针刺“非针”治疗原发性骨质疏松症40例

目的:比较针刺"非针"与口服西药治疗原发性骨质疏松症的疗效差异。方法:选择80例原发性骨质疏松症患者,按照随机数表法分为西药组和针刺组各40例,针刺组予针刺"非针"治疗,西药组给予口服钙尔奇D片治疗,治疗9个疗程后进行临床疗效评定和中医证候疗效评定。结果:经过9个疗程治疗后,针刺组有效率为90.00%,高于西医组的65.00%;针刺组中医证候有效率为92.50%,高于西药组的72.50%,两组有效率和中医证候有效率比较差异均有统计学意义(P<0.05)。结论:针刺"非针"治疗原发性骨质疏松症能改善原发性骨质疏松症临床症状。

针刺“非针”为主治疗腰椎间盘突出症31例

目的:观察针刺"非针"为主治疗腰椎间盘突出症的临床疗效。方法:选择62例腰椎间盘突出症患者随机分为两组,观察组和对照组各31例,观察组给予针刺"非针"治疗,对照组给予常规针刺治疗,两组治疗均每日1次,10d为一疗程,治疗2个疗程后进行疗效评定。结果:观察组有效率为93.55%,对照组有效率为70.97%,两组有效率比较其差异具有统计学意义(P<0.05)。结论:针刺"非针"为主能提高腰椎间盘突出症的治疗效果,值得临床推广。

Stress Distribution of Holed Geotextile Cross-section in Civil Engineering

Stress distribution of holed geotextile cross-section under uniaxial and double-axial tension is analyzed with the boundary element method (BEM). The calculation results indicate that stress distribution of holed geotextile cross-section is greatly related to the dimension of the specimen, the size of the hole, the shape of the hole and the tensile condition, and the stress concentration area of holed geotextile from the side of the hole to 3-4 times of the hole diameter should be strengthened in order to improve quality of the projects. These results could provide guidance for engineering application of geotextiles.

Path prediction of flexible needles based on Fokker-Planck equation and disjunctive Kriging model

Path prediction of flexible needles based on the Fokker-Planck equation and disjunctive Kriging model is proposed to improve accuracy and consider the nonlinearity and anisotropy of soft tissues.The stochastic differential equation is developed into the Fokker-Planck equation with Gaussian noise,and the position and orientation probability density function of flexible needles are then optimized by the stochastic differential equation.The probability density function obtains the mean and covariance of flexible needle movement and helps plan puncture paths by combining with the probabilistic path algorithm.The weight coefficients of the ordinary Kriging are extended to nonlinear functions to optimize the planned puncture path,and the Hermite expansion is used to calculate nonlinear parameter values of the disjunctive Kriging optimization model.Finally,simulation experiments are performed.Detailed comparison results under different path planning maps show that the kinematics model can plan optimal puncture paths under clinical requirements with an error far less than 2 mm.It can effectively optimize the path prediction model and help improve the target rate of soft tissue puncture with flexible needles through data analysis and processing of the mean value and covariance parameters derived by the probability density and disjunctive Kriging algorithms.

CLINICAL OBSERVATION ON THERAPEUTIC EFFECTS OF COMBINED TREATMENT OF NONINSULIN DEPENDENT DIABETES

Objective: To observe the therapeutic effect of combined treatment of diabetes mellitus (DM) and its complications. Methods: 30 cases of noninsulin dependent diabetes were treated by electroacupuncture (EA)of Tianzhu (天柱 BL 10), Dashu (大杼 BL 11), Fengmen (风门 BL 12), Jueyinshu (厥阴俞 BL 14), etc, massage at the acupoints along the Bladder Meridian, point injection of Vitamin B1, B6, B 12plus lidocaine at Neiguan (内关 PC 6) and Sanyinjiao (三阴交 SP 6, once every 3 days), cupping and physiotherapy comprehensively. The therapeutic effect was analyzed after 40 treatments. Results: After treatment, of the 30 cases, 23 (76.7%) experienced remarkable improvement in their symptoms and the rest 7 (23.3%) had improvement, with the total effective rate being 100%. Conclusion: The abovementioned combined treatment method works well in improving clinical symptoms of type Ⅱ DM patients.

World Federation of Acupuncture-Moxibustion Societies Clinical Practice Guideline on Acupuncture-Moxibustion:Non-Specific Low Back Pain recommendation summaries

Clinical Practice Guideline on Acupuncture and Moxibustion:Nonspecific low back pain was revised and released by the Standards Working Committee of World Federation of Acupuncture-Moxibustion Societies(WFAS)on October 9,2023.This is the first clinical practice guideline(CPG)on acupuncture and moxibustion for nonspecific low back pain approved by an international academic organization,which provides the evidence-based recommendations and practical therapeutic protocols for international acupuncture practitioners.This CPG was developed by following Grades of Recommendation,Assessment,Development,and Evaluation(GRADE)methodology,and the Principles of the World Health Organization Handbook for Guideline Development.The guideline development group(GDG)from different countries,with different professions,played a critical role in the formulation of clinical questions,recommendations,and therapeutic protocols.Recommendations are the key content of a CPG and the direct answers to clinical questions.Hence,this article focuses on the recommendations of this CPG.The recommendations were formulated using the modified Delphi method and the GRADE grid rules,based on the updated systematic reviews of clinical evidence.A total of seven recommendations for ten clinical questions were formulated in this CPG,including one conditional recommendation for either the intervention or the comparison based on very low quality of evidence,and six conditional recommendations for the intervention based on very low quality of evidence.

Observation of therapeutic effect on chronic non-bacterial prostatitis treated with warm needling moxibustion

Objective To observe the clinical effects of chronic non-bacterial prostatitis treated with warm needling moxibustion. Methods One hundred and twenty-five cases were randomly divided into warm needling moxibustion group （42 cases）, acupuncture group （41 cases） and western medicine group （42 cases）. Of which, in warm needling moxibustion group, acupuncture combined with warming acupuncture were provided①puncture on Shènshū（肾俞 BL 23）, Gānshū （肝俞BL 18） and Zhìbiān （秩边BL 54） without retention of needles,②Guānyuán （关元CV 4）, Zhō ngjí （ 中极CV 3）, Yīnlíngquán （ 阴陵 GB 34） and Sānyīnjiāo （三阴交 SP 6） ,with warming acupuncture, once a day; in acupuncture group, the prescriptions and needling technique were the same as those in warm needling moxibustion group, without moxibustion; in western medicine group, Cernilton was applied twice a day, one pill for each time. After one course treatment, the therapeutic effects and NIH-Chronic Prostatitis Symptom Index （NIH-CPSI） of 3 groups were compared. Results The total effective rate was 88. 10% in warm needling moxibustion group, 63.41% in acupuncture group, and 66.67% in western medicine group. The clinical effect in warm needling moxibustion group was superior to that in either acupuncture group or western medicine group （both P〈0.05）. The score of NIH-CPSI was 11.92 ±7.11 in warm needling moxibustion group, 16.08±6.83 in acupuncture group, and 15.66±5.88 in western medicine group. The score of each group was obviously reduced （both P〈0.01 ） after treatments, in which, the reduction in warm needling moxibustion group was most obvious （both P〈0.0t）. Conclusion A good therapeutic effect of chronic non-bacterial prostatitis was received by warm needling moxibustion.

Mechanism Study on Acupuncture for Non-insulin Resistant Polycystic Ovary Syndrome

Objective： To investigate the action mechanism of acupuncture for non-insulin resistant polycystic ovary syndrome （PCOS）. Methods： A total of 46 cases with non-insulin resistant PCOS were randomly allocated into an observation group of 23 cases and a control group of 23 cases. Cases in the observation group were treated by needling bilateral Weiwanxiashu （Ex-B 3）, whereas those in the control group were treated by needling bilateral Sanyinjiao （SP 6）. After 3-month treatments, a comparison was made on the changes of ovulations rates, Follicle-stimulating hormone （FSH）, luteinizing hormone （LH）, testosterone （T）, fasting insulin and body mass index （BMI）. Results： There were statistical differences in ovulation rates and LH/FSH before and after the treatment in the observation group （P〈0.05）, along with a statistical difference in testosterone changes （P〈0.01）. There were also statistical differences in LH and LH/FSH before and after the treatment in the control group （P〉0.05）; however, there were no statistical differences in ovulation rates and testosterone changes （P〈0.05）. There was significant difference in testosterone changes between the two groups after the treatment （P〈0.01）, along with a statistical difference in ovulation rates between the two groups （P〈0.05）. However, there were no statistical differences in LH/FSH and BMI between the two groups. Conclusion： Needling Weiwanxiashu （Ex-B 3） and Sanyinjiao （SP 6） can both improve the endocrine disorder of patients with non-insulin resistant PCOS; however, needling Weiwanxiashu （Ex-B 3） can obtain a better result than Sanyinjiao （SP 6） in increasing the insulin sensitivity and preventing insulin resistance.

Integrative self-assembly of covalent organic frameworks and fluorescent molecules for ultrasensitive detection of a nerve agent simulant

Binding of fluorescent molecules to the porous matrix through noncovalent interactions will synergistically expand their application spectrum. In this regard, we report an integrative self-assembly of molecule 1 with benzothiadizole and 9,9-dihexyl fluorene units, and covalent organic frameworks(COFs) via an emulsion-modulated polymerization process, within which molecules of 1 are able to interact with the scaffolds of COFs through CH-π interactions. Thus the π-πinteractions between the fluorescent molecules are largely suppressed, giving rise to their remarkable monomer-like optical properties. Of particular interest is that, given by the specific interaction between COFs and a nerve agent simulant diethyl chlorophosphite(DCP), these assembled composites show the ability of ultrasensitive detection of DCP with a detection limit of ~40 ppb. Moreover, the present integrative assembly strategy can be extended to encapsulate multiple fluorescent molecules, enabling the assemblies with white light emission. Our results highlight opportunities for the development of highly emissive porous materials by molecular selfassembly of fluorophores and molecular units of COFs.