. will cause high-frequency vibration of theodolite platform, increase the observation error of targets and even unbelievable results. In this paper, a correction method of non-landing measuring of theodolite based on static datum conversion is presented, which can effectively improve the observation accuracy of theodolite. The CCD camera is fixed to the theodolite platform to calculate the gesture shaking quantity of theodolite platform in geodetic coordinate system through the real time imaging of static datum. The observation results of theodolite are corrected by using such shaking quantity. The experiment shows that the correction accuracy exceeds 10 s of arc. The intrinsic parameter calibration technology of camera based on stellar angular distance and absolute conic put forward in this paper can prevent the estimated error of extrinsic parameters influencing the intrinsic parameter calibration and improve the intrinsic parameter calibration accuracy; the static datum conversion technology can reduce the influence of installation error of camera and theodolite platform on gesture measuring of the platform. The simulation experiment shows that when the shaking range of the platform is less than 30 min of arc, the influence of the three-axis installation error of camera within 3deg on the accuracy of correction results is less than 8 s of arc. The method in this paper can be extended to and used in the field of gesture shaking measuring and micro-structure deformation of various unstable platforms, therefore it is of important theoretical research significance and has wide engineering application prospect.
基金We thank the two anonymous referees, the editors, and Youping Li for helpful comments and suggestions. This research was supported by the National Natural Science Foundation of China (71273092), the Humanity and Social Science Foundation of Ministry of Education of China (10YJCZH108), and the Fundamental Research Funds for Central Universities of China.
文摘This paper presents a simple and straight-forward static model of the micro-foundations of the environmental Kuznets curve, in which the relationship between income and pollution depends on the relative magnitudes of the diminishing income-compensated price elasticity of environmental amenity and increasing marginal propensity to earn environmental amenity out of non-environment income. The smaller the income-compensated price elasticity and the larger the marginal propensity to earn out of non-environment income, the earlier the turning point emerges. This key feature of our model generalizes the specific features of many existing models and generates many of their implications.