Phase II Clinical Study of Three-Dimensional Printed Coplanar Template Combined with CT-Guided Percutaneous Core Needle Biopsy of Pulmonary Nodules in Elderly Patients

Background: As the population age structure gradually ages, more and more elderly people were found to have pulmonary nodules during physical examinations. Most elderly people had underlying diseases such as heart, lung, brain and blood vessels and cannot tolerate surgery. Computed tomography (CT)-guided percutaneous core needle biopsy (CNB) was the first choice for pathological diagnosis and subsequent targeted drugs, immune drugs or ablation treatment. CT-guided percutaneous CNB requires clinicians with rich CNB experience to ensure high CNB accuracy, but it was easy to cause complications such as pneumothorax and hemorrhage. Three-dimensional (3D) printing coplanar template (PCT) combined with CT-guided percutaneous pulmonary CNB biopsy has been used in clinical practice, but there was no prospective, randomized controlled study. Methods: Elderly patients with lung nodules admitted to the Department of Oncology of our hospital from January 2019 to January 2023 were selected. A total of 225 elderly patients were screened, and 30 patients were included after screening. They were randomly divided into experimental group (Group A: 30 cases) and control group (Group B: 30 cases). Group A was given 3D-PCT combined with CT-guided percutaneous pulmonary CNB biopsy, Group B underwent CT-guided percutaneous pulmonary CNB. The primary outcome measure of this study was the accuracy of diagnostic CNB, and the secondary outcome measures were CNB time, number of CNB needles, number of pathological tissues and complications. Results: The diagnostic accuracy of group A and group B was 96.67% and 76.67%, respectively (P = 0.026). There were statistical differences between group A and group B in average CNB time (P = 0.001), number of CNB (1 vs more than 1, P = 0.029), and pathological tissue obtained by CNB (3 vs 1, P = 0.040). There was no statistical difference in the incidence of pneumothorax and hemorrhage between the two groups (P > 0.05). Conclusions: 3D-PCT combined with CT-guided percutaneous CNB can improve the puncture accuracy of elderly patients, shorten the puncture time, reduce the number of punctures, and increase the amount of puncture pathological tissue, without increasing pneumothorax and hemorrhage complications. We look forward to verifying this in a phase III randomized controlled clinical study. .

Patient 3D验证左侧乳腺癌根治术后调强放疗中AXB和AAA算法的剂量学差异

目的基于Patient 3D,探究左侧乳腺癌根治术后调强放疗计划中Acuros XB(AXB)算法和各向异性解析算法(Anisotropic Analytical Algorithm,AAA)这2种算法的剂量学差异。方法选取左侧乳腺癌根治术后放疗患者26例,采用Eclipse15.5治疗计划系统(Treatment Planning System,TPS)设计固定野动态调强计划,使用AAA算法和AXB算法计算剂量沉积,导入IBA compass软件系统Patient 3D模块进行2种算法独立计算重建剂量,对比各结构的剂量学参数及验证结果。结果TPS计算结果表明,AXB算法左肺的V_(5)、D_(mean)显著低于AAA算法(P<0.05)。Patient 3D结果表明,2种算法各有优缺点,其中右肺、左肺、心脏、健侧乳腺的Dmean和D1,以及左肺V_(5)AXB算法与TPS优化结果一致性优于AAA算法。2种算法的横断面剂量重建γ分析比较,AAA算法在左肺剂量偏差较大。结论左侧乳腺癌根治术后调强放射治疗计划设计中,AAA算法和AXB算法均符合临床要求,AXB算法明显降低了左肺V5的百分体积,在左肺低剂量区更符合TPS实际优化剂量。

唑来膦酸联合碳酸钙D_(3)对老年骨质疏松患者骨代谢及预后的影响

目的:探讨唑来膦酸联合碳酸钙D_(3)对老年骨质疏松患者骨代谢及预后的影响。方法:采用前瞻性随机对照试验设计,选取2021年1月至2022年6月于该院就诊的104例老年骨质疏松患者,采用分层随机法分为对照组、研究组,各52例。两组患者均调整生活方式,补充钙剂,适当运动;对照组患者给予唑来膦酸治疗,研究组患者给予唑来膦酸联合碳酸钙D_(3)治疗。比较两组患者骨密度(BMD)、骨代谢、细胞因子、临床疗效和不良反应发生情况;并在患者治疗后每月随访1次,共随访3次,评价两组患者的短期预后。结果:治疗后,与对照组比较,研究组患者腰椎L_(1-4)、髋部、Wards三角区和股骨颈等部位BMD升高,差异均有统计学意义(P<0.05)。治疗后,与对照组比较,研究组患者Ⅰ型胶原氨基酸延长肽、骨钙素、Ⅰ型胶原羧基末端交联肽和抗酒石酸酸性磷酸酶-5b水平降低,骨碱性磷酸酶水平升高;与对照组比较,研究组患者骨保护素(OPG)表达量升高,核因子κB受体活化因子配体(RANKL)、核因子κB受体活化因子(RANK)表达量降低;与对照组比较,研究组患者肿瘤坏死因子α、白细胞介素6和γ-干扰素水平降低,上述差异均有统计学意义(P<0.05)。研究组患者的总有效率为94.23%(49/52),高于对照组的80.77%(42/52),差异有统计学意义(P<0.05)。研究组、对照组患者的不良反应发生率分别为9.62%(5/52)、7.69%(4/52),差异无统计学意义(P>0.05)。研究组短期预后优良率为90.38%(47/52),高于对照组的75.00%(39/52),差异有统计学意义(P<0.05)。结论:唑来膦酸联合碳酸钙D_(3)可能通过调控OPG/RANKL/RANK信号通路,改善细胞因子异常表达,纠正骨代谢异常,改善预后。

Characterization of oral and gut microbiome and plasma metabolomics in COVID-19 patients after 1-year follow-up

Background:Due to the outbreak and rapid spread of coronavirus disease 2019(COVID-19),more than 160 million patients have become convalescents worldwide to date.Significant alterations have occurred in the gut and oral microbiome and metabonomics of patients with COVID-19.However,it is unknown whether their characteristics return to normal after the 1-year recovery.Methods:We recruited 35 confirmed patients to provide specimens at discharge and 1 year later,as well as 160healthy controls.A total of 497 samples were prospectively collected,including 219 tongue-coating,129 stool and 149 plasma samples.Tongue-coating and stool samples were subjected to 16S rRNA sequencing,and plasma samples were subjected to untargeted metabolomics testing.Results:The oral and gut microbiome and metabolomics characteristics of the 1-year convalescents were restored to a large extent but did not completely return to normal.In the recovery process,the microbial diversity gradually increased.Butyric acid-producing microbes and Bifidobacterium gradually increased,whereas lipopolysaccharideproducing microbes gradually decreased.In addition,sphingosine-1-phosphate,which is closely related to the inflammatory factor storm of COVID-19,increased significantly during the recovery process.Moreover,the predictive models established based on the microbiome and metabolites of patients at the time of discharge reached high efficacy in predicting their neutralizing antibody levels one year later.Conclusions:This study is the first to characterize the oral and gut microbiome and metabonomics in 1-year convalescents of COVID-19.The key microbiome and metabolites in the process of recovery were identified,and provided new treatment ideas for accelerating recovery.And the predictive models based on the microbiome and metabolomics afford new insights for predicting the recovery situation which benefited affected individuals and healthcare.

Implementation of Level-3 Autonomous Patient-Specific Quality Assurance with Automated Human Interactive Devices

Purpose: Patient-specific quality assurance (PSQA) requires manual operation of different workstations, which is time-consuming and error-prone. Therefore, developing automated solutions to improve efficiency and accuracy is a priority. The purpose of this study was to develop a general software interface with scripting on a human interactive device (HID) for improving the efficiency and accuracy of manual quality assurance (QA) procedures. Methods: As an initial application, we aimed to automate our PSQA workflow that involves Varian Eclipse treatment planning system, Elekta MOSAIQ oncology information system and PTW Verisoft application. A general platform, the AutoFrame interface with two imbedded subsystems—the AutoFlow and the PyFlow, was developed with a scripting language for automating human operations of aforementioned systems. The interface included three functional modules: GUI module, UDF script interpreter and TCP/IP communication module. All workstations in the PSQA process were connected, and most manual operations were automated by AutoFrame sequentially or in parallel. Results: More than 20 PSQA tasks were performed both manually and using the developed AutoFrame interface. On average, 175 (±12) manual operations of the PSQA procedure were eliminated and performed by the automated process. The time to complete a PSQA task was 8.23 (±0.78) minutes for the automated workflow, in comparison to 13.91 (±3.01) minutes needed for manual operations. Conclusion: We have developed the AutoFrame interface framework that successfully automated our PSQA procedure, and significantly reduced the time, human (control/clicking/typing) errors, and operators’ stress. Future work will focus on improving the system’s flexibility and stability and extending its operations to other QA procedures.

Sustained heavy ethanol drinking affects CD4⁺cell counts in HIV-infected patients on stavudine (d4T), lamivudine (3TC) and nevirapine (NVP) treatment regimen during 9 months follow-up period

Sustained heavy ethanol drinking is a common problem globally and ethanol is one of the most abused drugs among individuals of different socio-economic status including the HIV-infected patients on antiretroviral drugs. Ethanol is reward drug and a CNS depressant especially at high doses. The study determined the effect of sustained heavy ethanol drinking by HIV-infected patients on d4T/3TC/NVP regimen on CD4+ cell counts in Uganda using WHO AUDIT tool and chronic alcohol-use biomarkers. A case control study using repeated measures design with serial measurements model was used. The patients on stavudine (d4T) 30 mg, lamivudine (3TC) 150 mg and nevirapine (NVP) 200 mg and chronic alcohol use were recruited. A total of 41 patients (20 in alcohol group and 21 in control group) were screened for chronic alcohol use by WHO AUDIT tool and chronic alcohol use biomarkers. They were followed up for 9 months with blood sampling done at 3 months intervals. CD4+ cell count was determined using Facscalibur Flow Cytometer system. Results were then sorted by alcohol-use biomarkers (GGT, MCV and AST/ ALT ratio). Data were analysed using SAS 2003 version 9.1 statistical package with repeated measures fixed model and the means were compared using student t-test. The mean CD4+ cell counts in all the groups were lower than the reference ranges at baseline and gradually increased at 3, 6 and 9 months of follow-up. The mean CD4+ cell counts were higher in the control group as compared to the chronic alcohol use group in both WHO AUDIT tool group and chronic alcohol-use biomarkers group though there was no significant difference (p > 0.05). Chronic alcohol use slightly lowers CD4+ cell count in HIV-infected patients on d4T/3TC/NVP treatment regimen.

血清Fbg、PTX3水平对老年髋关节置换术患者围术期主要不良心血管事件的预测价值

目的探讨血清纤维蛋白原(Fbg)、正五聚蛋白-3(PTX3)水平对老年髋关节置换术患者围术期主要不良心血管事件(MACE)的预测价值。方法收集2022年1月至2022年12月在山东大学齐鲁医院德州医院(下称该院)接受髋关节置换术患者201例作为研究组,并将患者根据围术期有无MACE发生分为非MACE组(183例)和MACE组(18例),另收集同期该院的健康体检者150例作为对照组。采用全自动生化仪和酶联免疫吸附试验(ELISA)检测受试者血清Fbg、PTX3水平;多因素Logistic回归分析老年髋关节置换术患者围术期MACE的影响因素;受试者工作特征(ROC)曲线评估血清指标对老年髋关节置换术患者围术期MACE的预测价值。结果与对照组相比,研究组血清的Fbg、PTX3水平均显著升高,差异有统计学意义(P<0.05)。老年髋关节置换术患者发生MACE有18例,MACE的发生率为8.95%。与非MACE组比,MACE组血清Fbg、PTX3水平均显著升高,差异有统计学意义(P<0.05)。血清Fbg、PTX3、肌钙蛋白Ⅰ(cTnⅠ)、心房钠尿肽(BNP)水平升高及左心室射血分数降低是老年髋关节置换术患者的围术期发生MACE的独立危险因素(P<0.05)。血清Fbg、PTX3水平及联合预测老年髋关节置换术患者围术期MACE发生的曲线下面积(AUC)分别为0.824、0.809、0.917,二者联合预测价值高于单独预测(Z_(二者联合-Fbg)=2.333,P=0.019;Z_(二者联合-PTX3)=3.110,P=0.001)。结论老年髋关节置换术患者围术期血清Fbg、PTX3水平升高,二者联合对围术期MACE发生具有较好的预测价值。

活性维生素D_(3)对维持性血液透析患者钙磷代谢、衰弱和疲乏状态的影响

目的:探究活性维生素D_(3)对维持性血液透析(MHD)患者的钙磷代谢、衰弱和疲乏状态的影响。方法:选取2021年3月—2023年3月景德镇市第三人民医院收治的82例MHD患者作为研究对象,随机分成对照组和观察组,各41例。对照组给予基础治疗,观察组在对照组的基础上加用活性维生素D_(3)治疗,治疗期3个月。观察两组治疗前后血清磷(P)、钙(Ca)、炎症因子[超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]、心功能指标[左心室质量(LVM)、左心室质量指数(LVMI)]、Tilburg衰弱指数(TFI)和疲劳量表(FS-14)评分。结果:治疗后,观察组血清Ca水平高于对照组,血清P、hs-CRP、IL-6、TNF-α、LVM和LVMI水平均低于对照组,差异均有统计学意义(P<0.05)。治疗后,观察组TFI评分、FS-14评分均低于对照组,差异均有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:活性维生素D_(3)用于MHD患者可有效改善钙磷代谢,改善微炎症状态,逆转左心室肥厚,缓解机体的衰弱和疲乏的症状。

Investigation of the treatment of 3 patients with thalamic abscesses and literatures review

Objective To investigate the effective treatment of abscesses in thalanmus. Methods 3 patients with solitary abscess in thalamus are analyzed retrospectively, who were treated from Sep. 2009 to Jul. 2010. There were one male and two female patients. One patient treated with stereotactic

Influence of organic anion transporting potypeptide(SLCO1B1 and SLCO1B3)genetic polymorphisms on mycophenolic acid in Chinese kidney transplantation patients

Objective To analyze the relationship between genetic polymorphisms of organic anion transporting polypeptide ( SLCO1B1 and SLCO1B3) and mycophenolic acid ( MPA) pharmacokinetics in Chinese kidney transplant recipients. Methods Gene mutations ( SLCO1B3 T334G,SLCO1B1 A338G) were detected in 68 recipi-

The value of B7-H3 expression in expressed prostatic secretions in differential diagnosis of patients with inflammatory elevation of PSA in t-PSA gray zone

Objective To investigate the value of BT-H3 in expressed prostatic secretions ( EPS) in differential diagnosis of patients with inflammatory elevation of PSA in t - PSA gray zone ( 4 - 10 ng /ml) . Methods One hundred and sixteen patients from ages of 19 to 80 years ( mean,40 years) were studied. In the group there

化疗患者5-羟色胺3受体拮抗剂路径化管理模式的建立与应用

目的建立化疗患者5-羟色胺3受体拮抗剂(5-HT3RA)路径化管理模式,提高化疗患者用药合理性。方法制定5-HT3RA规范化用药管控规则,并借助医疗智能及决策支持(MINDS)系统,以信息抓取结合医嘱前置审核的形式对使用5-HT3RA的化疗患者开展路径化管理,对用药指征、用法用量、疗程等实施全程化干预。通过比较实施路径化管理前后5-HT3RA无指征用药、用法用量不合理、重复用药、疗程不合理的变化情况以及5-HT3RA人均药费变化情况,对干预效果进行分析。结果共纳入9181例患者,实施路径化管理后,无指征用药率降低0.48%,单次剂量、给药频次、重复用药、疗程(化疗结束后3 d仍使用5-HT3RA)的不合理率分别降低10.48%、0.65%、1.33%、0.34%,5-HT3RA人均药费降低13.72元,以上差异均有统计学意义(P<0.05)。结论我院建立的化疗患者5-HT3RA路径化管理模式有效提高了用药合理性,为临床合理用药提供了新思路。

Construction of m6A modification related prognostic model in older patients with FLT3 mutated acute myeloid leukemia

Objective To screen m6A modification-related genes,and to establish a prognostic model in patients with FLT3 mutated acute myeloid leukemia (AML),especially in older patients and to evaluate the prognostic efficiency of the model.Methods Gene expression omnibus (GEO) datasets were used to analyze abnormally expressed m6A enzymes and reading proteins in FLT3mutated AML;correlation analysis was used to screen m6A modified-related genes in expression profiles.

Role of IL28B genotype in older hepatitis C virus-infected patients

The average age of hepatitis C virus(HCV)-infected individuals is becoming increasingly higher in Japan and steps should be taken to treat older individuals infected with HCV. Until an interferon-free regimen becomes available, peginterferon plus ribavirin will play a critical role in the treatment. The perception that older HCVinfected patients may be at higher risk than younger patients for adverse events from peginterferon plus ribavirin treatment but may obtain less clinical benefit from it may be based on the underrepresentation of older patients in clinical trials. A recent genomewide association study revealed that interleukin-28B(IL28B) genotype closely correlates with the treatment response against HCV. The relationship of IL28 B genotype with the treatment response in older HCV-infected patients is also unknown. In this review, we focused on the treatment response in older patients infected with HCV and the effects of IL28 B genotype. IL28 B major genotype is a useful predictor of sustained virological response in the interferon-including treatment of older patients infected with HCV. It also seems useful for avoiding adverse events, although the mechanisms ofthe effects of IL28 B genotype on the treatment outcome are still poorly understood and are currently under investigation. Further studies will be needed.

右美托咪定调节PI3K/AKT信号通路对老年全身麻醉患者术后认知功能的影响

目的探讨右美托咪定调节血清磷脂酰肌醇-3-羟基酶(PI3K)/丝氨酸-苏氨酸蛋白激酶(AKT)信号通路对老年全身麻醉患者术后认知功能的影响。方法选取2021年2月至2022年2月在荆门市第二人民医院行全麻手术的老年患者82例进行前瞻性研究,采用抽签法将所有患者分为观察组和对照组,各41例。观察组在全身麻醉诱导开始10 min内静脉泵入右美托咪定,0.8μg/kg,随后以0.2~0.5μg·kg^(-1)·h^(-1)维持泵注;对照组静脉泵等量0.9%氯化钠溶液。观察并记录两组患者术前10 min、拔管前10 min、拔管后30 min的血流动力学指标;记录两组患者术中麻醉药用量及复苏情况。应用精神状态检查表(MMSE)记录患者术前、术后6 h、术后1 d、术后3 d MMSE评分,比较两组患者术前及术后即刻、术后1 d、术后3 d血清PI3K及AKT蛋白表达水平;通过Spearman秩相关分析检验PI3K、AKT与全身麻醉患者术后认知功能的相关性。结果与对照组比较,观察组拔管前10 min、拔管后30 min平均动脉压明显降低、心率明显减缓,差异均有统计学意义(P<0.05)。观察组术中使用丙泊酚及瑞芬太尼用量明显少于对照组,术后复苏各指标时间短于对照组,差异均有统计学意义(P<0.05)。观察组术后6 h MMSE评分低于术前,对照组术后6 h、术后1 d MMSE评分均低于术前,差异均有统计学意义(P<0.05);观察组术后6 h MMSE评分为(25.15±5.22)分,明显高于对照组[(21.57±3.58)分],差异有统计学意义(P<0.05)。术后即刻、术后1 d、术后3 d,两组PI3K、AKT水平均显著高于术前,观察组术后即刻、术后1 d、术后3 d PI3K、AKT水平均显著低于对照组,差异均有统计学意义(P<0.05)。经单因素相关分析,患者MMSE评分与血清PI3K、AKT水平呈负相关。结论右美托咪定可有效保护老年全身麻醉患者术后认知功能,其作用机制可能与PI3K/AKT信号通路有关。

高龄髋部骨折病人开展3H护理干预后Barthel指数、Harris评分、心理状态的评估

目的:探讨医治高龄髋部骨折病人介入3H护理干预后患者Barthel指数、Harris评分、心理状态结果变化。方法:基于回顾分析,抽取研究对象为2019年6月-2020年3月骨科治疗的80例老年髋部骨折患者临床资料并统计。借助非盲法将患者平均分为2组,每组各40例。对照组为接受常规骨折护理患者,而观察组为接受3H护理理念的患者。观察2组并发症发生率、日常生活活动能力以及髋关节功能、护理前后心理状态、生活质量、护理满意度、遵医行为以及自护能力。结果:将2组于护理前做心理状况比较,差异无统计学意义,P>0.05。而护理后,观察组心理状况比对照组更佳,且并发症发生率低,差异有统计学意义,P<0.05;观察组反馈的Barthel、Harris评分等均优于对照组,2组比较有统计学意义,P<0.05。结论:面对高龄髋部骨折病人融入3H护理工作能保证骨关节恢复良好,维护患者的良好心态,促进其生活质量提升,临床推行价值可观。

128例慢性牙周炎Pg感染患者血清MMP-3、HMGB-1水平与病情严重程度的相关性分析

【目的】探讨128例慢性牙周炎牙龈卟啉单胞菌(Pg)感染患者血清基质金属蛋白酶-3(MMP-3)、高迁移率族蛋白-1(HMGB-1)水平与病情严重程度的相关性。【方法】选取2019年7月至2021年6月西安市第九医院收治的128例慢性牙周炎Pg感染患者(观察组),另外选取在西安市第九医院体检的110例健康志愿者(对照组)。比较两组研究对象临床资料及血清MMP-3、HMGB-1水平;128例慢性牙周炎根据Pg感染严重程度分为轻度组、中度组和重度组,分析血清MMP-3、HMGB-1水平与慢性牙周炎Pg感染患者病情严重程度的相关性。【结果】观察组血清MMP-3、HMGB-1水平均高于对照组(P<0.05);轻度组、中度组和重度组患者血清MMP-3、HMGB-1水平依次升高,且组间比较差异有统计学意义(P<0.05)。重度组牙周袋深度(PD)、龈沟出血指数(BSI)、简化软垢指数(DI-S)、降钙素原(PCT)、C反应蛋白(CRP)、血清MMP-3及HMGB-1水平均高于轻中度组(P<0.05)。Logistic多因素分析结果显示:PD及PCT、MMP-3、HMGB-1均是慢性牙周炎Pg感染患者病情严重程度的影响因素(OR=3.059、2.732、3.404、3.010,P<0.05)。【结论】慢性牙周炎Pg感染患者血清MMP-3、HMGB-1水平异常增高,且其与慢性牙周炎Pg感染患者病情严重程度存在一定的相关性。

TNIP1基因单核苷酸多态性及其mRNA表达水平与老年慢性心力衰竭患者肺部感染的相关性分析

目的探讨肿瘤坏死因子诱导蛋白3相互作用蛋白1(TNFAIP3-interacting protein 1,TNIP1)基因单核苷酸多态性及其mRNA表达水平与老年慢性心力衰竭患者肺部感染的相关性。方法选择2019年10月至2022年10月于上海建工医院重症医学科就诊的130例老年慢性心力衰竭患者作为研究对象,根据是否于院内发生肺部感染分为感染组(32例)和未感染组(98例)。对TNIP1基因的两个SNP位点rs6889239(T>C)、rs17728338(A>G)进行基因分型,并检测外周血TNIP1基因的mRNA表达水平。结果TNIP1基因rs6889239位点在感染组和非感染组之间的基因型分布以及等位基因频率的差异均无统计学意义(P>0.05);两组的rs17728338位点AA、AG、GG基因型分布比较差异有统计学意义(P<0.05),且感染组等位基因G的频率显著高于未感染组(P<0.05)。相较于未感染组,感染组患者的外周血TNIP1基因mRNA表达水平显著增加,差异有统计学意义(P<0.001)。受试者工作特征(Receiver operating characteristic,ROC)曲线分析结果显示外周血TNIP1基因表达水平预测慢性心力衰竭患者发生肺部感染的灵敏度和特异度分别为71.9%和95.9%。感染组和非感染组TNIP1基因rs6889239位点不同基因型患者的外周血TNIP1基因的表达水平比较差异均无统计学意义(P>0.05),而rs17728338位点不同基因型患者的外周血TNIP1基因表达水平比较差异有统计学意义(P<0.05)。结论TNIP1基因rs17728338表达水平与老年慢性心力衰竭患者发生肺部感染有关。

ω-3脂肪酸肠外营养治疗重症肿瘤患者的临床研究

目的研究ω-3脂肪酸肠外营养对重症肿瘤患者营养、炎症反应、免疫及预后的影响。方法将60例危重肿瘤患者随机分为研究组和对照组,每组患者30例。两组患者均使用等氮及等热卡的肠内营养和肠外营养。研究组在常规营养的基础上添加ω-3脂肪酸肠外营养,观察两组患者每周的营养状况指标、炎性反应指标、免疫功能指标、预后指标(ICU死亡率、ICU住院时间、感染并发症)。结果研究组患者的营养、炎性反应和免疫指标较对照组改善。研究组的ICU住院时间较对照组短。与对照组的ICU病死率和感染并发症发生率相比,研究组的ICU病死率和感染并发症发生率较低,但差异不明显(P死亡率=0.13,P感染率=0.165)。结论ω-3脂肪酸肠外营养治疗重症肿瘤患者能提高患者的营养状态和免疫功能,降低患者机体炎症反应,缩短患者的住院时间,而不会显著改善ICU死亡率和减少感染并发症的发生率。