Edge-to-edge matching(E2EM)model was used to predict the potency of LaB_(6) as the heterogeneous nucleation substrate for primary Al_(13)Mn_(4)Si_(8) phase formed during the solidification of Al−Si−Cu−Mn heat-resistan...Edge-to-edge matching(E2EM)model was used to predict the potency of LaB_(6) as the heterogeneous nucleation substrate for primary Al_(13)Mn_(4)Si_(8) phase formed during the solidification of Al−Si−Cu−Mn heat-resistant alloy.There are five pairs of orientation relationships(ORs)between LaB_(6) and Al_(13)Mn_(4)Si_(8) phases which meet the criteria of E2EM model.One pair of plane ORs((110)LaB_(6)//(110)Al_(13)Mn_(4)Si_(8))are demonstrated by TEM observation.This strongly indicates that the LaB_(6) phase can act as the heterogeneous nucleation substrate for the primary Al_(13)Mn_(4)Si_(8) phase.1.0 wt.%of Al−2La−1B master alloy was also added into Al−12Si−4Cu−2Mn alloy to evaluate the refining effect by microstructure observation and tensile test.Experimental results show that addition of Al−2La−1B master alloy can significantly refine the primary Al_(13)Mn_(4)Si_(8) phase,supporting the prediction accuracy of E2EM model.However,such refinement of primary Al_(13)Mn_(4)Si_(8) phase does not lead to an improvement in strength.This is due to the larger difference in elastic modulus between the finally formed Al_(13)Mn_(4)Si_(8) phase and aluminum matrix than that of Al_(15)Mn_(3)Si_(2) phase.展开更多
In this paper, quaternary 8-（1-acylethene-l-yl）-13-methylcoptisine chlorides targeting thioredoxin reductases （TrxRs） were designed to test the growth inhibitory activity against human cancer cell lines and the ef...In this paper, quaternary 8-（1-acylethene-l-yl）-13-methylcoptisine chlorides targeting thioredoxin reductases （TrxRs） were designed to test the growth inhibitory activity against human cancer cell lines and the effect on viability of the normal intestinal epithelial cell-6 （IEC-6） in vitro and to evaluate structure-activity relationship （SAR）. The introduced α, β-unsaturated ketone groups at C-8 consisting of n-alkanoyls possessing five to ten carbons or aroyls or cyclohexylcarbonyl increased the tested activity against the target cancer cell lines. By and large, this type of improvement was increasingly graced by the elongation of the aliphatic chain of the n-alkanoyls in the range of less than ten carbon atoms. The relatively more polar l-acylethene-l-yls displayed no effect on improving the activity. All the explored aroyls showed significant effect on improving the activity of the target compounds against the tested cancer cell lines with no SAR being observed, The findings of this study suggested that oil]water partition coefficient of the test compounds was one of the key factors impacting the target activity against the tested cancer cell lines. At the concentration of 10 μmol/L, except for the compounds with n-all（anoyls possessing seven or more carbons or with α-naphthoyl, none of the other compounds displayed obvious cytotoxicity on normal IEC-6 cell when co-incubated. The survival rate of IEC-6 cell ranged from 75% to 100% for the noncytotoxic compounds.展开更多
A new diterpenoid was isolated from the bark of Larix olgensis Henry var. koreana Nakai. Its structure was elucidated as 5S, 9S, 10R-labda-8 (17), 13-diene-6a, 15-diol l by spectroscopic methods.
A new jatrophane diterpenoid ester （2S, 3S, 4R, 5R, 7S, 8R, 13R, 15R） - 3, 5, 7, 8, 15- pentaacetoxy-9, 14-dioxojatropha-6（17）, 11E-diene was isolated from the whole plant of Euphorbia turczaninowii Kar. ＆ Kit.. ...A new jatrophane diterpenoid ester （2S, 3S, 4R, 5R, 7S, 8R, 13R, 15R） - 3, 5, 7, 8, 15- pentaacetoxy-9, 14-dioxojatropha-6（17）, 11E-diene was isolated from the whole plant of Euphorbia turczaninowii Kar. ＆ Kit.. Its structure was characterized by spectral analysis and confurmed by X-ray crystallographic analysis.展开更多
基金supported by Jiangsu Key Laboratory Metallic Materials, China (No. BM2007204)the Fundamental Research Funds for the Central Universities, China (No. 2242016k40011)。
文摘Edge-to-edge matching(E2EM)model was used to predict the potency of LaB_(6) as the heterogeneous nucleation substrate for primary Al_(13)Mn_(4)Si_(8) phase formed during the solidification of Al−Si−Cu−Mn heat-resistant alloy.There are five pairs of orientation relationships(ORs)between LaB_(6) and Al_(13)Mn_(4)Si_(8) phases which meet the criteria of E2EM model.One pair of plane ORs((110)LaB_(6)//(110)Al_(13)Mn_(4)Si_(8))are demonstrated by TEM observation.This strongly indicates that the LaB_(6) phase can act as the heterogeneous nucleation substrate for the primary Al_(13)Mn_(4)Si_(8) phase.1.0 wt.%of Al−2La−1B master alloy was also added into Al−12Si−4Cu−2Mn alloy to evaluate the refining effect by microstructure observation and tensile test.Experimental results show that addition of Al−2La−1B master alloy can significantly refine the primary Al_(13)Mn_(4)Si_(8) phase,supporting the prediction accuracy of E2EM model.However,such refinement of primary Al_(13)Mn_(4)Si_(8) phase does not lead to an improvement in strength.This is due to the larger difference in elastic modulus between the finally formed Al_(13)Mn_(4)Si_(8) phase and aluminum matrix than that of Al_(15)Mn_(3)Si_(2) phase.
基金supported by grants from the National Natural Science Foundation of China(No. 81373269)CAMS Innovation Fund for Medical Sciences(No. 2016-12M-1-010)National Science and Technology Project of China(No.2017ZX09305008002)
文摘In this paper, quaternary 8-（1-acylethene-l-yl）-13-methylcoptisine chlorides targeting thioredoxin reductases （TrxRs） were designed to test the growth inhibitory activity against human cancer cell lines and the effect on viability of the normal intestinal epithelial cell-6 （IEC-6） in vitro and to evaluate structure-activity relationship （SAR）. The introduced α, β-unsaturated ketone groups at C-8 consisting of n-alkanoyls possessing five to ten carbons or aroyls or cyclohexylcarbonyl increased the tested activity against the target cancer cell lines. By and large, this type of improvement was increasingly graced by the elongation of the aliphatic chain of the n-alkanoyls in the range of less than ten carbon atoms. The relatively more polar l-acylethene-l-yls displayed no effect on improving the activity. All the explored aroyls showed significant effect on improving the activity of the target compounds against the tested cancer cell lines with no SAR being observed, The findings of this study suggested that oil]water partition coefficient of the test compounds was one of the key factors impacting the target activity against the tested cancer cell lines. At the concentration of 10 μmol/L, except for the compounds with n-all（anoyls possessing seven or more carbons or with α-naphthoyl, none of the other compounds displayed obvious cytotoxicity on normal IEC-6 cell when co-incubated. The survival rate of IEC-6 cell ranged from 75% to 100% for the noncytotoxic compounds.
文摘A new diterpenoid was isolated from the bark of Larix olgensis Henry var. koreana Nakai. Its structure was elucidated as 5S, 9S, 10R-labda-8 (17), 13-diene-6a, 15-diol l by spectroscopic methods.
文摘A new jatrophane diterpenoid ester （2S, 3S, 4R, 5R, 7S, 8R, 13R, 15R） - 3, 5, 7, 8, 15- pentaacetoxy-9, 14-dioxojatropha-6（17）, 11E-diene was isolated from the whole plant of Euphorbia turczaninowii Kar. ＆ Kit.. Its structure was characterized by spectral analysis and confurmed by X-ray crystallographic analysis.
