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Guaranteed Cost Attitude Tracking Control for Uncertain Quadrotor Unmanned Aerial Vehicle Under Safety Constraints
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作者 Qian Ma Peng Jin Frank L.Lewis 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第6期1447-1457,共11页
In this paper,guaranteed cost attitude tracking con-trol for uncertain quadrotor unmanned aerial vehicle(QUAV)under safety constraints is studied.First,an augmented system is constructed by the tracking error system a... In this paper,guaranteed cost attitude tracking con-trol for uncertain quadrotor unmanned aerial vehicle(QUAV)under safety constraints is studied.First,an augmented system is constructed by the tracking error system and reference system.This transformation aims to convert the tracking control prob-lem into a stabilization control problem.Then,control barrier function and disturbance attenuation function are designed to characterize the violations of safety constraints and tolerance of uncertain disturbances,and they are incorporated into the reward function as penalty items.Based on the modified reward function,the problem is simplified as the optimal regulation problem of the nominal augmented system,and a new Hamilton-Jacobi-Bellman equation is developed.Finally,critic-only rein-forcement learning algorithm with a concurrent learning tech-nique is employed to solve the Hamilton-Jacobi-Bellman equa-tion and obtain the optimal controller.The proposed algorithm can not only ensure the reward function within an upper bound in the presence of uncertain disturbances,but also enforce safety constraints.The performance of the algorithm is evaluated by the numerical simulation. 展开更多
关键词 Attitude tracking control quadrotor unmanned aerial vehicle(QUAV) reinforcement learning safety constraints uncertain disturbances.
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On Dual-Mode Driving Control Method for a Novel Unmanned Tractor With High Safety and Reliability
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作者 Wei Lu Jiacheng Li +2 位作者 Huanhuan Qin Lei Shu Aiguo Song 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2023年第1期254-271,共18页
Due to the non-standardization and complexity of the farmland environment,it is always a huge challenge for tractors to achieve fully autonomy(work at Self-driving mode)all the time in agricultural industry.Whereas,wh... Due to the non-standardization and complexity of the farmland environment,it is always a huge challenge for tractors to achieve fully autonomy(work at Self-driving mode)all the time in agricultural industry.Whereas,when tractors work in the Tele-driving(or Remote driving)mode,the operators are prone to fatigue because they need to concentrate for long periods of time.In response to these,a dual-mode control strategy was proposed to integrate the advantages of both approaches,i.e.,by combing Self-driving at most of the time with Tele-driving under special(complex and hazardous)conditions through switching control method.First,the state switcher was proposed,which is used for smooth switching the driving modes according to different working states of a tractor.Then,the state switching control law and the corresponding subsystem tracking controllers were designed.Finally,the effectiveness and superiority of the dualmode control method were evaluated via actual experimental testing of a tractor whose results show that the proposed control method can switch smoothly,stably,and efficiently between the two driving modes automatically.The average control accuracy has been improved by 20%and 15%respectively,compared to the conventional Tele-driving control and Self-driving control with low-precision navigation.In conclusion,the proposed dualmode control method can not only satisfy the operation in the complex and changeable farmland environment,but also free drivers from high-intensity and fatiguing work.This provides a perfect application solution and theoretical support for the intelligentization of unmanned farm agricultural machinery with high safety and reliability. 展开更多
关键词 Dual-mode control safety and reliability self-driving(SD) tele-driving(TD) unmanned tractor
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Analysis of Building Construction Quality Control and Safety Management
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作者 Shiwei Sun 《Journal of Architectural Research and Development》 2023年第2期59-63,共5页
Quality control and safety management are two very important contents in building construction project management.Once the construction quality is not up to standard or a safety accident occurs,the economic benefits o... Quality control and safety management are two very important contents in building construction project management.Once the construction quality is not up to standard or a safety accident occurs,the economic benefits of the project will be severely impacted.However,there are still some problems in the quality and safety management of the project.In this paper the problems in construction quality control and safety management are analyzed,and effective countermeasures are put forward,in hopes to help improve construction quality and safety. 展开更多
关键词 Building construction Quality control Construction safety
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Development, Delivery and Evaluation of a Safety Training Program on Demolition for Blight Reduction
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作者 Emrah Kazan Mumtaz Usmen Tarik Najib 《Open Journal of Civil Engineering》 2024年第1期96-115,共20页
The main objective of the work presented in this paper was to develop a customized safety training program that can be incorporated into the demolition projects undertaken as part of blight reduction efforts in urban ... The main objective of the work presented in this paper was to develop a customized safety training program that can be incorporated into the demolition projects undertaken as part of blight reduction efforts in urban centers. A subsidiary objective was to devise and implement a safety program evaluation methodology, and gain insights on the relationships between knowledge acquisition through training and trainee demographics. Salient aspects of blight elimination efforts, as well as the main facets of building demolition practices and requirements, were reviewed. Information on various related safety and health hazards was studied in depth with a focus on demolition operations dealing with blighted properties. A unique safety hazard awareness training program was created for demolition workers, contractors and inspectors based on this research. In addition to devising a curriculum of relevant training topics along with traditional and online delivery systems to be employed, effectiveness evaluation instruments were formulated. Based on the limited data collected from the trainees it was concluded that the program was well-received by them and provided effective learning. It was also found that no statistically significant associations existed between the knowledge gain of the trainees, and either their experience level or union status, after taking this training. 展开更多
关键词 Blight Removal Demolition safety Hazard control Training Program
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大红山矿业构建“11538”安全管控体系的探索与实践
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作者 黄光朴 《有色金属设计》 2024年第3期32-36,共5页
大红山矿业运用多种采矿方法与选矿方法,安全管理难度和复杂程度较大,是全国特大型复杂地下矿山。阐述大红山矿业“11538”安全管控体系的构建和内容,通过该体系的实施,培育员工共同认可的安全价值观和安全行为规范,在企业内部营造自我... 大红山矿业运用多种采矿方法与选矿方法,安全管理难度和复杂程度较大,是全国特大型复杂地下矿山。阐述大红山矿业“11538”安全管控体系的构建和内容,通过该体系的实施,培育员工共同认可的安全价值观和安全行为规范,在企业内部营造自我约束、自主管理和团队管理的安全文化氛围,持续改善安全绩效的探索与实践。 展开更多
关键词 矿业安全 “11538”安全管控体系 绿色智能矿山 安全文化
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Research Advance on Absorption Law of Cadmium by Rice and Safety Control Technology of Cadmium in Rice Grain 被引量:6
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作者 陈群芳 叶瑶瑶 +3 位作者 徐青 范克关 王飞娟 朱诚 《Agricultural Science & Technology》 CAS 2014年第10期1801-1804,共4页
Heavy metal pol ution, especial y cadmium pol ution, has threatened the safety production of rice. The research advance on law of absorption, distribution and accumulation of cadmium in rice and on recent safety contr... Heavy metal pol ution, especial y cadmium pol ution, has threatened the safety production of rice. The research advance on law of absorption, distribution and accumulation of cadmium in rice and on recent safety control technology of cadmium in rice grain was summarized in this paper. We hoped to lay a foundation for the safety production of rice. 展开更多
关键词 RICE CADMIUM Low accumulation safety control technology
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Research on Technological Support System of Control and Management of Rural Tourism Safety
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作者 高玲 《Journal of Landscape Research》 2011年第8期91-95,共5页
As the sources of overt and covert potential safety hazards were widespread, the safety control and management of rural tourism became more complicated and difficult, which required more for technological support of r... As the sources of overt and covert potential safety hazards were widespread, the safety control and management of rural tourism became more complicated and difficult, which required more for technological support of rural tourism safety management. Based on the latitude of technological support, from the perspective of management practice of rural tourism safety, through analysis on inner symbiosis of management and technological support of rural tourism safety, the paper had studied three parts of control and management system of rural tourism safety, which were rural tourism safety identification, rural tourism safety isolation and control, and rural tourism safety treatment and solution; and the connotation of technological support during safety management had been discussed from the three aspects. It hoped to serve as reference for tourism safety management and control, so as to promote healthy, stable and sustainable development of tourism. 展开更多
关键词 RURAL TOURISM safety control and MANAGEMENT TECHNOLOGICAL SUPPORT system
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A holistic strategy for quality and safety control of traditional Chinese medicines by the “iVarious” standard system 被引量:16
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作者 Anzhen Chen Lei Sun +3 位作者 Hang Yuan Aiying Wu Jingguang Lu Shuangcheng Ma 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2017年第5期271-279,共9页
An effective quality control system is the key to ensuring the quality, safety and efficacy of traditional Chinese medicines(TCMs). However, the current quality standard research lacks top-level design and systematic ... An effective quality control system is the key to ensuring the quality, safety and efficacy of traditional Chinese medicines(TCMs). However, the current quality standard research lacks top-level design and systematic design,mostly based on specific technologies or evaluation methods. To resolve the challenges and questions of quality control of TCMs, a brand-new quality standard system, named "iVarious", was proposed. The system comprises eight elements in a modular format. Meaning of every element was specifically illustrated via corresponding research instances. Furthermore, frankincense study was taken as an example for demonstrating standards and research process, based on the "i Various" system. This system highlighted a holistic strategy for effectiveness,security, integrity and systematization of quality and safety control standards of TCMs. The establishment of"i Various" integrates multi-disciplinary technologies and progressive methods, basis elements and key points of standard construction. The system provides a novel idea and technological demonstration for regulation establishment of TCMs quality standards. 展开更多
关键词 iVarious QUALITY standard system TRADITIONAL CHINESE MEDICINES (TCMs) QUALITY and safety control HOLISTIC STRATEGY
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Food safety controls in different governance structures in China's vegetable and fruit industry 被引量:13
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作者 ZHOU Jie-hong LI Kai LIANG Qiao 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2015年第11期2189-2202,共14页
Food safety issues constitute an international topic discussed by many scholars. Although there is an extensive body of literature on comparisons of food safety control practices across different governance structures... Food safety issues constitute an international topic discussed by many scholars. Although there is an extensive body of literature on comparisons of food safety control practices across different governance structures, these studies have been conducted mainly in terms of qualitative and descriptive analysis. In addition, little attention has been given to family farms. This study addresses the food safety control practices adopted by firms with different governance structures in China. Food safety control is expressed by the following aspects, i.e., pollution-free, green, organic, and/or geographical indication prod- ucts certification, establishment of production records, and pesticide residue testing. Three types of governance structures that engage in agricultural production are distinguished: farmer cooperatives, agricultural companies, and family farms. The food safety control practices of various governance structures are investigated based on a database that comprises 600 vegetable and fruit enterprises in Zhejiang, China. The results show that (1) pesticide residue testing is adopted by the most firms, followed by products certification, and production records are adopted by the fewest firms, and (2) agricul- tural companies adopt more food safety control practices than family farms, while farmer cooperatives adopt the fewest food safety control practices. Governance structure features of a cooperative in terms of ownership, decision-making, and income distribution are the main reasons for the low level of food safety control in the cooperative. 展开更多
关键词 food safety control governance structure farmer cooperative agricultural company family farm
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Microbial safety control of compost material with cow dung by heat treatment 被引量:5
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作者 GONG Chun-ming 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2007年第8期1014-1019,共6页
Various kinds of pathogenic bacteria derived from the intestinal tract of animals exist in compost material like cow dung. In order to sterilize the pathogenic bacteria completely in compost material, the cow dung was... Various kinds of pathogenic bacteria derived from the intestinal tract of animals exist in compost material like cow dung. In order to sterilize the pathogenic bacteria completely in compost material, the cow dung was put into a heat treatment machine in pilot plan, and harmless condition in short time was examined. The results indicated, pathogenic indicator bacteria such as coliform bacteria, fecal coliform, Escherichia coli and salmonella were all 106 cfu/g dw at the beginning, died rapidly when cow dung temperature rose to above 50~C, and not detected at 54-68~C for 6-24 h heat treatment. Coliform bacteria and salmonella in heated cow dung were not detected by re-growth culture and enrichment culture examination. Moreover, it was hardly influenced on the fermentation ability of composting microbe, organic decomposition bacteria. During heat treatment, the mesophile decreased rapidly and the thermophile stabilized or increased, and the most of composting microbe were bacillus in cow dung by fluorescence microscope, this indicated that bacillus was dominator and composting microbe in composting process. 展开更多
关键词 microbial safety control pathogenic bacteria COMPOST cow dung heat treatment
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Control Efficiency and Crop Safety of 20% Cyhalofop-butyl WP on Grass Weeds in Direct Seeded Rice Fields
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作者 余铮 袁桂平 +2 位作者 谭显胜 王义成 金晨钟 《Agricultural Science & Technology》 CAS 2017年第3期537-539,542,共4页
The purpose was to define the control efficiency and safety of 20% cy- halofop-butyl WP on grass weeds in direct seeded rice fields, in order to provide the basis for chemical weeding. This study measured Leptochloa c... The purpose was to define the control efficiency and safety of 20% cy- halofop-butyl WP on grass weeds in direct seeded rice fields, in order to provide the basis for chemical weeding. This study measured Leptochloa chinensis(L.) Nees, Echinoch/oa crusgalli (L.) Beauv and other gramineous weed control efficiency with four concentrations of 20% cyhalofop-dutyl WP and 100 g/L cyhalofop-dutyl EC in direct seeded rice fields, and analyzed the yield-increasing effect and safety of rice. The results showed that 20% cyhalofop-butyl WP had a good control efficiency on grass weeds such as Leptochloa chinensis(L.) Nees, Echinoch/oa crusgalli(L.) Beauv and other grasses. The effective dosage of 90-150 g/hm2 was over 90.7% on Lep- foch/oa chinensis(L.) Nees and the comprehensive control effect of the grass weeds was above 86.7%, which was basically consistent with 100 g/L cyhalofop-dutyl EC. Furthermore, 20% cyhalofop-dutyl WP was high security for direct seeded rice fields. The yield of rice was increased by 10.18%-11.22% after spraying herbicide. There- fore, 20% of cyhalofop-dutyl WP can be used as a special herbicide for controlling Leptochloa chinensis(L.) Beauv in direct seeded rice fields, and has a good applica- tion prospect. 展开更多
关键词 CYHALOFOP-BUTYL Direct seeded rice field Weed control Grass weeds safety
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Design of motion control of dam safety inspection underwater vehicle 被引量:5
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作者 孙玉山 万磊 +2 位作者 甘永 王建国 姜春萌 《Journal of Central South University》 SCIE EI CAS 2012年第6期1522-1529,共8页
Plenty of dams in China are in danger while there are few effective methods for underwater dam inspections of hidden problems such as conduits,cracks and inanitions.The dam safety inspection remotely operated vehicle(... Plenty of dams in China are in danger while there are few effective methods for underwater dam inspections of hidden problems such as conduits,cracks and inanitions.The dam safety inspection remotely operated vehicle(DSIROV) is designed to solve these problems which can be equipped with many advanced sensors such as acoustical,optical and electrical sensors for underwater dam inspection.A least-square parameter estimation method is utilized to estimate the hydrodynamic coefficients of DSIROV,and a four degree-of-freedom(DOF) simulation system is constructed.The architecture of DSIROV's motion control system is introduced,which includes hardware and software structures.The hardware based on PC104 BUS,uses AMD ELAN520 as the controller's embedded CPU and all control modules work in VxWorks real-time operating system.Information flow of the motion system of DSIROV,automatic control of dam scanning and dead-reckoning algorithm for navigation are also discussed.The reliability of DSIROV's control system can be verified and the control system can fulfill the motion control mission because embankment checking can be demonstrated by the lake trials. 展开更多
关键词 dam safety inspection remotely operated vehicle (DSIROV) control system architecture embedded system automaticcontrol of dam-scanning dead-reckoning
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Efficacy and safety of transcutaneous auricular vagus nerve stimulation combined with conventional rehabilitation training in acute stroke patients: a randomized controlled trial conducted for 1 year involving 60 patients 被引量:9
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作者 Jia-Ni Li Chen-Chen Xie +7 位作者 Chang-Qing Li Gui-Fang Zhang Hao Tang Chuan-Na Jin Jing-Xi Ma Lan Wen Ke-Ming Zhang Ling-Chuan Niu 《Neural Regeneration Research》 SCIE CAS CSCD 2022年第8期1809-1813,共5页
Transcutaneous auricular vagus nerve stimulation(ta-VNS)is a novel noninvasive treat-ment for stroke that directly stimulates the peripheral auricular branch of the vagus nerve.There have been recent reports that ta-V... Transcutaneous auricular vagus nerve stimulation(ta-VNS)is a novel noninvasive treat-ment for stroke that directly stimulates the peripheral auricular branch of the vagus nerve.There have been recent reports that ta-VNS combined with conventional rehabilitation training promotes the recovery of neurological function of patients with acute stroke.However,these were small-sample-sized studies on the recovery of neurological function in patients after percutaneous vagus nerve stimulation in the subacute and chronic phases after stroke.This double-blinded randomized controlled trial involved 60 acute ischemic or hemorrhagic stroke patients aged 18-80 years who received treatment in the Second Affiliated Hospital of Chongqing Medical University.The subjects were randomly assigned to receive ta-VNS or sham ta-VNS combined with conventional rehabilitation training.The follow-up results over 1 year revealed that ta-VNS combined with conventional rehabilitation training greatly improved the recovery of motor and sensory functions and emotional responses compared with sham ta-VNS combined with conventional rehabilitation training.There were no obvious side effects.These findings suggest that ta-VNS combined with conventional rehabilitation training for the treatment of acute ischemic or hemorrhagic stroke patients is safe and effective. 展开更多
关键词 activity of daily living early stage treatment emotional disorder limb dysfunction neural regeneration randomized controlled clinical trial rehabilitation safety of treatment stroke transcutaneous auricular-vagus nerve stimulation
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Safety control for powder compaction of initiating explosive device 被引量:2
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作者 刘丰林 《Journal of Chongqing University》 CAS 2006年第1期16-18,共3页
Powder compaction is one of the most crucial processes in initiating explosive device manufacturing. The quality of powder compaction may influence the performances of product directly. Traditional powder compaction m... Powder compaction is one of the most crucial processes in initiating explosive device manufacturing. The quality of powder compaction may influence the performances of product directly. Traditional powder compaction mainly makes use of manual gravitational spiral loading machine or lever loading machine. Potential accident by the strike in powder compaction of initiating explosive device could risk life, property and the environment. To prevent this risk, automatic control system and control strategy can be used to guarantee no strike in pressing process. The scope of this paper is to analyze and review the control strategy for powder compact and discuss the experimental results for the application of the proposed strategy. 展开更多
关键词 safety control powder compaction initiating explosive device
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Safety Control Technology of Deepwater Perforated Gas Well Testing 被引量:1
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作者 Hao Liang Muwang Wu 《Engineering(科研)》 2019年第3期131-136,共6页
Due to the high difficulties, high investment, and high risks in deepwater oil and gas well testing, major safety problems can occur easily. A key to prevent accidents is to conduct safety assessment and control on de... Due to the high difficulties, high investment, and high risks in deepwater oil and gas well testing, major safety problems can occur easily. A key to prevent accidents is to conduct safety assessment and control on deepwater testing and to improve the testing technology. The deepwater of the South China Sea has some special environmental features: long distance from offshore, frequent typhoons in summer and constant monsoons in winter, and the presence of sandy slopes, sandy ridges and internal waves, coupled with the complex properties of oil and gas reserves which bring more challenges to deepwater well testing. In combination with deepwater well testing practice in the South China Sea, this paper analyzes the main potential risks in deepwater well testing and concludes that there are risks of failures of testing string, tools, and ground processes. Other risks are gas hydrate blockage, reservoir stratum sanding, and typhoon impacts. Specific precautions are also proposed in response to these risks in the paper. 展开更多
关键词 safety control WELL TESTING DEEPWATER RISK
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FOOD SAFETY CONTROL SYSTEM IN CHINA 被引量:1
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作者 Liu Wei-jun Wei Yi-min Han Jun Luo Dan Pan Jia-rong 《China Standardization》 2007年第4期2-9,共7页
Most countries have expended much effort to develop food safety control systems to ensure safe food supplies within their borders. China, as one of the world's largest food producers and consumers, pays a lot of a... Most countries have expended much effort to develop food safety control systems to ensure safe food supplies within their borders. China, as one of the world's largest food producers and consumers, pays a lot of attention to food safety issues. In recent years, China has taken actions and implemented a series of plans in respect to food safety. Food safety control systems including regulatory, supervisory, and science and technology systems, have begun to be established in China. Using, as a base, an analysis of the current Chinese food safety control system as measured against international standards, this paper discusses the need for China to standardize its food safety control system. We then suggest some policies and measures to improve the Chinese food safety control system. 展开更多
关键词 REGULATORY SYSTEM SUPERVISION SYSTEM Science and technology SYSTEM FOOD safety control SYSTEM
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Safety control strategy for vertebral lamina milling task 被引量:5
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作者 Luping Fan Peng Gao +5 位作者 Baoliang Zhao Yu Sun Xiaoxiao Xin Ying Hu Shoubin Liu Jianwei Zhang 《CAAI Transactions on Intelligence Technology》 2016年第3期249-258,共10页
Vertebral lamina milling task is one of the high-risk operations in spinal surgeries. The operation is to remove part of vertebral lamina and release the pressure on the spinal nerve. Because many important vessels an... Vertebral lamina milling task is one of the high-risk operations in spinal surgeries. The operation is to remove part of vertebral lamina and release the pressure on the spinal nerve. Because many important vessels and nerves are under the vertebral lamina, any incorrect operation may cause irreparable damage to patients. To improve the safety of lamina milling task, a fuzzy force control strategy is proposed in this paper. Primary experiments have been conducted on bone samples from different animals. The results show that, with the fuzzy force control strategy, the bone milling system can recognize all surgery states and halt the tool at the proper location, achieving satisfactory surgery performance. 展开更多
关键词 safety control Force feedback Fuzzy logic control Vertebral lamina milling Spinal surgery
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Nuclear power development and radiationsafety control in China
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作者 Hu Erbang(China institute for Radiation Protection, Taiyuan 030006 , China) 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 1995年第2期138-145,共8页
NuclearpowerdevelopmentandradiationsafetycontrolinChinaHuErbang(ChinainstituteforRadiationProtection,Taiyuan... NuclearpowerdevelopmentandradiationsafetycontrolinChinaHuErbang(ChinainstituteforRadiationProtection,Taiyuan030006,China)Nucl... 展开更多
关键词 nuclear power radiation safety control China.
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Control Approach to Nuclear Safety
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作者 Joseph Olorunju Omolehin Aminu Lukman Kamilu Rauf 《Applied Mathematics》 2012年第10期1215-1219,共5页
Despite the advantages of nuclear technology to mankind, it attendance accident is always catastrophic. In this work, the energy balance equations associated with nuclear technology are structured in parametric form t... Despite the advantages of nuclear technology to mankind, it attendance accident is always catastrophic. In this work, the energy balance equations associated with nuclear technology are structured in parametric form to form the basis of our Mathematical model solvable by the Conjugate Gradient Method (CGM). 展开更多
关键词 control NUCLEAR safety Reactors and CONTAINMENT
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Indirect comparison of efficacy and safety of chiglitazar and thiazolidinedione in patients with type 2 diabetes:A meta-analysis 被引量:1
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作者 Chu Lin Zong-Lin Li +4 位作者 Xiao-Ling Cai Sui-Yuan Hu Fang Lv Wen-Jia Yang Li-Nong Ji 《World Journal of Diabetes》 SCIE 2023年第10期1573-1584,共12页
BACKGROUND Chiglitazar is an emerging pan-agonist of all peroxisome proliferator activated receptors(PPAR)-α,δandγ,and has therapeutic potential for type 2 diabetes(T2D).However,to date,no clinical studies or meta-... BACKGROUND Chiglitazar is an emerging pan-agonist of all peroxisome proliferator activated receptors(PPAR)-α,δandγ,and has therapeutic potential for type 2 diabetes(T2D).However,to date,no clinical studies or meta-analyses have compared the efficacy and safety of chiglitazar and traditional PPAR-γagonist thiazolidinediones(TZDs).A meta-analysis concerning this topic is therefore required.AIM To compare the efficacy and safety of chiglitazar and TZD in patients with T2D.METHODS PubMed,Medline,Embase,the Cochrane Central Register of Controlled Trials,Reference Citation Analysis and Clinicaltrial.gov websites were searched from August 1994 to March 2022.Randomized controlled trials(RCTs)of chiglitazar or TZD vs placebo in patients with T2D were included.Indirect comparisons and sensitivity analyses were implemented to evaluate multiple efficacy and safety endpoints of interest.RESULTS We included 93 RCTs that compared TZD with placebo and one that compared chiglitazar with placebo.For efficacy endpoints,the augmented dose of chiglitazar resulted in greater reductions in hemoglobin(Hb)A1c[weighted mean difference(WMD)=-0.15%,95%confidence interval(CI):-0.27 to-0.04%],triglycerides(WMD=-0.17 mmol/L,95%CI:-0.24 to-0.11 mmol/L)and alanine aminotransferase(WMD=-5.25 U/L,95%CI:-8.50 to-1.99 U/L),and a greater increase in homeostasis model assessment-β(HOMA-β)(WMD=17.75,95%CI:10.73-24.77)when compared with TZD treatment.For safety endpoints,the risks of hypoglycemia,edema,bone fractures,upper respiratory tract infection,urinary tract infection,and weight gain were all comparable between the augmented dose of chiglitazar and TZD.In patients with baseline HbA1c≥8.5%,body mass index≥30 kg/m^(2)or diabetes duration<10 years,the HbA1c reduction and HOMA-βincrease were more conspicuous for the augmented dose of chiglitazar compared with TZD.CONCLUSION Augmented dose of chiglitazar,a pan-activator of PPARs,may serve as an antidiabetic agent with preferable glycemic and lipid control,betterβ-cell function preserving capacity,and does not increase the risk of safety concerns when compared with TZD. 展开更多
关键词 Chiglitazar THIAZOLIDINEDIONE Glycemic control β-cell function Drug safety
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