The joint Laplace transforms for killed diffusion occupation times

The approach of Li and Zhou(2014)is adopted to find the Laplace transform of occupation time over interval(0,a)and joint occupation times over semi-infinite intervals(-∞,a)and(b,∞)for a time-homogeneous diffusion process up to an independent exponential time e_(q)for 0<a<b.The results are expressed in terms of solutions to the differential equations associated with the diffusion generator.Applying these results,we obtain explicit expressions on the Laplace transform of occupation time and joint occupation time for Brownian motion with drift.

A Comparison of Turnaround-Times for Two Popular Specimen Types Used for Newborn Toxicology: Meconium and Umbilical Cord Tissue

Background: Prenatal exposure to illicit substances is responsible for several long-term negative health consequences. It is critical for healthcare professionals to know the extent and scope of prenatal substance exposure in their cases. Several studies exist with mixed results comparing the effectiveness of umbilical cord tissue (UCT) and meconium (MEC) as toxicology specimen types. The specific aim of this study is to compare the use of UCT and MEC regarding the time interval between the birth of the neonate, receipt of the specimen at the laboratory, and the hospital’s receipt of the final toxicology report. Method: The study queried de-identified results of 5358 consecutive UCT and 706 MEC from our laboratory. Results: The mean time from birth to receipt of the specimen at the laboratory for MEC and UCT was 4.5 days ± 2.9 days and 2.8 days ± 1.9 days, respectively. The mean time from birth to final report for MEC was 6.9 days ± 3.8 days, 5.7 days ± 3.3 days, and 8.4 days ± 3.8 days for all MEC specimens, negative MEC, and positive MEC, respectively. The mean time from birth to final report for UCT was 4.3 days ± 2.4 days, 3.5 days ± 2.2 days, and 5.4 days ± 2.2 days for all UCT, negative UCT and positive UCT, respectively. Discussion/Conclusion: Receipt of drug test results of the neonate prior to release from the hospital is critical. This study shows that UCT offers an advantage when results are needed quickly to make informed decisions about the health and well-being of newborns.

Characterization of Hydroxyapatite Extracted from Crab Shell Using the Hydrothermal Method with Varying Holding Times

Hydroxyapatite(HA)is a bio ceramic commonly utilized in bone tissue engineering due to its bioactive and osteoconductive properties.Crab shells are usually disregarded as waste material despite their significant CaCO_(3) content,and have not been widely utilized in the synthesis of HA.This study aims to synthesize and analyze HA derived from crab shells using the hydrothermal method with different durations of holding time.This study utilized precipitated calcium carbonate(PCC)derived from crab shells.With a hydrothermal reactor set at 160℃ and varying holding times of 14(HA_14),16(HA_16),and 18(HA_18)h,a PCC and(NH4)2HPO4 mixture was used to synthesize HA.The synthesis results were analyzed using scanning electron microscopy(SEM),fourier transform infrared spectroscopy(FTIR),and X-ray diffraction(XRD)tests.This study has accomplished the synthesis of HA from crab shells.Nonetheless,the final product of synthesis still contained CaCO_(3) as an impurity.The prolonged hydrothermal holding time of 14 to 18 h resulted in a reduction of impurities while increasing the percentage of crystal weight and crystallite size of HA.Specimen CH_18 is the best-quality product generated in this study.This specimen produced HA with the highest percentage of crystal weight and crystallite size compared to the other specimens.Furthermore,specimen CH_18 exhibited the lowest concentration of impurities.The Ca/P ratio in this specimen was also the closest to 1.67.The Ca/P ratio,crystallite size,and crystal weight percentage of this specimen are 1.54,19.06 nm,and 99.1%,respectively.

Picturing the Times

A man with his face painted to appear like a spirit,participates in the He Neak Ta ritual in Phum Boeung village,northwest of Phnom Penh,Cambodia,on June 11.Cambodian villagers took part in a rare traditional guardian spirit ceremony praying for good fortune,rain,and prosperity as part of efforts to preserve this ancient tradition.

Trends of the Times

BUILDING a resilient workforce of the future means understanding your workers.Over the past five years,the Adecco Group has interviewed over 82,000 employees across 25 countries-including China-to capture global workers’perspectives and equip employers with the tools to future-proof their workforce.These are some of the findings about the labor market trends that have transformed the world of work since 2020。

Picturing the Times

Girls with flowers on their heads at a celebration for the traditional Ngarot festival in West Java,Indonesia,on December 13,2023.The festival is a traditional ceremony to welcome the rice planting season.

Achieving Common Development in Step with the Times

As long as China and the EU adhere to strategic consensuses,keep in step with the times,and maintain mutual trust,they will be able to ensure the prosperity and stability of both sides.

Picturing the Times

On September 25,locals and tourists pose for photos with a giant decorative flower basket on Tiananmen Square in Beijing to celebrate the forthcoming National Day.The four Chinese characters adorning the basket mean"blessing the motherland."(IC PHOTO)

Picturing the Times

Cherry blossoms at Qingchuan Pavilion in Wuhan,capital of central China’s Hubei Province,attract throngs of visitors on March 23.Illuminated by night lights,the cherry blossoms shone brightly,creating fantastic scenes of light and shadow with neon-clad bridges and landmark buildings along the Yangtze River.

Picturing the Times

Tourists sightsee on a boat in a massive lotus pond scenic area in Xinghua,Taizhou,east China’s Jiangsu Province,on August 5.When summer peaks,lotus flowers enter their blooming season,attracting throngs of tourists to admire their beauty.

Optimal Multi-Timescale Scheduling of Integrated Energy Systems with Hybrid Energy Storage System Based on Lyapunov Optimization

The economic operation of integrated energy system(IES)faces new challenges such as multi-timescale characteristics of heterogeneous energy sources,and cooperative operation of hybrid energy storage system(HESS).To this end,this paper investigates the multi-timescale rolling opti-mization problem for IES integrated with HESS.Firstly,the architecture of IES with HESS is established,a comparative analysis is conducted to evaluate the advantages of the HESS over a single energy storage system(SESS)in stabilizing power fluctuations.Secondly,the dayahead and real-time scheduling cost functions of IES are established,the day-ahead scheduling mainly depends on operation costs of the components in IES,the real-time optimal scheduling adopts the Lya-punov optimization method to schedule the battery and hydrogen energy storage in each time slot,so as to minimize the real-time average scheduling operation cost,and the problem of day-ahead and real-time scheduling error,which caused by the uncertainty of the energy storage is solved by online optimization.Finally,the proposed model is verified to reduce the scheduling operation cost and the dispatching error by performing an arithmetic example analysis of the IES in Shanghai,which provides a reference for the safe and stable operation of the IES.

RL and AHP-Based Multi-Timescale Multi-Clock Source Time Synchronization for Distribution Power Internet of Things

Time synchronization(TS)is crucial for ensuring the secure and reliable functioning of the distribution power Internet of Things(IoT).Multi-clock source time synchronization(MTS)has significant advantages of high reliability and accuracy but still faces challenges such as optimization of the multi-clock source selection and the clock source weight calculation at different timescales,and the coupling of synchronization latency jitter and pulse phase difference.In this paper,the multi-timescale MTS model is conducted,and the reinforcement learning(RL)and analytic hierarchy process(AHP)-based multi-timescale MTS algorithm is designed to improve the weighted summation of synchronization latency jitter standard deviation and average pulse phase difference.Specifically,the multi-clock source selection is optimized based on Softmax in the large timescale,and the clock source weight calculation is optimized based on lower confidence bound-assisted AHP in the small timescale.Simulation shows that the proposed algorithm can effectively reduce time synchronization delay standard deviation and average pulse phase difference.

Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal cord.Here we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord injury.We report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal directions.Such Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder functions.Importantly,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord injury.These findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases

Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative diseases.However,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°C.We aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large cohort.Plasma samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline project.These samples were stored at-80°C for up to 6 years before being used in this study.Our results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage time.However,the level of total tau showed a negative correlation with sample storage time.Notably,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage time.This was not observed in individuals with cognitive impairment.Consequently,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage time.Therefore,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's disease.Furthermore,in cohort studies,it is important to consider the impact of storage time on the overall results.

基于TimeSVD++与DPC的推荐算法研究

针对使用奇异值分解(SVD)方法时需要填充矩阵的内容较多以及K-means算法受到K值的影响且数据集形状限制等问题,提出一种将TimeSVD++与改进的密度峰值聚类结合的方法。首先在SVD++的基础上引入参数时间因子,构建TimeSVD++模型;其次,采用将相似系数引入高斯核函数的方法,对密度峰聚类算法中的局部密度公式进行修正;引入信息熵确定最优截断距离,最后在数据集MovieLens-1M和MovieLens-100k上验证,并将实验结果与其它算法进行对比。结果表明:所提出的方法在MAE,RMSE,Recall和F1值指标上均优于其它的算法。

基于TIMES模型的北京市节能减排分析

为研究北京市未来节能减排的政策措施,以国际上流行的综合能源优化模型TIMES(The Integrated MARKAL-EFOM System)为分析工具,构建了北京市节能减排数据库,设计了基准情景和包含清洁能源改造、建筑节能及提高能效的深度节能减排情景,并对不同情景下的节能减排进行了对比和分析.结果显示,当前的能源效率和能源结构不能满足北京市节能减排的要求和能源环境的发展目标,大范围实行清洁能源改造和建筑节能才能有效控制能耗,减少大气污染排放.

高被引还是零被引:基于论文被引的最佳科研合作规模研究--来自Financial Times TOP 45商学院期刊的证据

近年来,科研论文的合著现象及其与论文影响力之间的关系受到广泛关注。本文以1997—2013年Financial Times TOP 45商学院国际期刊论文为研究对象,对作者数量与论文被引(高被引还是零被引)之间的关系进行实证研究,从论文影响力方面揭示商学领域是否存在最佳科研合作规模。研究发现:①与单独作者相比,多作者合作对论文总被引频次具有显著的正向影响,而且多作者合作论文成为高被引的概率更高,而成为零被引的概率更低;②作者数量与论文总被引频次之间存在显著的倒U形关系;进一步研究发现,作者数量与高被引论文概率呈倒U形关系,而与零被引论文概率呈正U形关系,且转折点均约为3人,表明商学领域存在使论文成为高被引而避免成为零被引的最佳合作规模;③分时间阶段实证结果表明,基于高被引和零被引的论文最佳合作规模逐步由2~3人增加至3~4人。

基于TIMES模型的客运交通低碳化研究——以北京市为例

为研究低碳城市环境下居民的客运交通出行,以综合能源优化模型——TIMES(The Integrated MARKALEFOM System)模型为分析工具,构建客运交通模型。该模型考虑了出行成本、出行选择行为、碳减排目标等的影响,同时以北京市为例,设计基准情景和3个参考情景并对不同情景进行分析和讨论。结果显示:当减少出行时间投资成本非常高时,居民很大程度上通过小汽车来满足居民出行需求。在CO2排放限制情景下,小汽车出行需求不断下降,道路公交和轨道交通出行需求稳步上升。基于上述结果得出北京市客运交通低碳化发展的对策和建议:即调控出行需求结构;优化交通出行结构;调整交通能源结构;完善交通治理结构。

Times管理方案在心内科护士多参数心电监护仪警报疲劳中的应用

探讨Times管理方案在心内科护士多参数心电监护仪警报疲劳中的应用效果,以提高护士临床警报知识水平,改善警报管理态度和行为,减轻护士的警报疲劳,降低心电监护仪错误警报发生率。

基于情绪ABC理论的正念训练对PCI患者的应用研究

目的探讨基于情绪ABC理论的正念干预对冠心病经皮冠状动脉介入治疗(PCI)术后患者的应用效果。方法选取2022年收治的80例冠心病PCI术后患者,随机分为试验组和对照组,每组40例。对照组给予心内科常规治疗与护理,试验组在常规护理的基础上给予基于情绪ABC理论的正念训练。分别于干预前、干预2个月后、干预6个月后评价患者的心肺功能[6 min步行距离(6 MWD)]、睡眠[匹兹堡睡眠质量指数(PSQI)]、焦虑抑郁[焦虑自评量表(SAS)、抑制自评量表(SDS)]、心脏不良事件的发生情况。结果干预前,2组患者6MWD、PSQI评分、SAS、SDS评分比较,差异均无统计学意义(P>0.05);干预2个月和6个月后,试验组6MWD、PSQI、SAS、SDS评分均优于对照组,差异有统计学意义(P<0.05);干预6个月后,2组患者心脏不良事件发生率比较,差异无统计学意义(P>0.05)。重复测量方差分析结果显示时间效应、组间效应、交互效应均有统计学意义(P<0.05)。结论基于情绪ABC理论的正念训练可提高患者的睡眠质量,改善负性情绪,提升心肺功能,值得临床推广应用。