In the present study,we aimed to investigate the hepatoprotective effect of Chinese herbal medicine Polygonatum sibiricum(PS).In this study,a rat acute liver injury(ALI)model was established by a single intraperitonea...In the present study,we aimed to investigate the hepatoprotective effect of Chinese herbal medicine Polygonatum sibiricum(PS).In this study,a rat acute liver injury(ALI)model was established by a single intraperitoneal injection of 50%CCl_(4) oil solution,and the rats were treated intragastrically with Polygonatum sibiricum aqueous extract(PSAE).The results showed that PSAE significantly decreased the serum levels of ALT,AST and ALP,increased the activities of glutathione(GSH)and superoxide dismutase(SOD),decreased malondialdehyde(MDA)activity in hepatic tissue,and decreased the reactive oxygen species(ROS)level in hepatocytes.The expressions of Nrf2,NQO-1,HO-1,Bcl-2,Bcl-x L mRNA,and HO-1 proteins were elevated,and the expression of p53 mRNA was decreased.In conclusion,PSAE exerted a powerful protective action against CCl_(4)-induced ALI in rats via effectively regulating the expressions of Nrf2-Keap1-ARE related genes and proteins,and inhibiting hepatocyte apoptosis.These outcomes provided evidence that PS had apparent hepatoprotective effect.展开更多
Arnphiphilic cyclodextrin-calixarene conjugates 1 and 2 were synthesized from "click claemxstry, and tnelr sen-asscmuly uchaviors were investigated by transmission electron microscopy, and atomic force microscopy...Arnphiphilic cyclodextrin-calixarene conjugates 1 and 2 were synthesized from "click claemxstry, and tnelr sen-asscmuly uchaviors were investigated by transmission electron microscopy, and atomic force microscopy. The results obtained show that 1 and 2 can self-assemble to form distinctly different aggregations, and the morphology of aggregations critically relies on the polarity and hydrophilicity of the solvent.展开更多
基金Natural Science Foundation of the Anhui Higher Education Institutions of China(Grant No.KJ2019A0166)the National Natural Science Foundation of China(Grant No.31772786)。
文摘In the present study,we aimed to investigate the hepatoprotective effect of Chinese herbal medicine Polygonatum sibiricum(PS).In this study,a rat acute liver injury(ALI)model was established by a single intraperitoneal injection of 50%CCl_(4) oil solution,and the rats were treated intragastrically with Polygonatum sibiricum aqueous extract(PSAE).The results showed that PSAE significantly decreased the serum levels of ALT,AST and ALP,increased the activities of glutathione(GSH)and superoxide dismutase(SOD),decreased malondialdehyde(MDA)activity in hepatic tissue,and decreased the reactive oxygen species(ROS)level in hepatocytes.The expressions of Nrf2,NQO-1,HO-1,Bcl-2,Bcl-x L mRNA,and HO-1 proteins were elevated,and the expression of p53 mRNA was decreased.In conclusion,PSAE exerted a powerful protective action against CCl_(4)-induced ALI in rats via effectively regulating the expressions of Nrf2-Keap1-ARE related genes and proteins,and inhibiting hepatocyte apoptosis.These outcomes provided evidence that PS had apparent hepatoprotective effect.
基金supported by the National Basic Research Program of China (973 Program, 2011CB932500)National Natural Science Foundation of China (20932004)
文摘Arnphiphilic cyclodextrin-calixarene conjugates 1 and 2 were synthesized from "click claemxstry, and tnelr sen-asscmuly uchaviors were investigated by transmission electron microscopy, and atomic force microscopy. The results obtained show that 1 and 2 can self-assemble to form distinctly different aggregations, and the morphology of aggregations critically relies on the polarity and hydrophilicity of the solvent.
