The idea of a human community with a shared future was proposed by the Communist Party of China(CPC)Central Committee with Comrade Xi Jinping at its core for the future development of human beings to face up to the mo...The idea of a human community with a shared future was proposed by the Communist Party of China(CPC)Central Committee with Comrade Xi Jinping at its core for the future development of human beings to face up to the most important question in today's world:“What is happening to the world and what should we do?”It profoundly answers the question of the world,history,and the times.The theory of a human community with a shared future is an innovative theory with a multidimensional formation logic that guides humanity toward continually seeking common interests and values.This paper dives into the profound motivations behind building a human community with a shared future from historical,cultural,and practical dimensions and analyzes its epochal value from both domestic and international perspectives.This not only helps exert China's role in the international community,contributing Chinese strength to the construction of a peaceful,stable,and prosperous human society,but also enhances the influence of the idea of a human community with a shared future in the international community,accelerating the building of a human community with a shared future that considers the legitimate concerns of all countries,and aiding in solving the crises facing the world.展开更多
Tunnel heading stability in two dimensions(2D)has been extensively investigated by numerous scholars in the past decade.One significant limitation of 2D analysis is the absence of actual tunnel geometry modeling with ...Tunnel heading stability in two dimensions(2D)has been extensively investigated by numerous scholars in the past decade.One significant limitation of 2D analysis is the absence of actual tunnel geometry modeling with a considerable degree of idealization.Nevertheless,it is possible to study the stability of tunnels in three dimensions(3D)with a rectangular shape using finite element limit analysis(FELA)and a nonlinear programming technique.This paper employs 3D FELA to generate rigorous solutions for stability numbers,failure mechanisms,and safety factors for rectangular-shaped tunnels.To further explore the usefulness of the produced results,multivariate adaptive regression spline(MARS)is used for machine learning of big dataset and development of design equations for practical design applications.The study should be of great benefit to tunnel design practices using the developed equations provided in the paper.展开更多
Two-dimensional(2D)transition metal chalcogenides(TMCs)hold great promise as novel microwave absorption materials owing to their interlayer interactions and unique magnetoelectric properties.However,overcoming the imp...Two-dimensional(2D)transition metal chalcogenides(TMCs)hold great promise as novel microwave absorption materials owing to their interlayer interactions and unique magnetoelectric properties.However,overcoming the impedance mismatch at the low loading is still a challenge for TMCs due to the restricted loss pathways caused by their high-density characteristic.Here,an interface engineering based on the heterostructure of 2D Cr_(5)Te_(8) and graphite is in situ constructed via a one-step chemical vapor deposit to modulate impedance matching and introduce multiple attenuation mechanisms.Intriguingly,the Cr_(5)Te_(8)@EG(ECT)heterostructure exhibits a minimum reflection loss of up to−57.6 dB at 15.4 GHz with a thin thickness of only 1.4 mm under a low filling rate of 10%.The density functional theory calculations confirm that the splendid performance of ECT heterostructure primarily derives from charge redistribution at the abundant intimate interfaces,thereby reinforcing interfacial polarization loss.Furthermore,the ECT coating displays a remarkable radar cross section reduction of 31.9 dB m^(2),demonstrating a great radar microwave scattering ability.This work sheds light on the interfacial coupled stimulus response mechanism of TMC-based heterogeneous structures and provides a feasible strategy to manipulate high-quality TMCs for excellent microwave absorbers.展开更多
Human beings are the mainstay and the ultimate goal of civilization.The history of human civilization is a continuous struggle to realize the respect,liberation,protection,and development of humanity.Human rights are ...Human beings are the mainstay and the ultimate goal of civilization.The history of human civilization is a continuous struggle to realize the respect,liberation,protection,and development of humanity.Human rights are an achievement of humanity and a symbol of progress,and the human rights civilization is an important component of human civilization.Understanding and interpreting human rights from the perspective of human rights civilization means that human rights are not only a concept or an idea but also a grand historical and long-term social practice.Up to now,the development of human rights civilization has roughly experienced four awakening eras:initialization,revolution,popularization,and globalization.In terms of its value dimensions,it has the characteristics of progressiveness,diversity,commonality,inclusiveness,indivisibility,openness,and so on.The historical position of human rights civilization and the development of its value dimensions have shown to the world that human rights are the common wealth of humanity,and human rights belong to all mankind;human rights are historical,concrete,and developmental;the concept of human rights is constantly evolving,and its connotations and categories are constantly expanding;achieving the free and well-rounded development of every person is the highest value realm of human rights civilization.The Chinese modernization endows Chinese civilization with modern strength and opens up new horizons for human rights civilization.The new pattern of human rights civilization to be created by Chinese modernization not only possesses the common characteristics of human rights civilization but also enjoys Chinese characteristics based on its own national conditions,enriching and developing the diversity of human rights civilization for all mankind.展开更多
Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock proteins.HSPB8 is involved in various cellular mechanisms mainly related to prote...Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock proteins.HSPB8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and migration.HSPB8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective autophagy.In line with this function,the pro-degradative activity of HSPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and aggregation.In cancer,HSPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under investigation.Moreover,HSPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar hemorrhage.Of note,HSPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other diseases.This is the case of cognitive impairment related to diabetes mellitus,in which HSPB8 exerts a protective activity by assuring mitochondrial homeostasis.This review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions,focusing on the beneficial effects of its modulation.Drug-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.展开更多
We develop a cosmological model in a physical background scenario of four time and four space dimensions ((4+4)-dimensions or (4+4)-universe). We show that in this framework the (1+3)-universe is deeply connected with...We develop a cosmological model in a physical background scenario of four time and four space dimensions ((4+4)-dimensions or (4+4)-universe). We show that in this framework the (1+3)-universe is deeply connected with the (3+1)-universe. We argue that this means that in the (4+4)-universe there exists a duality relation between the (1+3)-universe and the (3+1)-universe.展开更多
Different from the previous qualitative analysis of linear systems in time and frequency domains, the method for describing nonlinear systems quantitatively is proposed based on correlated dimensions. Nonlinear dynami...Different from the previous qualitative analysis of linear systems in time and frequency domains, the method for describing nonlinear systems quantitatively is proposed based on correlated dimensions. Nonlinear dynamics theory is used to analyze the pressure data of a contrarotating axial flow fan. The delay time is 18 and the embedded dimension varies from 1 to 25 through phase-space reconstruction. In addition, the correlated dimensions are calculated before and after stalling. The results show that the correlated dimensions drop from 1. 428 before stalling to 1. 198 after stalling, so they are sensitive to the stalling signal of the fan and can be used as a characteristic quantity for the judging of the fan stalling.展开更多
[Objective] The aim was to discuss the spatial pattern changes of land use in Tianjin new coastal area based on fractal dimensions.[Method] By dint of remote and geographic information system technology to obtain the ...[Objective] The aim was to discuss the spatial pattern changes of land use in Tianjin new coastal area based on fractal dimensions.[Method] By dint of remote and geographic information system technology to obtain the data of urban land use in new coastal area from 1993 to 2008,the boundary dimension,radius dimension and information dimension of each land use type were calculated based on fractal dimension.In addition,the revealed land use spatial dimension changes characteristics were analyzed.[Result] The spatial distribution of each land use type in new costal area had distinct fractal characteristics.And,the amount and changes of three types of dimension values effectively revealed the changes of complicatedness,centeredness and evenness of spatial pattern of land use in the study area.The boundary dimension of unused land and salty earth increased incessantly,which suggested its increasing complicatedness.The boundary of the port and wharf and shoal land was getting simpler.The radius dimension of the cultivated land was larger than 2,which suggested that its area spread from center to the surroundings;the one in salty land and waters distributed evenly within different radius space to the center of the city;the one in other land use types reduced gradually from center to the surroundings.The information dimension value in the woodland and orchard land,unused land and shoal land was small,and was in obvious concentrated distribution;the spatial distribution of cultivated and salty land concentrated in the outside area;the construction area in the port and wharf spread gradually on the basis of original state;the spatial distribution of waters and residents and mines were even.[Conclusion] Applying fractal dimensions to the study of spatial pattern changes of urban land use can make up for some disadvantages in classical urban spatial pattern quantitative research,which has favorable practical value.展开更多
The present status of self-elevating drilling units was analysed. Based on statistics of the main dimensions of self-elevating drilling units, a mathematical model was established using stepwise return procedures and ...The present status of self-elevating drilling units was analysed. Based on statistics of the main dimensions of self-elevating drilling units, a mathematical model was established using stepwise return procedures and a back-propagation neural network. mathematical model is applicable and reliable. The of the main dimensions of self-elevating drilling Analysis of examples of calculations showed that the model is useful for mastering the essential variations units and can be used for technical and economic analysis as well as in conceptual designs of drilling units.展开更多
文摘The idea of a human community with a shared future was proposed by the Communist Party of China(CPC)Central Committee with Comrade Xi Jinping at its core for the future development of human beings to face up to the most important question in today's world:“What is happening to the world and what should we do?”It profoundly answers the question of the world,history,and the times.The theory of a human community with a shared future is an innovative theory with a multidimensional formation logic that guides humanity toward continually seeking common interests and values.This paper dives into the profound motivations behind building a human community with a shared future from historical,cultural,and practical dimensions and analyzes its epochal value from both domestic and international perspectives.This not only helps exert China's role in the international community,contributing Chinese strength to the construction of a peaceful,stable,and prosperous human society,but also enhances the influence of the idea of a human community with a shared future in the international community,accelerating the building of a human community with a shared future that considers the legitimate concerns of all countries,and aiding in solving the crises facing the world.
基金supported by the Thailand Science Research and Innovation Fundamental Fund fiscal year 2023The fifth author (V.Kamchoom)acknowledges the financial support from the National Science,Research and Innovation Fund (NSRF)at King Mongkut's Institute of Technology Ladkrabang (KMITL),Thailand (Grant No.FRB66065/0258-RE-KRIS/FF66/53)+1 种基金the Climate Change and Climate Variability Research in Monsoon Asia (CMON3)from the National Research Council of Thailand (NRCT) (Grant No.N10A650844)the National Natural Science Foundation of China (NSFC).
文摘Tunnel heading stability in two dimensions(2D)has been extensively investigated by numerous scholars in the past decade.One significant limitation of 2D analysis is the absence of actual tunnel geometry modeling with a considerable degree of idealization.Nevertheless,it is possible to study the stability of tunnels in three dimensions(3D)with a rectangular shape using finite element limit analysis(FELA)and a nonlinear programming technique.This paper employs 3D FELA to generate rigorous solutions for stability numbers,failure mechanisms,and safety factors for rectangular-shaped tunnels.To further explore the usefulness of the produced results,multivariate adaptive regression spline(MARS)is used for machine learning of big dataset and development of design equations for practical design applications.The study should be of great benefit to tunnel design practices using the developed equations provided in the paper.
基金the National Natural Science Foundation of China(grant No.62174013,92265111)Central Government Guides Local Funds for Science and Technology Development(No.YDZJSX2022A021)the funding Program of BIT(grant No.3180012212214 and 3180023012204).
文摘Two-dimensional(2D)transition metal chalcogenides(TMCs)hold great promise as novel microwave absorption materials owing to their interlayer interactions and unique magnetoelectric properties.However,overcoming the impedance mismatch at the low loading is still a challenge for TMCs due to the restricted loss pathways caused by their high-density characteristic.Here,an interface engineering based on the heterostructure of 2D Cr_(5)Te_(8) and graphite is in situ constructed via a one-step chemical vapor deposit to modulate impedance matching and introduce multiple attenuation mechanisms.Intriguingly,the Cr_(5)Te_(8)@EG(ECT)heterostructure exhibits a minimum reflection loss of up to−57.6 dB at 15.4 GHz with a thin thickness of only 1.4 mm under a low filling rate of 10%.The density functional theory calculations confirm that the splendid performance of ECT heterostructure primarily derives from charge redistribution at the abundant intimate interfaces,thereby reinforcing interfacial polarization loss.Furthermore,the ECT coating displays a remarkable radar cross section reduction of 31.9 dB m^(2),demonstrating a great radar microwave scattering ability.This work sheds light on the interfacial coupled stimulus response mechanism of TMC-based heterogeneous structures and provides a feasible strategy to manipulate high-quality TMCs for excellent microwave absorbers.
基金part of“Research on Contemporary Chinese Outlook on Human Rights,”a major project of the Marxist theoretical research and development project(Project Approval Number 2O23MZDO25)“Research on the New Form of Chinese Human Rights Civilization,”a key project of The National Social Science Fund of China(Project Approval Number 21AZDO095)the Jilin University Philosophy and Social Science Research Innovation Team’s“Theoretical Interpretation and Discourse Shaping of the Chinese Human Rights Road”(Project Approval Number 2022CXTD05)。
文摘Human beings are the mainstay and the ultimate goal of civilization.The history of human civilization is a continuous struggle to realize the respect,liberation,protection,and development of humanity.Human rights are an achievement of humanity and a symbol of progress,and the human rights civilization is an important component of human civilization.Understanding and interpreting human rights from the perspective of human rights civilization means that human rights are not only a concept or an idea but also a grand historical and long-term social practice.Up to now,the development of human rights civilization has roughly experienced four awakening eras:initialization,revolution,popularization,and globalization.In terms of its value dimensions,it has the characteristics of progressiveness,diversity,commonality,inclusiveness,indivisibility,openness,and so on.The historical position of human rights civilization and the development of its value dimensions have shown to the world that human rights are the common wealth of humanity,and human rights belong to all mankind;human rights are historical,concrete,and developmental;the concept of human rights is constantly evolving,and its connotations and categories are constantly expanding;achieving the free and well-rounded development of every person is the highest value realm of human rights civilization.The Chinese modernization endows Chinese civilization with modern strength and opens up new horizons for human rights civilization.The new pattern of human rights civilization to be created by Chinese modernization not only possesses the common characteristics of human rights civilization but also enjoys Chinese characteristics based on its own national conditions,enriching and developing the diversity of human rights civilization for all mankind.
基金supported by:Fondazione Telethon-Italy(No.GGP19128 to AP)Fondazione Cariplo-Italy(No.2021-1544 to RC)+14 种基金Fondazione Italiana di Ricerca per la Sclerosi Laterale Amiotrofica(AriSLA)-Italy(No.MLOpathy to APTarget-RAN to AP)Association Française contre les Myopathies-France(AFM Telethon No.23236 to AP)Kennedy’s Disease Association-USA(2018 grant to RC2020 grant to MG)Ministero dell’Universitàe della Ricerca(MIUR)-Italy(PRIN-Progetti di ricerca di interesse nazionale(No.2017F2A2C5 to APNo.2022EFLFL8 to APNo.2020PBS5MJ to VCNo.2022KSJZF5 to VC)PRIN-Progetti di ricerca di interesse nazionale-bando 2022,PNRR finanziato dall’Unione europea-Next Generation EU,componente M4C2,investimento 1.1(No.P2022B5J32 to RC and No.P20225R4Y5 to VC)CN3:RNA-Codice Proposta:CN_00000041Tematica Sviluppo di terapia genica e farmaci con tecnologia a RNA(Centro Nazionale di Ricerca-CN3 National Center for Gene Therapy and Drugs based on RNA Technology to AP)Progetto Dipartimenti di Eccellenza(to DiSFeB)Ministero della Salute,Agenzia Italiana del Farmaco(AIFA)-Italy(Co_ALS to AP)Universitàdegli Studi di Milano(piano di sviluppo della ricerca(PSR)UNIMI-linea B(to RC and BT).
文摘Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock proteins.HSPB8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and migration.HSPB8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective autophagy.In line with this function,the pro-degradative activity of HSPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and aggregation.In cancer,HSPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under investigation.Moreover,HSPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar hemorrhage.Of note,HSPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other diseases.This is the case of cognitive impairment related to diabetes mellitus,in which HSPB8 exerts a protective activity by assuring mitochondrial homeostasis.This review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions,focusing on the beneficial effects of its modulation.Drug-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.
文摘We develop a cosmological model in a physical background scenario of four time and four space dimensions ((4+4)-dimensions or (4+4)-universe). We show that in this framework the (1+3)-universe is deeply connected with the (3+1)-universe. We argue that this means that in the (4+4)-universe there exists a duality relation between the (1+3)-universe and the (3+1)-universe.
基金Supported by the Natural Science Foundation of Jiangsu Province(BK2005018)the Graduate Research and Innovation Plan of Jiangsu Province(CX07B-061Z)~~
文摘Different from the previous qualitative analysis of linear systems in time and frequency domains, the method for describing nonlinear systems quantitatively is proposed based on correlated dimensions. Nonlinear dynamics theory is used to analyze the pressure data of a contrarotating axial flow fan. The delay time is 18 and the embedded dimension varies from 1 to 25 through phase-space reconstruction. In addition, the correlated dimensions are calculated before and after stalling. The results show that the correlated dimensions drop from 1. 428 before stalling to 1. 198 after stalling, so they are sensitive to the stalling signal of the fan and can be used as a characteristic quantity for the judging of the fan stalling.
基金Supported by National Natural Science Fund Program(40705038)~~
文摘[Objective] The aim was to discuss the spatial pattern changes of land use in Tianjin new coastal area based on fractal dimensions.[Method] By dint of remote and geographic information system technology to obtain the data of urban land use in new coastal area from 1993 to 2008,the boundary dimension,radius dimension and information dimension of each land use type were calculated based on fractal dimension.In addition,the revealed land use spatial dimension changes characteristics were analyzed.[Result] The spatial distribution of each land use type in new costal area had distinct fractal characteristics.And,the amount and changes of three types of dimension values effectively revealed the changes of complicatedness,centeredness and evenness of spatial pattern of land use in the study area.The boundary dimension of unused land and salty earth increased incessantly,which suggested its increasing complicatedness.The boundary of the port and wharf and shoal land was getting simpler.The radius dimension of the cultivated land was larger than 2,which suggested that its area spread from center to the surroundings;the one in salty land and waters distributed evenly within different radius space to the center of the city;the one in other land use types reduced gradually from center to the surroundings.The information dimension value in the woodland and orchard land,unused land and shoal land was small,and was in obvious concentrated distribution;the spatial distribution of cultivated and salty land concentrated in the outside area;the construction area in the port and wharf spread gradually on the basis of original state;the spatial distribution of waters and residents and mines were even.[Conclusion] Applying fractal dimensions to the study of spatial pattern changes of urban land use can make up for some disadvantages in classical urban spatial pattern quantitative research,which has favorable practical value.
基金Supported by the National 863 Plan Foundation under Grant No.2003AA414060
文摘The present status of self-elevating drilling units was analysed. Based on statistics of the main dimensions of self-elevating drilling units, a mathematical model was established using stepwise return procedures and a back-propagation neural network. mathematical model is applicable and reliable. The of the main dimensions of self-elevating drilling Analysis of examples of calculations showed that the model is useful for mastering the essential variations units and can be used for technical and economic analysis as well as in conceptual designs of drilling units.